Posted 23 November 2016 - 11:58 AM
So at our follow up after the funded cycle failure they really didn't have an answer for fertilization failure. I had AFC 36, triggered a day early with 12 mature eggs, 1 fertilized. RE said
ICSI failure is usually egg quality but didn't feel that drugs were wrong as I briefly was pregnant. I was on bcp/suprefact suppression, 150iu gonal-f that was dropped to 125 part way through and still developed
OHSS. Only theory was meds impacted egg quality??? but really no specific evidence to back it up. We have isolated MFI as far as they know.
Second round same suppression, dropped gonal-f 125iu to prevent overstim and added 75 luveris to boost egg quality. Gonal-f was increased to 200iu after second u/s as response seemed too low. AFC 18 and only 9 follicles reached above 15mm. Only 3 eggs retrieved 2 mature 0 fertilized. Our only hope at this point is that the protocol and dosages that they are using with me are destroying egg quality. I also think there is a problem with Ovidrel trigger as I am ending up with a low number of retrieved eggs compared to follicle count.
We moved our follow up with current clinic to Jan as we are not in a hurry to go back and want another opinion on things first. I know they won't have an answer for us or want to explore further testing. Hopefully Hannam or Markham can give us some answers or ideas for moving forward. At this point we are just working on accepting that we will not have children and setting goals for our life moving forwards. When is your follow-up?
Me:33 DH:37 Dx MFI
Ottawa Fertility Centre:
IUI#1 Feb 2016: gonal-f/centrotide
1.5mil post wash BFN
IUI#2 April 2016: gonal-f/centrotide
400,000 post wash BFN
IVF#1 July 2016:long agonist protocol(bcp/suprefact, gonal-f 150iu, Ovidrel)
AFC 28, 12 retrieved 8 mature, 1 fertilized with ICSI BFP ended in CP
IVF #2 Nov 2016:long agonist protocol(gonal-f 125 iu and luveris 75 added)
AFC 18, 3 eggs retrieved 2 mature, total ICSI failure
Hannam Fertility:
IVF#3 July 2017: Antagonist protocol( gonal-f, menopur, centrotide, double lupron trigger)
AFC 32, 17 eggs retrieved, 14 mature 6 eggs frozen as back up, 8 PICSI 3 fertilized and arrested at morula/stage 2 blast.
IVF#3.5 Thawed 6 eggs for fertilization with PICSI and AOA. 2 out 6 thawed, 1 fertilized and arrested day 3.
Final diagnosis of severe male factor with sperm head defect and unexplained egg cytoplasm dysfunction. Moving onto known embryo donation!
Create Fertility (Donor Embryos):
FET#1: December 2018 BFN
FET#2: February 2018 BFP