Posted 24 July 2016 - 02:40 PM
I'm just dabbling with low dose gonal f and trigger (fully monitored of course) while I'm waiting for IVF 2.5 in September. It's so funny how using clomid, letrozole, or injectables used to be such a huge deal to me, but now I think nothing of it. If it wasn't for the $$$, IVF doesn't even feel like a big deal anymore.
Anyway, I was listening to an RE on a podcast, and she said taking progesterone the day after ovulation is too early (which is in almost every IUI protocol). She said it slows down the cilia in the fallopian tubes, and can increase the chances of an ectopic. She also said it should only be taken around the time of implantation, because taking it too soon can turn on the receptivity genes in the uterine lining too early (while the embryo is still in the tubes). Apparently the receptive uterus is only good for 24-48 hours, so the window can be totally missed even with a healthy embryo.
I've been doing the progesterone 1dpo for every cycle, but I'm considering doing it 3/4 dpo. Does anyone know any more about this? If there's some truth to this, it's very strange that virtually every protocol I've seen has us taking it 1dpo.
Me: 37, amh 11.9 pmol, AFC 14-26 depending on month
FSH 7-12 (12 happened one random time after a lot of meds. It's usually around 7)
Compound heterozygous for MTHFR
DH: 42, SA is perfect and DNA frag completely normal
TTC since July 2014
Many many rounds of meds (clomid, fsh, letrozole), 4 IUIs, 5 chemicals but nothing more
IVF #1 (Feb 2016):
BCPs 3 weeks, 450IU gonal, 75 IU luveris, and Cetrotide as antagonist
Cancelled because 6 lead follicles were over 1.5 cm after only 3 days of stims!
Should've kept going because I ended up with 12 follicles and estradiol was 11,000.
Obviously they wouldn't let me try naturally, but kind of wish I did. This process is draining
IVF #1.2 (March 2016):
Natural Start. Same protocol as above and same thing happened.
6 lead follicles took off and were over 1.5 cm by day 3 (wonder if this is d/t high dosage)
12 follicles, 6 retrieved, 4 mature, all 4 fertilized
3 perfect by day 3, all arrested by day 5, nothing to transfer
IVF #2 (November 2016)
Switched clinics to Create.
Currently in full workup. Doing immunology and clotting testing, along with hysteroscopy to r/o anything other RE may have missed
Will have natural start, and do letrozole with 275IU gonal F
UPDATE October 2016: Natural BFP while waiting to start IVF in November. We're floored!
1st Beta 685 at 16dpo
2nd Beta 2468 at 19dpo
3rd Beta 5445 at 22dpo
4th Beta 11,618 at 25dpo (why on earth is my RE doing so many Betas?!)
U/S 6w4d: perfectly on schedule. HB 132. RE said there's only a 5% miscarriage rate at this point!
U/S 10w3d: growth still on schedule. HB 173.
Harmony results came back. Looks like a healthy GIRL!!!