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immune issues and miscarriage

IVF miscarriage

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5 replies to this topic

#1 ReadyandWaiting

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  • Gender:Female
  • Dx:Male Factor

Posted 10 March 2016 - 01:36 PM

Has anyone had experience with autoimmune issues and miscarriage? I am reading a lot about it and I even mentioned it to my RE at last visit and asked if we should be testing for it and/or if I should be taking anything... background: my dad has autoimmune issues and takes an injection for severe rheumatoid arthritis. I have now had two transfers with 3 high grade embryos (1 at fresh transfer, 2 at FET) and got a positive beta both times only to lose the pregnancies very early - biochemicals.


Anyway, my RE promptly told me not to worry and it's all 'witchcraft theories' with no real scientific backing. He says my situation has simply been bad luck. But the more I read, the more I understand why low dose prednisone (5-10mg) is being automatically added to many IVF programs in North America. Prednisone is a corticosteroid and lowers immune function - hence your body not rejecting or attacking the embryo. 


Any insight you may have would be great.



Me:38 Hubs:54

Unexplained/possible male factor - great count and motility, borderline morphology (5%)

IUI x 3, two cancelled (over responded to Gonal F), one completed: BFN


IVF #1 August 2015 - First EVER BFP! Turned out to be a chemical... hey, at least I actually got pregnant!

FET Nov 2015 - BFP! ... another chemical 


IVF #2 April 2016 - here we go! 

ET - April 11 (2 5d blasts)

5dp5dt - th_abfp.gif on FRER

11dp5dt Beta #1 - 235

15dp5dt Beta #2 - 1320


Plus THREE high quality embryos on ice... 







#2 annatarz79

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  • Dx:Unexplained

Posted 10 March 2016 - 01:48 PM

I really dont know if it is related. i have been tested negative for autoimmune issues and i have had 7 chemicals. so who knows. in 3 of my chemicals i was on medication the whole time for autoimmune even though i dont have it and stil... i had chemicals. 

#3 annatarz79

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  • Dx:Unexplained

Posted 10 March 2016 - 01:50 PM

oh i was also told to check if i have celiac disease. recent studies said that it might cause chemical pregnancies. this is treated with gluten free diet. good luck and if you find something out let me know please.

#4 mrshyatt0843

  • Just Hatched
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  • Dx:Tubal
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Posted 10 March 2016 - 04:36 PM

Wobenzym is a really awesome natural remedy for women who have an autoimmune disorder that causes miscarriage. 



*Note - link removed re advertising

#5 chickenfarmgirl

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  • Dx:DOR
  • My Clinic:Toronto West

Posted 04 April 2016 - 02:43 PM

You have to be your own advocate.  If you think there might be an autoimmune disorder then I would trust your gut.  I am so sorry about what your RE said.  It is tough to switch REs but can you get your family Dr to send you to a hematologist for tests??  



Warning - kids mentioned


I had recurrent miscarriages and was diagnosed with an autoimmune disorder (lupus anticoagulant) and DOR at 29 after much advocating.  All my losses were early, 2 had heartbeats.  My original Dr told me I was young and to keep trying until we got it right!  Multiple times i was tested for blood clotting disorders and each time the results were different.  I started working with acupuncturist who specialized in infertility.  Turns out my high estrogen was to blame for the multiple miscarriages and autoimmune it is called estrogen dominance.  My diet got a complete overhaul with no dairy, wheat or refined sugar.  I also did organic as such as possible and followed the blood type diet which actually coincided with the recommendations from my acupuncturist and where I was weak.  We also started IVF.  


Once I got a positive pg test, I started taking low dose aspirin and I was put on heparin at 3 months until delivery with both kids.  


*Note - outside link removed.  Re advertising.

#6 Dr. Dan Nayot

Dr. Dan Nayot
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Posted 10 April 2016 - 09:09 AM

HI ReadyandWaiting,


You touched on a hot subject in the infertility world - autoimmune.


We are still in the infancy stage of learning many aspects about autoimmunity and infertility - how to investigate? diagnose? treat?


I believe I touched on this subject in a previous thread. There are some well documented / researched areas of auto-immunity (e.g.. Hashimotos thyroiditis, Lupus, APAS, etc), but many sub-types that we know very little about. I think if it there is a strong family and personal history of autoimmunity, it is definitely worth exploring the options with your REI, Naturopath, etc.




-D. Nayot

EXECUTIVE BOARD MEMBER  - Infertility Awareness Association of Canada (IAAC) 
Twitter: @DrDanNayot

Also tagged with one or more of these keywords: IVF, miscarriage