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Outcome of FET (slow freeze embryos)


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#1 Lindsey

Lindsey
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Posted 26 March 2015 - 10:01 AM

Hi ladies,

 

We are gearing up to do a FET this cycle and I have so many questions!  There is no formal literature at the clinic so I'm curious to know of your outcome, or outcomes of those you know that cycled at AART.

 

Embryos / blasts were frozen using the slow freeze method in 2012 and prior.  I'm slightly upset they transitioned to vitrification for freezing the year after we cycled, as I questioned this so many times and we would have waited, given the awesome outcomes for thaw rate, and pregnancy success with a vitrified embryo / blast.

 

Anyhow - getting off topic!

 

I've been told loosely that success with a slow-freeze blastocyst is about 20%.

 

I have 4 frozen blasts.  19/20, 18/20, 15/20 and 14/20.  I really can't decide if we should transfer 1 or 2.  If the freezing was done via vitrification, then we would only choose 1.  But, because it was slow freeze - and the success rates are much lower, I am torn over transferring 1 or 2 . . .we would like to reduce the risk of multiples but still achieve a positive outcome . . .

 

Any insight?  If you did a FET, how many did you thaw, how many survived, how many transferred and what was the outcome?  You are welcome to share your age if relevant (I'm in my early 30's, my siggie is outdated).

 

Thanks, all.

 

Lindsey


Me: 29 Hubby: 35

TTC #1 since August 2008 (5 years)

My homepage: http://www.fertilityfriend.com/home/Lindseyspage

Me: DX blocked tubes in July 2009 - Right tube opened with pressure, left tube remained blocked. DX mild endometriosis (stage II) during LAP in January 2013 - much of the endo was cauterized.

Him: DX bilateral varicoceles in August 2010 - surgery successful (we have MFI issues - morphology at 2-3%)Karotyping, blood work, diagnostic tests - all normal

Pregnancies: 8+ (many chemicals) - all natural, 1 in 2010 (3 months post-op for DH) and 6 in 2011, a few early chemicals in 2012/2013. All ended in miscarriage.

Recurrent Pregnancy Loss: unexplained. 1 baby passed at 10 weeks due to Triploidy, 68 XXX -21.

Clomid: 8 cycles (BFN), COH +IUI - 1 cycle, BFN

AART - Halifax, NS - IVF w/ ICSI #1 - August 2012.  Great response, excellent lining, 14 eggs retrieved.  13 eggs mature, and 12 fertilized.  All had excellent grades until Day 5 - Day 5, we were left with 5 good ones, graded 20/20 (hatching), 19/20 (expanded), 18/20 (expanded) and 15/20, 14/20.  One 20/20 blast transferred (we wanted to transfer 2, but RE recommended one) and 4 frozen, resulting in a BFN.  DH and I devastated, and exploring international adoption and further immune testing / treatment. 

I requested another LAP to see if anything has changed (mild endo found and cauterized Jan. 2013).

BFP!! - April 2013 - 3 months post-LAP and on a Letrozole (Femara) cycle (natural cycle, no trigger, normal BD).  Faint BFP very early, at 7 DPO (a full week before AF was due) - earliest BFP yet!

Betas:  11 DPO = 115, 13 DPO = 305, 15 DPO = 795 (31 and 34 hour doubling time)

2 ultrasounds in May show baby measuring 2-3 days ahead with great HB!  NT Scan on June 13, 2013.

 

L4g6m3.png

 


#2 EMJRI

EMJRI
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  • Interests:Any Maritime Ladies (or gents) that would like to join a support group I started, please PM me. We have over 230 amazing ladies from all over the maritimes.
  • Dx:Tubal
  • My Clinic:AART

Posted 26 March 2015 - 10:08 AM

Hey Lindsey 

I can't be of much help but we did a FET in July 2012, they were also frozen the old way and they were both 19/20 grade. we had them frozen on Feb 14th 2012 (so they were only in there for a few months, not that that actually matters lol) but neither survived the thaw. We only had 2 to freeze so we decided to go with both being thawed.

Carolynn D. did a FET the same week I did my last fresh cycle and she now has her handsome little boy. I'm not sure on how many were thaw or put back but hers were done the old way as well. (maybe she could give you some sight)

 

All the best on the FET :)

Emily  


Me: 31 years old

DH: 31 years old

TTC: 8 years

 

Plan A - IVF #1 Jan 2012           Ectopic 

 

Plan B - FET #1 July 2012         Embryos didn't make the thaw
 

Plan C - IVF #2 Feb 2013          Brax born December 7th 2013. 

 

Plan D - IVF #3 April 2016         BFN

 

Plan E - FET #2 Aug 2016         BFP Due April 22, 2017

 

 

 

 

 

 

 
 

 
 

 


#3 Lindsey

Lindsey
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  • Location:Nova Scotia
  • Interests:Cooking, Research, All sports, Yoga, spending time with family and friends, movies, traveling
  • Dx:Male Factor
  • My Clinic:AART Halifax

Posted 26 March 2015 - 10:31 AM

Thank you so much, Em!

 

I really appreciate the reply. I may try to send a message to Carolynn to see if she would be willing to share her success story.

 

I remember you creating a FB group for AART - would you happen to know if any ladies that are members of the group did a FET?  I'm fishing for some stories! :)

 

I'm leaning towards thawing the 19/20 and the 14/20 blast . . hoping both make it, and if yes, transferring both.  Or if one makes it, transferring the one.  It's such a tough decision when I don't have the facts in front of me.  With 8 miscarriages, there is either some chromosomal or implantation / immune issue going on so I'm wondering if I should take that into consideration and go for transferring two, if possible . . this is not easy and I'm quite torn at the moment.

 

I'm so happy you got your beautiful, healthy and handsome little man.

 

Lindsey


Me: 29 Hubby: 35

TTC #1 since August 2008 (5 years)

My homepage: http://www.fertilityfriend.com/home/Lindseyspage

Me: DX blocked tubes in July 2009 - Right tube opened with pressure, left tube remained blocked. DX mild endometriosis (stage II) during LAP in January 2013 - much of the endo was cauterized.

Him: DX bilateral varicoceles in August 2010 - surgery successful (we have MFI issues - morphology at 2-3%)Karotyping, blood work, diagnostic tests - all normal

Pregnancies: 8+ (many chemicals) - all natural, 1 in 2010 (3 months post-op for DH) and 6 in 2011, a few early chemicals in 2012/2013. All ended in miscarriage.

Recurrent Pregnancy Loss: unexplained. 1 baby passed at 10 weeks due to Triploidy, 68 XXX -21.

Clomid: 8 cycles (BFN), COH +IUI - 1 cycle, BFN

AART - Halifax, NS - IVF w/ ICSI #1 - August 2012.  Great response, excellent lining, 14 eggs retrieved.  13 eggs mature, and 12 fertilized.  All had excellent grades until Day 5 - Day 5, we were left with 5 good ones, graded 20/20 (hatching), 19/20 (expanded), 18/20 (expanded) and 15/20, 14/20.  One 20/20 blast transferred (we wanted to transfer 2, but RE recommended one) and 4 frozen, resulting in a BFN.  DH and I devastated, and exploring international adoption and further immune testing / treatment. 

I requested another LAP to see if anything has changed (mild endo found and cauterized Jan. 2013).

BFP!! - April 2013 - 3 months post-LAP and on a Letrozole (Femara) cycle (natural cycle, no trigger, normal BD).  Faint BFP very early, at 7 DPO (a full week before AF was due) - earliest BFP yet!

Betas:  11 DPO = 115, 13 DPO = 305, 15 DPO = 795 (31 and 34 hour doubling time)

2 ultrasounds in May show baby measuring 2-3 days ahead with great HB!  NT Scan on June 13, 2013.

 

L4g6m3.png

 


#4 EMJRI

EMJRI
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  • Gender:Female
  • Location:Halifax
  • Interests:Any Maritime Ladies (or gents) that would like to join a support group I started, please PM me. We have over 230 amazing ladies from all over the maritimes.
  • Dx:Tubal
  • My Clinic:AART

Posted 26 March 2015 - 10:48 AM

No problem hun,

If you want I can add you to the group, there are two groups - the AART one I created and theres one that another created its call "life after AART" its for all of us who finally have a baby, maybe not from a cycle. there are a few of us in both groups are are planning to cycle again and do either FET or IVF. (let me know if you'd like to be added to either groups or both).

 

It really is such hard decision to make, and with having so many miscarriages it might be easier knowing you went with two but that would be me thinking (I also always wanted to put back two, so I'm basis lol)

thank you, he's been great to us and we are in the process of trying again - well the planning stages, we were going to do a FET a few months ago but put our house up for sale and had to put baby making on hold for a few months.

 

And your little man, tiny but adorable as ever!!

Emily


Me: 31 years old

DH: 31 years old

TTC: 8 years

 

Plan A - IVF #1 Jan 2012           Ectopic 

 

Plan B - FET #1 July 2012         Embryos didn't make the thaw
 

Plan C - IVF #2 Feb 2013          Brax born December 7th 2013. 

 

Plan D - IVF #3 April 2016         BFN

 

Plan E - FET #2 Aug 2016         BFP Due April 22, 2017

 

 

 

 

 

 

 
 

 
 

 


#5 EverHopefull!

EverHopefull!
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Posted 26 March 2015 - 11:27 AM

Hi Lindsey,

 

This past November we did an FET with one highly graded day 5 blastocyst that was frozen in October 2010 (we only had one, if we had two I would have transferred both).  Our RE told us there was a 70% chance it would survive the freeze/thaw process.  She also told us the odds of success were the same as they were when it was frozen, rather than what the odds would be for us today with a fresh cycle (which would be less because I went and aged 4 years darn it!).  So for us that was 50% chance of success (based on my age 4 years ago). 

 

Unfortunately it didn't work out for us, but I wanted to let you know that according to my RE the odds might be much higher than 20% (based on your age). 

 

Good luck!


  • EMJRI likes this

TTC since December 2004

One successful IVF

Many, many unsuccessful IF treatments

Finally a successful DE cycle!  babyEver is due July 1st.

 


#6 babsicle

babsicle
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  • Gender:Female
  • Dx:Unexplained
  • My Clinic:genesis

Posted 26 March 2015 - 11:33 PM

Hi!

I am currently 19 weeks pregnant from a fet in Dec. We only transferred 1, frozen using the old method in April 2013 (I had my beautiful daughter from that fresh cycle). It can work!!!!!!!
Me 33 DH 32
Ttc since april 2011
April 2013 started first ivf (and hopefully only)
April 4- started menopur and bravelle (primed with estrace for a week first)
April 8- e2 @240, bravelle upped
April 10- e2 @ 840, dosages stay the same. Several follies seen on left, only one on right. Orgulatran started today.
April 12- e2 @ 2026, dosages stay the same, back on sunday for more bloodwork and an u/s. More follies seen today, most are around 11mm. Dr. N says not done cooking yet, keep up with the stims:)
April 14- e2 @5060, trigger tomorrow night!!!!!
April 15- trigger at 11 pm :)
April 16- Drug free day :)
April 17-egg retrieval (6 eggs)
April 18-fertilization report! 5/6 eggs fertilized with ivf
April 20-Day 3: all 5 embryos looking great! All 8-10 cells, 4 A graded and 1 B graded. Pushing on to day 5.
April 22- Day 5: one blast transferred, lining is exceptional. 2 emby's frozen, 2 more growing overnight that might be frozen tomorrow!
April 23-clinic phoned today, the other two blasts were too low quality to freeze :(
April 27- 5dp5dt bfn
April 28- 6dp5dt bfp (squinter)........very bloated
April 29- 7dp5dt bfp (still a squinter).........even more bloated
April 30- 8dp5dt beta=101
May3- 11dp5dt beta = 244
May 6- 14dp5dt beta= 835
May 10-18dp5dt= 4760
May 22- first u/s showing one perfect bean measuring exactly on track! Hb 125 :)
Jan 7 2014- happy healthy baby girl born via emergency c section

Fet#1-december2014(all natural last minute decision)
Nov 13- phone consultation to start the process
Nov 20- ultrasound to see if fet is a go
Nov 22- start opk testing
Nov 28-positive opk
Dec 1- progesterone starts daily
Dec 3- day 5 fet (only one thawed)
Dec 8- 5dp5dt very very faint bfp
Dec 9- 6dp5dt still very faint bfp
Dec 10- 7dp5dt darker bfp
Dec 11- 8dp5dt darker bfp
Dec 12- 9dp5dt bfp on digital
Dec 15- 12dp5dt beta 388
Dec 17- 14dp5dt beta 763
Dec 26- 23dp5dt beta 21172
Dec 27- u/s 6 weeks 1 day heart beat of 125
Jan 9- u/s 8 weeks, measuring at 8 weeks 2 days with heart beat of 160!
Feb 3- u/s 11 weeks 4 days, measuring 11 weeks 6 days. HB 163.
March 25- u/s at 18 weeks 5 days. Baby looked healthy and it's a girl:)
August 9th 2015- heathy baby girl born via c-section at 38 weeks. 7 pounds 11 ounces.

Our hearts are full :)

#7 Lindsey

Lindsey
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  • 170 posts
  • Gender:Female
  • Location:Nova Scotia
  • Interests:Cooking, Research, All sports, Yoga, spending time with family and friends, movies, traveling
  • Dx:Male Factor
  • My Clinic:AART Halifax

Posted 27 March 2015 - 09:29 AM

Em - thanks so much for adding me to the FB groups - much appreciated!  I hope you will be able to cycle again soon, I know how tricky it is when things get in the way, not to mention the financial aspect.

 

Everhopeful - thanks so much for replying!  I'm glad to know the stats may be a bit higher than what my RE quoted me - to be frank, it was a very rushed appointment and I'm not quite sure the stats she quoted me were accurate (she was running 2 hours behind and the appointment was pretty flustered).  I really hope the stats are higher for a 5-day, highly graded frozen blast, as long as it survives the thaw without too much damage.  I see you cycled at VFC!  That's my hometown - I was going to cycle with Dr. Hudson in 2013 (long-distance) - great clinic.  I see you're in the TWW and wishing you much success!  Will you be testing soon?

 

Babsicle - your story gives me hope!  Huge congrats on your BFP with the lone FET!  Were you are Genesis or was through through AART?  I see you just had an ultrasound and all looks well, you must be thrilled - I'm so happy for you.  Stories like yours make me think transferring one can and may lead to success.

 

If the clinic permits, I may try to just thaw the one 19/20 blast and see how it fares and if all good, do a single frozen transfer, but only if my stats are greater than 25-30% . . .if low chance of success, we may thaw two and put two back.  I keep going back and forth - it's such a difficult decision.

 

My hope is that I become pregnant naturally and find out in the TWW while I'm on suprefact, during down regulation.  I've heard of this happening; however, I would be concerned as I would be "sniffing" for a few days and messing around with my hormones, but I have read many positive outcomes so you just never know . . .


Me: 29 Hubby: 35

TTC #1 since August 2008 (5 years)

My homepage: http://www.fertilityfriend.com/home/Lindseyspage

Me: DX blocked tubes in July 2009 - Right tube opened with pressure, left tube remained blocked. DX mild endometriosis (stage II) during LAP in January 2013 - much of the endo was cauterized.

Him: DX bilateral varicoceles in August 2010 - surgery successful (we have MFI issues - morphology at 2-3%)Karotyping, blood work, diagnostic tests - all normal

Pregnancies: 8+ (many chemicals) - all natural, 1 in 2010 (3 months post-op for DH) and 6 in 2011, a few early chemicals in 2012/2013. All ended in miscarriage.

Recurrent Pregnancy Loss: unexplained. 1 baby passed at 10 weeks due to Triploidy, 68 XXX -21.

Clomid: 8 cycles (BFN), COH +IUI - 1 cycle, BFN

AART - Halifax, NS - IVF w/ ICSI #1 - August 2012.  Great response, excellent lining, 14 eggs retrieved.  13 eggs mature, and 12 fertilized.  All had excellent grades until Day 5 - Day 5, we were left with 5 good ones, graded 20/20 (hatching), 19/20 (expanded), 18/20 (expanded) and 15/20, 14/20.  One 20/20 blast transferred (we wanted to transfer 2, but RE recommended one) and 4 frozen, resulting in a BFN.  DH and I devastated, and exploring international adoption and further immune testing / treatment. 

I requested another LAP to see if anything has changed (mild endo found and cauterized Jan. 2013).

BFP!! - April 2013 - 3 months post-LAP and on a Letrozole (Femara) cycle (natural cycle, no trigger, normal BD).  Faint BFP very early, at 7 DPO (a full week before AF was due) - earliest BFP yet!

Betas:  11 DPO = 115, 13 DPO = 305, 15 DPO = 795 (31 and 34 hour doubling time)

2 ultrasounds in May show baby measuring 2-3 days ahead with great HB!  NT Scan on June 13, 2013.

 

L4g6m3.png

 


#8 babsicle

babsicle
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  • 67 posts
  • Gender:Female
  • Dx:Unexplained
  • My Clinic:genesis

Posted 27 March 2015 - 10:44 AM

I live on Vancouver island and have done all cycling with genesis. Thank you for the well wishes. My clinic has only ever been willing to transfer one (for both our fresh and fet cycles) so the choice was out of our hands. Best of luck to you whatever you decide to do:)
Me 33 DH 32
Ttc since april 2011
April 2013 started first ivf (and hopefully only)
April 4- started menopur and bravelle (primed with estrace for a week first)
April 8- e2 @240, bravelle upped
April 10- e2 @ 840, dosages stay the same. Several follies seen on left, only one on right. Orgulatran started today.
April 12- e2 @ 2026, dosages stay the same, back on sunday for more bloodwork and an u/s. More follies seen today, most are around 11mm. Dr. N says not done cooking yet, keep up with the stims:)
April 14- e2 @5060, trigger tomorrow night!!!!!
April 15- trigger at 11 pm :)
April 16- Drug free day :)
April 17-egg retrieval (6 eggs)
April 18-fertilization report! 5/6 eggs fertilized with ivf
April 20-Day 3: all 5 embryos looking great! All 8-10 cells, 4 A graded and 1 B graded. Pushing on to day 5.
April 22- Day 5: one blast transferred, lining is exceptional. 2 emby's frozen, 2 more growing overnight that might be frozen tomorrow!
April 23-clinic phoned today, the other two blasts were too low quality to freeze :(
April 27- 5dp5dt bfn
April 28- 6dp5dt bfp (squinter)........very bloated
April 29- 7dp5dt bfp (still a squinter).........even more bloated
April 30- 8dp5dt beta=101
May3- 11dp5dt beta = 244
May 6- 14dp5dt beta= 835
May 10-18dp5dt= 4760
May 22- first u/s showing one perfect bean measuring exactly on track! Hb 125 :)
Jan 7 2014- happy healthy baby girl born via emergency c section

Fet#1-december2014(all natural last minute decision)
Nov 13- phone consultation to start the process
Nov 20- ultrasound to see if fet is a go
Nov 22- start opk testing
Nov 28-positive opk
Dec 1- progesterone starts daily
Dec 3- day 5 fet (only one thawed)
Dec 8- 5dp5dt very very faint bfp
Dec 9- 6dp5dt still very faint bfp
Dec 10- 7dp5dt darker bfp
Dec 11- 8dp5dt darker bfp
Dec 12- 9dp5dt bfp on digital
Dec 15- 12dp5dt beta 388
Dec 17- 14dp5dt beta 763
Dec 26- 23dp5dt beta 21172
Dec 27- u/s 6 weeks 1 day heart beat of 125
Jan 9- u/s 8 weeks, measuring at 8 weeks 2 days with heart beat of 160!
Feb 3- u/s 11 weeks 4 days, measuring 11 weeks 6 days. HB 163.
March 25- u/s at 18 weeks 5 days. Baby looked healthy and it's a girl:)
August 9th 2015- heathy baby girl born via c-section at 38 weeks. 7 pounds 11 ounces.

Our hearts are full :)

#9 EverHopefull!

EverHopefull!
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  • Gender:Female
  • Dx:Unexplained
  • My Clinic:Genesis/VFC

Posted 01 April 2015 - 12:19 PM

Hi Lindsey - I'm cycling with VFC right now, but my FET (from my 2010 IVF) was at Genesis in Vancouver.  We moved to the Island so it makes more sense to go to VFC.  I liked Genesis, but I'm pretty happy not having to take the ferry back and forth!  And I really love Dr G at VFC!

 

Yes, I did a home test yesterday (I have no will power) and it came back negative.  It was only 7dp3dt though, so it was silly for me to be testing.  My beta isn't until Monday April 6th.  I will try my best not to home test again before then.   Happily I wasn't upset at all by it, I just have a good feeling about this cycle!  Hopefully that isn't just Dr. G's calming influence!!


TTC since December 2004

One successful IVF

Many, many unsuccessful IF treatments

Finally a successful DE cycle!  babyEver is due July 1st.

 


#10 CloverGirl

CloverGirl
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  • Dx:Unexplained
  • My Clinic:AART

Posted 22 November 2015 - 07:13 PM

Hi ladies, 

Thanks for sharing your experiences. I am currently in the same boat - considering a FET in 2016. We also froze embryos (2) with slow freeze process. One was not developing on schedule so really we feel we have one 15/20. I have just contacted the clinic for information as I haven't found much on their website. We no longer live in NS either so we'll be flying in for transfer if the embryo survives the thaw. Just trying to decide if we're certain we want to do this again but the window is closing, so it's forefront on our minds! I haven't been able to find reliable thaw rates either…it varies so much by clinic!

 

Best of luck to all of you :)


Me: 39 DH: 40
Unexplained IF
TTC #1 since Jan 2006
9 unsuccessful rounds of Clomid
IVF #1 April/May 2008, 2blasts transferred

BFP June 2008 - Twin Girls :)

Jan 2009, healthy twin girls born at 39 weeks

2015, considering FET with remaining frozen embryo