Heparin treatment - Immune Disorders - IVF.ca Forums

Jump to content



Photo

Heparin treatment


  • Please log in to reply
4 replies to this topic

#1 mountainchick

mountainchick
  • Global 100+
  • 614 posts
  • Gender:Female
  • Location:British Columbia
  • Dx:Other
  • My Clinic:VFC

Posted 28 March 2014 - 03:59 PM

Hi there

 

I am getting ready to do a FET in April and just got my protocol. I have Hashimotos (with really high thyroid antibodies right now). I have family members with autoimmune issues too (Type 1 diabetes, alopecia, rheumatoid arthritis).

 

I wanted the "kitchen sink" approach with my next FET, so I am getting intralipids, Medrol, and Fragmin (until week 12) for adjunctive therapy. My RE said I didn't need Neupogen since I am taking the Fragmin.

 

I am wondering if any of you had the fragmin/heparin treatment with no history of APA or blood clotting disorders? I was tested in 2012 for immune issues, and I was negative for ANA and APA. Can this change for APA? I know my thyroid antibodies can be normal sometimes, and then sky rocket.

 

Does the heparin/fragmin only help with anti-phospholipid antibodies or does it have some other immune benefits as well? I am having second thoughts about taking the heparin if I previously tested negative for ANA and APA. But I will consider taking it if there are other immune benefits.

 

Thanks for any input. I will be asking my RE about this as well.

 


TTC since I was 28; Started fertility treatments at 35.

Dx: Male factor, Hashimotos, fibroids

April 2011-13 eggs retrieved: all dead except 1 immature egg that was ICSI'd; no embryos to transfer

Switched from Calgary RFP to VFC

IVF#2: November 2012, donor egg cycle- chemical pregnancy

FET#1: Feb 2013- m/c @ 6 weeks

Sept 2013: Abdominal myomectomy done. Giant fibroids removed with my uterus intact! I love Dr. Allaire!

January 2014: Surrogacy- FET cycle, BFN.

FET#2: May 2014-BFP

May 26 beta=335,  May 28 beta=812, May 30 beta=2004          

Baby girl born January 2015 heart.gif


#2 Lisa1995

Lisa1995
  • 1000+
  • 1417 posts
  • Gender:Female
  • Location:Toronto
  • Dx:Unexplained
  • My Clinic:was Lifequest, now Markham

Posted 28 March 2014 - 04:15 PM

Funny Mountainchick, you were able to answer my intralipids question for me (thanks btw!) and I can tell you about my experience with Lovenox (blood thinner)! I am ANA and APA negative but the blood tests I had done in the US (they don't even test for this in Canada) showed that I do have 2 clotting disorders - Factor XIII and PAI-1 mutations and 2 heterozygous mutations of MTHFR for all of these a blood thinner is indicated for treatment. I took Lovenox until around 26 weeks.


TTC #1: starting in Feb 2005 "unexplained" (immune issues, elevated NK cells, 2 heterozygous MTHFR and 2 heterozygous thrombophilias - Factor XIII and PAI-1 mutations)
me-42, DH-42, married since 1995!
Tried: Naturopath, Chinese herbs, Acupuncture, Homeopathy
4 un-medicated IUI's BFN
IVF # 1 18 eggs retrieved, 16 mature, 8 out of 16 fertilized (1/2 ICSI, half IVF), 5 made it to day 5 blast, transferred two, froze 3
first ever BFP m/c
FET #1 medicated, transferred two, started spotting 2 days later, full blown AF 5 days later (decided I don't react well to Estrace, will do natural frozen next time) BFN
FET #2 natural (but still with progesterone (crinone) support, transferred last blast from IVF #1 BFN
IVF #2 16 eggs retrieved, decided not to do ICSI this time since cycle #1 showed eggs could fertilize on their own, only 3 fertilized! None made it to blast for transfer no transfer! Disaster!
IVF #3 decided to add some repronex to the stims and do all ICSI. 18 eggs, 17 mature and 15 fertilized, 8 made it to day 5 blast. Transferred two blasts, froze 6 BFN
FET#3 added 3 HCG booster shots and doubled up on the crinone to prevent me from spotting early (as I often do), transferred 2 blasts, no spotting but a BFN anyway
FET #4- added ovidral just before my natural ovulation so they could pin point it more accurately with the 36 hour window, HCG shots again, plus double crinone BFN
January 2009 Consult with new RE in Markham - he finds a small septum, resected April 29, 09 - tells me to now try my last two frozen blasts
FET #5 - ET scheduled for June 15 (natural cycle with trigger, HCG booster and crinone) - BFN
On to Plan B- Switch clinic to Markham for
#4 Fresh IVF with IVIg, exploring immune testing - start BCP Sept 20. ER around week of Oct. 25
9 eggs retrieved, 1 immature, 1 fractured. 7 to work with. 4 out of 7 fertilized (Day 3: 1 8 cell grade 1, 2 8 cell grade 2 and 1 morula). Day 5 transferred 1 great blast and 1 morula (1 morula and 1 10 cell did not make it to freezing).
Beta Nov. 11 - BFP! (550) I am in shock!
Issues with spotting, Nov 20, second beta 11,000 and early ultrasound: saw gestational sac and yolk sac in the right place but concern about a cyst or possible ectopic near my ovary as well, 4 more ultrasounds over a 10 day period, last ultrasound on Dec. 2 'cyst' has not grown and baby measuring on target at 7wks, 1day with a heart beat of 153bpm.
Now taking Lovenox due to 2 heterozygous thrombophilias
Ultrasound on Dec. 18 (9 weeks, 5 days) baby on track, hb 167
Ultrasound on Dec. 22 due to extra heavy spotting, baby still measuring on track, hb 167 and dancing
Ultrasound on Jan. 8 (12 weeks, 5 days) baby on track, hb 160, baby doing crunches!
18 week anatomy scan scheduled for Feb. 16 - they lost my blood work for the second part of the IPS so no results for that today (they took blood again) but the 18 week scan went great, baby looked awesome and even gave us a little wave in between sucking her thumb and inspecting her toes. Yes, I said "her" - it's a little girl!
20 week ultrasound at Mt. Sinai and they agree, so far so good.
IPS results are in and they are excellent!
EDD: July 19, 2010
Baby girl arrived at 39 weeks, 2 days! July 14, 2010 3:12 am, weighing 7 pounds even.
May 2013 - The IVF Journey continues...one last try to see if a sibling is in the cards...
Did LIT, IVIg, Lovenox and low dose aspirin. 5 eggs retrieved, 1 immature, 1 fractured, 3 to work with, 2 fertilized with ICSI.
June 5, day 3 transfer of 2 8 cell grade 2 embryos.BFN
April 2014, one very last try - natural IVF with intralipids this time, 2! dominant follicles, 2 mature eggs retrieved, both fertilize with ICSI, day 3 transfer scheduled for April 13, transferred 1 8-cell grade one and 1 6-cell grade one (also using Lovenox and low dose ASA) -BFN, we are really done, not sure if it is now my immune system, or old eggs now too.


#3 mountainchick

mountainchick
  • Global 100+
  • 614 posts
  • Gender:Female
  • Location:British Columbia
  • Dx:Other
  • My Clinic:VFC

Posted 28 March 2014 - 04:44 PM

Thanks Lisa! My clinic called me and said that not only does Fragmin help with APA, but it is also used as an immune therapy (helping to suppress or calm the immune system) in conjunction with the intralipids and Medrol.

 

I've always wanted to have further testing done through the Alan Beers centre, but never did. I know I likely have other immune issues, but at least I am working with an RE who supports immune therapy.


TTC since I was 28; Started fertility treatments at 35.

Dx: Male factor, Hashimotos, fibroids

April 2011-13 eggs retrieved: all dead except 1 immature egg that was ICSI'd; no embryos to transfer

Switched from Calgary RFP to VFC

IVF#2: November 2012, donor egg cycle- chemical pregnancy

FET#1: Feb 2013- m/c @ 6 weeks

Sept 2013: Abdominal myomectomy done. Giant fibroids removed with my uterus intact! I love Dr. Allaire!

January 2014: Surrogacy- FET cycle, BFN.

FET#2: May 2014-BFP

May 26 beta=335,  May 28 beta=812, May 30 beta=2004          

Baby girl born January 2015 heart.gif


#4 KittyKat

KittyKat
  • Global 100+
  • 556 posts
  • Gender:Female
  • Dx:DOR
  • My Clinic:VFC

Posted 28 March 2014 - 11:23 PM

Mountain - I will also be on fragmin for my FET. I have no clotting issues and no "known" immune issues but I am getting the full immune protocol. I have wanted the blood thinners since my natural pregnancy that ended in miscarriage as I had severe clotting issues during that process, 2 weeks later would still pass clots the size of my fist. It was horrible and something deep down just told me I should push for blood clotting treatment, also I wanted the whole shebang for this FET. The only thing we aren't doing is the endometrial scratch but will add that if this one doesn't work, hopefully it does and we don't have to worry about that! I have a girlfriend who used the heparin and was being treated solely for immune so I am pretty sure it is part of the immune therapy! Looks like we will be close with our cycles! Wishing you lots of hood sticky positive vibes!
  • mountainchick likes this
Me - diagnosis RPL/DOR/Egg Quality issue
DH - all good

4+ years TTC - about me page for details

#5 mountainchick

mountainchick
  • Global 100+
  • 614 posts
  • Gender:Female
  • Location:British Columbia
  • Dx:Other
  • My Clinic:VFC

Posted 29 March 2014 - 10:37 AM

Thanks Kitty Kat!  I have been trying to read up on the studies using Heparin with IVF. Your clotting sounds horrible. Will you be taking Fragmin until week 12, or longer?

 

I did the biopsy, but 2 months prior to cycle, so I am not sure it will be that effective. The clinic said it was good for 2 months... I am not going to worry, as I have always had implantation with my transfers. FX. Wishing you all the best with this upcoming cycle too!


TTC since I was 28; Started fertility treatments at 35.

Dx: Male factor, Hashimotos, fibroids

April 2011-13 eggs retrieved: all dead except 1 immature egg that was ICSI'd; no embryos to transfer

Switched from Calgary RFP to VFC

IVF#2: November 2012, donor egg cycle- chemical pregnancy

FET#1: Feb 2013- m/c @ 6 weeks

Sept 2013: Abdominal myomectomy done. Giant fibroids removed with my uterus intact! I love Dr. Allaire!

January 2014: Surrogacy- FET cycle, BFN.

FET#2: May 2014-BFP

May 26 beta=335,  May 28 beta=812, May 30 beta=2004          

Baby girl born January 2015 heart.gif