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Over 40 - what protocol/meds got you pregnant?

over 40 protocol medication estrace priming antagonist

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#1 Wantingour1st

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Posted 25 April 2013 - 02:41 PM

Hi, i'm not sure if many will reply to this but for those over 40 and got pregnant, what protocol did you take and medication?

 

i heard estrace priming, antagonist protocol is good. 

 

this would be: estrace (estrogen) 4mgs, menopur 75, gonal F 300, Ganirelix, ovidrel trigger shot, then prometrium (progesterone).  thanks


me 43, FSH 5, AMH 8.8 pmol/L is "Low Ovarian Reserve" which is 2.3 to 15.7 pmol/L

dh 41, low sperm, good for IVF

 

chance of IVF working because of age: 5% or less

 

we're taking lots of vitamins, (always did but now are taking a few different ones: InnoQnol CoQ10, PQQ, Inositol powder, baby aspirin, Prednisone (cuz i'm MTHFR I did a blood test & shows positive for blood clotting), Synthroid/Eltroxin (for my slightly elevated antibodies to thyroid I got after IVF) DHEA, Melatonin, Folapro (active form of folate), Royal Jelly, Bee Pollen, L’arginine, L’carninitine, Grape Seed, Pycnogenol, Resveratrol, Astaxanthin, NAC, Macca, E, C, D, Chinese Tea, homeopathic detox Unda numbers, weekly acupuncture, No dairy, no wheat, no sugar, everything organic I can find.


#2 Lea

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Posted 25 April 2013 - 03:35 PM

I got pregnant at 41 and if I remember correctly, I was taking, Gonal F, Cetrotide (sp)? Menopur

So I started on day 3 of my cycle with Gonal F (300iu), menopur (150iu), taken for 10-12 days. Cetrotide was taken the last 4-5 days of my stim cycle I believe.

Then 3 days before ET I started taking endometrium.

I got pregnant on this last and final cycle with triplets, miscarried 1 and delivered healthy twins.

Best of luck to you!

Lea
  • gibasgirl likes this
me 42 DH 44
TTC: November 2005
MF: low sperm count

July 2007 #1 IVF & ICSI = BFN
---------------------------------------
2 frosties in the freezer!
FET #1 Jan 25 /08 = BFN
---------------------------------------
May 2008 #2 IVF & ICSI = cancelled
---------------------------------------
July 2008 #2 IVF & ICIS = BFP!!
4 frosties in the freezer.
Our Daughter, Dani, Born April 29, 2009.
----------------------------------------
FET - April 2010 = Fat lady sang....though not the tune i was hoping for - BFN
----------------------------------------
Sept 2010 #3 IVF/ICIS
Synarel check sept 15 - E2 81
B/W sept 19 - E2 430
B/w & u/s sept 22 - E2 2063
B/w & u/s sept 25 - E2 5878
B/w & u/s sept 26 - E2 8282
ER - Sept 28 - 12 eggies
ET - Oct 1..... transfered 3-8 cell grade A
Beta Oct 14 - Fat lady is singing that nasty tune again - BFN
-----------------------------------------
RE follow up November 1st. RE says Dh swimmers are of poor quality and my eggs MAYBE old 'cause i'm 40 (lovely) only way to rule out my egg quality is to try donor sperm.
November 30 - great now i find out my tubes are blocked! frigg!
-----------------------------------------
Jan 2011 #4 IVF
Lupron supression check Jan 20 - E2 - 753 (needs to be under 200)
Jan 25 b/w E2 - 109
Jan 30 b/w - E2 - 714
Feb 1 b/w & u/s - E2 - 1705
Feb 4 b/w & u/s - E2 - 5795
Feb 5 b/w & u/s - E2 - 7946
ER - Feb 7 - 12 eggies
ET - Feb 10....transferred 1-9 cell, 2-8 cell - grades 1 & 2
Beta - Feb 24 14dp3dt - 37
Beta #2 - Feb 26 - 16dp3dt - 85
Beta #3 - Mar 4 - 444 rose by 73%
u/s mar 18 - no sac. no nothing.......beta 791
march 31 - ectopic pregnancy confirmed - thanks fat lady!!!!!
-------------------------------------------
FET Sept 28, 2011
Beta - Oct 13. Oh this Fat Lady - she sucks! BFN
-------------------------------------------
Purchased my ticket for my last & final ride on the rollercoaster!
Nov 2011 IVF/ICIS #5
Nov 25 b/w - E2 - 179
Nov 30 b/w & u/s - E2 - 2196
Dec 3 b/w & u/s - E2 - 4973
Dec 5 b/w & u/s - E2 - 9050
Dec 7 - ER - 9am
Dec 10 - ET - 4 embies.....3-8 cell, 1-7 cell....all Grade 1
Beta - Dec 25, Christmas day!!!!!, Santa, I'm not asking for much.....just a double line!!!
Early beta Dec 22 - 421!! Thank you Santa!
Beta Dec 29 - 2659
U/S - Jan 16 - OMG, TRIPLETS!!!! ALL measuring 7 wks ALL with very strong h/b
U/S - Jan 30 - Triplets doing well. Strong h/b, measuring on track 9+weeks.
Feb 3 - Appt. with High Risk OB - misscarried 1 baby, Twins are strong.
U/S - Feb 10 - Twins are doing well!!
NT Scan Feb 17 - very good Heart beats 160-165
U/S - March 8 - 14 weeks - babies are doing great
U/S - March 30 - 17 weeks - can find out gender........but i passed - i want the ultimate surprise!
U/S - April 19 - 20 Weeks - cervix length - awesome....5.6cm!
U/S - April 27 - 21 weeks - babies are doin' good!
U/S - May 10 - 23 weeks - cervix length 5cm - babies good - heart rates 140 -149.
U/S - May 24 - 25 weeks - check up went well.....confirmed that i will be induced or scheduled c-section for 38 weeks!!
U/S - June 8 - 27 weeks - cervix length still locked and loaded.......5cm babies looking good - baby A 2lb 7oz baby B 2lb 12oz
U/S - June 28 -30 weeks - baby A still bum down and baby b head down.....it's looking like a c-section for me!
U/S - July 13 - 32 weeks - baby A has turned (head down) their weights - baby A 3lbs 15 oz and baby B 4lbs 3oz
U/S - July 23 - 34 weeks - both babies doing well - measuring right on track.
U/S - July 27 - 34 weeks - part 2 - just getting a 'quick' u/s done - babies lookin' good...though, baby B is being squished by baby A.....
U/S - Aug 3 - 35 weeks - induction date decided!! thank goodness - 'cause I am done!!!!!!!!!!!!!!!!!!! Induction date is August 18th - but I am already 2-3cm dialated - so we'll see if I meet 'the date'. Baby A weighs 6 lb 6 oz and baby B is 5lb 15 oz.
U/S - Aug 13 - 37 weeks - still sitting at 3cm dilated - confirmed induction date with L&D August 18th.

This pregnancy has been a long haul and I'm glad that it's nearly over!

Our 2 healthy baby boys arrived on Sunday August 19th - we are thrilled and over the moon......family is finally complete and now we can move on to the next chapter in our lives.......

#3 mouse

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Posted 25 April 2013 - 06:16 PM

I was given a single, precisely timed Cetrotide shot, menopur, bravelle, ganirelix, and trigger for my successful cycle. Due to a mix up between REs, I triggered on day 8 or 9 instead of 10. It was also the cycle I took the fewest supplements and did the most activity. At my first u/s 3 sacs were seen but by 9 weeks it was clear we had one perfect babe.

 

Fingers crossed you, too, find the golden egg!


  • gibasgirl likes this
The plural of anecdote is not data.

Charity gives a meal; justice provides a place at the table.

#4 #[email protected]

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Posted 26 April 2013 - 06:16 PM

Hi!
For me on cycle #3, I was on microdose flare (micro lupron BID) and 450 iu of bravelle.  I did a bunch of extra things but am not convinced they worked.  Exercise and massage seemed to make me feel the best.

Good luck to you.


Me - 44, DH - 45
3 CONSECUTIVE IVF CYCLES AT 43 YEARS OLD = 16 eggs > 13 embryos > 10 transferred > 1 BABY!!!!


Years of anovulation (but this has saved me some eggs for my 40's!) and decreased count/motility.
4 years of trying naturally and tests - then surprise pregnancy in 2003, DD born 11/2003
6 cycles of clomid/iui - BFN, 2 cycles of FSH/IUI - x2 chemical pregnancy, 1 cycle of FSH/IUI - bfp! DS born 08/2006

2009 I decide I want another. Crazy I know - DH has had Vx.
2012 DH finally on board. Has TESE (super ouch).
03/12 and 04/12: FSH = 5, AFC = 4
IVF#1 - June 2012 - long lupron, 300 Bravelle, 150 Menopur, ICSI - 10 follicles, 3 eggs (WTF??), 2 fertilized, transferred 2 Day 3 4-cells - bfn.
IVF#2 - Aug/Sept 2012 - flare, 450 Bravelle, ICSI, 5 eggs, 4 fertilized, transferred 4 (2 8-cell, 2 10-cell) - chemical

IVF#3 - LAST CHANCE FOR ROMANCE![/b]
Oct/Nov 2012 - flare, lupron BID, 450 Bravelle, ICSI
Sept 15 - start BCP
Oct 11 - endo biopsy
Oct 14 - last BCP
Oct 17 - baseline: E2=286, start lupron microdose twice daily
Oct 19 - start 450 Bravelle
Oct 24 - U/S: 7 10mm follicles, bw: E2=964
Oct 26 - U/S, bw 9 follicles (all 10 -16mm), bw: E2=1867, lining: 9mm
Oct 28, u/s, bw 9 follicles (1 @10mm, 7 @16-17mm, 1 @23.5mm), bw: 3600+, lining: 10mm

Oct 29, u/s, bw 9 follicles (1 @12mm, 8 @18-21mm), bw: 5500+, lining: 10mm - trigger AND 450 Bravelle!
Oct 31 - ER 8 eggs!
Nov 1 - 7 fertilised!
Nov 2 - three grade 2 (all 4-cell), two grade 3 (2-cell and 5-cell) and two grade 4 (all 5-cell)
Nov 3 -two grade 2 (all 8-cell), four grade 3 (8-cell and 10-cell) and one grade 4 (6-cell)

Nov 4 - four good morulas, one border-line quality morula, two 10-cell embies
Nov 5 - ET of 2 blasts (2BB, 3BA), one cavitating morula and one other crap morula - NO FROSTIES!

Nov 10 - Day 10 - HPT ---- BFP!
Nov 14 - beta = 78

Nov 16 - beta = 179
Dec 7 - first u/s! 7w2d: CRL=10mm, HR=139
Dec 11 - first appt w/ high risk OB & another in office u/s (all good)
Dec 18 - u/s 8w6d: CRL=21mm, HR=172
Dec 27 - genetic testing and consult
Jan 11 - nuchal testing and IPS with soft markers (FTS) (for fun as will have already done NIPS) - NT=1.19mm = PERFECT
Jan 21 - 13w5d on u/s - we are having a boy!!!!!
July 24 - due! induced on July 6th - healthy, 7 lbs 2 oz at 37w3d - can't believe this happened!!

#5 nettibug

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Posted 28 April 2013 - 09:11 PM

PG at 44 using microdose HCG - ganirelix antagonist protocol (with follistim and menopur, ovidrel trigger) - AND - saizen.  Unfortunately ended with miscarriage but most likely will repeat the same protocol when I can TTC again.


Single with secondary infertility, AMA, DOR, RPL.  TTC started with four failed IUI's.

IVF #1: converted to another IUI after 2 of 10 follies went rogue during stims --> BFN

IVF #2: 6 eggs retrieved, 5 fertilized with ICSI --> 3dt of 4 high grade embryos with AH --> BFN

IVF #3: 6 eggs retrieved, 4 fertilized with ICSI --> vitrified at 2PN (had to put TTC on hold)

IVF #4: 11 eggs retrieved, 9 fertilized with ICSI --> 5dt of 3 blasts  --> th_abfp.gif --> lost HB at 8w4d 8388.gif

IVF #5: 7 eggs retrieved, 6 fertilized with ICSI --> 5dt of 2 blasts --> th_abfp.gif --> missed m/c at 7w3d 8388.gif 

IVF #6: cancelled due to poor response --> IUI --> totally unexpected th_abfp.gif --> chemical 8388.gif

Getting off the IVF train and happily moving on to international adoption

Dossier approved & registered!  Waiting for a referral...  kaffeetrinker_2.gif

Nine months later, still waiting...

 

 






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