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HIGH DNA FRAGMENTATION - DO I HAVE HOPE?

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#1 hope25

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Posted 30 July 2012 - 09:33 AM

Hi everyone,

I'm new to this site/forum. I have heard wonderful things and look forward to having the necessary support and resources I require while going this very scarey and emotionally exhausting process.

DH and I have been TTC for almost 2 years. Through testing we have found out that we have a male factor infertility issue. DH has very low sperm count (3MM) and low motility. We have been referred to a wonderful fertility clinic who continued to do testing to ensure we had the best plan of action in place. Found out DH had high DNA fragmentation from a DNA assay test (45%), however, RE still seems hopeful for pregnancy success.

I have done a lot of research on the internet and have found nothing put negative and poor results which is completely devestating. Has anyone ever had or know of anyone who has had pregnancy success with high fragmentation issues?? DH and I are completely beside ourselves, and want to make sure before we go ahead with the financial/emotional commitment of IVF ICSI we know that we've done all we can do to maximize our success rates.

Thanks for listening to my story.

Me: 30
DH: 31
TTC since July 2011
Dx: MFI [low count/motility/morph] + high DFI @ 39%

IVF/ICSI#1
Protocol: OCP Controlled Antagonist
Dec 25, 2012: Start BCP [Marvelon 21] {26 days}
Jan 12, 2013: Scheduled Endometrial Biopsy
Jan 26, 2013: Treatment Day#1
Feb 6, 2013: Est. Egg Retrieval
Feb 11, 2013: Est. Embryo Transfer

*** Cycle suspended due to polyp growth on uterus **

Feb 1, 2013: Hysterscopy

Feb 16, 2013: Revised Treatment Day #1

Feb 26, 2013: Egg Retrieval [8 retrieved//6 mature//5 fertilized]

Mar 3, 2013: Embryo Transfer [2 blasts//none to freeze]

Mar 18, 2013: th_abfp.gif First Beta hCG = 1215

March 21, 2013:  th_abfp.gif  Second Beta hCG = 3501

April 1, 2013: Ultrasound - 1 beautiful heartbeat! yahoo.gif

 

 


#2 Heregoesnothing

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Posted 30 July 2012 - 10:19 AM

Hi hope and welcome. I wish I could offer you a positive story, but i am still waiting for mine as well! We suspect that my DH has DNA fragmentation since our fertilization rates using ICSI are very low (35% instead of the regular 75%). We have not done the DNA frag. test as it would change very little for us in terms of treatments. We are from Qc - so we have 3 rounds covered by health care... We will be using up our 3 tries regardless of the results from DNA frag. test.

Firstly, if your RE hasn't recommended donor sperm, then I think that's a great indicator that you guys still have a chance to conceive with the help of IVF and ICSI. What I've found concerning MF is that Canada is lagging behind considerably in terms of technological advancements. There are two procedures which are used almost everywhere ELSE in the world!!! - IMSI (instead of ICSI) - Where they use a very powerful microscope to better select sperm. This technique is better than ICSI and is great for severe MF. Also, there's another technique called PICSI... Though I don't think it's as good as IMSI, this is technique in which they perform ICSI and after put sperm in a petri dish that has some sort of protein solution. The sperm that stick to the protein solution are said to be the sperm which can penetrate the egg. I've been emailing back and forth with a clinic from Prague who use this technique... I was informed that it would increase fertilization rates by 5%... So I'm not sure how 'good' of a technique it is. But, some food for thought!

I'm not sure if your insurance will cover any of your treatment costs, but given that you already have to pay quite a lot of money to perform IVF, you might want to look into international/ abroad IVF... or keep it on the back burner incase you need it! Some of these clinics certainly seem to be way ahead of the game!

Anyways, good luck! Keep me posted with regards to what you choose to do!

May 2013 - We welcome our baby boy 

Nov. 28th 2015 - We welcome our baby girl

 

3 day 3 embryos on ice 

 

For a more detailed look on my cycles, visit my 'about me' page


#3 hope25

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Posted 30 July 2012 - 10:35 AM

Thank you 'heregoesnothing', I really appreciate your response and your feedback. I'm so sorry to hear your struggles and wish you and your DH a little miracle soon.

My benefits only cover up to 80% of fertility medication, up to $3,000 per lifetime - so in otherwords, I got nada! Which is why I want to make sure I'm covering all my angles before I dive into an IVF treatment where the odds are stacked against us.

My RE hasn't suggested donor sperm at the moment for the mere fact that we haven't gone through an IVF treatment yet. My eggs are of good quality so my RE anticipates success due to the fact that I may produce a lot of eggs and better our odds - but truthfully I'm scared of failure.

If you don't mind me asking, what is your DH's DNA Frag. percentage?

Me: 30
DH: 31
TTC since July 2011
Dx: MFI [low count/motility/morph] + high DFI @ 39%

IVF/ICSI#1
Protocol: OCP Controlled Antagonist
Dec 25, 2012: Start BCP [Marvelon 21] {26 days}
Jan 12, 2013: Scheduled Endometrial Biopsy
Jan 26, 2013: Treatment Day#1
Feb 6, 2013: Est. Egg Retrieval
Feb 11, 2013: Est. Embryo Transfer

*** Cycle suspended due to polyp growth on uterus **

Feb 1, 2013: Hysterscopy

Feb 16, 2013: Revised Treatment Day #1

Feb 26, 2013: Egg Retrieval [8 retrieved//6 mature//5 fertilized]

Mar 3, 2013: Embryo Transfer [2 blasts//none to freeze]

Mar 18, 2013: th_abfp.gif First Beta hCG = 1215

March 21, 2013:  th_abfp.gif  Second Beta hCG = 3501

April 1, 2013: Ultrasound - 1 beautiful heartbeat! yahoo.gif

 

 


#4 Heregoesnothing

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Posted 30 July 2012 - 10:45 AM

We didn't do the test, so we don't know... we just suspect because out of 13 eggs retrieved, only 5 fertilized using ICSI. DH's sperm is affected on all angles... he has low everything! But is not considered severe. ICSI is supposed to bypass all of this. And because I have 13 mature eggs, they don't think it's an egg quality issue.

I think your RE is right though, the more eggs you produce the better. You learn so much after doing one cycle. It helps to guide you in IVF #2 if needed.

Does 45% mean that 45% of his sperm is 'not good'? Not sure how it all works.

May 2013 - We welcome our baby boy 

Nov. 28th 2015 - We welcome our baby girl

 

3 day 3 embryos on ice 

 

For a more detailed look on my cycles, visit my 'about me' page


#5 hope25

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Posted 30 July 2012 - 10:52 AM

Yes... 45% means that 45% of my DH sperm is fragmented and in most cases will not be able to fertilize the egg. They say that anything less than 10% is said to be 'normal'. We are quite devestated by these results.

Me: 30
DH: 31
TTC since July 2011
Dx: MFI [low count/motility/morph] + high DFI @ 39%

IVF/ICSI#1
Protocol: OCP Controlled Antagonist
Dec 25, 2012: Start BCP [Marvelon 21] {26 days}
Jan 12, 2013: Scheduled Endometrial Biopsy
Jan 26, 2013: Treatment Day#1
Feb 6, 2013: Est. Egg Retrieval
Feb 11, 2013: Est. Embryo Transfer

*** Cycle suspended due to polyp growth on uterus **

Feb 1, 2013: Hysterscopy

Feb 16, 2013: Revised Treatment Day #1

Feb 26, 2013: Egg Retrieval [8 retrieved//6 mature//5 fertilized]

Mar 3, 2013: Embryo Transfer [2 blasts//none to freeze]

Mar 18, 2013: th_abfp.gif First Beta hCG = 1215

March 21, 2013:  th_abfp.gif  Second Beta hCG = 3501

April 1, 2013: Ultrasound - 1 beautiful heartbeat! yahoo.gif

 

 


#6 Heregoesnothing

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Posted 30 July 2012 - 11:17 AM

Well, I am hopeful for you. This means that 55% of it is good! So, maybe your fertilization rates will be like mine - but we were still able to transfer 2 embryos. I am currently doing a cycle again right now. I will let you know how it goes. I have meet with many, many RE's and not one of them told me that we didn't have a chance. Given that I am healthy everyone is really optimistic. Remember that ICSI helps choose the best, so it should bypass his poor numbers, and low motility.

Have you done all the tests on your side to ensure that all is in order? Might not be a bad idea. Also, I'm a BIG believer in second opinions. You're in TO. Take advantage of it. Sometimes, just speaking with other Dr's helps you understand better what's going on, and they might even suggest things that other Drs don't. You have nothing to lose!

Is DH on the famous cocktail of vitamins?
  • gibasgirl likes this

May 2013 - We welcome our baby boy 

Nov. 28th 2015 - We welcome our baby girl

 

3 day 3 embryos on ice 

 

For a more detailed look on my cycles, visit my 'about me' page


#7 hope25

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Posted 30 July 2012 - 11:49 AM

Yes - I really pray that we will have success in the future. I have done all necessary tests needed and all came back great. No issues to be concerned with. As for the vitamin cocktail - yes DH recently purchased a slu of them over the weekend - hoping that they'll make some difference.

Also, my DH has an appt with the urologist on Aug 17 to review his results and provide his feedback on how he thinks he can improve his numbers, or figure out if there's anything causing this. My DH is fit/30 years old/eats well/very active/comes from a highly fertile family - we are just beside ourselves wondering how this has happened or what is the cause.

Me: 30
DH: 31
TTC since July 2011
Dx: MFI [low count/motility/morph] + high DFI @ 39%

IVF/ICSI#1
Protocol: OCP Controlled Antagonist
Dec 25, 2012: Start BCP [Marvelon 21] {26 days}
Jan 12, 2013: Scheduled Endometrial Biopsy
Jan 26, 2013: Treatment Day#1
Feb 6, 2013: Est. Egg Retrieval
Feb 11, 2013: Est. Embryo Transfer

*** Cycle suspended due to polyp growth on uterus **

Feb 1, 2013: Hysterscopy

Feb 16, 2013: Revised Treatment Day #1

Feb 26, 2013: Egg Retrieval [8 retrieved//6 mature//5 fertilized]

Mar 3, 2013: Embryo Transfer [2 blasts//none to freeze]

Mar 18, 2013: th_abfp.gif First Beta hCG = 1215

March 21, 2013:  th_abfp.gif  Second Beta hCG = 3501

April 1, 2013: Ultrasound - 1 beautiful heartbeat! yahoo.gif

 

 


#8 If at first

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Posted 30 July 2012 - 12:17 PM

Hope25: I am in a similar situation, but my husband has 72% fragmentation, with everything else on the SA above average. We are so confused. He is 32 and very fit, doesn't smoke or have any of the other indicators.

Our RE didn't seem to dwell on it very much-we are doing our first medicated IUI cycle right now and she never mentioned ICSI for us. I also have some thin lining issues from a past surgery so we are focusing on thickening it.

I don't have an answer but I am going to bring this up at our next appointment. I will keep you posted of any news, and please do the same!

Journey on 'about me' page

 


#9 hope25

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Posted 30 July 2012 - 12:29 PM

ifatfirst... IUI was brought up for us but not suggested. My DH also suffers from low sperm count and motility and the probability of success through IUI is not favorable and I personally do not want to go through the added emotional stress. My RE believes the best successful outcome for us is through IVF ICSI so that he can choose the sperm to use to increase our chances.

Has your husband met with a urologist to look into the possible reasoning behind his high %? Perhaps something they can do to reduce it? Do you know if he has a veriocle vein?

Ive also heard that for high DNA fragmentation, it is sometimes prefered to surgically remove the sperm, as sometimes it becomes fragmented once it leaves the testicles?

I will definitely continue to keep you updated with any progress or news I may have.

Me: 30
DH: 31
TTC since July 2011
Dx: MFI [low count/motility/morph] + high DFI @ 39%

IVF/ICSI#1
Protocol: OCP Controlled Antagonist
Dec 25, 2012: Start BCP [Marvelon 21] {26 days}
Jan 12, 2013: Scheduled Endometrial Biopsy
Jan 26, 2013: Treatment Day#1
Feb 6, 2013: Est. Egg Retrieval
Feb 11, 2013: Est. Embryo Transfer

*** Cycle suspended due to polyp growth on uterus **

Feb 1, 2013: Hysterscopy

Feb 16, 2013: Revised Treatment Day #1

Feb 26, 2013: Egg Retrieval [8 retrieved//6 mature//5 fertilized]

Mar 3, 2013: Embryo Transfer [2 blasts//none to freeze]

Mar 18, 2013: th_abfp.gif First Beta hCG = 1215

March 21, 2013:  th_abfp.gif  Second Beta hCG = 3501

April 1, 2013: Ultrasound - 1 beautiful heartbeat! yahoo.gif

 

 


#10 If at first

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Posted 30 July 2012 - 04:50 PM

Hope:
I actually called my dr office today to confirm the #s, and yes, his DNA frag analysis showed 72% abnormal. I only spoke to our secretary, not the doctor, so I didn't get a chance to ask any questions.
She truly did not dwell on this at our last meeting, which is so confusing to me based on what I am reading online.

I wonder if REs are hesitant to move directly to IVF without trying IUI first at my clinic? Maybe my own issues are mroe serious and she wants to work on them first?

Since she didn't spend too much time on it in our appointment, we never discussed him seeing a urologist. All she said was that he could take a mixture of vitamins that might be helpful.

What I keep reading in my own research is that sperm can be drastically improved with these vitamins and acupuncture and that three months is generally the turnaround time for new sperm to be generated.

Journey on 'about me' page

 


#11 If at first

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Posted 30 July 2012 - 04:52 PM

I want to add that I wish I knew the seriousness of this result before starting my IUI cycle because it's such an incredible emotional roller coaster and I feel completely defeated having learned this... we haven't even done the IUI itself yet!

Journey on 'about me' page

 


#12 Heregoesnothing

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Posted 30 July 2012 - 05:33 PM

If at first, if your RE has considered IUI, it's because your numbers are good enough! In my case, DHs numbers are too low. Remember that they do a sperm wash in IUI, and you have good swimmers! The fast ones (AKA: the healthy ones) will make it to the egg on their own.

BTW: my DH is also very healthy! He has a small varicose vein which we haven't really thought about until today and this thread! I made an appointment with the urologist again to see if it's worth the surgery. She had told,us the first time that she didn't think it would make a difference, but since our fertilization rates are so low, the surgery could possibly help with at least that. If it means 1 or 2 more embryos, I'm in! Also, my DH has 3 uncles who have had a difficult time getting pregnant. So, there's definitely a genetic component.

May 2013 - We welcome our baby boy 

Nov. 28th 2015 - We welcome our baby girl

 

3 day 3 embryos on ice 

 

For a more detailed look on my cycles, visit my 'about me' page


#13 hope25

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Posted 30 July 2012 - 07:45 PM

Ifatfirst... I think if you're going to put yourself through this emotional roller coaster you try and maximize your odds to fullest capability and then just have faith. Is your hubby taking vitamins to help reduce his DNA fragmentation? I have a list that has been suggested by my RE that I can give to you. I've heard of cases where they've dropped almost 20% - and daily ejaculations believe or not is also supposed to help. But have faith and things will work out - you're in my thoughts - keep me updated on your journey.

Heregoesnothing - you're absolutely right - I think every little bit helps - and it never hurts to get a different point of view and get information from a specialist who actually specializes in this stuff - the surgery may not increase numbers or motility but it should help with the quality. My brother in law had the surgery and he later went on to conceive on the first cycle of IUI. Keep me posted and I really hope you get the answers you're looking for!!!

Me: 30
DH: 31
TTC since July 2011
Dx: MFI [low count/motility/morph] + high DFI @ 39%

IVF/ICSI#1
Protocol: OCP Controlled Antagonist
Dec 25, 2012: Start BCP [Marvelon 21] {26 days}
Jan 12, 2013: Scheduled Endometrial Biopsy
Jan 26, 2013: Treatment Day#1
Feb 6, 2013: Est. Egg Retrieval
Feb 11, 2013: Est. Embryo Transfer

*** Cycle suspended due to polyp growth on uterus **

Feb 1, 2013: Hysterscopy

Feb 16, 2013: Revised Treatment Day #1

Feb 26, 2013: Egg Retrieval [8 retrieved//6 mature//5 fertilized]

Mar 3, 2013: Embryo Transfer [2 blasts//none to freeze]

Mar 18, 2013: th_abfp.gif First Beta hCG = 1215

March 21, 2013:  th_abfp.gif  Second Beta hCG = 3501

April 1, 2013: Ultrasound - 1 beautiful heartbeat! yahoo.gif

 

 


#14 conky

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Posted 02 August 2012 - 07:08 AM

Hi there!

My now husband had high DNA fragmentation (about 37%). He also had low motility and morphology and a varicocele (I had issues too). He had a varicocele embolization as well as taking some vitamins/minerals (multivitamin, vit E, zinc, selenium). 6 months later everything was retested and his motility and morphology hadn't really changed at all but his DNA fragmentation had improved to about 27%. We don't know if the embolization helped the DNA frag, but we don't think so. I suspect it was the vitamins/minerals he was taking or else just coincidence. Because the DNA frag test isn't one that's often repeated more than once or at all, it's possible results would have varied naturally anyway.

When we did IVF I was still concerned about the 27% because it's borderline and still not good and my understanding is that it often results in late first trimester miscarriages so it's a long waiting game on top of the usual worry in early pregnancy if you're lucky enough to get that far. However, I'm happy to report that we now have healthy 8 month old fraternal twins so it looks like it wasn't a factor after all.

I think DNA fragmentation isn't really well understood, soplease don't be discouraged. Do what you can, make sure your guy is as healthy as possible and hope for the best. Ultimately it probably won't change your course of action. I wish you lots of luck.
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#15 conky

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Posted 02 August 2012 - 07:11 AM

Yes... 45% means that 45% of my DH sperm is fragmented and in most cases will not be able to fertilize the egg. They say that anything less than 10% is said to be 'normal'. We are quite devestated by these results.


Just wanted to add that I'm pretty sure DNA fragmentation doesn't affect fertilization. The problem is that it often leads to first trimester miscarriages. So you can't judge it by fertilization rates or blame it for not getting pregnant (but you could suspect it in the case of miscarriages).

Also, I just noticed you're with Dr. Hannam. He was our doctor too! We also dealt with Dr. Jarvi at Mt. Sinai...not sure if you've been referred to him or maybe someone else at Mt. Sinai. Dr. Hannam acknowledged that DNA fragmentation can pose a challenge, but he never discouraged us from trying and as I mentioned before, it didn't change our course of action. It's something you want to improve if you can to better your chances, but he's not going to tell you not to try IUI/IVF/whatever it is. Both Dr. Hannam and Dr. Jarvi are wonderful.

#16 Heregoesnothing

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Posted 02 August 2012 - 07:16 AM

Thanks for sharing and congrats on your pregnancy. Hope 25, If at first, we're next!
  • gibasgirl, If at first and hope25 like this

May 2013 - We welcome our baby boy 

Nov. 28th 2015 - We welcome our baby girl

 

3 day 3 embryos on ice 

 

For a more detailed look on my cycles, visit my 'about me' page


#17 hope25

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Posted 02 August 2012 - 01:06 PM

Conky - Thank you so much for sharing your story. I read your post to my husband... as we both love to hear such positive news. My husband has been referred to Mt. Sinai - his appt is on August 17th, but I can't seem to remember what the urologists name was. I'm pretty positive we're in capable hands. Again, thank you so much for giving me hope.

Me: 30
DH: 31
TTC since July 2011
Dx: MFI [low count/motility/morph] + high DFI @ 39%

IVF/ICSI#1
Protocol: OCP Controlled Antagonist
Dec 25, 2012: Start BCP [Marvelon 21] {26 days}
Jan 12, 2013: Scheduled Endometrial Biopsy
Jan 26, 2013: Treatment Day#1
Feb 6, 2013: Est. Egg Retrieval
Feb 11, 2013: Est. Embryo Transfer

*** Cycle suspended due to polyp growth on uterus **

Feb 1, 2013: Hysterscopy

Feb 16, 2013: Revised Treatment Day #1

Feb 26, 2013: Egg Retrieval [8 retrieved//6 mature//5 fertilized]

Mar 3, 2013: Embryo Transfer [2 blasts//none to freeze]

Mar 18, 2013: th_abfp.gif First Beta hCG = 1215

March 21, 2013:  th_abfp.gif  Second Beta hCG = 3501

April 1, 2013: Ultrasound - 1 beautiful heartbeat! yahoo.gif

 

 


#18 mattinjersey

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Posted 28 September 2012 - 12:33 PM

I had a similar situation, about 45% DNA frag. Several miscarriages resulted.
I tried the vitamins.
But the results did not improve.
I think we shall move onto to Donor Sperm.
Kind of a bummer, but there it is!

#19 hope25

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Posted 28 September 2012 - 02:44 PM

hi mattinjersey,

I'm so deeply sorry to hear about youro miscarriages.

My husband is currently taking vitamens, however, he's also scheduled for a surgical procedure next month (Oct 11) with a radialogist to remove his vericose veins (he has two). We're hoping this will help reduce his DNA fragmentation and better our odds for IVF.

Have you explored any further options other than taking vitamens prior to moving straight to donor sperm?

Me: 30
DH: 31
TTC since July 2011
Dx: MFI [low count/motility/morph] + high DFI @ 39%

IVF/ICSI#1
Protocol: OCP Controlled Antagonist
Dec 25, 2012: Start BCP [Marvelon 21] {26 days}
Jan 12, 2013: Scheduled Endometrial Biopsy
Jan 26, 2013: Treatment Day#1
Feb 6, 2013: Est. Egg Retrieval
Feb 11, 2013: Est. Embryo Transfer

*** Cycle suspended due to polyp growth on uterus **

Feb 1, 2013: Hysterscopy

Feb 16, 2013: Revised Treatment Day #1

Feb 26, 2013: Egg Retrieval [8 retrieved//6 mature//5 fertilized]

Mar 3, 2013: Embryo Transfer [2 blasts//none to freeze]

Mar 18, 2013: th_abfp.gif First Beta hCG = 1215

March 21, 2013:  th_abfp.gif  Second Beta hCG = 3501

April 1, 2013: Ultrasound - 1 beautiful heartbeat! yahoo.gif

 

 


#20 RYLIE91011

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Posted 05 September 2013 - 02:01 PM

Hi, I know this thread is old... So I dont even know if anyone will read this... but I needed to say that I read your updated signatures I'm so happy to see the latest developments! congrats to all!

I'm still waiting for my BFP and this is giving me tons of hope!!!  xoxo


Me: 37, TTC since July 2011

Husband: 38- thought it was DNA fragmentation-turns out maybe not

DX: Unexplained, possibly polyp (removed),

 

Nov 2012: Totally natural IVF cycle, 2 eggs retrieved, one fertilized, day2 transfer of a "perfect" 4 cell embryo, BFN

 

Jan 23 2013: starting modified natural cycle (150 puregon day 4, 6, 8) day 4 US: 5 follicles on L side, 7 follicles on R side
Feb 4 2013: ER: 9 eggs retrieved. Cyst drained during ER as well.
Feb 5th: 1 egg mature+ICSI, fertilized. 3 immature eggs maturing in lab, 5 immature.
Feb 6th: 1 embryo dividing well, 3 eggs matured and ICSI done, waiting to see if fertilized. 5 discarded. tentative transfer day feb 8th.
Feb 8th: ET, 1xday 4 (cells have started to compact.) 3 leftovers have fertilized.
Feb 11th: call from embryologist: 3 leftovers arrested. nothing to freeze.
Feb 14th: 6dp4dt, HPT-BFN major bummer.
Feb 20th, Beta BFN

 

April 2013:Fresh Cycle. Antagonist protocol. 150puregon/day+Orgalutran+Ovidrel.

April 8th: 12 eggs collected, 8 mature, 7 fertilized. 7 blasts, 6 hatching, 1 hatched.

April 13th: 1 great looking hatching blast transferred.  6 blasts frozen.

April 22: crying my eyes out,cry.gif feel period coming. BETA on the 24th.

April 24th: NEGATIVE BETA, but got call saying that I can start preparing for FET right away

 

May 14th: FET 1 hatching blast BETA May 24th.

May 17-18: cramps at 3dpFET, then on and off since

May 18th: hpt BFN 

May24th: BETA day: BFN. Told to wait out a cycle before pursuing another FET.

 

June 2013: Hubs did a second DNA fragmentation test with another urologist for a second opinion.  Test came back at 15% abnormal, so... now within the norm... huh??? So happy but wondering how it went from 59% fragmented down to 15% fragmented.  Morphology still low.

 

July 15 2013: Hysteroscopy, Endo Biopsy done.  They've removed a polyp as well.  Still waiting for full results... darn summer vacations, making test results delayed... so anxious.

 

August 28th 2013: Green light to start Estrace today for FET

Sept 4: on duty Dr. (not Dr. Tan) gave me a big NO on a double transfer due to me having blasts and my age URGH!

Sept 11th: Transfer day.  surprise! Dr tells me they're transferring 2 hatching blasts.  lower quality though...

Sept 23: Beta: negative.

WTF appointment Sept 26.

 

5 3 frozen hatching blasts left.

Immune Testing: positive for high CD56 (and other stuff moderate)

 

December 21 2013: Cycle starts! Immune protocol: Prednisone, Lovenox, Estrace, PIO, Doxy, Medrol, Calcium

Perfect lining (triple stipe, first time the technician is so happy with it!)

Transfer on Jan 7th, Empty Bladder transfer. (so much easier!)

1 blast didnt make it thru thaw, 2 great ones left, transferred both. so nothing left from our 2nd cycle.

Embryologist particularly thrilled with an almost fully hatched blast.

Jan 20: Beta 208

Viability Scan Feb 3

Feb 3: no gestational sac found. Beta 5.9.

 

March 2014: IVF#3

7 eggs, 6 mature, 4 blasts.

Immune: prednisone, Lovenox, Intralipids. 

transferred 2, 2 frozen.

April 3rd: BFN.

 

Thats it.  consult at MFC.  BIG polyp found right on implantation site.  Seems to have been there all along and was never properly removed or not completely in the past. 

 

Clinic Switch to MFC- a world of difference.

 

Aug 21: polyp removal-hysteroscopy- done by a specialist in polyp removal.

Sept 8th: FET cycle starts.

Sept 24: transfer 2 medium quality day 5 embryos (3AA and 2AB)

Oct 3: BETA  (sneaked a FRER on my way home from blood test: very dark BFP) at 9dp5dt: 279

repeat Beta Oct 6: 1276

viability scan: Oct 21st

 

 

 






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