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Recurrent miscarriage


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#1 Beauts

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Posted 07 February 2012 - 02:24 PM

Is there any treatment that you are aware of for recurrent early miscarriage when all medical tests have been done and all blood work, ultrasounds, etc are normal? I am a 38 year old female (just turned) who has has 3 losses (5 weeks, 5.5 weeks and 10 weeks but baby stopped growing at 6.5 weeks). I an currently taking CoQ10 800mg a day, resveratrol, baby aspirin, B6, wheat germ oil, norwegian salmon oil and royal jelly.

#2 doubleranebow

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Posted 07 February 2012 - 05:06 PM

I have had 4 early miscarriages. I saw Dr. Laskin at LifeQuest as he is the recurrent miscarriage specialist and Head of the T.E.R.M programme, "Treating Unexplained Recurrent Miscarriage". His first suggestion were progesterone suppositories on specific days of my cycle as well as Letrozole, a fertility med. Then we tried, three IUI's with gonal-f with no sucess. We then did PGD on my eggs and discovered a pervasion egg quality issue. He then suggested using donor eggs.

#3 Beauts

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Posted 07 February 2012 - 05:40 PM

I have had 4 early miscarriages. I saw Dr. Laskin at LifeQuest as he is the recurrent miscarriage specialist and Head of the T.E.R.M programme, "Treating Unexplained Recurrent Miscarriage". His first suggestion were progesterone suppositories on specific days of my cycle as well as Letrozole, a fertility med. Then we tried, three IUI's with gonal-f with no sucess. We then did PGD on my eggs and discovered a pervasion egg quality issue. He then suggested using donor eggs.


How early were your losses? Sorry you had to go through 4 losses...!

#4 sharlene

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Posted 07 February 2012 - 06:01 PM

I was wondering if you've had your emryos tested - when I had a miscarriage, I had a D & C so the tissue could be analyzed - I wanted to know if it was something that would happen every time I got pregnant or just some random chromosome abnormality that may or may not happen again.

Just a thought.

Good luck - I wish you success!

#5 Beauts

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Posted 07 February 2012 - 07:27 PM

I was wondering if you've had your emryos tested - when I had a miscarriage, I had a D & C so the tissue could be analyzed - I wanted to know if it was something that would happen every time I got pregnant or just some random chromosome abnormality that may or may not happen again.

Just a thought.

Good luck - I wish you success!


No I didn't...the first one they wouldn't do it because it was only my first and the next 2 were only 5.5 and 5 weeks along so chemicals technically and too early on for any tissue testing.
When you did have yours tested, what was the outcome?

#6 Laura1976

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Posted 07 February 2012 - 08:19 PM

Sorry for your losses ladies. I was wondering if you have had RPL (recurrent pregnancy loss) testing done? I had the testing done for unexplained IF and I found a few issues that may very well be preventing me from getting pregnant.
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See 'About me Page' for more cycle history

November 29/11 - Unexplained IF/Recurrent loss testing

Compliment C3 & C4 below acceptable range
LA Ratio DRVVT above acceptable range
Lupus Inhibitor demonstrated
Antiphospholipid IgG above acceptable range
Antiphospholipid IgM above acceptable range (more than double)


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IVF/ICSI #2 (with Intralipid therapy) January/February (Victoria Fertility Clinic)
BCP December 16 -29/11 & January 6 - 28/12
Vitamin D (2000iu daily) and Iron Supplement (Ferrous Gluconate 300mg daily) - Start December 24 until Dr advises otherwise, PregVit 5 (Starting January 12/11), Vitamin E (800iu daily) until Heparin begins (Starting January 14/11) Fish Oil (1200iu daily)
Superfact (0.5mg) - Start January 22/12
Dexamethasone (0.5mg) - Start February 4/12 until beta

After ER - Doxycycline (100mg), Estrance (2mg), Prometrium (200mg 3x day), heparin 5000 units (2x day), calcium (1500mg daily), low dose aspirin (81mg daily)
Intralipids - February 13/12 and day of ET
Neupogen Uterine Flush - Day of ER

February 2/12 - E2 35p/mol
February 4/12 - 300iu Gonal-F & 75iu Repronex
February 9/12 - U/S & E2 - RIGHT- 11, 9, 10, 19, 8, 12, 11, 10, 13, 6 LEFT: 12, 7, 10, 10, 8, 6, 5, 5 E2 2635

February 9/12 Gonal-F lowered to 225iu Repronex remains at 75iu
February 11/12 - U/S & E2 - Right 14, 10, 11, 12, 10, 13, 12, 12, 14, 7 LEFT: 11, 8, 10, 13, 9, 8, 8 E2 5610
February 13/12 - U/S an E2??? & Intralipid Therapy
February 16/12 - E/R 20 eggs, 17 mature and ICSI'ed, 3 left to fertilize by regular IVF
February 17/12 - Fert Report 16 fertilized by ICSI, 1 fertilized by IVF
February 20/12 - Neupogen injection
February 21/12 - Transferred 2 Blastocysts ( 1 x Grade 19 Early Blast, 1 x Grade 19 Expanded Blast) and Intralipid Therapy and Acupuncture

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#7 sharlene

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Posted 08 February 2012 - 12:51 AM

I was wondering if you've had your emryos tested - when I had a miscarriage, I had a D & C so the tissue could be analyzed - I wanted to know if it was something that would happen every time I got pregnant or just some random chromosome abnormality that may or may not happen again.

Just a thought.

Good luck - I wish you success!


No I didn't...the first one they wouldn't do it because it was only my first and the next 2 were only 5.5 and 5 weeks along so chemicals technically and too early on for any tissue testing.
When you did have yours tested, what was the outcome?


I got to the first ultrasound at 5w2d (if I recall correctly) and all was great. At the next u/s at 6w2d, there should have been a heartbeat, but wasn't. We checked again at 7w and still no heartbeat - I had the D & C at what should have been 8w - and the testing showed two trisomies (14 & 18) - so the embryo never would have become a baby - nothing with those two trisomies has ever been born. This news was good for me to hear - since it wasn't necessarily going to happen with every pregnancy. Sure enough, my next IVF, all went perfectly and I have a 13 month old.

#8 Beauts

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Posted 15 February 2012 - 02:22 PM

Wondering if you have any advice Dr. Fiona?

#9 Beauts

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Posted 09 March 2012 - 02:19 PM

Bump for Dr. Fiona.

#10 sharlene

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Posted 09 March 2012 - 11:08 PM

Bump for Dr. Fiona.


The thread has gotten a little old - start a new thread and she will be more likely to see it and respond.

Good luck - I hope she has some good ideas.

#11 rollergirl

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Posted 09 March 2012 - 11:45 PM

Have you had your blood karotyped??.....That will give you the details getting down to the nitty gritty of the chromosomes....I had 2 miscarriages and currently pregnant.....had amino done and was told the babies had a balanced translocation. Speaking english one piece of chromosome swapped with another.....my DH and I got tested and it turned out that the twins inherited the chromosome anomaly and one of us is a carrier. We are in really good health so that means the twins will be healthy and the Dr., and the geneticist did not foresee any health problems related to the chromosome issues.

I thought that I had all of the bloodwork done too but this is just a suggestion....

Gool luck!!
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#12 DrFionaMcCulloch

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Posted 23 March 2012 - 10:38 AM

Hi Beauts,

Oh, sorry...for some reason I missed this thread altogether!

Firstly I'm so sorry for all the losses experienced by everyone in this thread. I would definitely agree with the other posters and have testing done to determine if there are any factors. You would want to look at chromosomal/karyotype factors, thyroid, hormones, and also immunological factors. The treatment of recurrent miscarriage is quite complex so knowing the full picture before starting is very helpful. Progesterone support is key in most cases however there may be other things going on. You can read my article on autoimmune infertility which talks about some of the tests you can request for these issues: http://drfiona.white...ility-concerns/ If you wanted to consult with me on natural options, once you have the testing done you can always send it to me and I can have a look at it for you. Otherwise, some treatments that would be helpful in all cases (except chromosomal) would include high epa content omega 3 fatty acid (approx 1500mg epa per day), progesterone, methylfolate, and enzyme therapy (but this would have to be customized to your case).

Thank you so much for your question, and sorry I missed seeing it!

Dr Fiona
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