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#1 judes

judes
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  • Gender:Female
  • Location:Montreal
  • Dx:PCOS
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Posted 16 September 2011 - 01:41 PM

Hey Everyone!

Dunno if this thread will get traction, but I figured it never hurts to have it there. So this is the spot to hang out for those who graduated or have moved on from MFC and wants to keep in touch.

Me: 34 Him: 35
Married since 2006 TTC ever since
Diagnosis: PCOS 

 

For complete history, see about me.

 

2012

 

IVF 1.3
12/26 - Mackenzie born 7:54 am, 6 lbs 3 oz

wFsTm5.png

 

2013 - Project sibling

 

IVF 2.1

4/17 - consult - Project sibling is a go.  same protocol as last time pending bloodwork and sonohysterogram. 

Projected beginning of cycle - August 2013.

 

5/8 - sonohysterogram: tubes clear, no residual placental tissue, ovaries still polycystic. Green light to cycle when ready.

 

8/9 - baseline scan. begin meds, 150 puregon, 50 menopur

8/13 - add orgalutran

8/18 - trigger half ovidrel, half hcg

8/20 - ER - 17 retrieved. 8/21 - 8 mature, 7 fertilised

8/23 - ET - One 8-cell grade 2 embryo transfered

8/26 - One embaby made it to the freezer!

9/1 - HPT - BFP!!!!

9/5 - Beta - 295!

9/9 - Beta - 1550!

9/18 - we have a heartbeat. Little Shrimp is 4.5mm and heart is beating at 109 bpm

10/25 - Turns out Little Shrimp is actually Little Shrimps! We had identical twins! Twin A 174 bpm, Twin B 183 bpm. Both measuring 11wks + 4 days

 

11/1 - NT scan. 1.5 and 1.6mm. Twins both measuring 12wks + 5 days, 2 days ahead.

 

Week 24 - put on modified bed rest due to softening of the cervix

Week 27 - hospitalised with pre-term contractions

Week 29 - put on strict bed rest

 

Seamus and Ronan born March 13 at 31 weeks and 2 days

 

Ronan came home April 7 and Seamus came home April 11.

 

SFCBm4.png
 

My blog - Geeky.Mama.Life

 

My YouTube channel - Geeky Mama Life

 

My day in the life vlog - Geeky.Mama.Vlogs

 

 

 


#2 Lucretia

Lucretia
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  • Dx:Male Factor

Posted 16 September 2011 - 02:07 PM

fingers crossed that I graduate from MFC on September 26th :)

#3 judes

judes
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  • 1053 posts
  • Gender:Female
  • Location:Montreal
  • Dx:PCOS
  • My Clinic:Montreal Fertility Centre

Posted 16 September 2011 - 02:13 PM

Cheerleaders for Dims :th_acheerlead: :th_acheerlead: :th_acheerlead: Good luck!

Me: 34 Him: 35
Married since 2006 TTC ever since
Diagnosis: PCOS 

 

For complete history, see about me.

 

2012

 

IVF 1.3
12/26 - Mackenzie born 7:54 am, 6 lbs 3 oz

wFsTm5.png

 

2013 - Project sibling

 

IVF 2.1

4/17 - consult - Project sibling is a go.  same protocol as last time pending bloodwork and sonohysterogram. 

Projected beginning of cycle - August 2013.

 

5/8 - sonohysterogram: tubes clear, no residual placental tissue, ovaries still polycystic. Green light to cycle when ready.

 

8/9 - baseline scan. begin meds, 150 puregon, 50 menopur

8/13 - add orgalutran

8/18 - trigger half ovidrel, half hcg

8/20 - ER - 17 retrieved. 8/21 - 8 mature, 7 fertilised

8/23 - ET - One 8-cell grade 2 embryo transfered

8/26 - One embaby made it to the freezer!

9/1 - HPT - BFP!!!!

9/5 - Beta - 295!

9/9 - Beta - 1550!

9/18 - we have a heartbeat. Little Shrimp is 4.5mm and heart is beating at 109 bpm

10/25 - Turns out Little Shrimp is actually Little Shrimps! We had identical twins! Twin A 174 bpm, Twin B 183 bpm. Both measuring 11wks + 4 days

 

11/1 - NT scan. 1.5 and 1.6mm. Twins both measuring 12wks + 5 days, 2 days ahead.

 

Week 24 - put on modified bed rest due to softening of the cervix

Week 27 - hospitalised with pre-term contractions

Week 29 - put on strict bed rest

 

Seamus and Ronan born March 13 at 31 weeks and 2 days

 

Ronan came home April 7 and Seamus came home April 11.

 

SFCBm4.png
 

My blog - Geeky.Mama.Life

 

My YouTube channel - Geeky Mama Life

 

My day in the life vlog - Geeky.Mama.Vlogs

 

 

 


#4 CatL

CatL
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  • 577 posts
  • Gender:Female
  • Location:Gatineau
  • Interests:Windsurfing, wakeboarding, skating, reading, cooking
  • Dx:Unexplained
  • My Clinic:OFC/MFC/Ovo

Posted 16 September 2011 - 07:34 PM

Go Dims Go!!! :Emoticons0096: I'll throw in some cheerleaders too :-)!!
<p>Me: 36 (homozygous MTHFR + heterozygous Factor V Leiden) DH: 40 (slightly low morphology (7%))
May 2006 Natural pg - 1st M/C at 11 wks
Aug 2006 Natural pg - 2nd M/C at 8 wks
Dec 2006 Natural pg - DD born Sept 2007!!!

TTC #2 since Feb. 2009
IUI #1 May 2010 - BFN
IUI #2 June 2010 - BFN
IUI #3 Sept 2010 - BFN
IUI #4 Oct 2010 - BFN

IVF #1 - Long Protocol
Puregon 225iu, ER Feb. 23rd (8 total, 5 fert)
ET Feb. 26th (2x8cell grade 3), no frosties :-(
1st Beta Mar. 11th - 243!!!!
2nd Beta Mar. 14th - 667 :-)
1st u/s Mar. 28th - singleton measuring 6w5d and HB 118...Yippi!
2nd u/s Apr. 12th - no HB...3rd M/C at 9w2d :-(((

IVF #2 - Antagonist protocol
Day 3 u/s showed 14-15 follies
CD 3-6 2x2mg Estrogen daily, CD 6 start 100iu Puregon/75iu Repronex
ER - Aug. 31st, 2011 (12 eggs/10 mature, 9 fert)
ET - Sept. 4th, 2011 (sET grade 2 blast), no frosties :-(
Sept. 10 6dp5dt +HPT :-)))!
Sept. 15 beta = 9 :-(( Chemical Pg

IVF #3 - Estrogen Priming Antagonist Protocol - Dec. 2011
Estrace, 225 ui Gonal-F/75 ui Repronex
ER - Dec. 29th, 2011 (12 eggs/11 mature, 6 fert)
ET - Jan. 1st, 2012 (two 8 cells, grade 1), 2 frosties :-))
Jan. 8th 7dp3dt +HPT...Please let this be the one!!!
Jan. 13th 12dp3dt Beta 642, 15dp3dt Beta 3112
Feb. 3rd 7w1d u/s - Twins!! HBs 143 + 144
Mar. 9th NT scan (12w1d) - still 2 babies developing perfectly :-))

Our girls were born Sept.7th, 2012 (38 wks 1 day) weighing in at 6 lbs and 6 lbs 12 ounces!!<a href="http://lilypie.com/"><img src="http://lbdf.lilypie....com/z9eqm4.png" width="400" height="80" border="0" alt="Lilypie Pregnancy tickers" /></a>

#5 Hostlucy

Hostlucy
  • Global 100+
  • 426 posts
  • Gender:Female
  • Dx:N/A
  • My Clinic:OVO/MFC/McGill

Posted 16 September 2011 - 08:02 PM

Hey everyone,

I love the idea of this thread! I'm still going to be part of the other one though :)

Dims, you WILL graduate in 2 weeks. :th_acheerlead:
Me: 43 DH: 43
IVF #1 BFN
IVF #2 BFN
IVF #3 BFP!!

9 eggs retrieved, 7 mature, 4 fertilized, 3 transfered
2 -5 cell grade 2-3, 1-9 cell grade 3
10dp3dt + hpt
12dp3dt beta = 109, 237 & 25dp3dt 15418
1st u/s May 16 - twins!! Babies measure 6w1d
Twin A hb 111, Twin B hb 101
June 3, Twin B didn't make it
DS born December 26, 2009

IVF #4 BFN
IVF #5 BFN
IVF #6 BFP!!
11 eggs retrieved, 11 mature, 7 fertilized!
1 6 cell and 1 8 cell embryo transfered, good quality
2 4 cell embryos frozen
9dp3dt faint + on First Response
12dp3dt beta = 97, 167, 295, 408
1st U/S 08/18/11 Baby measures 6w1d, no HB detected
2nd U/S 08/25/11 Baby measures 6w4d, HB normal
3rd U/S 09/13/11 Baby measures 9w1d, 174bpm

12/2011 -Baby diagnosed with Tetralogy of Fallot with absent pulmonary valve
DS born April 4, 2012

#6 Lucretia

Lucretia
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  • Gender:Female
  • Dx:Male Factor

Posted 16 September 2011 - 10:34 PM

thank you, ladies, you are great :Emoticons09780: :Emoticons09780:

#7 Lucretia

Lucretia
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Posted 26 September 2011 - 12:06 PM

well, ladies, I didnt graduate with fanfares today (baby measures behind :( ), but I am done with MFC for now. I have a calendar appointment for McGill in December, if my current pregnancy turns out to be a non-viable one, I will most probably cycle there (unless they give me a cycle date for May...). Cat, I am sorry for your bad experience there, I hope they find your blood work - whatever the negatives in McGill they do offer PGD and embryo freezing! Good luck to you and Judes in your next cycle Posted Image

#8 judes

judes
  • Cyclebase
  • 1053 posts
  • Gender:Female
  • Location:Montreal
  • Dx:PCOS
  • My Clinic:Montreal Fertility Centre

Posted 26 September 2011 - 01:44 PM

Dims - Perhaps the embryo will still catch up? I honestly don't know much about embryo growth (haven't gotten to that step yet). Thinking of you and sending your embryo tons of positive and cheerleading vibes. Posted Image

Me: 34 Him: 35
Married since 2006 TTC ever since
Diagnosis: PCOS 

 

For complete history, see about me.

 

2012

 

IVF 1.3
12/26 - Mackenzie born 7:54 am, 6 lbs 3 oz

wFsTm5.png

 

2013 - Project sibling

 

IVF 2.1

4/17 - consult - Project sibling is a go.  same protocol as last time pending bloodwork and sonohysterogram. 

Projected beginning of cycle - August 2013.

 

5/8 - sonohysterogram: tubes clear, no residual placental tissue, ovaries still polycystic. Green light to cycle when ready.

 

8/9 - baseline scan. begin meds, 150 puregon, 50 menopur

8/13 - add orgalutran

8/18 - trigger half ovidrel, half hcg

8/20 - ER - 17 retrieved. 8/21 - 8 mature, 7 fertilised

8/23 - ET - One 8-cell grade 2 embryo transfered

8/26 - One embaby made it to the freezer!

9/1 - HPT - BFP!!!!

9/5 - Beta - 295!

9/9 - Beta - 1550!

9/18 - we have a heartbeat. Little Shrimp is 4.5mm and heart is beating at 109 bpm

10/25 - Turns out Little Shrimp is actually Little Shrimps! We had identical twins! Twin A 174 bpm, Twin B 183 bpm. Both measuring 11wks + 4 days

 

11/1 - NT scan. 1.5 and 1.6mm. Twins both measuring 12wks + 5 days, 2 days ahead.

 

Week 24 - put on modified bed rest due to softening of the cervix

Week 27 - hospitalised with pre-term contractions

Week 29 - put on strict bed rest

 

Seamus and Ronan born March 13 at 31 weeks and 2 days

 

Ronan came home April 7 and Seamus came home April 11.

 

SFCBm4.png
 

My blog - Geeky.Mama.Life

 

My YouTube channel - Geeky Mama Life

 

My day in the life vlog - Geeky.Mama.Vlogs

 

 

 


#9 GratefulMommy

GratefulMommy
  • Global 100+
  • 242 posts
  • Gender:Female
  • Location:Montreal
  • Dx:Other
  • My Clinic:MFC

Posted 26 September 2011 - 08:01 PM

So sorry to hear that baby measures behind. Hugs. Keeping my fingers crossed that everything is ok.
Where do I start?

I have an irregularly shaped uterus, I have had a uterine septum removed, I have an endocervical folds that are most probably causing persistent fluid in my uterus, I had chronic endometritis for over a year, a luteal phase defect, I had two dermoid cysts (benign tumours the size of oranges) on my ovaries removed, I am MTHFR heterozygous, and have been told that I may have an "egg quality" issue.You name it, I've got it :(


Miracle DS born December 2008

December 2009: TTC#2

June 2010: Started at McGill. Transferred to Montreal Reproductive Center- had a horrible experience Switched to Montreal Fertility Center- So happy there!

IVF #1-
short protocolER: April 21/11- 8 eggs, 7 mature 5 embryosOn day 3: 4x4 cell grade 2 and 1x2 cell grade 15 day transfer of 1 blast on April 26/11 (two surprise blast frosties)
Beta on May 6/11. BFN :(

June 2011: On the waiting list for adoption from South Korea

July 2011:Persistent chronic endometritis (endometrial inflammation from a complication post c-section) finally cured!

FET #1:
September 8th 2011- transfer of 2 blasts
Beta on September 19/11 BFN :(

IVF #2-
short protocol againER: Oct. 5/11- 13 eggs collected, 11 mature and fertilized2DPER- : 11 embryos were grades 2&3 and 2,3,4 and 5 cells
Oct. 10/11 5 day transfer of 1 blast.
Two blast frosties
Beta on October 20/11 BFN :(

Consultation @OVO- October 2011.
Re-consulted @McGill. Staying with MFC for now.

Operative hysteroscopy with Dr. M on February 23, 2012 to hopefully remove and endocervical cyst or polyp. --- no cyst or polyp, but endocervical folds were found that are most probably damage from a cerclage from my previous pregnancy. The folds cannot be removed but should not effect implantation.

Phone consult booked with Dr. Librach, a reproductive immunologist, to explore possible immune issues. (Feb. 16, 2012) rescheduled for February 28th, 2012. Dr. Librach said that I most probably have immune issue based on my history and symptoms. With next transfer I will be:-Having an intralipid infusion,-using steroids-Using baby aspirin-Praying that it works!And traveling back and forth from Toronto for treatments along with cycling at MFC.

FET #2
Started Estrace April 9, 2012
Estimated transfer date: April 26, 2012
CYCLE CANCELLED- lining didn't look right even though it grew but only after 16 days

FET #3 (actually FET #2 Take 2)Started Estrace May 9th, 2012- lining not cooperating again :(Cycle cancelled again.

This was our last try before going down a new path...I'm done. My body and soul can't take this anymore.

May 2012: Looking into surrogacy.
June 2012: Now looking for a surrogate
Sept 2012: We may have found the most wonderful surrogate! Keep your fingers crossed after so much heartache (after contacting over 250 surrogates and getting close with about 4 before all contact stopped?)

May 2012: It looks like it is going to be at least 4 more years. Adoption from South Korea has slowed down.

September 2012: South Korea waiting list closed because there are no proposed children. Hopefully things will pick up.

On the waiting list for adoption from Kazakhstan ( looking at a probable 2 year wait.)

October 2012: Called to sign a contract with Alliance Des Familles du Quebec. In Shock! Might be adopting from Kazakstan earlier than anticipated!

November 2012: Waiting for my surrogate to have her sonohystogram.Signed contract with Alliance Des Familles du Quebec and opened file with SAI.

Starting home study in January 2013.So, right now, it seems like its always all or nothing! Pursuing surrogacy (in the screening stage/pre-contract) and international adoption from Kazakhstan. I'm praying that we will choose the right path. I'm so conflicted and don't know what to do.

Adoption process on pause.

Surrogacy journey: Amazing surrogate passed psych and cleared medically. We will be meeting with dr. M to make plan.

May 2013: Getting ready for FET in a May. I high quality blast to my surrogate. BFN

Took the summer 2013 off.

November 2013: Ovarian stimulation -7 follicles. Only 1 egg :( Possible ET to GS Friday November 29, 2013. NOPE. EGG was abnormal.

April 4, 2014: Last cycle with incredible surrogate ended with a BFN

April 28, 2014: Submitted file for home study. Collecting documents to complete my file.

August 2014: Still waiting for home study...

Starting home study soon! Stay tuned...

#10 rea2011

rea2011

    Rea

  • Cyclebase
  • 90 posts
  • Gender:Female
  • Location:Montreal
  • Interests:working out, jogging, reading, photography, my dog & laughing with my gals.
  • Dx:Male Factor
  • My Clinic:Montreal Reproductive Center (Dr. Tan)

Posted 26 September 2011 - 08:21 PM

Dims, hang in there. I've heard tons of stories (from close friends of mine and co-workers) ... where the odds are against their embryo ... but the little bean clings on and makes it. I am thinking of you and your little bean. Posted Image

6 months trying before intervention
Me: 2.9cm Endometrioma on left ovary
Fiancee: 1-5% morphology (depending on the month)
Laparoscopy (May 2011)

RPL Testing (March 2012): All normal

HLA Testing for my fiancé, myself and donor sperm (August 2012)
2 Failed IUIs (March & April 2011)
CLINIC MFC 1st IVF (July. 2011) - TAKE 1: 18 eggs, 15 fertilized by ICSI, all arrested on day 5. Transfer CANCELLED.
CLINIC MFC 1st IVF (Aug. 2011) - TAKE 2: 10 eggs, 8 fertilized by ICSI, pushed for day 3 transfer...1 embryo transferred. BFN.
CLINIC MFC 2nd IVF (Sept. 2011) - TAKE 1: 16 follicles & 1 small cyst....I ovulated...Cycle CANCELLED.
CLINIC MRC 2nd IVF (Jan. 2012) - TAKE 2: 18 eggs, 12 mature, 12 fertilized by ICSI. 2 Blasts transfered (1 perfect & other average). BFN.
CLINIC MRC 3rd IVF (April 2012) - Intralipid & Cortisone Therapy. 20 follicles, 18 eggs, 15 mature, 18 fertilized by ICSI.

5 Blasts (2 good quality, 3 average). Embryo Testing on all 5. 2/5 are normal.
FET June 5th of the 2 good quality, CGH normal embryos. BFN.
Clinic MRC 4th IVF (March 2013)- Invested in HLA Tested Donor Sperm and using Dr Sher's Agonist-Antagonist Conversion Protocol.  14 follicles, retrieved 7, only 3 mature, but 3 fertilized (1 excellent, 2 good Day 3 embryos)

All 3 transferred on Day 3. BFP (HcG level 900)

 

**My Advice: When you know something is wrong, go with your gut!!! I knew we had MASSIVE sperm issues, not egg quality issues. Imagine, after tons of failed IVF cycles with my Fiancee's sperm, I get a BFP on the first try with donor sperm.  Hopefully, this pregnancy will make it 'til the end. God bless.

 

hLGBm4.png


#11 CatL

CatL
  • Cyclebase
  • 577 posts
  • Gender:Female
  • Location:Gatineau
  • Interests:Windsurfing, wakeboarding, skating, reading, cooking
  • Dx:Unexplained
  • My Clinic:OFC/MFC/Ovo

Posted 26 September 2011 - 10:37 PM

Dims, I'm really sorry you have to live through this stress...You need to stay positive, you baby has a strong heartbeat plus, as Rea mentioned, there is a lot of variability in the growth of a fetus. What did the doctor say? How far behind is the baby measuring? I'll be sending you lots of positive vibes that the little catchs up ((hugs))
<p>Me: 36 (homozygous MTHFR + heterozygous Factor V Leiden) DH: 40 (slightly low morphology (7%))
May 2006 Natural pg - 1st M/C at 11 wks
Aug 2006 Natural pg - 2nd M/C at 8 wks
Dec 2006 Natural pg - DD born Sept 2007!!!

TTC #2 since Feb. 2009
IUI #1 May 2010 - BFN
IUI #2 June 2010 - BFN
IUI #3 Sept 2010 - BFN
IUI #4 Oct 2010 - BFN

IVF #1 - Long Protocol
Puregon 225iu, ER Feb. 23rd (8 total, 5 fert)
ET Feb. 26th (2x8cell grade 3), no frosties :-(
1st Beta Mar. 11th - 243!!!!
2nd Beta Mar. 14th - 667 :-)
1st u/s Mar. 28th - singleton measuring 6w5d and HB 118...Yippi!
2nd u/s Apr. 12th - no HB...3rd M/C at 9w2d :-(((

IVF #2 - Antagonist protocol
Day 3 u/s showed 14-15 follies
CD 3-6 2x2mg Estrogen daily, CD 6 start 100iu Puregon/75iu Repronex
ER - Aug. 31st, 2011 (12 eggs/10 mature, 9 fert)
ET - Sept. 4th, 2011 (sET grade 2 blast), no frosties :-(
Sept. 10 6dp5dt +HPT :-)))!
Sept. 15 beta = 9 :-(( Chemical Pg

IVF #3 - Estrogen Priming Antagonist Protocol - Dec. 2011
Estrace, 225 ui Gonal-F/75 ui Repronex
ER - Dec. 29th, 2011 (12 eggs/11 mature, 6 fert)
ET - Jan. 1st, 2012 (two 8 cells, grade 1), 2 frosties :-))
Jan. 8th 7dp3dt +HPT...Please let this be the one!!!
Jan. 13th 12dp3dt Beta 642, 15dp3dt Beta 3112
Feb. 3rd 7w1d u/s - Twins!! HBs 143 + 144
Mar. 9th NT scan (12w1d) - still 2 babies developing perfectly :-))

Our girls were born Sept.7th, 2012 (38 wks 1 day) weighing in at 6 lbs and 6 lbs 12 ounces!!<a href="http://lilypie.com/"><img src="http://lbdf.lilypie....com/z9eqm4.png" width="400" height="80" border="0" alt="Lilypie Pregnancy tickers" /></a>

#12 Lucretia

Lucretia
  • Cyclebase
  • 623 posts
  • Gender:Female
  • Dx:Male Factor

Posted 27 September 2011 - 04:05 PM

thanks girls, you are the best support group ever :)
Dr M didnt really say anything except that the margin of error during u/s is +/- 3 days and obviously 5 days difference is something that is not in the usual ranges, but he has seen many cases where this results in a healthy baby while of course there are cases when this will not be a viable pregnancy - only time can tell. He did send me to a very good specialist though, so I am crossing fingers and waiting to see the new doctor.

#13 judes

judes
  • Cyclebase
  • 1053 posts
  • Gender:Female
  • Location:Montreal
  • Dx:PCOS
  • My Clinic:Montreal Fertility Centre

Posted 27 September 2011 - 07:29 PM

Dims - I am glad to hear that Dr. M. referred you to a good specialist. When is your appointment? In the meantime, hang in there. We'll be thinking of you and your little bean :)

Me: 34 Him: 35
Married since 2006 TTC ever since
Diagnosis: PCOS 

 

For complete history, see about me.

 

2012

 

IVF 1.3
12/26 - Mackenzie born 7:54 am, 6 lbs 3 oz

wFsTm5.png

 

2013 - Project sibling

 

IVF 2.1

4/17 - consult - Project sibling is a go.  same protocol as last time pending bloodwork and sonohysterogram. 

Projected beginning of cycle - August 2013.

 

5/8 - sonohysterogram: tubes clear, no residual placental tissue, ovaries still polycystic. Green light to cycle when ready.

 

8/9 - baseline scan. begin meds, 150 puregon, 50 menopur

8/13 - add orgalutran

8/18 - trigger half ovidrel, half hcg

8/20 - ER - 17 retrieved. 8/21 - 8 mature, 7 fertilised

8/23 - ET - One 8-cell grade 2 embryo transfered

8/26 - One embaby made it to the freezer!

9/1 - HPT - BFP!!!!

9/5 - Beta - 295!

9/9 - Beta - 1550!

9/18 - we have a heartbeat. Little Shrimp is 4.5mm and heart is beating at 109 bpm

10/25 - Turns out Little Shrimp is actually Little Shrimps! We had identical twins! Twin A 174 bpm, Twin B 183 bpm. Both measuring 11wks + 4 days

 

11/1 - NT scan. 1.5 and 1.6mm. Twins both measuring 12wks + 5 days, 2 days ahead.

 

Week 24 - put on modified bed rest due to softening of the cervix

Week 27 - hospitalised with pre-term contractions

Week 29 - put on strict bed rest

 

Seamus and Ronan born March 13 at 31 weeks and 2 days

 

Ronan came home April 7 and Seamus came home April 11.

 

SFCBm4.png
 

My blog - Geeky.Mama.Life

 

My YouTube channel - Geeky Mama Life

 

My day in the life vlog - Geeky.Mama.Vlogs