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Second failed FET


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#1 Tryingformybaby

Tryingformybaby
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  • Dx:Unexplained
  • My Clinic:Shady Grove

Posted 08 November 2021 - 05:25 PM

Just found out my second FET failed. PGT tested, ERA complaint. I was told 85% survived the thaw for the second time. Anyone have this happen? Im 39 - 4 retrievals - has two genetically normal embryos. Devastated doesnt begin to explain. No idea where to from here.

#2 hopefuldadsomeday

hopefuldadsomeday
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  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 08 November 2021 - 08:11 PM

@Tryingformybaby Sorry to hear your FET didn't succeed.  I believe even with PGS-testing, success rate is usually about 60-70%, so maybe it's just due to bad luck.  Our clinic ran two new tests for our most recent FET cycle called ALICE and EMMA.  They ran the test during our mock cycle and it turned out my wife had low grade infection (possibly from her C-section?) and she did a course of antibiotics before proceeding with the actual transfer.  Might be worth discussing with your clinic?  Hope your next attempt is successful!

 

https://www.igenomix.../alice-clinics/

 

https://www.igenomix...s/emma-clinics/


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#3 Tryingformybaby

Tryingformybaby
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  • Dx:Unexplained
  • My Clinic:Shady Grove

Posted 08 November 2021 - 08:58 PM

Thanks so much for your reply. Ill ask about it. Hope it works out for your guys soon!

#4 Cotton3

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Posted 09 November 2021 - 08:35 AM

Some REs are guilty of overselling PGS. Mine told me untested embryos have 40% chance, tested 65%.



#5 Progenesis IVF

Progenesis IVF
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Posted 21 December 2021 - 03:31 AM

IVF is termed to have failed repeatedly when there is failure to achieve clinical pregnancy even after transfer of at least four good quality embryos in a minimum of three fresh or frozen cycles in women under 40 years of age. While most of the ART (Assisted Reproductive Technology) clinics report an implantation rate of 40-60%, the exact incidence in lacking due to the difference in. definition of implantation.

Repeated IVF failure can be attributed to quite a few reasons. These can be embryo related, parental chromosomal abnormalities which leads to abnormal embryo formation or oocyte aneuploidies dur to advanced maternal age.
A few other causes listed are:
  • High sperm DFI (DNA Fragmentation Index)
  • Intra-Uterine adhesions (scar tissue)
  • Congenital abnormalities in uterus
  • Presence of Hydrosalpinx
  • Fibroids Adenomyosis
  • Thin endometrium
  • Autoantibodies
  • High BMI
  • Polyps
  • Defective endometrial receptivity
  • Immunological factors


#6 Mheysie

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Posted Today, 12:05 AM

Hey. Sorry to hear about your transfer Weve also had 2 failed FET after PGTA, ERA, 2 polypectomies. My doctor is adding steroids and intralipids for possible autoimmune problems although my bloodwork didnt show anything. And yes, devastation does not begin to explain how I feel. I have not been the same since the 2nd failed transfer.