Any hope to have 1 PGS normal among three blasts at age 42? - IVF Ages 35+ - IVF.ca Forums

Jump to content



Photo
- - - - -

Any hope to have 1 PGS normal among three blasts at age 42?


  • Please log in to reply
8 replies to this topic

#1 MGMO

MGMO
  • Just Hatched
  • 3 posts
  • Dx:Male Factor

Posted 06 November 2021 - 09:54 PM

I just sent three good grade blastocysts for PGS testing. I am 42 years old. Can I have any hope?

I have heard that at my age only 20% of the blasts are normal. In that case I will not have any normal PGS.

 

Please share your information and success stories?

 

Thank you



#2 Bearyhopeful

Bearyhopeful
  • Just Hatched
  • 2 posts
  • Dx:N/A

Posted 07 November 2021 - 08:03 AM

@MGMO, I am 41 and have gone through 4 IVF cycles. In our last cycle in August 2021, we were lucky enough to have 3 day 6 blastocysts. They were sent out for PGS testing and we were overjoyed to learn 2 were normal! So there is hope! Best wishes and please keep us updated.

#3 Cotton3

Cotton3
  • Member
  • 98 posts
  • Dx:Male Factor

Posted 07 November 2021 - 12:29 PM

https://www.news-med...iago-Munne.aspx



#4 MGMO

MGMO
  • Just Hatched
  • 3 posts
  • Dx:Male Factor

Posted 07 November 2021 - 06:56 PM

Thank you Brearyhopeful: Congratulations. May I ask how many blastocysts did you have in other cycles that did not give you a normal one?

 

Thank you Cotton3: The link was interesting and useful. 



#5 MGMO

MGMO
  • Just Hatched
  • 3 posts
  • Dx:Male Factor

Posted 07 November 2021 - 09:20 PM

One thing interesting in the article you (Cottone3) sent is that the probability of having a normal embryo in the old age range is higher than what I found in other resources.

I found that for 42 yo, only 20% of the blastocysts are genetically normal but here it is 34% (with 1-3 day 5 embryos) !

If I want to consider the 20%, I have almost no chance, unless I be lucky person which I am not usually.

 

This is my second IVF cycle. In my first cycle I have only one blast which was abnormal.



#6 Cotton3

Cotton3
  • Member
  • 98 posts
  • Dx:Male Factor

Posted 08 November 2021 - 07:26 AM

Unfortunately even if there is a normal embryo, that is only 65-80% chance of a take home baby. My RE says 65%, I've seen other sources say the 80%.



#7 Bearyhopeful

Bearyhopeful
  • Just Hatched
  • 2 posts
  • Dx:N/A

Posted 08 November 2021 - 03:04 PM

@MGMO, I have an ovarian cyst and a bunch of fibroids so in our last 3 IVF cycles, they were only able to retrieve eggs from one ovary. I also have egg quality issues, likely due to age and my cyst. In the 4 cycles we did, we got a total of 27 eggs, only 5 made it to be day 5/6 blasts. We did test all 5 and 3 were normal.

#8 hopefuldadsomeday

hopefuldadsomeday
  • Global 100+
  • 745 posts
  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 08 November 2021 - 03:22 PM

My wife underwent 3 rounds of IVF when she was 36/37. First cycle only gave 2 blasts (1 normal), second cycle only 1 blast (normal), and third cycle only 1 blast (normal).

 

First FET was unsuccessful (later determined through ERA needed 1 more day of progesterone).  Second FET successful.  Third successful, but waiting for 8 week scan.

 

Hope all 3 of your embryos come back normal and you have a successful transfer!


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#9 happyfrog

happyfrog
  • Global 100+
  • 164 posts
  • Dx:Unexplained
  • My Clinic:Invicta

Posted 08 November 2021 - 03:31 PM

It depends on many reasons, I know ladies aged 40+ who conceived naturally with no issues, and women who are 25+ and have had a few negative IVFs. Trust your doc, follow their recommendations, and prepare your body and mind for the future treatment. All the best