looking for some insight and suggestions based on your experiences:
I'm 35 (turning 36 at the end of this month) hubby is also 36. We have been TTC for 2.5 years. We did 2 rounds of IUI with letrozole which failed in fall 2020. my AMH is good and my AFC was also good. Regular periods and I ovulate regularly on my own.
Did our first IVF ICSI cycle in Saskatoon at Aurora March/April 2021. We were recommended to do ICSI due to low binding enzyme on DH sperm. Did 12 ug Rekoville 225u Menopur, cetrotide antag. for 3 days before trigger (double). We had # eggs : retrieved 11, 8 were mature and ICSI performed. 5 fertilized and made it to day 3 but at day 5 we had only 1 blast. 2 stopped growing between 3/5 and the other 2 were given another day to grow but weren't quality enough to freeze at day 6. I had a chemical/early implantation failure as at beta my HCG was 3, repeated 2 days later it was 0.
After that cycle failed we both had karyotype testing which was normal for both and DNA frag was excellent (below 6%). DH #'s are excellent motility and count.
July 2021 2nd cycle changed meds to 75u Menopur and 300 Puregon. Orgalutron antag. Trigger of Pregnyl. This time I had 14 eggs retrieved (thought I would have more as i was SO bloated and on the US there were approx 10 per side) 12 were mature and performed ICSI. 6 fertilized and made it to day 3. At day 5 we had 4 however only 1 had reached early blast. We transferred that blast and another pre-blast embryo which they performed assisted hatching (on both) and gave the other 2 another day to grow but they stopped. My beta is in 3 days but I'm not optimistic.
After our first cycle failed, Doc thought maybe sperm issue (hence karyotype and DNA frag) but both were normal. I'm ready to start seeking a second opinion- is it egg quality?Sperm quality? lab quality/technology?
We have paid out of pocket for all treatments, and luckily we have the means to travel if need be. Where would you go if you were in my shoes for the best quality, most advanced care in Canada?