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Thoughts on ERA?


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3 replies to this topic

#1 Adia888

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Posted 14 July 2021 - 11:39 AM

After 4 egg retrievals, we have one PGT-A normal blastocyst. Our doctor is recommending a supplemented natural FET but no ERA. Doing the ERA would also be logistically very difficult for us as we live across the country. For those who have done a natural or supplemented natural transfer, did you do an ERA? Why or why not? I have also heard an endometrial scratch may be beneficial before transfer but our doctor does not recommend that either. What do you all think?

#2 hopefuldadsomeday

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Posted 15 July 2021 - 09:56 PM

Anecdotal evidence, ERA was the difference maker for us (but medicated cycle).  All our embryos were PGS-tested.  Our first FET cycle, transfer was on day 5 and despite a decent lining, resulted in BFN.  Did a ERA test and test showed my wife needed an extra day of progesterone.  Our second FET cycle, despite thinner lining and using exact same protocol but just 1 extra day of progesterone, and resulted in our DD.  My wife currently doing another mock ERA cycle now before we attempt another FET next month.


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415


#3 amazing grace

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Posted 17 July 2021 - 05:01 PM

ERA  made no difference for me. Transfers at my clinic were usually done on Day 5 but most clinics now changed that to Day 6 anyways. 



#4 Jerbitts

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Posted 05 August 2021 - 12:41 AM

There are mixed results to ERA. So I think that it really depends on who you are talking to.