Genetic Testing of Blastocyst - IVF Ages 35+ - IVF.ca Forums

Jump to content



Photo
- - - - -

Genetic Testing of Blastocyst


  • Please log in to reply
7 replies to this topic

#1 moonrose

moonrose
  • Just Hatched
  • 1 posts
  • Gender:Female
  • Dx:Unexplained

Posted 25 May 2021 - 06:46 PM

Hello Everyone,

 

I am so new to the IVF journey. I tried searching for more information on genetic testing of blastocysts. I am so confused as to what the right thing to do may be. Has anyone had any experience in doing this with their IVF procedures? Any help/insight would be very much appreciated. 



#2 Jerbitts

Jerbitts
  • Global 100+
  • 115 posts
  • Dx:N/A

Posted 26 May 2021 - 09:31 PM

I have no idea with that. I hope someone chimes in and gives us more information.



#3 Xalo3

Xalo3
  • Global 100+
  • 175 posts
  • Dx:PCOS
  • My Clinic:Markham Fertility

Posted 26 May 2021 - 11:01 PM

I have done PGT for 2 out of my 3 IVFs. This last cycle I got 2 embryos however they could only test one and it came back abnormal. My fingers are crossed the one they couldn't test is normal and we get great news after our FET.

#4 Xalo3

Xalo3
  • Global 100+
  • 175 posts
  • Dx:PCOS
  • My Clinic:Markham Fertility

Posted 26 May 2021 - 11:02 PM

I should also add I would have done PGT for all 3 cycles however the second cycle didn't end up having any embryos that could be tested.

#5 Threemakesbaby

Threemakesbaby
  • Just Hatched
  • 3 posts
  • Dx:DOR

Posted 29 May 2021 - 01:20 PM

Hello,

 

I'm not sure what your situation is, but the clinic I went to recommended genetic screening because of my age - i was 41 at the time and my egg count was low. After two round of retrieval I was left with two blastocysts (day 5 embyros). Those two little blasts were then sent for screening where we found out one was "good" and the other was a "high level mosaic". The clinic I went to said that they don't implant women with "high level mosaic" blastocysts essentially because it won't result in a live birth or the offspring won't survive. In the end we had two day 5 eggs but only one was viable. It saved us from going through another heartache...



#6 Cotton3

Cotton3
  • Member
  • 65 posts
  • Dx:Male Factor

Posted 30 May 2021 - 01:10 PM

Pro

Avoid transferring abnormal embryos that can cause BFNs and miscarriages, saves time and emotional energy

Can help rule out causes of infertility (e.g. if several normal transfers don't work you can look into uterine or immunological causes of infertility)

Can help you decide whether or not to do another IVF cycle before trying a FET

Can be cost effective if you have many embryos

 

Con

Cost

The biopsy of the embryo can't possibly help it

Can't make good embryos where there are none

False positives - can throw away good embryos

Only detects large chromosomal problems, a PGS normal embryo is not a guarantee (40 vs 65%)



#7 hopefuldadsomeday

hopefuldadsomeday
  • Global 100+
  • 733 posts
  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 09 June 2021 - 06:46 PM

We did PGS-testing for all 3 of our IVF cycles.  Reason was that my wife had 3 previous miscarriages (1 confirmed due to genetic abnormality) and we wanted to minimize the chance of another one.  We ended up producing 4 blasts out of 3 cycles, and 3 were tested normal.


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Sep 2021?


#8 happyfrog

happyfrog
  • Global 100+
  • 146 posts
  • Dx:Unexplained
  • My Clinic:Invicta

Posted 21 June 2021 - 08:40 AM

Two friends of mine combined IVF with PGS NGS due to male factor and eggs quality, both got pregnant.