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First FET failed..whats next?

failed FET FET

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#1 pebbles158

  • Member
  • 16 posts
  • Dx:Unexplained

Posted 09 May 2021 - 06:10 PM

I had my FET in late April. The beta test after two weeks came back negative. Upon asking the nurse, she told me that the beta reading was 0.1 that means the embryo never implanted anywhere inside.


Has anyone been throught this situation where embryo never implanted? where did it go then? 


I am devastated to say the least. I am waiting to speak to my RE. How long one had to wait before trying for 2nd FET? What is the minimum wait between transfers?


Were there any more tests done to determine the failure and to prepare the uterus better for the next transfer?


I had done ERA and had been on medicated cycle with Estrace pills and Progeterone suppositories and injections on alternate days.  

#2 From0to3

  • Global 100+
  • 170 posts
  • Gender:Female
  • Location:Vancouver
  • Dx:Unexplained
  • My Clinic:PCRM

Posted 11 May 2021 - 10:53 AM

Hi Pebbles,
This 0 implantation happenned to me as well with my first fresh cycle and with 2 'perfect' hatching embryos my RE said he would bet money on. It was very difficult to understand how the 2 embryos didnt even begin to implant especially when of such good quality. I waited 1 or 2 months for my next transfer and one of the 2 implanted but resulted in miscarriage at 9 weeks even after the heartbeat. My RE recommended immune testing but no issues were found and my infertility continued to be unexplained. That was it for embryos from that cycle even after extracting 17 eggs. I began my next cycle 2 months later and only extracted 6 eggs. Those 6 eggs lead to 5 embryos and my now 3 children and 2 embies on ice. When nothing implanted I still remember the feelings of hopelessness and that ivf was simply impossible but sometimes it takes a couple cycles for it to work with unfortunately very few predictors of success. Im so sorry you are going through this and its so easy to give up hope but there can be light at the end of the tunnel even if it doesnt feel like it right now. ❤
  • melissa87 likes this

IVF#1:17 Eggs, 4-5 Day Blasts: Transferred 2: th_abfn.gif

 FET#1: Transferred 2: th_abfp.gif m/[email protected] th_agrr.gif 

IVF#2: 5 Eggs, 5-5 Day Blasts: Transferred 2: th_abfp.gif Boy/Girl Twins born DEC 2013 babygirl.gif babyboy.gif 


FET#2:Transferred 1: th_abfp.gif Baby Girl born July 2016 babygirl.gif  


2 Frosties Remaining.

#3 Mcbealz

  • Member
  • 22 posts
  • Gender:Female
  • Dx:Unexplained

Posted 12 May 2021 - 06:05 PM

Hey Pebbles,

Sorry for this failed cycle. I was also in this boat in Nov when my only one embryo didn’t implant. I was devastated and angry, felt hopeless for a while. If you don’t mind me asking what was your ERA result? 

#4 Jerbitts

  • Global 100+
  • 115 posts
  • Dx:N/A

Posted 12 May 2021 - 11:53 PM

I agree with Mcbealz, knowing your ERA result might give some insight. I am sorry, all you're experiencing right now is shared by a lot of us.

#5 pebbles158

  • Member
  • 16 posts
  • Dx:Unexplained

Posted 18 May 2021 - 09:47 AM

Hey Pebbles,
Sorry for this failed cycle. I was also in this boat in Nov when my only one embryo didn’t implant. I was devastated and angry, felt hopeless for a while. If you don’t mind me asking what was your ERA result?

my ERA result revealed that i needed an extra day of progestreone. So i needed 6 days instead of 5 days od progestreone for fet

#6 hopefuldadsomeday

  • Global 100+
  • 746 posts
  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 20 May 2021 - 03:24 AM

Have your embryos been PGS tested?  If you had an ERA done, lining was good, and embryo was PGS tested, I would just chalk it up to bad luck and your next FET will hopefully be successful.  If your embryos weren't PGS tested, then possibly it was an abnormal embryo.  Good luck with your next FET!

March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!

#7 Alpha80

  • Member
  • 21 posts
  • Dx:Cancer

Posted 20 May 2021 - 06:48 AM

I am hoping that the next one would be a success! 

#8 happyfrog

  • Global 100+
  • 165 posts
  • Dx:Unexplained
  • My Clinic:Invicta

Posted 21 June 2021 - 08:47 AM

agree witt Global 100, if implantation is the issue, PGS NGS might be the best way to improve chances on the 2nd try. Good luck!

#9 niki mccarthy

niki mccarthy
  • Member
  • 3 posts
  • Dx:N/A

Posted 11 August 2021 - 11:52 AM

I had 2 failed cycles and finally my FET was successful. It took a long time but finally happened.

We are going through another FET in December for a second child. 

Don't get too discouraged. Its trial and error.

#10 Progenesis IVF

Progenesis IVF
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  • Dx:N/A
  • My Clinic:Progenesis IVF

Posted 29 December 2021 - 06:55 AM

IVF is termed to have failed repeatedly when there is failure to achieve clinical pregnancy even after transfer of at least four good quality embryos in a minimum of three fresh or frozen cycles in women under 40 years of age. While most of the ART (Assisted Reproductive Technology) clinics report an implantation rate of 40-60%, the exact incidence in lacking due to the difference in. definition of implantation.

Repeated IVF failure can be attributed to quite a few reasons. These can be embryo related, parental chromosomal abnormalities which leads to abnormal embryo formation or oocyte aneuploidies dur to advanced maternal age.
A few other causes listed are:
  • High sperm DFI (DNA Fragmentation Index)
  • Intra-Uterine adhesions (scar tissue)
  • Congenital abnormalities in uterus
  • Presence of Hydrosalpinx
  • Fibroids Adenomyosis
  • Thin endometrium
  • Autoantibodies
  • High BMI
  • Polyps
  • Defective endometrial receptivity
  • Immunological factors
It is imperative to determine the reason behind the repeated failure of IVF before taking a look at the treatment options. For diagnosing the cause of repeated IVF failure uterine evaluation through Hysteroscopy comes handy.
Endometrial Receptive Array (ERA) is used to evaluate the receptivity of the uterus. This helps in determining the time when the uterus is completely ready to receive the embryo and the procedure can be scheduled accordingly. When high sperm DFI causes repeated IVF failure, advanced technology like MACS during ICSI can be chosen for selection of sperm with low DFI.

The couple must maintain a healthy lifestyle along with proper diet, regular meditation, yoga, exercise and refrain from smoking, alcohol and habit-forming drugs during the course of treatment. Patients must also be mindful of approaching a proper IVF consultant and IVF center to avoid the stress of failure. Better results can be achieved by following the proper guidelines and instructions by the consultant.

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