
Any success story after failed implantation of top quality embroy s a..
#1
Posted 27 June 2020 - 12:39 PM
Please for those that have experienced it before what did you do differently to ensure implantation?
#2
Posted 27 June 2020 - 01:30 PM
#3
Posted 27 June 2020 - 01:52 PM
Motherof3 I am so sorry about your result. Even if all the stars align, your embryo is perfect and your lining is perfect, there's still only a 55-65% chance of a transfer resulting in a pregnancy. Was this your first transfer? Have a discussion with your RE as each person's body and experiences are different.
- annatarz79 likes this
#4
Posted 27 June 2020 - 07:44 PM
Mine AA quality PGS-normal embryo with lining @13, trilaminar, Failed.. I even had ERA and receptive done due to my age 41, and very precious embryo after 3ivfs... I even had endometrial scratch (polypectomy + small fibroidectomy done a month prior to transfer)... my REI was ecstatic while transferring (which was wrong) but she says it was slam dunk.. but still didnt work
This is immensely disheartening.
Prior Hx of miscarriage or normal pregnancy definitely adds to better odds but no guarantee.
#5
Posted 28 June 2020 - 07:31 AM
@maybe, so sorry to know you are also going through this. What do you intend to do differently next cycle? I really need ideas.
As returnable said; top quality PGS tested normal embryo has 60-65% implantation success.
Mine AA quality PGS-normal embryo with lining @13, trilaminar, Failed.. I even had ERA and receptive done due to my age 41, and very precious embryo after 3ivfs... I even had endometrial scratch (polypectomy + small fibroidectomy done a month prior to transfer)... my REI was ecstatic while transferring (which was wrong) but she says it was slam dunk.. but still didnt work
This is immensely disheartening.
Prior Hx of miscarriage or normal pregnancy definitely adds to better odds but no guarantee.
#6
Posted 28 June 2020 - 07:33 AM
@returnable thanks though that's my second transfer with a very good embroys. The embroys in the first transfer wasn't good enough.
I will just go for another cycling believing for a better outcome.
Motherof3 I am so sorry about your result. Even if all the stars align, your embryo is perfect and your lining is perfect, there's still only a 55-65% chance of a transfer resulting in a pregnancy. Was this your first transfer? Have a discussion with your RE as each person's body and experiences are different.
#7
Posted 28 June 2020 - 08:54 AM
No plans as of yet. May be another cycle hoping for embryo, which was so difficult to find during last 3cycles... and then what? I have done everything already and hope for miracle next time has slimmed down tremendously.
Did you have prior pregnancies or first time trying?
How old are you, meaning hope for normal embryos?
Did you do ERA and receptiva before this last transfer?
#8
Posted 28 June 2020 - 09:31 AM
IVF#1:17 Eggs, 4-5 Day Blasts: Transferred 2:
FET#1: Transferred 2: m/[email protected]
IVF#2: 5 Eggs, 5-5 Day Blasts: Transferred 2: Boy/Girl Twins born DEC 2013
FET#2:Transferred 1: Baby Girl born July 2016
2 Frosties Remaining.
#9
Posted 28 June 2020 - 10:51 AM
@maybe grief all you can and get yourself up and going. We will fight through till we achieve result. Nothing can console me but to have my babies. As for your questions, I'm 35, never been pregnant before. Haven't done ERA yet will suggest that to my RE During my next cycle. I told my RE that I'm ready for another cycle. He suggested that I wait for my menstrual cycle to Start so we get the drugs out of my body.
I also heard that back to back cycling has greater chance of producing numerous follicles.
Keep me updated on your plans.
Currently going through different stages of grief and disbelief. I wake up startled several times a night.
No plans as of yet. May be another cycle hoping for embryo, which was so difficult to find during last 3cycles... and then what? I have done everything already and hope for miracle next time has slimmed down tremendously.
Did you have prior pregnancies or first time trying?
How old are you, meaning hope for normal embryos?
Did you do ERA and receptiva before this last transfer?
#10
Posted 28 June 2020 - 11:21 AM
Next time, get ERA done, as well receptiva (inflammation score) if your RE finds it appropriate. Although, none of this ensures success but ERA definitely helps somewhat.
Wish you best of luck and hope for the same for myself and everybody on this boat !
#11
Posted 28 June 2020 - 12:43 PM
I am so sorry to hear about your failed cycle. As stated above, nothing is guaranteed with ivf. Like many above, I have done one donor egg Ivf cycle which yielded 15 embryos. 8 of the embryos were top. Nothing led to a live birth. Out of that, I had a termination at 17 weeks due to a birth defect incompatible with life, five failed fet cycles, a miscarriage and an ecotopic. I have done every test under the sun, ERA, Endo scratch, endo biopsy, the works and nothing helped. Sometimes as in my case there are just no answers as to why it works for some and not for others.
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#12
Posted 30 August 2020 - 09:58 AM
I am sorry to read your story. Unfortunately, there are too many reasons why implantation fails. A friend of my sis had genetic issues, and only IVF PGS NGS worked out for her.
#13
Posted 31 August 2020 - 11:00 PM
Hatching blastocyst. You will likely hear that hatching blastocyst has better chance for implementation. When you do PGS/PGD, the embryologist will need to drill a hole and take some cells for testing so PGS/PGD usually will lead to hatching blastocyst. If you dont do PGS/PGD, you can still poke a hole in the embryo (I Think ) and thats called assisted hatching. Anyhow, you will also hear mixed opinions about drilling a hole in the embryo.
We also learned that one potential issues for implantation failure could be the bodys natural killer cells. Because in FET, embies injected to the uterus are sort of considered foreign objects and the woman bodys natural killer cells could fight the embies, causing the embies not to implant. If you were going to do FET, you cAn ask your doctor to check the body NK level and there is something called intralipid that can help lowering the NK level. Some ladies in New York (because Im from NYC) had successful FET with and without intralipid. You will hear mixed opinions about intralipid.
Blood circulation is important.
Embies will need to stick to the lining. My wife used estrogen patches in the failed FET, and those patches caused allergy, so even today, we never figured out whether her body was able to absorb the estrogen from the patches. From this experience, no more patches going forward ever. She is taking estrace orally now.
Wife did a stimulated/natural FET last Thursday and transferred two normal embies. we did everything that we could to potentially address a number of issues learned from previous attempts. We hope this time will work. Everyone is different. Things that work on one might not work on another person.
#14
Posted 29 September 2020 - 04:34 PM
amazing grace - I am sorry you are going through this. Have you tested your genetics, I mean karyotyping. Aneuploidies might be an issue in your case.