6 replies to this topic

[moomac]

Have had 8 single frozen embryo transfers (combination of Day 3 and Day 5) with only one pregnancy that ended in a miscarriage at 10 weeks.

 

My questions are:

1) What tests can be performed to assess the cause of my repeated implantation failure (i.e. killer cells, blood clotting disorder etc)?

 

2) What evidence based approaches are known to help with RIF? (i.e. Intralipids, Prednisone, Fragmin, HCG wash, Embryo glue etc). Looking for approaches that have a decent to strong evidence base.

 

3) Of the suggested approaches to help with RIF are any of the known adverse effects on baby or pregnancy? Has the intervention been used long enough to know potential long-term effects?

 

Thank you,

 

 

[socialgirl]

Hi moomac,

 

I would consider getting the ERA test. I did one in the Summer of 2018 and it showed that I needed an extra day of progesterone.

 

Have you also considered doing PGS testing?

 

Good luck with everything! I pray that the fertility gods are smiling on you.

[hw209]

I second the ERA test. Some doctors dont believe in it but in your case I think it would be worthwhile trying it. Also, you could try acupuncture, it can help prepare your body for implantation/to accept the embryo and has no adverse effects.

[hbbg]

Hi Im in a similar boat- 9 embryos transferred, day 3 & 5, frozen, fresh. Even with an Era and the correct date. Not pigs tested. My RE strongly suspects immune issues. So the plan is another full ivf, pgs & immune testing bloodwork.

[amazing grace]

I have done it all!!!! I had three early miscarriages, five failed frozen transfers, a termination at 17 weeks due to anencephaly and just recently an ectopic pregnancy. I have had immune testing. immune protocol, ERA, intralipids. acupuncture and can't remember all the other things. 7 years later, still no baby. I believe sometimes no answer is found, unfortunately. 

[DrMichaelHartman]

The evidence for most interventions for recurrent implantation failure, including most of the ones mentioned in this thread, are unfortunately very poor. When things aren't working people are willing to try anything. Ultimately whether an embryo decides to stick or not after RIF may have nothing to do with the intervention people tried, and likely has more to do with the embryo.

That being said many of the interventions do not have any significant harm, but some do have significant cost.

[tabkay]

Hello.
I am so sorry, I came across this and thought if I should ask here.
We are in the same boat of RIF.
All the immune testings and other testing, do we pay out of pocket or is it covered?
Thank you