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PGS / PGD during IVF

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#1 honeybaby090587

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Posted 30 December 2018 - 04:43 AM



My dear husband's semen analysis reported oligoasthenoteratozoospermia with very low sperm count. Chromosome Y deletion test was done and was diagnosed with Y chromosome deletion (complete deletion of AZFc) which is the reason for bad sperm quality. No other Chromosomal abnormalities were detected in DNA test. IVF with ICSI is the only option but if we end with a boy, Y chromosome deletion will be inherited which means all sons will have same problem and we dont want to pass on this problem to our next generation. PGS/PGD test can be done to diagnose any genetic diseases in the embryo or check for chromsome imbalance (these tests will also have have gender information of the embryo). I have an option to get IVF done in either of India, Singapore or Australia and I understand PGS/PGD is allowed in these countries only if there are genetic issues. Could you please help me clarify below questions with respect to country specific laws?

1. Is Y Chromosome deletion considered as genetic issue and will they allow us to do PGD/PGS done during IVF?
2. Since this genetic issue is gender specific, will they allow disclosing of gender of the embryo and allow implanting only girl embryo?

Thanks in advance!

#2 jtstan

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Posted 30 December 2018 - 02:28 PM

Hey there, the fertility lawyer section of this site is pretty quiet...not sure how often the volunteer lawyer checks in to respond. I think the best place to ask about laws surrounding gender selection due to genetic issue is the clinics you’d be interested in cycling in. After all they are generally the most versed in the laws surrounding it as they are the ones that have to adhere to them. Will the male embryos 100% have the genetic issues? If so and you only want to transfer female embryos then you wouldn’t need PGD, just PGS with gender selection. I do know that you can have this done in the states purely on preference for one gender, genetic issues aside. So there’s that as last resort if they will not agree to it. Best of luck!

#3 mouse


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Posted 30 December 2018 - 06:00 PM

Given that the regulations regarding assisted reproductive technology varies so much from country to country you're likely best off checking with a lawyer in your home country. I'd expect that they'd have more insight into the specifics in Singapore as well as any considerations to take into account if you pursue treatment in India or Australia.  Fingers crossed for you!

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#4 honeybaby090587

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Posted 31 December 2018 - 12:48 PM

Thank you for valuable response. I put this query in general section and ask if anyone has exprience with PGS during IVF. Their experience might help me with some info. Thank you