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Is it normal for total motility to drop off after freezing?


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6 replies to this topic

#1 PastryGal

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Posted 11 November 2018 - 10:54 AM

Since there is no volunteer andrologist I figured I would ask this here in case anyone can offer any information.

 

It is my understanding that the normal total motility standard for ejaculated samples is over 40%.

 

I have read some studies that show that it is normal for total motility to decrease after freezing, however some of these studies are older and may now be outdated.

 

If it is normal for total motility to drop off after freezing, is there a corresponding "normal standard" for motility post thaw?

 

I ask because DH recently had a sample frozen which had a total motility of 47% before freezing (in the normal range) and the total motility post thaw was 23%. We were told that this means that DH's sample is of poor quality because the total motility post thaw has to be over 40% to be considered normal. 

 

If anyone has any information it would be appreciated!


4 failed IUIs (2015 and 2016), 1 failed IVF (2016)

DE IVF 2017 - one embryo transferred, ended in miscarriage

FET 2018 - BFN

No embryos left - taking some time to decide what is next.


#2 DorothyandToto

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Posted 11 November 2018 - 11:32 AM

PastryGal,

I have read studies saying exactly what you are saying about the motility lowering after thaw. Is ICSI a possibility for you two? My husband has low to normal motility in a fresh sample and the doctor says we have much better chances with ICSI.
Best of luck.

Kristie

#3 schlepp

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Posted 11 November 2018 - 11:55 AM

We had this happen with TESA sperm. It resulted in very low fertilization and only 1 blast that didn't implant. We think it was a sign of quality.


(age 38) June 2016 IVF #1 antagonist, 13 mature eggs, 4 fertilized, 1 blast frozen

October 2016 FET #1 cancelled, thin lining

Changed clinics

(age 39) April 2017 FET #1.1 BFN

July 2017 partner has vasectomy reversal

Feb & March 2018 - Medicated IUI x2 - BFN (even with 7 mature follicles on the 2nd IUI)

(age 40) May 2018 IVF#2, lupron flare, 7 mature eggs, 5 fertilized, 1 blast & 1 morula fresh transfer, BFN. 1 low quality blast frozen

June 2018 IVF#3 mini stim, 1 egg, immature

Sept/Oct 2018 IVF#4 antagonist with HGH - CANCELLED due to high estrogen/29mm cyst

Oct 2018 IVF#4.1 antagonist with HGH - 7 eggs, all mature, 6 fertilized, 2 blasts on day 6, PGS tested/euploid

November 2018 FET #2 w/immune protocol and 1 PGS tested -  BFN

Locus Medicus testing for virus, bacteria and immune issues. Husband treated.

(age 41) April 2019 IVF#5 converted to IUI#3 due to follicle growth. BFP 12 day post IUI. Di/Di twins.

Dec 17 2019 - Baby boy and girl born at 36 weeks + 2 days. Everyone very healthy. 

 

See my 'about me' page for more detail on my treatment history.


#4 schlepp

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Posted 11 November 2018 - 12:00 PM

If you have mature sperm I would recommend using PICSI. We ended up with mature sperm because we had surgery and used PICSI with better fertilization and blast rates.


(age 38) June 2016 IVF #1 antagonist, 13 mature eggs, 4 fertilized, 1 blast frozen

October 2016 FET #1 cancelled, thin lining

Changed clinics

(age 39) April 2017 FET #1.1 BFN

July 2017 partner has vasectomy reversal

Feb & March 2018 - Medicated IUI x2 - BFN (even with 7 mature follicles on the 2nd IUI)

(age 40) May 2018 IVF#2, lupron flare, 7 mature eggs, 5 fertilized, 1 blast & 1 morula fresh transfer, BFN. 1 low quality blast frozen

June 2018 IVF#3 mini stim, 1 egg, immature

Sept/Oct 2018 IVF#4 antagonist with HGH - CANCELLED due to high estrogen/29mm cyst

Oct 2018 IVF#4.1 antagonist with HGH - 7 eggs, all mature, 6 fertilized, 2 blasts on day 6, PGS tested/euploid

November 2018 FET #2 w/immune protocol and 1 PGS tested -  BFN

Locus Medicus testing for virus, bacteria and immune issues. Husband treated.

(age 41) April 2019 IVF#5 converted to IUI#3 due to follicle growth. BFP 12 day post IUI. Di/Di twins.

Dec 17 2019 - Baby boy and girl born at 36 weeks + 2 days. Everyone very healthy. 

 

See my 'about me' page for more detail on my treatment history.


#5 PastryGal

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Posted 11 November 2018 - 09:57 PM

Thanks DorothyandToto and Schlepp!

 

We have used ICSI in the past but I will look into PICSI a bit more before my next appointment and see if it is a possibility.


4 failed IUIs (2015 and 2016), 1 failed IVF (2016)

DE IVF 2017 - one embryo transferred, ended in miscarriage

FET 2018 - BFN

No embryos left - taking some time to decide what is next.


#6 Aimeehug

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Posted 13 November 2018 - 01:35 PM

I don't know the research but We froze sperm for an IUI because we went to Cuba. DH's samples were awesome when not frozen, but the motility and volume plummeted after freezing, I can't remember the numbers now, but it was hardly even worth it to do an IUI.

We're never freezing sperm again if we can help it.


me: 34 DH: 35 TTC since: Sep 2015

 

Jan 2018- Lap for Endo, and septum removal surgery

Mar-Aug 2018- 3 failed IUIs

Nov 2018- IVF...got my very first ever positive. 

Dec 19 2018- confirmed loss. at 5 weeks. cry.gif

Feb. 2019- preparing for first FET. Let's do this!

March 13, 2019- Transfer date for FET #1

March 18, 2019- turned 34 and got a squinter 5dp5dt.

March 22, 2019- Positive Beta! 

April 8, 2019- 1st ultrasound. all good except a small SCH.


#7 PastryGal

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Posted 14 November 2018 - 08:04 PM

Thanks Aimeehug for the reply. It does sound like somewhat of a drop off is normal. I have a few more weeks to wait but wondering what my clinic will have to say.


4 failed IUIs (2015 and 2016), 1 failed IVF (2016)

DE IVF 2017 - one embryo transferred, ended in miscarriage

FET 2018 - BFN

No embryos left - taking some time to decide what is next.