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0% morphology


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#1 Harlo17

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Posted 10 October 2018 - 04:28 PM

I am sure you have been asked this more times than you can count but what is the deal with 0% morphology? My husband and I are about to start our 4th round of ivf. We have a son out of the first 3 rounds. Every cycle all our embryos arrested on day 4. Except my son, one of two blasts I got in 3 cycles at 27/28. In the first 3 rounds his morphology came back between 2-3%. That was 3 years ago. We just checked his semen again before starting ivf next month and this time morphology is at 0. All of parameters are within normal range. Our doctors always say that the reason our embryos die on day 4 is because I have poor egg quality but I have normal FSH and AMH. I don't produce a ton of eggs, 6-12 per cycle but there have been no comments from embryologists that my eggs look a certain way. So what is the deal with 0% morphology? Is it is a concern. Can ICSI get past it? Is natural conception possible? Is that the reason our embryos are all arresting?

Me 30 Hubby 33

TTC Since October 2013

1 natural conception miscarriage Nov 2014 at 10 weeks 8388.gif

3 IUI's -  th_abfn.gif

3 IVF Retrievals

1 Fresh Transfer th_abfn.gif

1 Frozen Transfer th_abfp.gif Finally success with a Frozen Mosaic Embryo! Baby Boy Born May 2017 babyboy.gif

 

About to start IVF#4 for Baby #2 with poor egg quality 


#2 mouse

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Posted 10 October 2018 - 05:41 PM

Just so you're not hanging around waiting, I wanted to let you know that all our experts are volunteers and we haven't had an andrologist for some time now.  The members may be able to share their experiences with you, but if you're looking for specific medical advice it's best to contact your own care team.

 

Fingers crossed for you!


The plural of anecdote is not data.

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#3 Watermelon

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Posted 22 October 2018 - 03:12 PM

My partner has poor morphology. It has ranged from 0-2%. When we did our second round of IVF, they placed my immature eggs in with his sperm and let them have a shot on their own since they could not be ICSIed. I was floored when one of those eggs fertilized naturally. After 7 years of trying, I'd just assumed his sperm were incabale of fertilizing an egg given I'd never been pregnant outside of IVF. Our IVF was still disastrous (our embryos arrest like yours around day 4). That said, I got pregnant naturally the cycle immediately following that IVF (WTF!?). So.....yes it is possible to conceive with very poor morphology.

Me -29 31- unexplained poor egg quality. I was told I had endometriomas.....but repeat ultrasounds at other clinics have said no sign of endometriomas. Maybe PCOS-like ovaries, but no PCOS - AMH, AFC are great. No one can explain why my eggs are so poor sad.png

DH 30 - severe teratospermia, count and motility are excellent.

May 2014 - 2.5mg femara - BFN (ovulated night before)

June 2014 - IUI with 5mg femara - BFN (ovulated night before)

August 2014 - IVF with ICSI - Antagonist protocol, 150Bravelle, 75 menopur, stimmed 8 days

- 19 follicles (all 15-22mm at trigger), 12 eggs retrieved, 7 mature,, 5 fertilized with ICSIsad.png

- only 7 mature eggs with an estrogen of 20000?! wtf?! Sigh...Freeze All

-only one BB Blast made it. Freeze "all" became "freeze one". All others arrested between day 3 and 4 sad.png

January 2015 - FET of lone embryo - c'mon little figher

- BFP!!! Beta 1 475 at 10dp5dt , Beta 2 - 1495 at 12dp5dt

Baby boy born Sept 28/15


#4 hopefuldadsomeday

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Posted 25 October 2018 - 01:43 PM

I have poor morphology (1%) and my wife got "pregnant" naturally 3 times but miscarried.  With 0% morphology, I'd imagine your clinic will suggest using ICSI to help overcome this, good luck!


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif