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#1 maybebaby

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Posted 09 July 2008 - 03:10 PM

Great, just when I'm ramping up for my one and only IVF try.
I read this:

The risk of having genetically
abnormal offspring in ICSI has been
estimated to be three times greater
than the general population.

However, the causes of genetically
abnormal conceptions in IVF and
ICSI pregnancies have not been
established.

They may be due to the
ICSI procedure itself, embryo culture
conditions, and the use of genetically
abnormal eggs and sperm.
additional information will help us
determine whether the ICSI treatment
itself or other factors increases the risk
of genetic abnormalities.

What do you think? I wanted ICSI to increase my chances since this is a one shot deal.
:(
ME-41 DH-41 TTC 5 years AFC: 5 left, 9 right / Sperm Count & Motility good, morphology?
m/c - September 2004 & October 2005 (both natural) / furbaby - December 2005
HSC to 'have a look' - January 2006 / HSC to remove uterine polyp - November 2007
BFN after IUI - April 2008 (puregon & ovidrel) / BFN after IUI - June 2008 (puregon & ovidrel)
Cancelled proposed IVF for August 2008. Have decided not to pursue aggressive means of conception.
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#2 Rosa

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Posted 09 July 2008 - 03:14 PM

Hi,

I think I've read that most experts believe it's due to the quality of the sperm since most ICSI is done when there are problems with the sperm. So most experts believe it's due to the underlying genetic material and not the procedure itself. But of course, who knows for sure.

I have done ICSI to increase/guarantee fertilization. I know that Dr. Hollands thinks ICSI is done too often so that clinics can guarantee some fertilization after such an expensive procedure.

I wouldn't stress too much over it....so many people on this board have done ICSI with really good results. It's hard at our age since it's so much doom and gloom if you read the scientific studies......but I think we need to have some faith to keep going forward in this struggle.
Me 45, DH 41
TTC 3 years
Uterine polyps, high prolactin levels and tested positive for anti-cardio lipin
5 failed IUI's
IVF #1 July 2007, 32 eggs retrieved (many immature), 12 fertilzed, 9 made it to day 3, transferred 3 embbies, BFN
FET #1 - 3 embryos Oct 07, beta Nov 2nd, another BFN
IVF #2 - Nov 2007, on Lupron and birth control pill, 11 days of stims 225 Gonal F plus 75 Repronex and 150 Gonal F at night, retrieved 18 eggs Dec 11th, 8 fertilized through ICSI and 4 naturally
Transfer - 3, 8 cell embryos Dec 14th, BETA Dec 28th, BFN
7 frozen
FET #2 - June 5/08, BFN
hysteroscopy and polypectomy on Sept 25/08, removed 1 polyp
FET #3 - used up my last 4 frosties Oct 27/08
Beta Nov 9/08 125 BFP 13dp3dt
Beta Nov 11/08 315 15dp3dt
Beta Nov 15/08 over 2000 19dp3dt
Beta Nov 18/08 7365 22dp3dt
U/S date Nov 29/08, a singleton, heart beat 131 beats per minute
U/S date Dec 7/08, heart beat 160 beats per minute, growth good 8 w 2 days
U/S date Dec 13/08, heart beat 157 beats per minute, growth good at 9 w 1 day, baby moving around
U/S date Dec 27/08, heart beat 165 beats per minute, growth good at 11 weeks 1 day, baby moving around, now has arms and legs and was kicking
nuchal test US Jan 2/08 TEXTBOOK NORMAL Thank you God!
IPS pregnancy test results NORMAL, risk is 1/800 of Down's Syndrome and 1/1,100 for spina bifida
anatomical u/s NORMAL, it's a girl!
Due date July 18, 2009 in the home stretch

Sophia Anne born July 22, 2009 at 12:41 AM via emergency C-Section.

Fell down the stairs Aug 4, 2010, fractured C7, T1, T3 and 4 ribs (neck and upper spine). Still healing and hoping bones fuse on their own.

#3 Hero08

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Posted 09 July 2008 - 03:15 PM

Hi Maybe - we did ICSI because like you it was a one shot deal. The dr. and I had an argument about it beforehand because he didn't think we'd need it. I made sure everyone knew I didn't want to take chances and when we talked to the embryologist he said it could go either way. I took a deep breath and decided to leave nothing to chance. I think we had 15 mature eggs and 12 were fertilized with ICSI. 10 embryos made it and 5 were transferred and 5 were frozen. At this point I'm glad we did it. I would have hated to not have enough (or any) fertilize. Not a chance I was willing to take.
Me: 43 DH: 38
TTC for 4 years
3 iuis w/ clomid
1 1/2 yrs TCM
IVF #1 a success!
ER June 12, 2008 ET June 15 (5 transferred)
Beta June 29 1133
First Ultrasound July - 2 heartbeats
Official Due Date Mid Feb 2009 (38 weeks)
Gabriella Rose (5lb 14oz) and Chloe Jane (6lb 3oz)
born 5am Feb 19, 2009

#4 maybebaby

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Posted 09 July 2008 - 03:26 PM

Thanks, ladies! Whew, what would I do without you gals?!
:wub:

#5 Hero08

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Posted 09 July 2008 - 03:28 PM

That's how I feel. Now I just need you guys to get pregnant and join me for all the fun! Good luck!!!!!!!!
Me: 43 DH: 38
TTC for 4 years
3 iuis w/ clomid
1 1/2 yrs TCM
IVF #1 a success!
ER June 12, 2008 ET June 15 (5 transferred)
Beta June 29 1133
First Ultrasound July - 2 heartbeats
Official Due Date Mid Feb 2009 (38 weeks)
Gabriella Rose (5lb 14oz) and Chloe Jane (6lb 3oz)
born 5am Feb 19, 2009

#6 hopeful_flyer

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Posted 09 July 2008 - 03:29 PM

We need it next time. My eggies have tough shells apparently. :(

Damn hard boiled eggs...

grrrrrrrrrr.
ttc #1 Since Jan 2006. as of April 09 that means ttc for 40 months. Jebus. *sigh*
Bilaterally blocked tubes discovered Dec 2007
IVF#1 June, 2008 agonist protocol
300IU gonal f, 13 days of stims. Nothing to transfer.
EPIC FAIL
IVF#2 Started BCP for Antagonist protocol Oct 9, 2008 (menopur and centrotide)
Last BCP, Nov 2, 2008
First U/S Nov 2, start 300iu Menopur Nov 7, 2008
Back for daily scans and bloods starting Nov 11, 2008
U/S showed 5 follies between 1.1 and 1.25 start Centrotide today.
Nov 13 U/S showed 7 follies between 1.2 and 1.5
Next U/S Nov 14 10 follies
Trigger Nov 15
ER date, Nov 17th
6 retrieved.
4 mature and ICSI'd, 3 dividing on day 1.
3 still alive on day 2
ET Nov 20, 2008. All 3 going back!
8 cell grade 2, 6 cell grade 2, 7 cell grade 3 put back.
8dp3dt Brown spotting
AF arrived Nov 28, WAY early, thanks a lot...*sigh*
Beta Dec 1, 2008 (what is the point? NONE)
RE appointment April 27, 2009 to discuss IVF#2, and then I think we are done. Oh well, was a fun ride? *snicker*

I swear by my life and my love of it that I will not live for the sake of another man, nor ask another man to live for the sake of mine. -Atlas Shrugged

“Unthinking respect for authority is the greatest enemy of truth.”- Einstein.

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#7

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Posted 10 July 2008 - 02:06 PM

We did ICSI with both of our cycles. My DH's SA was ok, but not the best. So we did it anyway. Now, we had great fertilization, but they wouldn't progress I guess when transferred. We tried, and then found out my eggs are crap. But another doc says they aren't. So I am going to get another opinion and go from there. Never know. But it seems nothing goes my way anyway!!!

Hero--you transferred 5, just wondering if that was your choice or your the doctors. And are you pregnant or waiting for the 2ww?? That is wonderful that you got 5 to transfer. WOW.

#8 Rufus

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Posted 11 July 2008 - 05:58 PM

I asked my RE about this today and she explained the increased risk as meaning that the incidence of genetic anomalies goes from "extremely rare" to "rare". It's not like it is a .3% risk normally and jumps to something like 5% although it is statistically significant.

We'll be doing half and half even though we have no MFI.
Me: 44 DH: 48
After 3 fresh cycles and 1 FET:
Beautiful Baby Girl arrived January 10, 2010

Final FET: late February 2012
Started estrace Feb 8
Lining check: Feb 21...need a few more days
Feb 23...need 5 more days!
Feb 28 - good to go!!

Embryo transfer: March 4 "a perfect transfer" of 2 blasts (1 survived thaw with 100% of cells intact, 1 with 50% of cells intact)

Beta: March 17 - negative

#9 maybebaby

maybebaby
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Posted 11 July 2008 - 06:47 PM

Thanks, Rufus. That makes me feel better.

RE suggested half and half, but for my $1,200 bucks they might as well go all ICSI! I just received all the consent papers and will be pouring over that this weekend.
:sigh:
ME-41 DH-41 TTC 5 years AFC: 5 left, 9 right / Sperm Count & Motility good, morphology?
m/c - September 2004 & October 2005 (both natural) / furbaby - December 2005
HSC to 'have a look' - January 2006 / HSC to remove uterine polyp - November 2007
BFN after IUI - April 2008 (puregon & ovidrel) / BFN after IUI - June 2008 (puregon & ovidrel)
Cancelled proposed IVF for August 2008. Have decided not to pursue aggressive means of conception.
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