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AMT blood test


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#1 Rosa

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Posted 04 July 2008 - 11:07 PM

I had a followup appointment with my RE to talk about my failed cycles. One thing she mentioned I should do before trying IVF again is a blood test called AMT. It's supposed to be a much more accurate test that will determine your true ovarian reserve. She said FSH levels are guidelines but sometimes they're not totally accurate and don't reflect your true ovarian reserve.

It's a relatively new test and she said it would cost about $75 to do.

Has anyone had this test?

I will do it before trying IVF again as it will help me decide whether to stop TTC.

I would like to hear any feedback or your views on this blood test.

I have to tell you the idea of taking that test and having it come back and say "Rosa your eggs are past the sell by date" would be pretty devastating for sure.
Me 45, DH 41
TTC 3 years
Uterine polyps, high prolactin levels and tested positive for anti-cardio lipin
5 failed IUI's
IVF #1 July 2007, 32 eggs retrieved (many immature), 12 fertilzed, 9 made it to day 3, transferred 3 embbies, BFN
FET #1 - 3 embryos Oct 07, beta Nov 2nd, another BFN
IVF #2 - Nov 2007, on Lupron and birth control pill, 11 days of stims 225 Gonal F plus 75 Repronex and 150 Gonal F at night, retrieved 18 eggs Dec 11th, 8 fertilized through ICSI and 4 naturally
Transfer - 3, 8 cell embryos Dec 14th, BETA Dec 28th, BFN
7 frozen
FET #2 - June 5/08, BFN
hysteroscopy and polypectomy on Sept 25/08, removed 1 polyp
FET #3 - used up my last 4 frosties Oct 27/08
Beta Nov 9/08 125 BFP 13dp3dt
Beta Nov 11/08 315 15dp3dt
Beta Nov 15/08 over 2000 19dp3dt
Beta Nov 18/08 7365 22dp3dt
U/S date Nov 29/08, a singleton, heart beat 131 beats per minute
U/S date Dec 7/08, heart beat 160 beats per minute, growth good 8 w 2 days
U/S date Dec 13/08, heart beat 157 beats per minute, growth good at 9 w 1 day, baby moving around
U/S date Dec 27/08, heart beat 165 beats per minute, growth good at 11 weeks 1 day, baby moving around, now has arms and legs and was kicking
nuchal test US Jan 2/08 TEXTBOOK NORMAL Thank you God!
IPS pregnancy test results NORMAL, risk is 1/800 of Down's Syndrome and 1/1,100 for spina bifida
anatomical u/s NORMAL, it's a girl!
Due date July 18, 2009 in the home stretch

Sophia Anne born July 22, 2009 at 12:41 AM via emergency C-Section.

Fell down the stairs Aug 4, 2010, fractured C7, T1, T3 and 4 ribs (neck and upper spine). Still healing and hoping bones fuse on their own.

#2 stillsmiling

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Posted 04 July 2008 - 11:21 PM

Rosa,

I have heard of the test but none of the RE's I've seen offer that one yet. I would love to have it. Like you, I would hate to get bad news but I would rather get bad news on a test than keep having unsuccessful IVFs.

If you do decide to have it, I wish you all the best and hope for very positive results.

Namaste,

Cindy
DP (Joey) 36, me (Cindy) 36
1st IVF January 08
02/07/2008 BFP then m/c
2nd IVF Sept 08 =BFN
3rd IVF Feb 09 = another BFN
changing directions
partner 6 IUI's all BFN
July 2009, started donor egg cycle.
ET Sept 11 = another BFN
One more DE cycle hopefully in January 2010.

Hope is like a bird that senses the dawn and carefully starts to sing while it is still dark.

my blog http://cindysblog-ba...e.blogspot.com/

#3 mouse

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Posted 05 July 2008 - 06:44 AM

The Anti-Müllerian hormone test (AMT or AMH) has been around for a while and is sometimes combined with FSH and Inhibin-B analysis to more comprehensively assess ovarian reserve. The plan ahead test I've linked to in other posts uses these three and while I can't speak for practices in the US or Canada yet, these tests are offered by REs in SE Asia and the Middle East/Gulf States although with some you have to ask for them.

I'm having the three tested - just waiting for Day 3 now - in spite of the risk for bad news because I'd rather know up front whether my ovarian reserve is less than average for my age. This will help me decide whether and how to proceed before I pour my scant resources (not to mention emotions) into procedures that are already 'chancey' enough. While getting bad news will be difficult indeed, it won't be any worse than going through IVF and not having a positive result. If my eggs are done-for, they're done for - no matter which way I find out about it.

http://humrep.oxford...full/17/12/3065
http://humrep.oxford...full/17/12/3065 http://jncimono.oxfo...full/2005/34/18
http://www.obgyn.net..._ovarianreserve

http://www.life-style-choices.com/us/

edited to fix a url

Edited by mouse, 05 July 2008 - 06:56 AM.

The plural of anecdote is not data.

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#4 maybebaby

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Posted 07 July 2008 - 05:01 PM

Excerpt from: http://www.drmalpani.com/oopause.htm

If you are not comfortable with using donor eggs, you can try the following measures to improve your ovarian reserve.

1. Yoga
2. Acupuncture
3. DHEA, 25mg thrice a day.

However, do remember that none of these interventions has been proven to help - so you need to try out a clinical trial on yourself !

Read the inspiring book, Inconceivable, at http://www.amazon.co...s/dp/0767908201

You can also check your Day 3 FSH levels after 2-3 months to see if they improve. If you live in the USA, the good news is that you can now check your blood test levels of your hormones yourself. You can do this at https://www.mymedlab...tests.php?s=236.
ME-41 DH-41 TTC 5 years AFC: 5 left, 9 right / Sperm Count & Motility good, morphology?
m/c - September 2004 & October 2005 (both natural) / furbaby - December 2005
HSC to 'have a look' - January 2006 / HSC to remove uterine polyp - November 2007
BFN after IUI - April 2008 (puregon & ovidrel) / BFN after IUI - June 2008 (puregon & ovidrel)
Cancelled proposed IVF for August 2008. Have decided not to pursue aggressive means of conception.
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#5

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Posted 07 July 2008 - 06:51 PM

The Anti-Müllerian hormone test (AMT or AMH) has been around for a while and is sometimes combined with FSH and Inhibin-B analysis to more comprehensively assess ovarian reserve. The plan ahead test I've linked to in other posts uses these three and while I can't speak for practices in the US or Canada yet, these tests are offered by REs in SE Asia and the Middle East/Gulf States although with some you have to ask for them.

I'm having the three tested - just waiting for Day 3 now - in spite of the risk for bad news because I'd rather know up front whether my ovarian reserve is less than average for my age. This will help me decide whether and how to proceed before I pour my scant resources (not to mention emotions) into procedures that are already 'chancey' enough. While getting bad news will be difficult indeed, it won't be any worse than going through IVF and not having a positive result. If my eggs are done-for, they're done for - no matter which way I find out about it.

http://humrep.oxford...full/17/12/3065
http://humrep.oxford...full/17/12/3065 http://jncimono.oxfo...full/2005/34/18
http://www.obgyn.net..._ovarianreserve

http://www.life-style-choices.com/us/

edited to fix a url


Hi,

I am in Calgary, AB Canada. I did a lot of research on this subject through medline, and I also found that many world clinics used AMH and FSH tests prior to IVF to measure ovarian reserve. After, one failed IVF cycle, I asked three RE specialists in Calgary if the AMH test was a better indicator. They didn't take me seriously. They also didn't seem to appreciate my questioning their protocol! I was told that one test is not better than another. However, now I have found out after two failed attempts that my ovarian reserve is low-I am 38!! I have spent $10,000 on drugs to find this out!! There must be a better test so that people could spend their money more wisely. Now, I am looking into egg donor programs in Seattle-no wait list unlike Calgary, and Denver. However, it is expensive-approx. $30,000. It just seems that many questions are left unanswered and a lot of money is going to pay for these drugs!! If you find out anything about these other tests, pls. let me know.

Sincerely,
Winsett

#6 Rosa

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Posted 07 July 2008 - 10:59 PM

Hi Winsett, I'm in Toronto. I respond well to the meds and have produced a lot of eggs/embryos. When the doctors started treating me, they didn't even offer the AMT test as an option. They simply looked at FSH and antral follicle count, as well as my reaction to the meds, and they've assumed that my ovarian reserve is fine. My RE didn't say she thought I had diminshed ovarian reserve, but that I should do the AMT test before trying another round of fresh IVF is my next FET with my 4 frosties fails. She explained this test to me to say that FSH levels fluctuate during the cycle, but that the AMT levels are consistent and decline as you age and your reserve diminshes.

I will do more research on AMT. Seems like for $75 I should just do the test. I totally agree with you that REs here do not do enough tests before providing treatment. I found out that I needed fragmin and baby aspirin on my cycles, but the tests were never done until now (after 2 fresh failed IVFs and 1 failed FET). Who knows if one of them would have worked if I had been given the proper meds. My clinic also failed to diagnose my high prolactin levels. I kept telling my RE that I wasn't having regular periods anymore....she just said it was my reaction to the IVF meds, when it was actually low prolactin levels. Very frustrating.

I am seriously considering going to the United States for 1 last IVF try if my next FET fails. At least I'll know I've given it the best shot possible.
Me 45, DH 41
TTC 3 years
Uterine polyps, high prolactin levels and tested positive for anti-cardio lipin
5 failed IUI's
IVF #1 July 2007, 32 eggs retrieved (many immature), 12 fertilzed, 9 made it to day 3, transferred 3 embbies, BFN
FET #1 - 3 embryos Oct 07, beta Nov 2nd, another BFN
IVF #2 - Nov 2007, on Lupron and birth control pill, 11 days of stims 225 Gonal F plus 75 Repronex and 150 Gonal F at night, retrieved 18 eggs Dec 11th, 8 fertilized through ICSI and 4 naturally
Transfer - 3, 8 cell embryos Dec 14th, BETA Dec 28th, BFN
7 frozen
FET #2 - June 5/08, BFN
hysteroscopy and polypectomy on Sept 25/08, removed 1 polyp
FET #3 - used up my last 4 frosties Oct 27/08
Beta Nov 9/08 125 BFP 13dp3dt
Beta Nov 11/08 315 15dp3dt
Beta Nov 15/08 over 2000 19dp3dt
Beta Nov 18/08 7365 22dp3dt
U/S date Nov 29/08, a singleton, heart beat 131 beats per minute
U/S date Dec 7/08, heart beat 160 beats per minute, growth good 8 w 2 days
U/S date Dec 13/08, heart beat 157 beats per minute, growth good at 9 w 1 day, baby moving around
U/S date Dec 27/08, heart beat 165 beats per minute, growth good at 11 weeks 1 day, baby moving around, now has arms and legs and was kicking
nuchal test US Jan 2/08 TEXTBOOK NORMAL Thank you God!
IPS pregnancy test results NORMAL, risk is 1/800 of Down's Syndrome and 1/1,100 for spina bifida
anatomical u/s NORMAL, it's a girl!
Due date July 18, 2009 in the home stretch

Sophia Anne born July 22, 2009 at 12:41 AM via emergency C-Section.

Fell down the stairs Aug 4, 2010, fractured C7, T1, T3 and 4 ribs (neck and upper spine). Still healing and hoping bones fuse on their own.