Please Help - Thin Uterine Lining Issue - Page 5 - IVF Ages 35+ - IVF.ca Forums

Jump to content



Photo
- - - - -

Please Help - Thin Uterine Lining Issue

uterine lining thin uterine lining endometrial lining FET frozen embryo transfer lining

  • Please log in to reply
140 replies to this topic

#101 hopefuldadsomeday

hopefuldadsomeday
  • Global 100+
  • 746 posts
  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 01 June 2018 - 03:30 PM

Ms-tdot - this happened to my wife too on her first FET.  First 2 weeks, oral estrace 5.8mm.  3rd week oral estrace+vaginal estrace+vaginal sildenafil 6.25mm.  4th weeks estradot patches, lining regressed to 5.7mm and fluid buildup.  I'm glad to hear you had success though!


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#102 hopefuldadsomeday

hopefuldadsomeday
  • Global 100+
  • 746 posts
  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 04 June 2018 - 08:08 PM

Transfer done today, my wife said it went smoothly (except they were running behind schedule and she really had to pee!).  The two week wait begins...my wife wants to wait for the beta, I want her to test early.  I'll suggest to her to POAS and I won't tell her the results, haha!


  • SunshineTTC, Seem14, FMandAM and 1 other like this

March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#103 Seem14

Seem14
  • Global 100+
  • 194 posts
  • Gender:Female
  • Location:British Columbia
  • Dx:Tubal
  • My Clinic:Olive Fertility Clinic

Posted 07 June 2018 - 09:57 PM

Hopefuldad - I've seen plenty of your post, and I just wanted to pop by this thread and congratulate you and your wife!!!! Im just so happy that you were able to transfer!!!! :) good luck on the TWW and right now enjoy the PUPO stage!!! Wishing you and your wife all the best!

#104 Pomme

Pomme
  • Member
  • 14 posts
  • Gender:Female
  • Dx:DOR

Posted 08 June 2018 - 08:16 AM

Guys ! I just want to keep you updated!
As you know I was struggling with my lining...
I was stuck around 5.7-6.0mm with Estrace vaginally and orally!
They added Viagra for the last 2 weeks and this morning my lining was a 7.3mm trilaminar!!!

We will transfer probably next week! I just cant believe it ! I cried like theres no tomorrow in the doctors office and I hugged him!!!
  • FMandAM, schlepp, returnable and 1 other like this

#105 FMandAM

FMandAM
  • Global 100+
  • 155 posts
  • Gender:Female
  • Dx:DOR
  • My Clinic:OFC in Canada, Reprogenesis in the CR

Posted 08 June 2018 - 08:35 AM

Pomme, that's incredible! It's all about finding the combination that works for the individual, I'm so happy for you!

 

Can I ask, were you using it orally or vaginally? How many times a day?


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#106 schlepp

schlepp
  • Global 100+
  • 935 posts
  • Gender:Female
  • Location:Toronto
  • Dx:Male Factor

Posted 08 June 2018 - 10:48 AM

Lining update: I'm on a mini stim IVF cycle (which is going terribly in my opinion but we retrieve Sunday so that jury is still out) and started off with a 4.5mm lining on day 7. Now at day 15 and at 9mm, I was at 6mm on day 13. The weird part is that other than vitamin E, I stopped all of my lining supplements this cycle. We are doing a freeze all and I'm so exhausted from back to back cycles that I decided to give myself a break from the l arginine, tea 3x a day and black cohosh (although I always stop black cohosh for stims). After such a huge struggle with my lining (which was naturally at 5mm) I am wondering what changed. My estrogen is still very low as this is mini stim and I guess the femara suppressed it. So it was at 500 on day 13. Although my lining is consistently graded B, which can't be good. Ironically it was 7mm and an A on day day 3 this month. Odd. 

 

This is probably not helpful to those of you struggling but I thought I would share as the lining struggle is long and frustrating. Maybe eventually it can change? Or there is some kind of cumulative effect after doing the supplements for 18+ months. 


(age 38) June 2016 IVF #1 antagonist, 13 mature eggs, 4 fertilized, 1 blast frozen

October 2016 FET #1 cancelled, thin lining

Changed clinics

(age 39) April 2017 FET #1.1 BFN

July 2017 partner has vasectomy reversal

Feb & March 2018 - Medicated IUI x2 - BFN (even with 7 mature follicles on the 2nd IUI)

(age 40) May 2018 IVF#2, lupron flare, 7 mature eggs, 5 fertilized, 1 blast & 1 morula fresh transfer, BFN. 1 low quality blast frozen

June 2018 IVF#3 mini stim, 1 egg, immature

Sept/Oct 2018 IVF#4 antagonist with HGH - CANCELLED due to high estrogen/29mm cyst

Oct 2018 IVF#4.1 antagonist with HGH - 7 eggs, all mature, 6 fertilized, 2 blasts on day 6, PGS tested/euploid

November 2018 FET #2 w/immune protocol and 1 PGS tested -  BFN

Locus Medicus testing for virus, bacteria and immune issues. Husband treated.

(age 41) April 2019 IVF#5 converted to IUI#3 due to follicle growth. BFP 12 day post IUI. Di/Di twins.

Dec 17 2019 - Baby boy and girl born at 36 weeks + 2 days. Everyone very healthy. 

 

See my 'about me' page for more detail on my treatment history.


#107 FMandAM

FMandAM
  • Global 100+
  • 155 posts
  • Gender:Female
  • Dx:DOR
  • My Clinic:OFC in Canada, Reprogenesis in the CR

Posted 08 June 2018 - 11:11 AM

Schlepp, that's a crazy jump! Do you know how many grades there are for lining? I was only ever told whether mine was trilaminar or not, I was never given an a grade.

 

Fingers crossed your ovaries happy-surprise you the same way your lining did!


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#108 returnable

returnable
  • 1000+
  • 3349 posts
  • Gender:Female
  • Location:Whitby, ON
  • Interests:travelling,gardening,cooking
  • Dx:DOR
  • My Clinic:Trio, cycle monitoring at Lakeridge

Posted 08 June 2018 - 11:32 AM

Schlepp - Wow what a lining change from your normals. I am sorry you are struggling with the stims this time.

 

FMandAM  - ditto on the lining quality. I was only ever told triple stripe or not.



#109 schlepp

schlepp
  • Global 100+
  • 935 posts
  • Gender:Female
  • Location:Toronto
  • Dx:Male Factor

Posted 08 June 2018 - 12:53 PM

returnable and FMandAM - I know it goes down to at least a D grade as on IVF#2 CD5, I had a D lining, 4mm with fluid noted. I should remember to ask my RE if B can still have trilaminar. On IVF#1 2 years ago, I had a 5mm lining on CD15 (11 days of high dose stims) with free fluid. But that was at a clinic that didn't seem to grade the lining.

 

I wonder if my lining has taken this long to recover from 11 years on the mirena IUD. I had the IUD removed in the summer of 2015 so it has been almost 3 years. Who knows. I still feel like the lining issue is a big mystery and a total luck to resolve. 


(age 38) June 2016 IVF #1 antagonist, 13 mature eggs, 4 fertilized, 1 blast frozen

October 2016 FET #1 cancelled, thin lining

Changed clinics

(age 39) April 2017 FET #1.1 BFN

July 2017 partner has vasectomy reversal

Feb & March 2018 - Medicated IUI x2 - BFN (even with 7 mature follicles on the 2nd IUI)

(age 40) May 2018 IVF#2, lupron flare, 7 mature eggs, 5 fertilized, 1 blast & 1 morula fresh transfer, BFN. 1 low quality blast frozen

June 2018 IVF#3 mini stim, 1 egg, immature

Sept/Oct 2018 IVF#4 antagonist with HGH - CANCELLED due to high estrogen/29mm cyst

Oct 2018 IVF#4.1 antagonist with HGH - 7 eggs, all mature, 6 fertilized, 2 blasts on day 6, PGS tested/euploid

November 2018 FET #2 w/immune protocol and 1 PGS tested -  BFN

Locus Medicus testing for virus, bacteria and immune issues. Husband treated.

(age 41) April 2019 IVF#5 converted to IUI#3 due to follicle growth. BFP 12 day post IUI. Di/Di twins.

Dec 17 2019 - Baby boy and girl born at 36 weeks + 2 days. Everyone very healthy. 

 

See my 'about me' page for more detail on my treatment history.


#110 hopefuldadsomeday

hopefuldadsomeday
  • Global 100+
  • 746 posts
  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 15 June 2018 - 07:40 PM

BFN for us.  Any ladies have any thoughts if it's better to try again right away or take a break?  Our clinic has give us the option to do either.  The plan is do a mock cycle for an ERA test than attempt a transfer again the month after.  I'm impatient so I want to go again right away.  My wife is concerned that if we do 3 cycles in a row, her lining might not respond as well to the estrogen, so we're leaning towards taking a month off first.


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#111 returnable

returnable
  • 1000+
  • 3349 posts
  • Gender:Female
  • Location:Whitby, ON
  • Interests:travelling,gardening,cooking
  • Dx:DOR
  • My Clinic:Trio, cycle monitoring at Lakeridge

Posted 15 June 2018 - 09:04 PM

I'm sorry for your result hopeful. I think breaks are required more emotionally rather than physically. For the average woman since the body naturally foes through estrogen/progesterone monthly cycles I don't think back to back testaments make a difference. It seems like your RE agrees.

#112 SunshineTTC

SunshineTTC
  • 1000+
  • 1037 posts
  • Gender:Female
  • Location:Regina, SK
  • Dx:DOR
  • My Clinic:VFC

Posted 15 June 2018 - 11:51 PM

Hopefuldad I just wanted to say I was so sorry to hear the cycle didn't work out, I was really hoping for you.  Hope the best snuggliest kitty finds you and your wife to help you through.  For back to back transfers I would think like returnable that if just estrogen/progesterone were used, "in theory" it should be fine, but I really don't know?


Me: 40 41 42 43 44 45, single, FSH 6, LH 2 (FSH not high, but exceeded 2:1 ratio), DOR (AFC 5-7, v.low AMH), all else normal/healthy.

After a difficult 6 year journey of everything going wrong, amazing baby boy born Dec 2018.  Donor sperm + DEB-USA donor eggs.  Detailed journey in 'about me'.

 


#113 FMandAM

FMandAM
  • Global 100+
  • 155 posts
  • Gender:Female
  • Dx:DOR
  • My Clinic:OFC in Canada, Reprogenesis in the CR

Posted 19 June 2018 - 02:16 PM

Hopefuldad, I'm so sorry. What a disappointment.

 

As for whether or not it's okay to do cycles back to back, my clinic never had an issue with it, however I also never had a BFP. They also had to take into account that my cycles are highly irregular on their own, so if they had waited for me to cycle on my own in between FET cycles, that gap could have been anywhere from 25-100 days which would just be frustrating for everyone.


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#114 Pomme

Pomme
  • Member
  • 14 posts
  • Gender:Female
  • Dx:DOR

Posted 06 July 2018 - 03:03 PM

Hi All! Sorry I was so busy last weeks!!!

FMandAM - I did Viagra 4 times a day vaginal :) In two weeks I gained 2.1mm !!!
Next time we try Delestrogen shots plus Viagra!

Hopefuldadsomeday- I am so so so sorry :( I know how it feels... We had our transfer on June 14th and a BFN on June 26th ! I am taking a small break and should start again in two weeks ... This time with the estrogen shots and my Dr will add Neupogen wash, neupogen shots, intralipids and hcg wash hahaha We want a sticky uterus :)

#115 hopefuldadsomeday

hopefuldadsomeday
  • Global 100+
  • 746 posts
  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 07 August 2018 - 11:45 AM

Hi ladies, hope all are doing well.  We took a 1 month break and now we're back cycling again.

 

We are doing a mock cycle for an ERA test.  My wife went for her first ultrasound check today (CD12) and her lining is already at 7.5mm???  She will going back on Friday for another check, I'm almost tempted to skip the ERA and attempt a transfer if her lining gets any thicker!

 

Pomme - did you end up trying viagra/delesetrogen?


  • SunshineTTC and returnable like this

March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#116 JIC

JIC
  • 1000+
  • 1077 posts
  • Gender:Female
  • Location:Toronto
  • Dx:Unexplained

Posted 07 August 2018 - 08:04 PM

Hopefuldad that is great news to hear. Did she change her protocol at all?

Nov 2016 Feb 2017 4 failed iui

Mar 2017 IVF 3 pgs abnormal embryos

Oct 2017 IVF 1 pgs normal embryo

Dec 2017 FET  6.5 mc

May 2018 Donor FET 5 week mc

Feb 2019 Donor FET 5.5 week mc

Mar 2021 completed adopt ready

 


#117 returnable

returnable
  • 1000+
  • 3349 posts
  • Gender:Female
  • Location:Whitby, ON
  • Interests:travelling,gardening,cooking
  • Dx:DOR
  • My Clinic:Trio, cycle monitoring at Lakeridge

Posted 08 August 2018 - 08:07 AM

Hopefuldad that is awesome! What is her protocol and did you do anything else? I'm still struggling with my lining. I haven't tried the injectable estrogen or Viagra, and I'm not sure my RE would be willing to go that route.



#118 schlepp

schlepp
  • Global 100+
  • 935 posts
  • Gender:Female
  • Location:Toronto
  • Dx:Male Factor

Posted 08 August 2018 - 08:19 AM

Hopefuldad - That is great news! I would still do the ERA since you're looking at the timeline for progesterone pre-transfer, right? Embryos are so precious when you only have a couple. But I totally understand the temptation due to thin lining.

 

returnable - I hope things turn around for you. Lining is so fickle! I am nervous about mine as I quit a lot of the lining supplements to give myself a break for a few months. No idea where it is at as we are taking a couple of months off. 

 

I just saw this the other day. For those of you on viagra for thin lining, not sure it makes a difference as you would not be using after transfer but it freaked me out. Wondering if REs will decide to stop prescribing for lining issues. Not sure what the life of the medication is inside the body. 

 

https://www.cbc.ca/n...s-die-1.4760383


(age 38) June 2016 IVF #1 antagonist, 13 mature eggs, 4 fertilized, 1 blast frozen

October 2016 FET #1 cancelled, thin lining

Changed clinics

(age 39) April 2017 FET #1.1 BFN

July 2017 partner has vasectomy reversal

Feb & March 2018 - Medicated IUI x2 - BFN (even with 7 mature follicles on the 2nd IUI)

(age 40) May 2018 IVF#2, lupron flare, 7 mature eggs, 5 fertilized, 1 blast & 1 morula fresh transfer, BFN. 1 low quality blast frozen

June 2018 IVF#3 mini stim, 1 egg, immature

Sept/Oct 2018 IVF#4 antagonist with HGH - CANCELLED due to high estrogen/29mm cyst

Oct 2018 IVF#4.1 antagonist with HGH - 7 eggs, all mature, 6 fertilized, 2 blasts on day 6, PGS tested/euploid

November 2018 FET #2 w/immune protocol and 1 PGS tested -  BFN

Locus Medicus testing for virus, bacteria and immune issues. Husband treated.

(age 41) April 2019 IVF#5 converted to IUI#3 due to follicle growth. BFP 12 day post IUI. Di/Di twins.

Dec 17 2019 - Baby boy and girl born at 36 weeks + 2 days. Everyone very healthy. 

 

See my 'about me' page for more detail on my treatment history.


#119 returnable

returnable
  • 1000+
  • 3349 posts
  • Gender:Female
  • Location:Whitby, ON
  • Interests:travelling,gardening,cooking
  • Dx:DOR
  • My Clinic:Trio, cycle monitoring at Lakeridge

Posted 08 August 2018 - 08:43 AM

Hopefuldad - That is great news! I would still do the ERA since you're looking at the timeline for progesterone pre-transfer, right? Embryos are so precious when you only have a couple. But I totally understand the temptation due to thin lining.

 

returnable - I hope things turn around for you. Lining is so fickle! I am nervous about mine as I quit a lot of the lining supplements to give myself a break for a few months. No idea where it is at as we are taking a couple of months off. 

 

I just saw this the other day. For those of you on viagra for thin lining, not sure it makes a difference as you would not be using after transfer but it freaked me out. Wondering if REs will decide to stop prescribing for lining issues. Not sure what the life of the medication is inside the body. 

 

https://www.cbc.ca/n...s-die-1.4760383

 

I have been completely dedicated to the supplements, but now I have an inkling that a medication I take for non-FET related issues may be having a negative effect on uterine blood flow. One of my doctors checked his resources and saw nothing written about negative effects during the first trimester or pre-impantation, but I'm thinking with relatively low number of people in the world that could be impacted, perhaps it just hasn't been on anyone's radar. I also sifted through the medical journals and didn't find anything, but based on the mechanism of the medication, I think there is a possibility. I switched to an alternate, and hope to see some development at my next lining check on Friday.

 

For the Viagara concern, the half life of Viagara is 4 hours, so in 24 hours, you are at down to 3% of the absorbed dose for both Viagara and its metabolites. Based on this (and my non-medical doctor opinion), the potential impact to a fetus would be non-existent.



#120 schlepp

schlepp
  • Global 100+
  • 935 posts
  • Gender:Female
  • Location:Toronto
  • Dx:Male Factor

Posted 08 August 2018 - 09:44 AM

 

 

 

I have been completely dedicated to the supplements, but now I have an inkling that a medication I take for non-FET related issues may be having a negative effect on uterine blood flow. One of my doctors checked his resources and saw nothing written about negative effects during the first trimester or pre-impantation, but I'm thinking with relatively low number of people in the world that could be impacted, perhaps it just hasn't been on anyone's radar. I also sifted through the medical journals and didn't find anything, but based on the mechanism of the medication, I think there is a possibility. I switched to an alternate, and hope to see some development at my next lining check on Friday.

 

For the Viagara, concern, the half life of Viagara is 4 hours, so in 24 hours, you are around 3% of the absorbed dose for both Viagara and its metabolites. Based on this (and my non-medical doctor opinion), the potential impact to a fetus would be non-existent.

 

returnable - great to know on the viagara. 

I also have the feeling that something else impacted my lining. I really think 11 years of an IUD with progesterone and the resulting lack of AF or minimal, is what has compromised my lining. I am wondering if it has improved recently only because it has basically recovered and figured out how to grow. But maybe I'm jinxing myself and it will be low again next cycle. 

Hope the alternative medication is the key to success for you.


(age 38) June 2016 IVF #1 antagonist, 13 mature eggs, 4 fertilized, 1 blast frozen

October 2016 FET #1 cancelled, thin lining

Changed clinics

(age 39) April 2017 FET #1.1 BFN

July 2017 partner has vasectomy reversal

Feb & March 2018 - Medicated IUI x2 - BFN (even with 7 mature follicles on the 2nd IUI)

(age 40) May 2018 IVF#2, lupron flare, 7 mature eggs, 5 fertilized, 1 blast & 1 morula fresh transfer, BFN. 1 low quality blast frozen

June 2018 IVF#3 mini stim, 1 egg, immature

Sept/Oct 2018 IVF#4 antagonist with HGH - CANCELLED due to high estrogen/29mm cyst

Oct 2018 IVF#4.1 antagonist with HGH - 7 eggs, all mature, 6 fertilized, 2 blasts on day 6, PGS tested/euploid

November 2018 FET #2 w/immune protocol and 1 PGS tested -  BFN

Locus Medicus testing for virus, bacteria and immune issues. Husband treated.

(age 41) April 2019 IVF#5 converted to IUI#3 due to follicle growth. BFP 12 day post IUI. Di/Di twins.

Dec 17 2019 - Baby boy and girl born at 36 weeks + 2 days. Everyone very healthy. 

 

See my 'about me' page for more detail on my treatment history.


#121 hopefuldadsomeday

hopefuldadsomeday
  • Global 100+
  • 746 posts
  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 08 August 2018 - 11:30 AM

JIC -  we're on the exact same protocol as last time, so seems like estradiol injections and sildenafil suppositories is the magic combination for my wife.

 

Returnable - I think worth mentioning to your RE about injectable estrogen and see if he's willing to try it?  Otherwise, I hope the solution is a simple as changing the medication you're taking.

 

Schlepp - with the sildenafil vaginal suppositories we stop using them as soon as the progesterone is started, so hopefully should have no/minimal effects on the embryo.


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#122 returnable

returnable
  • 1000+
  • 3349 posts
  • Gender:Female
  • Location:Whitby, ON
  • Interests:travelling,gardening,cooking
  • Dx:DOR
  • My Clinic:Trio, cycle monitoring at Lakeridge

Posted 10 August 2018 - 09:29 AM

So after switching from my regular blood pressure med to an alternate one for the past 6 days, my lining is now at 7.6 mm. I don't think it is a big coincidence. I do wish that doctors took a more comprehensive approach, but understand that sometimes things can get lost. Also, they rely heavily on published information and don't think what the possible effects of other medications could be based on their biochemical mechanism in the body. If I didn't read up on this, and I know not everyone has the ability or comfort, I'd still be struggling.

 

Just like Schlepp's issue with IUDs I shake my head that IUDs are now the more favoured forms of birth control by the medical community for young girls/women. Are we setting them up for struggles with infertility?

 

End of purge... biggrin.png


  • SunshineTTC, muffin#1, FMandAM and 3 others like this

#123 hopefuldadsomeday

hopefuldadsomeday
  • Global 100+
  • 746 posts
  • Dx:Unexplained
  • My Clinic:Olive Fertility

Posted 10 August 2018 - 11:23 AM

Returnable - I'm glad to hear the change in medication helped!  If you don't mind me asking, which medication were you on before?

 

As for us - lining check today showed no improvement, still at 7.5mm so they're starting her on progesterone and going ahead with ERA.  I hope it will give us some answers!


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#124 returnable

returnable
  • 1000+
  • 3349 posts
  • Gender:Female
  • Location:Whitby, ON
  • Interests:travelling,gardening,cooking
  • Dx:DOR
  • My Clinic:Trio, cycle monitoring at Lakeridge

Posted 10 August 2018 - 03:06 PM

It's Candesartan. It's an "angiotensin beta blocker". I use it for blood pressure and to protect my kidneys from damage. Its mechanism is to relax the blood vessels. It is not good for 2nd and 3rd trimester as it negatively impacts the development of the circulatory system so I had had a lot of discussion already with my doctors about alternatives. It's a wonderful drug as it does a good job at what it is supposed to do for me, and there are no side effects. The alternates don't work as well as have other side effects. There was no indication in literature to say that it had any negative effects in terms of uterine blood flow or effects during conception or pregnancy, but I always had a suspicion that it may be an issue. I should have followed my gut from the beginning.


  • hopefuldadsomeday likes this

#125 JIC

JIC
  • 1000+
  • 1077 posts
  • Gender:Female
  • Location:Toronto
  • Dx:Unexplained

Posted 20 August 2018 - 06:39 AM

I am searching this thread and must not be awake yet because I am sure the answers are here somewhere. I know my lining thickness from cd12 was good.
What is the desired thickness as time of transfer?
Approx how much is the lining suppose to thicken per day upto transfer and does it slow down once on progesterone?

Nov 2016 Feb 2017 4 failed iui

Mar 2017 IVF 3 pgs abnormal embryos

Oct 2017 IVF 1 pgs normal embryo

Dec 2017 FET  6.5 mc

May 2018 Donor FET 5 week mc

Feb 2019 Donor FET 5.5 week mc

Mar 2021 completed adopt ready

 






Also tagged with one or more of these keywords: uterine lining, thin uterine lining, endometrial lining, FET, frozen embryo transfer, lining