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Please Help - Thin Uterine Lining Issue

uterine lining thin uterine lining endometrial lining FET frozen embryo transfer lining

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#76 FMandAM

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Posted 23 May 2018 - 04:27 AM

Transfer is scheduled for Friday if my lining is fine.
  • returnable and hopefuldadsomeday like this

DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#77 returnable

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Posted 23 May 2018 - 09:31 AM

FMandAM - I hope all works out for you. I assume they check your lining tomorrow? Let us know.

 

hopefuldad - good luck at the lining check tomorrow. What kind of symptoms is your wife experiencing? I haven't really noticed symptoms with any of the medications I have taken throughout this journey except for the DHEA, CoQ10 and Lupron.



#78 hopefuldadsomeday

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Posted 23 May 2018 - 11:17 AM

FMandAM - good luck!

 

Returnable - hope this is not too much information.  My wife is experiencing breast tenderness and according to her, the vaginal discharge is consistent with higher estrogen levels (I didn't ask her to elaborate!).   Also, this is subjective, but she is a little bit quicker to get angry with me than usual, lol!

 

One other change we made, is we got the compounding pharmacy to make the sildenafil vaginal suppositories in a smaller size.  Our last batch, they were quite large and my wife found they were not dissolving completely, she finds the smaller ones are dissolving much better.


  • FMandAM likes this

March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#79 hopefuldadsomeday

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Posted 24 May 2018 - 11:10 AM

Quick update, wife had lining check today and measured 6.5mm (my wife made the doctor measure 3x, haha!)  I know still thin by conventional standards, but considering our first FET took 3 weeks to get to 6.2mm and today is only CD 12, we're pretty happy about this!  They were going to continue for another week to see if it would get thicker, but my wife was worried because last time her lining started deteriorating after 3 weeks, so they will bring her in again on Tuesday.  Hopefully it will thicken even more, and *fingers crossed* we can actually transfer this time!


  • FMandAM likes this

March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#80 returnable

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Posted 24 May 2018 - 01:53 PM

FX. I know what you mean about standards. I'd be yipping too :) Good luck on Tuesday. Regarding your wife's symptoms, I had similar. I guess I don't consider them that bad so hardly think about them as symptoms. 



#81 SunshineTTC

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Posted 24 May 2018 - 02:50 PM

Good luck hopefuldad!  Discharge = EWCM (google... smile.png  Many women get great globs of it even just using oral estrace prior to transfer, so hopefully having noticeably more of it is a good sign that the injectable is perhaps working better for your wife.

 

P.S. Did you get a cat?? (cat snuggles might be good for linings too?)


Me: 40 41 42 43 44 45, single, FSH 6, LH 2 (FSH not high, but exceeded 2:1 ratio), DOR (AFC 5-7, v.low AMH), all else normal/healthy.

After a difficult 6 year journey of everything going wrong, amazing baby boy born Dec 2018.  Donor sperm + DEB-USA donor eggs.  Detailed journey in 'about me'.

 


#82 hopefuldadsomeday

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Posted 24 May 2018 - 05:59 PM

So, they drew her estradiol level today and it came back quite high 9203 pmol/L, which would explain why her lining is thicker this time around.  Should we be concerned that the high estrogen level might impair endometrial receptivity?  For reference, her estradiol levels on trigger date for IVF #1/#2/#3 were 9295, 14865, 13205 respectively.  Unfortunately they didn't draw estradiol levels during her first medicated FET so we can't compare to that.

 

SunshineTTC - thanks for the info, I google EWCM and I'm 100% sure that is what she was referring to haha!  As for the cat, we're sitting on the fence.  We went to visit the cat sanctuary and my wife really wants one.  However, it's a big commitment, so we want to be sure before we adopt one.  There is a cat at our local adoption centre that I think is totally meant for us, they say that she prefers to be home by herself during the day while we're at work but loves to snuggle at night.  My wife has already started looking at cat toys, what bed she wants to buy for the cat, etc. lol


  • veni vidi vici likes this

March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#83 SunshineTTC

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Posted 24 May 2018 - 10:32 PM

Estradiol not sure, I've definitely heard that too high can negatively impact a cycle, but I don't know what the definition is?  I think on fresh cycles E2 normally goes a lot higher than FET.

 

Cat toys... you will buy them, and your cat will instead become completely captivated by a random toilet paper roll, twist tie, pen, etc.  My cat does love her tunnel though, and her "turbo scratcher".  And laser pointers are great fun.  Daytime bed for in front of window... night time bed snuggling in your bed :)


Me: 40 41 42 43 44 45, single, FSH 6, LH 2 (FSH not high, but exceeded 2:1 ratio), DOR (AFC 5-7, v.low AMH), all else normal/healthy.

After a difficult 6 year journey of everything going wrong, amazing baby boy born Dec 2018.  Donor sperm + DEB-USA donor eggs.  Detailed journey in 'about me'.

 


#84 Pomme

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Posted 25 May 2018 - 05:17 PM

Hi everyone!!!
And especially Hopefuldadsomeday !

I can totally relate on your wifes experience with thin lining!
I have the exact same values : 5.8 on CD10! And today CD19 again a 5.8 !!!!
Its my first FET and first try and Im on
Oral Estrace 2mg 2x daily
Vaginal Estrace 2mg 3x daily

Now theyre addind Viagra (25mg 4x daily) which I dont really understand because my bloodflow was fine according to the Doppler test !

Anyways... If my cycle is cancelled I thought about asking for Deloestrogen Injections and it really gives me hope to see that it seems to work with your wife!!! We have 3 beautiful embryos and cant wait to transfer them :)
Please keep me posted and I wish you the best of luck with this cycle! Im sure youll find the right protocol and youll soon be a wonderful dad!

I took some notes on protocols that were sucessful for other woman if youre interested:

- Viagra
- Estrace and then patches
- Injections of Estrace
- Climara Patches or Estradot Patch
- Taximophen
- Gradually increase Estrace + Taximophen
- Terbutaline + Viagra
- BCP + Estrace graduel on next cycle
- Sildenifil (Viagra) inserts 4x daily 25mg+ Terbutaline 5mg 3x daily
- Day 3 Neupogen Wash (G-CSF) and then Week 1 : 0.5mg Estrace Vaginal daily + 2 patche Climara + 20mg Taximophen / Week 2 : 1mg Estrace + 3 patch + 20mg Climara / Week 3: 1.5mg Estrace + 4 patch

#85 hopefuldadsomeday

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Posted 27 May 2018 - 01:19 AM

Pomme - I replied to you in the other thread, but you're in a similar situation as us.  We have 3 frozen embryos but just waiting for an adequate lining to transfer with, so frustrating!  Will keep you updated after our 2nd lining check on Tuesday!  Hope the sildenafil works for you in the meantime though!


  • returnable likes this

March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#86 Pomme

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Posted 27 May 2018 - 08:20 AM

Hopefuldadsomeday- Will think about you on Tuesday !!! Crossing my fingers so hard! Those frozen babies will have a cozy home Im sure!

#87 FMandAM

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Posted 28 May 2018 - 01:06 PM

Hopefuldad, so exciting! Keeping everything crossed for you for tomorrow!

DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#88 hopefuldadsomeday

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Posted 29 May 2018 - 11:23 AM

FMandAM - how did your transfer go?

 

Pomme - any update on you?  Did the sildenafil work?

 

Update, had lining check today and they measured between 7.5mm and 8mm (even thicker than our first 2 IVF cycles on max stims!), so we are go for transfer (tentatively Monday, they will call us this afternoon to confirm)!!!!  Looks like estradiol injection was the solution for us! 

 

To summarize our history

 

IVF #1: 6.66mm

IVF #2: 6.73mm

IVF #3: 9.51mm (anomaly?)

FET#1 (medicated) : 6.25mm

FET #2 (natural) : 4.85mm


  • SunshineTTC, FMandAM, schlepp and 1 other like this

March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#89 FMandAM

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Posted 29 May 2018 - 12:36 PM

Hopefuldad, that's amazing! What terrific news! You guys must be so pumped! Really, really happy for you!!

Transfer was fine for me last Friday. Lining was at 7.1mm, so the bare minimum again. Different doctor and the transfer itself was very smooth, which is an anomaly for me because my cervix faces sideways and generally they have to poke around a bit.

I was disappointed with my lining results and with the care I received in general but transferred anyways because I'm really ready for this part of my life to be over. I've come to realize that I used to be super proud of all the things my body could do and I'm sick. to. death. of being defined and brought down by the one thing it can't. Beta is June 8th but I'll likely test before. A BFP would be wonderful but even if it's a BFN I'm happy to starting a new chapter regardless of which direction I'm going!

DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#90 returnable

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Posted 29 May 2018 - 01:34 PM

Hopefuldad - that is GREAT news. I can't believe you bounced to such a thick lining. Good luck!

 

FMandAM - how are you doing? 7.1 mm is good. My RE is happy with that thickness and the clinic has good success above 7 mm.

 

Pomme - any updates?


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#91 Chil22

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Posted 29 May 2018 - 11:13 PM

Hopeful Dad that is great news. I didnt even know about injectable estrogen until I was at a clinic in Florida and the doctor mentioned he uses it all the time as a rescue when the lining is isnt cooperating with other methods of estrogen. I am glad to hear about in action. Best of luck next week!
  • hopefuldadsomeday likes this

#92 Pomme

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Posted 01 June 2018 - 08:18 AM

Hi All!!!

I was expecting it... Sildenafil/Viagra is clearly will not do the magic for me !
6.0mm this morning... Slightly better and I am « quite » happy
Also trilaminar so we are at least not losing this :)
Waiting for next steps but will definitely ask to add patches or Deloestrogen Injections in order to help that lining get to 7.0mm

#93 hopefuldadsomeday

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Posted 01 June 2018 - 11:24 AM

Pomme - I'm glad it hasn't regressed and it's trilaminar which is good!  Some studies suggest that 6mm be used as a cutoff too.  Hope they can find something to boost it up past 7mm though, keep us updated!


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#94 FMandAM

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Posted 01 June 2018 - 12:03 PM

Pomme, my doctor overseas started telling me to begin progesterone once I hit 6mm or more because the progesterone will add a bit (for me it added 1.1mm both cycles). Prior to this year however I had many cycles cancelled at 6mm, and he never explained why he started allowing it though I suspect he was just tired of dealing with me.

 

I don't think that 6mm is ideal by any stretch of the imagination and I would have preferred my doctor to keep working with me to see if we could get it thicker, but he insisted it was fine at 6mm.

 

ETA: a girl I know from another site told me that her doctor explained that different people metabolize estrogen differently so pills work for some, patches for others and injections for others. It just depends on your personal makeup and it can take time to find a combo that works for your body. I found the estradiol valerate shots were AWFUL but they did the trick better than pills or patches (though patches worked slightly better than the pills for me as well, if I recall correctly).


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#95 hopefuldadsomeday

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Posted 01 June 2018 - 12:27 PM

FMandAM - Different studies have 6, 7, or 8mm as cutoffs but I agree with you that 6mm is not ideal.  We did hit 6.25mm in our first cycle but we weren't comfortable transferring, especially since we only have 3 embryos.  However, if after multiple cycles we still couldn't hit 7mm, I think we would have tried at 6mm.  In our 2nd natural FET, our final lining check showed 4.85mm.  If you can believe it, the doctor doing the ultrasound (not our regular RE), advised us to go ahead with a transfer, I was like WTF???!!!  I pointed out to her that multiple studies have shown that there is minimal chance of success with such a thin lining.  She dismissed our concerns, saying that this was her "natural thickness" anyways.  Thankfully, we stood our ground and my wife had a really good phone consult with our regular RE the next day.

 

Have you POAS yet?  Fingers crossed for you!


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#96 ms-tdot

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Posted 01 June 2018 - 12:52 PM

Hi All - Im going to jump into this thread because my last interaction on this forum was in 2016 (and Im sad to say I see some familiar names in the Thin lining hell category.

I had 2 PGS tested embryos from an IVF cycle in 2016. Ive never had a lining over 6 and have consistently had fluid in the uterus and poor structure. Despite getting only to 5.5 and with some fluid, we transferred 1 in the summer of 2016. Negative.

My RE thought that the fluid my be caused by my C-section scar, so in the spring of 2017 I had laparoscopic surgery to correct the scar defect. The next few cycles of 2017 my lining looked worse than ever - Thin, full of fluid and now with scarring.

This spring, I decided I had to move on with my life and would transfer the last embryo at any thickness so long as there wasnt fluid (I had a natural ectopic on the fall of 2017, so didnt want to risk that again).

Protocol: 80 mg of tamoxifen, day 3 to day 7. Though I normally respond late, on the first cycle monitoring on day 11, I have a 20 mm follicle, 5.1 mm lining and, for the first time, no fluid. We decide to trigger and transfer a week later (did a lining check day before transfer: 5.6 mm).

I was at peace that my journey had ended, that we had done all we could do, and I could move on with my life.

And then we got our beta results at 10dp5dt: 88. The biggest shock of my life is still an understatement.

Numbers increased as they should and I just had my 6w1d u/s where we saw the heartbeat.

Im my over two years of scanning every infertility forum/blog I could find, I had never seen anyone have success under 6 mm. Obviously, this is statistically irrelevant, but I share this because I had come to believe that getting pregnant with such a thin lining is impossible.

Good luck to everyone on here who is on the middle of transfers and to anyone who stumbles on this post because of their thin lining.
  • FMandAM, hopefuldadsomeday, Chil22 and 1 other like this

#97 FMandAM

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Posted 01 June 2018 - 12:54 PM

Hopefuldad, I'm not sure if I'm going to POAS or not... I usually have a few HPTs kicking around the house but I used the last one last cycle and I strangely have zero inclination to go out and get more right now. Could change tomorrow, I'm just rolling with however I feel right now!

 

I can't believe you had someone recommend transfer at 4.85mm, especially when it was only your second attempt at getting a thicker lining!


  • hopefuldadsomeday likes this

DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#98 FMandAM

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Posted 01 June 2018 - 12:58 PM

ms-tdot, thank you for your story!


  • ms-tdot likes this

DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#99 Pomme

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Posted 01 June 2018 - 02:20 PM

Hopefuldadsomeday - 4.85!!!! Wow Hopefully you stick to your ground! You dont want to waste an embryo below a 5!
I am super happy that I reached a 6mm today to be honest BUT ... The thing is Im on my CD24 and last US I had a bit of fluid but we continued the Estrace pills and added Sildenafil despite the fluid.
Today no fluid but 3 little black dots (maybe the fluid is starting to resolve or...I will het my period really soon) whick me : CANCELLED CYCLE I guess.

I feel like the more they extend the protocol (over 20 days of meds) the worst it is.

Thats why I would prefer to wait for my period (the fluid might all disappear like it did the first time) and then try patches or injections to make sure I respond faster and maybe (I hope) with no fluid ...

I also have only 3 embryos so I think it might be a better idea to try every protocol and use the best one for my situation.

Ms-Tdot - Woww congrats!!!! I can totally relate to your story! That fluid is KILLING Me!
My US are always perfect on CD10-CD12 and then the more we had Estrogen the worst it gets and theres flyid most of the time when we go over CD12!
I was so happy to reach 6mm but there is still 3 tiny dot of fluid (last week therewas more though)
You give me hope and we agreed with my husband to try other protocol not to « waste » our embryos ... Worst case scenario we will start PIO next time we reach 6mm :)
Just crossing my fingers that my Dr will give me the patches for next cycle! And then IM if patches doesnt help (even though Im scared of those ones)

#100 ms-tdot

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Posted 01 June 2018 - 02:48 PM

Pomme, we eventually realized through countless cycles that estrogen is terrible for my lining. Obviously I need a little of it to grow beyond my day 3 baseline, but as soon as we let a cycle go longer (either with exogenous estrofen or from my follicles), fluid would creep in and the structure would degrade. This cycle I was tempted to use certrotide to see if we could grow a little bit more over a day or two and my RE (smartly) said this is the best its looked. So we went for it. Obviously a huge risk and I had basically given up at the point, so Im in a different position from others.





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