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Please Help - Thin Uterine Lining Issue

uterine lining thin uterine lining endometrial lining FET frozen embryo transfer lining

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#51 Graceland

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Posted 24 April 2018 - 08:36 PM

Link: https://ivf.ca/forums...12#entry2647481

Twin girls born December 2017 after 7 years of TTC

See 'About Me' for full details


#52 hopefuldadsomeday

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Posted 25 April 2018 - 12:12 AM

Hi Graceland, thanks for all the information.  Interesting how the PRP didn't work for you, we had high hopes from the small studies we read.  I'm so happy to hear you were finally successful though, gives the rest of us some hope!

 

Anyways, my wife had a good discussion with our primary RE.  The plan is now to try injectable estrogen first.  If that fails, we'll try mini-stim protocol.  And following that, he may consider some of the experimental treatments.  We will hold off on the ERA until we find a protocol that works for my wife. 

 

Again, thank you ladies for all the information and support!


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#53 FMandAM

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Posted 25 April 2018 - 12:51 PM

Hopefuldad, that sounds like a very logical next step. Fingers crossed this is the magic ticket for you guys!


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#54 returnable

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Posted 25 April 2018 - 01:00 PM

hopefuldad - where are you obtaining your injectable estrogen?



#55 hopefuldadsomeday

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Posted 25 April 2018 - 02:24 PM

Returnable - apparently it's not commercially available, so the clinic will have it ordered in from a specialty compounding pharmacy that also makes their PIO in cottonseed oil.  I believe the pharmacy is based in Toronto, I can look up the name if you want.


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#56 returnable

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Posted 25 April 2018 - 03:01 PM

Returnable - apparently it's not commercially available, so the clinic will have it ordered in from a specialty compounding pharmacy that also makes their PIO in cottonseed oil.  I believe the pharmacy is based in Toronto, I can look up the name if you want.

 

No need for now, but thanks.



#57 FMandAM

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Posted 25 April 2018 - 04:07 PM

Returnable - apparently it's not commercially available, so the clinic will have it ordered in from a specialty compounding pharmacy that also makes their PIO in cottonseed oil.  I believe the pharmacy is based in Toronto, I can look up the name if you want.

 

Returnable, this is what my clinic did as well. I believe the product is called Delestrogen in the US but here in Canada it's not commercially available so a facsimile has to be created by a compounding pharmacy.


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#58 returnable

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Posted 30 April 2018 - 09:01 AM

An update from me on lining. As I said I was taking the following for the past month+:

 

In the meantime, I am going full on on the supplements. I found the paper that assessed uterine bloodflow and the effect of Vitamin E, L'Arginine and viagara and am taking the dosing they suggest (600 IU vitamin E daily and 6 g L'Arginine daily). I am also drinking three cups of red raspberry leaf tea spaced throughout the day and 40 mg black cohosh twice daily. Since my ERA is vaginal estrace/PIO protocol only, I'll see if there is any change and let you guys know my results.

 

After 15 days of vaginal estrace, I only measured 5.0 mm this morning. This is my worst result so far this far into an estrace supported cycle. I'm sure the RE will just increase the dose today to see if any progress is made. It seems like with every subsequent cycle my response is getting worse.



#59 hopefuldadsomeday

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Posted 30 April 2018 - 12:29 PM

Returnable - I'm sorry to hear your lining is not improving.  My wife and I have been doing exhaustive research on this topic.  The most recent article I found on this topic is here: https://www.indianfe...ive-technology/ .  The journal is based in India but pretty much summarizes all the articles we've found.  Basically, nothing has really been shown to conclusively help improve thin uterine lining.  The future may be in PRP/stem cells but we'll be too old by the time that goes mainstream (although there are some clinics that offer PRP instillation).  If the estradiol injection/mini-stim protocol doesn't work for us, we may look into seeing if our Dr is willing to try tamoxifen as there are some studies that suggest it may work.  I hope your lining improves with the higher dose though!


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March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#60 lumnay

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Posted 30 April 2018 - 10:29 PM

I haven't really read the previous posts but I thought I'd add my two cents here since I've recently received messages. I had thin lining issues that we thought was preventing me from having successful FET cycles. This is what we did: I was given injectibles to help me ovulate since we suspected my body didn't like too much synthetic estrogen (estrace). Right before I ovulated, my lining went up to 9-10mm and there were mature follicles. I was given HCG shot and I started progesterone cream a few days prior to the transfer. I also requested to have Aspirin and Medrol to be included in my protocol. My RE was very helpful and I owe it to him and his team. By the way, when he did the transfer he said his two other patients with same issues had positive pregnancy tests days prior so he wished me luck and that I'd be the next one to get positive result. Guess what, I did. In fact, I just put my twin babies to bed an hour ago.

By the way, this post is not meant to give false hopes but to share what worked for me. I wish you all the best and I hope whatever happens you'll be gentle and kind to yourself. We all do what we can. Infertility is a difficult struggle.
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Who stole ambushed my stork?  So many failed cycles with nothing to show but bills, receipts, and empty bottles of medications/herbs/supplements. See my profile for details...

 

UPDATE: I'm counting the days and hours waiting for this miracle to unfold. Christina Perri's A Thousand Years pretty much sums up my experience.


#61 hopefuldadsomeday

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Posted 30 April 2018 - 10:34 PM

Hi Lumnay, thanks for posting your experience.  Gives us a little bit of hope!

 

Here is an article I found about using extended estrogen therapy (e.g. 3 months+) for thin lining.  Something we might bring up with our RE depending on our response this cycle.

 

https://www.ncbi.nlm...les/PMC4794872/


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#62 FMandAM

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Posted 16 May 2018 - 03:59 PM

An update from me on lining. As I said I was taking the following for the past month+:

 

In the meantime, I am going full on on the supplements. I found the paper that assessed uterine bloodflow and the effect of Vitamin E, L'Arginine and viagara and am taking the dosing they suggest (600 IU vitamin E daily and 6 g L'Arginine daily). I am also drinking three cups of red raspberry leaf tea spaced throughout the day and 40 mg black cohosh twice daily. Since my ERA is vaginal estrace/PIO protocol only, I'll see if there is any change and let you guys know my results.

 

After 15 days of vaginal estrace, I only measured 5.0 mm this morning. This is my worst result so far this far into an estrace supported cycle. I'm sure the RE will just increase the dose today to see if any progress is made. It seems like with every subsequent cycle my response is getting worse.

 

Returnable, in your low-dose stim cycle were you put on estrogen at any point? I've had fairly abysmal lining results so far on 75 IU of Gonal-F daily and my clinic has started me on Estrace 3x daily in addition to the Gonal-F shots (which are pens and holy moly they are so amazing compared to the hideous IM estradiol valerate injections!). I'm wondering if this is a typical, proven, effective course of treatment or if it's sort of a Hail Mary on their part...

 

So far my lining checks have been 4.7mm on CD9 and then 5.3mm on CD13. Next u/s is tomorrow (CD16, day 13 of Gonal). No follicles whatsoever at either of my checks so far, so the Gonal isn't having any effect on my ovaries at all. Last cycle on the pentoxifylline + estrogen combo I had 4-5 follicles every check, and I've never had none before so this is new territory.


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#63 returnable

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Posted 17 May 2018 - 11:26 AM

 

Returnable, in your low-dose stim cycle were you put on estrogen at any point? I've had fairly abysmal lining results so far on 75 IU of Gonal-F daily and my clinic has started me on Estrace 3x daily in addition to the Gonal-F shots (which are pens and holy moly they are so amazing compared to the hideous IM estradiol valerate injections!). I'm wondering if this is a typical, proven, effective course of treatment or if it's sort of a Hail Mary on their part...

 

So far my lining checks have been 4.7mm on CD9 and then 5.3mm on CD13. Next u/s is tomorrow (CD16, day 13 of Gonal). No follicles whatsoever at either of my checks so far, so the Gonal isn't having any effect on my ovaries at all. Last cycle on the pentoxifylline + estrogen combo I had 4-5 follicles every check, and I've never had none before so this is new territory.

 

 

No and during it, while I was struggling with lining, I thought, why not? I did do double the dose that you are. Are they not seeing any follicles, or just any that are developing? Did you take BCPs or anything before you started on this one?



#64 hopefuldadsomeday

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Posted 17 May 2018 - 01:37 PM

I'm wondering if there is a reason for thin lining, why they don't go full dose right away?  My wife right now is on estradiol injections only, I wonder why they wait until CD12 lining check before considering adding vaginal estrace as well.  My wife is now also doing meditation at night, imagining her lining is thick and fluffy, lol!


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#65 returnable

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Posted 17 May 2018 - 02:40 PM

Too much estrace can negatively impact the structure of the lining, which leads to poorer outcomes with transfers. If you are asking about full dose gonal-F, in my case the RE wanted to have a response at the lowest cost, so we didn't do the same IUs as during my stim cycles.


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#66 hopefuldadsomeday

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Posted 17 May 2018 - 03:04 PM

^Oh, I didn't know that too much estrogen would impact structure of lining!  But it would certainly explain why on our first FET, after 4 weeks of estrogen her lining actually decreased and had fluid buildup.  My wife and I were discussing about possibly even doing another round of IVF with our 3rd protocol which resulted in a 9mm lining to hopefully bank another embryo and attempt a transfer with the thicker lining.


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#67 FMandAM

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Posted 17 May 2018 - 03:21 PM

 

 

Returnable, in your low-dose stim cycle were you put on estrogen at any point? I've had fairly abysmal lining results so far on 75 IU of Gonal-F daily and my clinic has started me on Estrace 3x daily in addition to the Gonal-F shots (which are pens and holy moly they are so amazing compared to the hideous IM estradiol valerate injections!). I'm wondering if this is a typical, proven, effective course of treatment or if it's sort of a Hail Mary on their part...

 

So far my lining checks have been 4.7mm on CD9 and then 5.3mm on CD13. Next u/s is tomorrow (CD16, day 13 of Gonal). No follicles whatsoever at either of my checks so far, so the Gonal isn't having any effect on my ovaries at all. Last cycle on the pentoxifylline + estrogen combo I had 4-5 follicles every check, and I've never had none before so this is new territory.

 

 

No and during it, while I was struggling with lining, I thought, why not? I did do double the dose that you are. Are they not seeing any follicles, or just any that are developing? Did you take BCPs or anything before you started on this one?

 

 

Returnable, today I had one follicle (9mm) and she said she thought she could see two more teensy weensy ones so maybe they'll grow to a measurable size by my next u/s (assuming this cycle doesn't get cancelled). This is the first time any follicles have been visible this cycle, so I was happy to hear that something was happening. Lining was 6mm so still headed in the right direction, just very, very slowly. The estrace obviously hasn't been a magic bullet that fixed everything overnight.

 

I wasn't on BCP or any type of suppression meds before this (I jumped straight from the failed FET cycle to this one) so that's not the reason things look so bleak. Anyways, my clinic will let me know tomorrow how to proceed.


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#68 returnable

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Posted 17 May 2018 - 03:24 PM

Maybe you just needed the higher dosage to start with. I was at 150IU and was disappointed because both you and another lady were on 75IU. I'm sorry that you are starting off so slow. Hopefully things pick up, and the lining considering you only have tiny ones looks like it is developing. Fingers crossed.


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#69 FMandAM

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Posted 17 May 2018 - 03:24 PM

I'm wondering if there is a reason for thin lining, why they don't go full dose right away?  My wife right now is on estradiol injections only, I wonder why they wait until CD12 lining check before considering adding vaginal estrace as well.  My wife is now also doing meditation at night, imagining her lining is thick and fluffy, lol!

 

Hopefuldad, not sure if your wife would be interested but there's a meditation series from a company called Circle and Bloom specifically for women undergoing fertility treatment. I haven't tried it personally, I've just heard about it from other women.


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#70 FMandAM

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Posted 17 May 2018 - 03:28 PM

Maybe you just needed the higher dosage to start with. I was at 150IU and was disappointed because both you and another lady were on 75IU. I'm sorry that you are starting off so slow. Hopefully things pick up, and the lining considering you only have tiny ones looks like it is developing. Fingers crossed.

 

My main fear is that I'll have to cancel because I've run out of Gonal-F. I've got 5 more doses in the pen I think and then that's it -- can't get any more here and I'm not flying overseas to buy it. Hopefully that's enough time to get everything where it needs to be.


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#71 returnable

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Posted 18 May 2018 - 08:30 AM

Oh I forgot about that. Perhaps if you run out I assume the follicles will still keep developing naturally and there is still hope for a transfer window. I am sorry you are going through all this. We're all thinking of you.



#72 FMandAM

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Posted 18 May 2018 - 02:18 PM

Beyond frustrating, my clinic emailed me just as they were closing that I should take some extra Estrace today and tomorrow, stop the Gonal and start progesterone on Sunday. ET scheduled for next Friday, apparently. No trigger because there's no dominant follicle and my lining is way, WAY less than ideal. They sat on the lining results for over 24 hours before deciding what to do, and I've got a million questions and concerns and of course now they're closed for the weekend. I don't know why I can't just stay on the Gonal for another few days, is there some reason that's a bad idea? Like it will damage the lining or something? As of today it's been 14 days.


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#73 returnable

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Posted 19 May 2018 - 07:45 PM

I have no advice here. I'm sorry.

#74 hopefuldadsomeday

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Posted 22 May 2018 - 02:32 PM

FMandAM -  any update from your clinic?

As for us, lining check this Thursday, we're obviously quite nervous.  My wife said she can definitely feel more side effects from the injectable estrogen compared to the tablets/patches, but whether that actually translates to a thicker lining or not is the big question.


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#75 FMandAM

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Posted 23 May 2018 - 04:27 AM

Well I'm currently sitting in a plane at the Munich airport waiting to take off for Vienna... They insisted I follow the protocol they had decided on, so here I am. I'm demanding an ultrasound tomorrow so that if my lining is still thin (which I expect it will be) they don't have to re-freeze a thawed embryo.

DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.






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