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Please Help - Thin Uterine Lining Issue

uterine lining thin uterine lining endometrial lining FET frozen embryo transfer lining

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#26 returnable

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Posted 06 March 2018 - 12:14 PM

Good luck. I hope you find a solution soon.


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#27 FMandAM

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Posted 28 March 2018 - 03:10 PM

Cycle officially cancelled, after adding patches and sildenafil suppositories, her lining actually DECREASED to 4.7mm.  WTF?  RE has suggested we try a natural FET next cycle.  Will update next cycle.  Thanks for the support ladies!

 

Hi hopefuldadsomeday, so sorry to hear you and your wife are having issues with lining, it's such a frustrating problem!

 

It's still early in this cycle for me, but after 7 or 8 cancelled cycles (all due to thin lining) I seem to be responding to a combination of estradiol valerate injections and oral pentoxifylline. The injections are done every three days at home and the estradiol valerate had to be made by a compounding pharmacy as there is no Canadian manufacturer. In all prior cycles my lining did not get thicker than about 6.8mm (at CD20) but at a CD7 ultrasound yesterday I was already measuring 7mm. I have another ultrasound next week to check the progress and I'm really hopeful that it will be over 8mm.

 

Anyways, I just wanted to let you know that there are different protocols out there for lining issues and each woman responds differently so although it's a maddening (and expensive!!!) process don't give up hope. Before this I was on massive doses of estrogen patches plus tablets (oral and vaginal) and I also tried vaginal sildenafil (Viagra) and nothing really worked. In addition to the meds I drink almost exclusively red raspberry leaf tea (blech!) and pomegranate juice and I take 1000IU per day of vitamin E and 3600mg of L-Arginine daily (all on the recommendation of my doctor). I also go to acupuncture 1-2 times per week and I recently started myofascial release therapy.

 

Best of luck and please keep us updated!


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DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#28 returnable

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Posted 29 March 2018 - 07:08 AM

Wow FMandAM I am so happy you finally found something that seems to be working. I can't believe that they do not manufacture the injectable estradiol in Canada. No wonder no one here uses it in their protocol.

 

My RE is getting me to do an ERA so that with the (hopeful) good results, he can convince our third party to take those results and waive the 8 mm requirement.

 

In the meantime, I am going full on on the supplements. I found the paper that assessed uterine bloodflow and the effect of Vitamin E, L'Arginine and viagara and am taking the dosing they suggest (600 IU vitamin E daily and 6 g L'Arginine daily). I am also drinking three cups of red raspberry leaf tea spaced throughout the day and 40 mg black cohosh twice daily. Since my ERA is vaginal estrace/PIO protocol only, I'll see if there is any change and let you guys know my results.


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#29 FMandAM

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Posted 29 March 2018 - 10:18 AM

Returnable I don't know if it's making a difference or not but the other thing I'm doing is hanging out with a heating pad on my uterus for about an hour every evening. I was going to try castor oil packs again but honestly they're so messy and gross that I couldn't make myself start. I hadn't heard of the black cohosh for the endometrium, if I stall under 8mm I might try that next cycle! I've also been on vitamin C, vitamin D3 and B12 for a few months now, so possibly those are helping me. I'm not specifically taking them for my lining, just for general health.

 

ETA: hopefuldadsomeday, I forgot to mention that my doctor here told me that her next step would have been low-dose Gonal-F injections but because of some logistical issues (my treating clinic is overseas so my clinic here is operating as a satellite monitor, and they don't prescribe gonadotropins for satellite clients) we skipped that and went to the pentoxifylline+estradiol valerate protocol. Personally I think what works for each individual woman will depend on what the underlying issue is; I'm convinced in my case that there isn't adequate bloodflow to the endometrium, which is why a medication that changes the bloodflow is having an effect.


DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#30 Iamveryfearless

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Posted 29 March 2018 - 10:22 AM

Hi Hopefuldadsomeday,

I have the same issue as your wife. Ive been dealing with this since 2015 when I was made aware of my thin lining. I have had 2 failed FETs and 4 cancelled transfers.

I have tried trental but not for a long period of time. My dr thinks being on it for 2-3 months to make a difference. I have a history of thin lining. I was also on birth control for 15 years. While waiting we will look into surrogacy as we are really losing hope and time.

History:
TTC since 2013
42 👩🏻 39 🧔
2003 & 2015 D&C
3 miscarriages
3 ER = 3 PGS embryos
2 failed FETs
1 remaining embryo
History:
TTC since 2013
42 👩🏻 39 🧔
2003 & 2015 D&C
3 ER = 3 PGS embryos (1 remaining embryo)
Thin lining issues
3 miscarriages
2 failed FETs (FET #1 - 6/2016; FET #2 - 11/2016 - Biochemical)
Blog: www.iamveryfearless.com

#31 amazing grace

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Posted 31 March 2018 - 02:58 PM

Aside from the estrace patches and 1.5 mg of vaginal estrace 1/day, I found what really kicked my lining into gear was B12 vitamins, 1200mg daily. I also did brisk walking for 30 minutes each day. Warm camomile tea once a day and uterus warming for 30 minutes each day. My lining which was usually a 6-7mm lining jumped to over 9mm for all my FET's. Big improvement, although I was successful with my first fresh transfer which ended with a termination unfortunately, with a lining of 7.5mm. 


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#32 Iamveryfearless

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Posted 02 April 2018 - 12:10 PM

Thank you amazing grace.  I will try B12 as I have read it has helped as well.  Did you put a heating pad on low on your stomach for warming the uterus?  I am sorry your fresh transfer did not result in a pregnancy.  I wish you all the best. 


History:
TTC since 2013
42 👩🏻 39 🧔
2003 & 2015 D&C
3 ER = 3 PGS embryos (1 remaining embryo)
Thin lining issues
3 miscarriages
2 failed FETs (FET #1 - 6/2016; FET #2 - 11/2016 - Biochemical)
Blog: www.iamveryfearless.com

#33 amazing grace

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Posted 03 April 2018 - 06:00 PM

Thank you for your kind words. Yes I did use a heating pad and put it on low, combined with drinking warm tea and keeping my feet warm as well (socks). B12 I strongly encourage but check with your RE in regards to dosage. Best of luck with your lining and I hope it works!



#34 hopefuldadsomeday

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Posted 20 April 2018 - 11:52 AM

So update, natural FET, lining check on CD 12 is only 5.8mm...her follicle is only 14mm so they will bring her back in on Sunday for one more check but we're not optimistic...not sure where to go from here?  Mini-stim protocol?  We always thought the hardest part would be to get good embryos, never imagined that transferring would be our major roadblock...

 

We've tried raspberry leaf tea, pom juice, vit E, l-arginine, acupuncture, heating pads, sildenafil vaginal suppositories...


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#35 FMandAM

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Posted 20 April 2018 - 12:38 PM

Hopefuldad, so sorry you're having this issue again. You could ask the doctor to check her B12 levels and if they're on the low end of normal (or deficient) she could supplement. The other thing I thought might have been beneficial for my lining was myofascial release therapy.

 

I'm sure your doctor will have a game plan for you moving forward. And in the meantime here's a bit of hope: after months of barely breaking the 6mm mark I went up to 7mm on CD7 this cycle (on pentoxifylline), then unexpectedly dropped to 6.4mm by CD12 where I stayed until CD17 (confirmed by ultrasound). Decided to proceed with the transfer anyways, started progesterone on CD19 and at the ultrasound on CD24 (transfer date) my lining was 7.4mm. I actually think the extra two days from CD17-CD19 made the difference because I had two follicles almost ready to rupture at my CD17 ultrasound.

 

It can be done, it may just take a frustratingly long time to figure out what works and in the end you may not even know what the magic combination was. Keep plugging, you'll get there!


  • hopefuldadsomeday and Iamveryfearless like this

DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#36 amazing grace

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Posted 20 April 2018 - 04:19 PM

Hopeful read my post above. I am a strong advocate for B12. It really helped boost my lining to over 10mm. 


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#37 Iamveryfearless

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Posted 20 April 2018 - 04:36 PM

Hi FM and AM, 

 

Can you tell me a little more about the myofascial release?

 

Hopefuldad, so sorry you're having this issue again. You could ask the doctor to check her B12 levels and if they're on the low end of normal (or deficient) she could supplement. The other thing I thought might have been beneficial for my lining was myofascial release therapy.

 

I'm sure your doctor will have a game plan for you moving forward. And in the meantime here's a bit of hope: after months of barely breaking the 6mm mark I went up to 7mm on CD7 this cycle (on pentoxifylline), then unexpectedly dropped to 6.4mm by CD12 where I stayed until CD17 (confirmed by ultrasound). Decided to proceed with the transfer anyways, started progesterone on CD19 and at the ultrasound on CD24 (transfer date) my lining was 7.4mm. I actually think the extra two days from CD17-CD19 made the difference because I had two follicles almost ready to rupture at my CD17 ultrasound.

 

It can be done, it may just take a frustratingly long time to figure out what works and in the end you may not even know what the magic combination was. Keep plugging, you'll get there!


History:
TTC since 2013
42 👩🏻 39 🧔
2003 & 2015 D&C
3 ER = 3 PGS embryos (1 remaining embryo)
Thin lining issues
3 miscarriages
2 failed FETs (FET #1 - 6/2016; FET #2 - 11/2016 - Biochemical)
Blog: www.iamveryfearless.com

#38 hopefuldadsomeday

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Posted 20 April 2018 - 04:57 PM

FMandAM - thanks for sharing your experience and your words of encouragement!  I will ask our RE about pentoxifylline but he doesn't seem to think blood flow is our issues (hence he was reluctant to even try sildenafil - it looks like it hasn't helped in our case)

 

Amazing grace - how long were you on B12 before you saw results?  I just checked with my wife and her vitamin supplement only had 200mcg of B12, so I will buy her a 1000mcg supplement.


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#39 FMandAM

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Posted 20 April 2018 - 05:24 PM

Hi Iamveryfearless, the clinic I go to uses the John F. Barnes myofascial release approach (just got that from their website, I have no idea if there are other approaches/styles). The sessions are interesting and feel like a mix of massage, acupressure and physio. She does a lot of sustained pressing and pulling and frequently checks my posture while sitting and standing. She also gives me homework to do in between sessions.

The clinic I go to has only registered massage therapists doing the release therapy and it's billed as massage so I'm able to submit it to my insurance for a partial refund.

DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#40 hopefuldadsomeday

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Posted 21 April 2018 - 12:40 AM

So I'm reading there is some early promise to using PRP (platelet rich plasma) as a intrauterine infusion in patients with persistent thin endometrial lining.  Anybody know if any clinics in Canada offer this?  There are a few clinics in the USA that offer this and something we may look into if other treatment options here fail.  Seems like it's done on day 12 and 14 of the cycle, so we could theoretically have it done in the USA and come back into Canada for the ET...


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#41 FMandAM

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Posted 21 April 2018 - 11:37 PM

Hi Hopefuldad, I don't think there are any clinics in Canada offering PRP yet but I could be wrong. Have you also looked into a neupogen (sp?) wash? I believe that's another possible treatment for thin lining.

DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#42 hopefuldadsomeday

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Posted 22 April 2018 - 02:24 PM

Quick update - lining measured 4.5mm today.  Doctors say it is unlikely they can get her lining to thicken and suggest we transfer anyways.  We've decided to cancel this cycle and do an ERA test and transfer in June.  If that fails, we'll ask our doctor about experimental treatment (they did not seem keen on trying those).  We've read a few articles about potential with tamoxifen as well, so that might be an option...

 

https://www.ncbi.nlm...pubmed/28345485

 

Sigh...this is so frustrating...and a little scary since the prognosis for thin lining is poor...thanks for all the support ladies!   I wish you weren't here in this thread with us but it's nice to know we're not alone in this struggle.

 

Iamveryfearless - wishing you the best, please update us with the results of your trental!

 

FMandAM - thanks for the suggestion for neupogen, I'll bring it up with our RE in the future, but again they seem to be averse to trying experimental treatments.  Hope you have success as well!


March 2016 - Miscarriage #1 (chemical pregnancy)

August 2016 -  Miscarriage #2 (Trisomy-16)

December 2016 - Miscarriage #3 (unknown - suspected chromosomal abnormality)

IVF #1 - Aug 2017 (estrogen priming antagonist protocol) - 9 eggs retrieved, 3 fertilized, 2 blastocysts, only 1 PGS normal embryo 5BB mitoscore 25.1 (frozen)

IVF #2 - Nov 2017 (estrogen priming antagonist protocol - with testosterone priming and growth hormone) - 7 eggs retrieved, 5 fertilized with ICSI, 1 blastocyst PGS-normal 5BB mitoscore 33.12 (frozen)

IVF #3 - Jan 2018 (estrogen priming antagonist protocol with growth hormone) -  4 eggs retrieved, 2 fertilized with ICSI, 1 blastocyst PGS-normal 6BB mitoscore 29.82 (frozen)

FET #1 - March 2018 - cancelled due to thin lining (6.25mm)

FET #1.2 - April 2018 - cancelled due to thin lining again! (4.85mm)

FET #1.3 - June 4, 2018 (lining 7.5mm!) - th_abfn.gif

ERA Aug 2018 - Pre-receptive by 1 day

FET #2 - Sep 18, 2018 (lining 6.9mm) th_abfp.gif  Beta #1: Sep 30, 2018 - 682  Beta #2: Oct 6,2018 - 6656 U/S: Oct 15 - measuring 6w4d (CRL 6.87mm), HR 127bpm! U/S: Oct 25 - measuring 8w1d (CRL 16.69mm), HR 168bpm!  Discharged to midwives!  June 7, 2019: It's a girl!  DD born 7lb 2oz babygirl.gif

FET #3 - Oct 4, 2021 (lining 8.8mm!)  th_abfp.gif  Beta #1: Oct 14, 2021: 415, Beta #2: Oct 21, 2021: 4778 U/S: Nov 1, 2021 - measuring 6w4d, CRL 6.6mm, HR 133bm! U/S: Nov 15, 2021 - measuring 8w6d (CRL: 22.3mm), HR 182bpm!  Discharged to midwives!


#43 amazing grace

amazing grace
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  • Dx:Unexplained

Posted 22 April 2018 - 02:42 PM

Hopeful,

I am on 1200mg of B12. I take one each day. I was on B12 prior to my FET for about 3months. That ended in a negative but I continue to take it. 



#44 amazing grace

amazing grace
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  • Dx:Unexplained

Posted 22 April 2018 - 02:46 PM

Forgot, I always struggled with lining issues after my D/C. It was always between 5-7mm. After I started taking B12, My lining really improved and got to over 10mm. I also included patches (2 patches for 7 days then switch), low does vaginal estrace 1.5mg, cammomile tea, exercise, warm pad on uterus daily for 30 minutes and warm feet (as per chinese medicine).  Hope it helps.


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#45 Iamveryfearless

Iamveryfearless
  • Just Hatched
  • 5 posts
  • Gender:Female
  • Location:Los Angeles
  • Dx:Other
  • My Clinic:California Fertility Partners

Posted 22 April 2018 - 02:54 PM

Thank you so much for sharing your protocol!  

Forgot, I always struggled with lining issues after my D/C. It was always between 5-7mm. After I started taking B12, My lining really improved and got to over 10mm. I also included patches (2 patches for 7 days then switch), low does vaginal estrace 1.5mg, cammomile tea, exercise, warm pad on uterus daily for 30 minutes and warm feet (as per chinese medicine).  Hope it helps.


History:
TTC since 2013
42 👩🏻 39 🧔
2003 & 2015 D&C
3 ER = 3 PGS embryos (1 remaining embryo)
Thin lining issues
3 miscarriages
2 failed FETs (FET #1 - 6/2016; FET #2 - 11/2016 - Biochemical)
Blog: www.iamveryfearless.com

#46 amazing grace

amazing grace
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Posted 22 April 2018 - 02:55 PM

So very welcome! 



#47 Iamveryfearless

Iamveryfearless
  • Just Hatched
  • 5 posts
  • Gender:Female
  • Location:Los Angeles
  • Dx:Other
  • My Clinic:California Fertility Partners

Posted 22 April 2018 - 05:32 PM

One more quetstion - what kind of patches did you use?  Were these estrogen patches?  

 

So very welcome! 


History:
TTC since 2013
42 👩🏻 39 🧔
2003 & 2015 D&C
3 ER = 3 PGS embryos (1 remaining embryo)
Thin lining issues
3 miscarriages
2 failed FETs (FET #1 - 6/2016; FET #2 - 11/2016 - Biochemical)
Blog: www.iamveryfearless.com

#48 amazing grace

amazing grace
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  • Dx:Unexplained

Posted 23 April 2018 - 05:40 PM

Yes estrogen patches. They are called Climara.



#49 FMandAM

FMandAM
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  • 155 posts
  • Gender:Female
  • Dx:DOR
  • My Clinic:OFC in Canada, Reprogenesis in the CR

Posted 24 April 2018 - 12:34 PM

Quick update - lining measured 4.5mm today.  Doctors say it is unlikely they can get her lining to thicken and suggest we transfer anyways.  We've decided to cancel this cycle and do an ERA test and transfer in June.  If that fails, we'll ask our doctor about experimental treatment (they did not seem keen on trying those).  We've read a few articles about potential with tamoxifen as well, so that might be an option...

 

https://www.ncbi.nlm...pubmed/28345485

 

Sigh...this is so frustrating...and a little scary since the prognosis for thin lining is poor...thanks for all the support ladies!   I wish you weren't here in this thread with us but it's nice to know we're not alone in this struggle.

 

Iamveryfearless - wishing you the best, please update us with the results of your trental!

 

FMandAM - thanks for the suggestion for neupogen, I'll bring it up with our RE in the future, but again they seem to be averse to trying experimental treatments.  Hope you have success as well!

 

Hopefuldad it's so, so frustrating when a doctor won't go outside their familiarity box, isn't it? My opinion is that I'm presenting as a client (I hate referring to myself as a patient because, frankly, I'm paying for the services and that makes me a client!) who isn't responsive to the standard treatment so they shouldn't keep trying the same standard options over and over again.

 

I want to encourage you to seek a second opinion if you feel that your doctor isn't giving you and your wife the best care possible. When my doctor overseas ran up against a prescription issue and it was discovered that I wouldn't be able to procure the gonal-f here in Canada, he sort of shut down and basically told me that was the only other thing I could try. From my own research I knew it wasn't, so I made an appointment with my "satellite" fertility doctor here in Canada to talk about my case and she had some excellent suggestions (using the pentoxifylline was her idea, for example).

 

I realize you've got embryos at the clinic with your doctor but it's possible to move embryos to a new clinic if you find a different doctor you feel is going to give you more individualized care.


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DE IVF overseas in Jan 2017 = BFN with no frosties

 

DE IVF overseas in July 2017 = ET cancelled because of poor lining, DH went without me and we froze both blasts that made it to day 5.

 

Mock cycle in August 2017 = by George I think we've got it! Lining responded well to a new protocol, FET scheduled for September 2017.

 

FET overseas September 2017 = cancelled due to poor lining. This is getting really frustrating now. Change of protocol again.

 

FET overseas October 2017 = cancelled due to poor lining.

 

FET overseas November 2017 = tried doing a natural cycle FET but a surprise O on CD6 cancelled those plans.

 

FET overseas December 2017 = natural cycle FET cancelled, again due to an early O (CD10) and thin lining.

 

FET overseas January 2018 = cancelled due to a 31mm cyst on left ovary.

 

FET overseas March 2018 = lining reached 6.4mm on a combo of pentoxifylline, estradiol valerate injections and Estrace. Trilaminar so despite being a bit thin the doctor said let's go. Flew solo to the CR for the transfer and found out my lining had grown to 7.4mm between my last u/s and the transfer date! Woohoo, go me! BFN 12dp5dt.

 

FET overseas May 2018 = lining reached 6mm on low-dose Gonal-F and the doctor insisted on going ahead with the transfer, despite there being no dominant follicle yet so there was no chance I would ovulate. On transfer day my lining was a disappointing 7.1mm. Transferred our last frostie (5AB hatching blast) on May 25, BFN on 13dp5dt.

 

Nothing left in the freezer, the bank account or the emotional reserves; this is the end of the pregnancy road for us.


#50 Graceland

Graceland
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  • Gender:Female
  • Location:Ottawa
  • Dx:Other
  • My Clinic:Hannam (now)

Posted 24 April 2018 - 08:25 PM

My RE, Dr. Hannam at the Hannam Fertility Centre in Toronto, helped me do a PRP infusion to help my extremely stubborn lining. Unfortunately it didn't help. What did help was a combination of oral estrogen of increasing dosages throughout the cycle and vaginal Sildenafil. My lining only got to around 7 mm, but it was enough. I recently gave birth to twins. If you read my 'About Me' page, you'll see my looooooong history and my lining issues. Happy to share further if it could possibly help. I'm so sorry you're going through this. There are a couple of thin lining threads that really helped me. I'll try bumping them for you in case you haven't read them before.
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Twin girls born December 2017 after 7 years of TTC

See 'About Me' for full details






Also tagged with one or more of these keywords: uterine lining, thin uterine lining, endometrial lining, FET, frozen embryo transfer, lining