Hi everyone,
All my lab results look very good on paper. We were diagnosed with male factor only.
But then I'm not responding well to the drugs.
As you can see in my signature, I had two cancelled ivf cycles. One before retrieval as I had onlg 4 big follicles. The next one after retrieval as all of the 6 retrieved eggs were immature. They couldn't attempt fertilization.
My thyroid is well controlled, TSH is 1.65.
And I'm a Lupus patient (so far only skin is affected according to the doctors).
Do you guys think that Lupus (autoimmune disease) plays a role in ovarian response?
Poor ovarian response caused by immue issues?
Started By
NewWorld
, Jun 18 2017 12:12 PM
No replies to this topic
#1
NewWorld
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- Global 100+
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- 230 posts
- Gender:Female
- Dx:DOR
- My Clinic:Calgary, now Victoria
Posted 18 June 2017 - 12:12 PM
Me: 29 30, Husband: 32 33
Dx: low morphology (1%), probably DOR (AMH 11.8)
DH on Nutraception, Chinese herbs & Acupuncture --> No improvement
August 2016 - IUI #1 Clomid 100mg, trigger Pregnyl 5000. 2.3 million post-wash sperm count--> BFN One month break because of cysts. October 2016 - IUI #2 cancelled due to early ovulation One month break for SHG December 2016 - IUI #3 Clomid 100mg, trigger Pregnyl 5000. 3 million post-wash sperm count--> BFN February 2017 - IVF #1 to IUI
Antagonist protocol: started at 150 IU Gonal-F and 75 IU Luveris, baby aspirin. After 4 days of injections, increased Gonal-F to 300 IU. Luveris still at 75 IU, started Cetrotide 0.25mg. Only 4 mature follicles --> Converted to Superovulation IUI.
Trigger Pregnyl 10000 3 million post-wash sperm count. Taking baby aspirin and Prometrium.-->BFN Two cycles break required for the ovaries to recover.
May 2017 - IVF #2 - cancelled after retrieval Antagonist protocol: Dose increased to 300 IU Gonal-F and 150 IU Menopur. 8 days of stimulations. 6 eggs retrieved. All immature. Fertilization was not attempted. Taking Chinese Herbs, DHEA, high dose of Ubiquinol and Inositol powder. Switching to VFC, consulting with Dr. Hudson on July 17th Diagnosed with DOR. Asked to continue DHEA until retrieval August 2017 - IVF #3 Agonist/Antagonist Conversion Protocol. Suprefact, Puregon, Repronex, Dexamethasone, Orgalutran, Trigger with HCG & Decapeptyl, Intralipid. July 27 - Started Suprefact and stopped Chinese Herbs due to unknown interactions. August 9 - CD 1 August 11 - Suppression confirmed August 18 - last dose of Suprefact August 20 - starting 300 IU Puregon, 150 IU Repronex, 1mg Dexamethasone & baby asprin August 24 - added Orgalutran, first ultrasound and blood work in Calgary August 26 - Flew to Victoria, first ultrasound and blood work with Dr. Hudson August 30 - Hoping for 5-6 eggs. Triggered with 10,000 IU of Pregnyl and 0.2mg of Decapeptyl. September 1 - Retrieval with Dr. Graham, 9 eggs retrieved, Intralipid infusion after the retrieval September 2 - day 1 update - 6 eggs were mature, all ICSI'd and fertilized September 3 - day 2 update - 2 of 6 embryos are at grade 1, 4 of 6 are at grade 2. Probably day 5 transfer September 4 - day 3 update - day 5 transfer confirmed September 6 - Transfer with Dr. Hudson, transferred 1 grade 2 blast, not sure yet how many will be frozen September 7 - 1 day 6 grade 3 expanded blast frozen September 14 - evening of 8dp5dt - BFP (faint positive) September 18 - 12dp5dt - beta 220 September 20 - 14dp5dt - beta 446 September 22 - 16dp5dt - beta 1030
Dx: low morphology (1%), probably DOR (AMH 11.8)
DH on Nutraception, Chinese herbs & Acupuncture --> No improvement
August 2016 - IUI #1 Clomid 100mg, trigger Pregnyl 5000. 2.3 million post-wash sperm count--> BFN One month break because of cysts. October 2016 - IUI #2 cancelled due to early ovulation One month break for SHG December 2016 - IUI #3 Clomid 100mg, trigger Pregnyl 5000. 3 million post-wash sperm count--> BFN February 2017 - IVF #1 to IUI
Antagonist protocol: started at 150 IU Gonal-F and 75 IU Luveris, baby aspirin. After 4 days of injections, increased Gonal-F to 300 IU. Luveris still at 75 IU, started Cetrotide 0.25mg. Only 4 mature follicles --> Converted to Superovulation IUI.
Trigger Pregnyl 10000 3 million post-wash sperm count. Taking baby aspirin and Prometrium.-->BFN Two cycles break required for the ovaries to recover.
May 2017 - IVF #2 - cancelled after retrieval Antagonist protocol: Dose increased to 300 IU Gonal-F and 150 IU Menopur. 8 days of stimulations. 6 eggs retrieved. All immature. Fertilization was not attempted. Taking Chinese Herbs, DHEA, high dose of Ubiquinol and Inositol powder. Switching to VFC, consulting with Dr. Hudson on July 17th Diagnosed with DOR. Asked to continue DHEA until retrieval August 2017 - IVF #3 Agonist/Antagonist Conversion Protocol. Suprefact, Puregon, Repronex, Dexamethasone, Orgalutran, Trigger with HCG & Decapeptyl, Intralipid. July 27 - Started Suprefact and stopped Chinese Herbs due to unknown interactions. August 9 - CD 1 August 11 - Suppression confirmed August 18 - last dose of Suprefact August 20 - starting 300 IU Puregon, 150 IU Repronex, 1mg Dexamethasone & baby asprin August 24 - added Orgalutran, first ultrasound and blood work in Calgary August 26 - Flew to Victoria, first ultrasound and blood work with Dr. Hudson August 30 - Hoping for 5-6 eggs. Triggered with 10,000 IU of Pregnyl and 0.2mg of Decapeptyl. September 1 - Retrieval with Dr. Graham, 9 eggs retrieved, Intralipid infusion after the retrieval September 2 - day 1 update - 6 eggs were mature, all ICSI'd and fertilized September 3 - day 2 update - 2 of 6 embryos are at grade 1, 4 of 6 are at grade 2. Probably day 5 transfer September 4 - day 3 update - day 5 transfer confirmed September 6 - Transfer with Dr. Hudson, transferred 1 grade 2 blast, not sure yet how many will be frozen September 7 - 1 day 6 grade 3 expanded blast frozen September 14 - evening of 8dp5dt - BFP (faint positive) September 18 - 12dp5dt - beta 220 September 20 - 14dp5dt - beta 446 September 22 - 16dp5dt - beta 1030
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