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Egg damage from ICSI


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#1 BayB Dreams

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  • Dx:Endometriosis

Posted 11 March 2017 - 03:22 PM

I had 15 mature eggs, ICSI was preformed on all of them and 6 out of the 15 were damaged during the ICSI procedure.  To me that seems like quite a high number to have been damaged considering ICSI is recommend to couples with a low number of mature eggs retrieved to help ensure fertilization.  Is it normal for that many to be damaged from ICSI?


2011-surgery to remove endometriosis and adhesions

        -took clomid then tried letrozole with th_abfn.gif 

       

 

2012-2 IUI cycles with letrozole with th_abfn.gif 

        -1 IUI cycle with Bravelle and trigger shotth_abfp.gif 

 

2013-Wonderful Daughter was born

 

2015-letrozole IUI cycle BFN

        -Bravelle and trigger shot IUI cycle th_abfn.gif 

 

Switched clinics

 

2016-surgery to remove endometriosis and adhesions

        -IUI with Menopur and trigger shot th_abfn.gif 

        -IUI with Menopur and trigger shot, cycle cancelled due to too high of a response

 

2017:

Feb 17-25 Estrace 2x daily

Feb 26-?  150iu Menopur, 225 iu Puregon, (added in orgalutron March 2)

 

Blood work and ultrasound results:

March 2 CD 6:  E2 962 pmol/L

March 5 CD 9 SD 8: E2 3011 pmol/L, Left ovary 15.91mm, 12.54mm, 13.52mm, 10.93mm, Right ovary 10.76mm, 12.71mm, 13.35mm, 10.82mm, Endo 10.34.  Was told there are about 14 follicles growing and it was estimated that about 10 will make it to the right size to contain a mature egg.

March 7 CD 11 SD 10: E2 6081 pmol/L, Left ovary 11.69mm, 16.69mm, 11.82mm, 13.44mm, 12.76mm, 12.22mm, 18.11mm, Right ovary 17.84mm, 14.73mm, 15.03mm, 16.41mm, 14.28mm, 11.55mm, 11.61mm, Endo 15.67.

March 8 CD 12 SD 11: Left ovary 18.48mm, 17.70mm, 19.90mm, 14.89mm, 14.98mm, 18.15mm, Right ovary 19.03mm, 18.99mm, 17.23mm, 13.48mm, 18.76mm, Endo 12.69.

THE TRIGGER WILL BE PULLED TONIGHT, EGG RETRIEVAL WILL BE FRIDAY MARCH 10TH.   EEEEKS!!!!

March 10: Egg Retrieval.


#2 amp77

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Posted 11 March 2017 - 09:57 PM

Sounds high but we didn't do ICSI so I didn't look into it in detail.  I just wanted to say that I am sorry that it turned out that way.  I hope someone else has answers for you and I hope that you end up with some fantastic embryos!


  • BayB Dreams likes this

Age 39, DH 43 in Oct.

TTC on and off since 2007 before our second IVF, in 2014, brought us our beautiful son.

 

FET #1 -  Sept 2016

Day 1 - Sept. 9

Monitoring - Sept. 18-22

Lining Check - Sept. 22 (11.3 mm)

Transferred 5B-BB Sept. 25 - BFP!!!  HCG 890 @ 12dp5dt and Progesterone 95.
Midwife appointment Sept. 19 and first ultrasound Nov. 4
3 Frosties left

 

<a href="https://lilypie.com/"><img src="https://lbdf.lilypie.com/9GKrm4.png" width="400" height="80" border="0" alt="Lilypie Pregnancy tickers" /></a>

 

-------------------------------------------------------------------------------------------------------------------------------------

 

Seems like forever ago...

 

Age 37, DH 40.

TTC on and off since 2007

Unexplained Infertility

 

IVF #1 - April 2014 - BFN - no frosties

 

IVF #2 - July 2014 - BFP - 5B-AB and 4 frosties (5B-BB, 2x4B-BB and 3B-BB)

Apr. 13, 2015 - Daniel Erik was born at 5:05 am, weight 8 lbs, 13 oz, and 22" long.  He is perfect in every way.

 

 


#3 BayB Dreams

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Posted 11 March 2017 - 10:25 PM

Thank you amp77, and congrats on your past IVF success :)


2011-surgery to remove endometriosis and adhesions

        -took clomid then tried letrozole with th_abfn.gif 

       

 

2012-2 IUI cycles with letrozole with th_abfn.gif 

        -1 IUI cycle with Bravelle and trigger shotth_abfp.gif 

 

2013-Wonderful Daughter was born

 

2015-letrozole IUI cycle BFN

        -Bravelle and trigger shot IUI cycle th_abfn.gif 

 

Switched clinics

 

2016-surgery to remove endometriosis and adhesions

        -IUI with Menopur and trigger shot th_abfn.gif 

        -IUI with Menopur and trigger shot, cycle cancelled due to too high of a response

 

2017:

Feb 17-25 Estrace 2x daily

Feb 26-?  150iu Menopur, 225 iu Puregon, (added in orgalutron March 2)

 

Blood work and ultrasound results:

March 2 CD 6:  E2 962 pmol/L

March 5 CD 9 SD 8: E2 3011 pmol/L, Left ovary 15.91mm, 12.54mm, 13.52mm, 10.93mm, Right ovary 10.76mm, 12.71mm, 13.35mm, 10.82mm, Endo 10.34.  Was told there are about 14 follicles growing and it was estimated that about 10 will make it to the right size to contain a mature egg.

March 7 CD 11 SD 10: E2 6081 pmol/L, Left ovary 11.69mm, 16.69mm, 11.82mm, 13.44mm, 12.76mm, 12.22mm, 18.11mm, Right ovary 17.84mm, 14.73mm, 15.03mm, 16.41mm, 14.28mm, 11.55mm, 11.61mm, Endo 15.67.

March 8 CD 12 SD 11: Left ovary 18.48mm, 17.70mm, 19.90mm, 14.89mm, 14.98mm, 18.15mm, Right ovary 19.03mm, 18.99mm, 17.23mm, 13.48mm, 18.76mm, Endo 12.69.

THE TRIGGER WILL BE PULLED TONIGHT, EGG RETRIEVAL WILL BE FRIDAY MARCH 10TH.   EEEEKS!!!!

March 10: Egg Retrieval.


#4 returnable

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Posted 12 March 2017 - 08:03 AM

Did the clinic tell you that the eggs were specifically damaged by ICSI?

December 2016 IVF - no chromosomally normal embryos to transfer

February 2017 IVF - no chromosomally normal embryos to transfer

 

We are done with my eggs


#5 SunshineTTC

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Posted 12 March 2017 - 01:49 PM

What clinic are you at?  Although there is a very small chance of ICSI causing damage, this does not normally happen (at all) with competent embryologists.  However ICSI does not guarantee fertilization, and it is definitely possible that 6 out of 15 might not have fertilized with ICSI.


  • CdnHockeyGal and Murried like this

Me: 40 41 42 43, single, FSH 6, LH 2 (FSH not high, but exceeds 2:1 ratio), DOR (AFC 5-7, v.low AMH), all else normal/healthy.

 


#6 BayB Dreams

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Posted 12 March 2017 - 02:28 PM

Hi returnable and SunshineTTC, when the lab called and told me 6 out of the 15 didn't make it I asked the reason why and the woman explained several reasons to me why eggs don't 'make it' after ICSI, one of the reasons being that they were damaged from ICSI and I was told that was the case with my 6 that didn't make it.  It does seem like such a high number to have been damaged by the procedure considering specialists specifically will recommend ICSI to couples who only have a small number of eggs after retrieval to help ensure they get fertilized, but if the damage rate is that high it wouldn't make sense for them to do that.  I'm glad I have 9 embryos but I can't help but be upset that 40% of my eggs were damaged right off the bat since there's no telling how many out of the ones left are going to develop properly and come back normal after CCS.


2011-surgery to remove endometriosis and adhesions

        -took clomid then tried letrozole with th_abfn.gif 

       

 

2012-2 IUI cycles with letrozole with th_abfn.gif 

        -1 IUI cycle with Bravelle and trigger shotth_abfp.gif 

 

2013-Wonderful Daughter was born

 

2015-letrozole IUI cycle BFN

        -Bravelle and trigger shot IUI cycle th_abfn.gif 

 

Switched clinics

 

2016-surgery to remove endometriosis and adhesions

        -IUI with Menopur and trigger shot th_abfn.gif 

        -IUI with Menopur and trigger shot, cycle cancelled due to too high of a response

 

2017:

Feb 17-25 Estrace 2x daily

Feb 26-?  150iu Menopur, 225 iu Puregon, (added in orgalutron March 2)

 

Blood work and ultrasound results:

March 2 CD 6:  E2 962 pmol/L

March 5 CD 9 SD 8: E2 3011 pmol/L, Left ovary 15.91mm, 12.54mm, 13.52mm, 10.93mm, Right ovary 10.76mm, 12.71mm, 13.35mm, 10.82mm, Endo 10.34.  Was told there are about 14 follicles growing and it was estimated that about 10 will make it to the right size to contain a mature egg.

March 7 CD 11 SD 10: E2 6081 pmol/L, Left ovary 11.69mm, 16.69mm, 11.82mm, 13.44mm, 12.76mm, 12.22mm, 18.11mm, Right ovary 17.84mm, 14.73mm, 15.03mm, 16.41mm, 14.28mm, 11.55mm, 11.61mm, Endo 15.67.

March 8 CD 12 SD 11: Left ovary 18.48mm, 17.70mm, 19.90mm, 14.89mm, 14.98mm, 18.15mm, Right ovary 19.03mm, 18.99mm, 17.23mm, 13.48mm, 18.76mm, Endo 12.69.

THE TRIGGER WILL BE PULLED TONIGHT, EGG RETRIEVAL WILL BE FRIDAY MARCH 10TH.   EEEEKS!!!!

March 10: Egg Retrieval.


#7 mouse

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Posted 12 March 2017 - 05:05 PM

I have had ICSI done and had none damaged - but I'm old and my eggs may be have been harder/tougher for sperm to penetrate. Is it possible that your eggs, or this batch in particular, are somehow more permeable/fragile and therefore more prone to this sort of damage?
  • CdnHockeyGal likes this
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