I'm unfamiliar with this kind of protocol. I have an endometriosis nodule in the posterior cul de sac likely involving bowel. (never had a lap, only seen via MRI and US) I've had 4 cycles of FET. 1st - successful. 2nd and 3rd unsuccesful, and 4th cancelled due to poor endometrial lining. 1st one involved BCP, suprefact, dexamethasone, estrace and progesterone. 2nd and 3rd involved BCP, suprefact, progesterone,estrace, and medrol for assisted hatching. Estrace was aggravating my endo. 4th go was BCP, suprefact, dexamethasone, estrace, progesterone. Started breakthrough bleeding and lining was too thin so FET was cancelled. Now my Fertility specialist wants to do something called a "supernatural" cycle that involves:
Birth control pill, Letrozole 5 mg for 5 days starting on cycle day 3
Ultrasound and blood work on cycle day 10
If endometrium satisfactory, monitor for LH surge
2 days after a late surge start Endometrin 100 mg intravaginally twice daily and Estrace 2 mg orally once daily
Medrol for assisted hatching
However, the surgeon I saw last week said I should do 3 months of lupron before our FET as she has seen success with endo patients that way. She mentioned that surgery to remove the nodule would not help our IVF success. I can't seem to find any literature on the success of a "supernatural" cycle with patients that have Endometriosis, and to top it off my cycles are no where near regular. What method do you suggest? We have only one good quality embyo left. (day 3)
Thanks so much for your opinion!