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FET - transferring 2 embryos vs. 1? Increases or cuts the chance of pregnancy?


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#1 Alicja

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Posted 10 January 2017 - 01:46 PM

Hi ladies. I have a question in regards to your thoughts on FET - transferring TWO embryos vs. one. Which of you had 2 embryos transferred during FET - and did any of them implant, resulted in pregnancy, or failed?

 

Recently my friends forwarded an article to me, which said the recent study showed that '...Using TWO embryos for IVF could cut the chance of having a baby by 25% because the womb may reject them if one is of poor quality' - a study of almost 1500 embryos was carried out at Nurture Fertility clinic in Nottingham.

 

From my own experience: in 2014 - FET, we had 2 embryos transferred  - none of them implanted.

2016 - again, FET - 2 embryos transferred - none of them implanted (thankfully, we have a wonderful 1-year old son from the same fresh cycle).

 

This year we'll be undergoing another FET (still have 3 frozen embryos) and was thinking about transferring 2 of them. But after reading about this study, I'm contemplating having just 1 transferred (since we already failed twice, after 2-embryo transfers).

 

Which of you had 2 embryos transferred during FET - and did they implant? And 2nd question, if it's not too much to ask, how old were you at the time of transfer? (I'll be 39 by the time of my next FET). Thank you for your help and good luck!

 



#2 2014Hopeful

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Posted 10 January 2017 - 03:34 PM

The only time I've ever gotten pregnant is when I transferred 2 embryos. The is no scientific data to prove it but to me it always felt like the two helped each other out ;)

Me: 36 DH:46

 

Diagnosed with PCOS and DH Low sperm count

 

3 failed IUIs from June 2012 to Jan 2013

 

IVF #1 OVO March 2013: Gonal F 150/Luveris 75, but slowly increase Gonal F to 300 due to poor response.

 

14 follicles; 11 matured

Transferred 1 5 day blast and froze one.

BFN

 

FET #1 OVO: JUNE 2013; BFN

 

Switched clinics, going to Ottawa Fertility centre.

 

IVF #2 OFC SEPT 2013: Gonal F 150/Luveris 150; increased Gonal F to 250.

8 Follicles, 6 Matured, 3 Ferilized

Transferred 2 3 day embryos (8 cells)

BFN

 

IVF #3 OFC Jan 2014: Gonal F 300/Luveris 150

20 Follicles, 15 Matured, 4 Fertilized

Did a Freeze all due to OHSS

 

FET #2 OFC Feb 2014: Transferred 2 day 3 embryos and froze one

Beta March 4 2014

BFP!!!!!

 

Baby girl born November 18, 2014.

 

 

FET #3 OFC Feb 2016

Transferred our one and only frozen 3 day

BFN

 

IVF # 4 OVO March 2016.

12 Follicles; 10 Matures; 5 fertilized

Froze 4 day 3 embryos due to high progesterone level.

 

FET #4 OVO May 2016

Transferred 1 3 day 8 cell

BFN

 

FET #5 OVO July 2016

Day 1 June 13th - start climara June 15th

First ultrasound booked June 28th

Transferred 1 3 day 8 cell embryo July 4th

BETA July 15th

Another BFN cry.gif

 

Transferred my 2 remaining day 3 embryos to OFC.

Scheduled for a Sept FET. Planning to transfer both.

 

FET #6 OFC Sept 2016

Sept 28: Transferred 1 3 day embryo (the second did not survive thaw) Sept 28th

BFN

 


#3 ilovemydogs

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Posted 10 January 2017 - 04:58 PM

My preference is one at a time. If for some reason things aren't ideal in a transfer month I would prefer to lose one embryo than two.

Also, while twins can be great I've also heard some difficult situations as well with them and it wasn't worth the risk for me.

My first FET I only had one (negative), second I did two and regretted it (again negative). On my donor cycle, which is basically same prep as FET except embryos are fresh, I opted for one (negative).
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Finally seeing the light at the end of the tunnel.

See "About Me" for details.

#4 Newbegirl500

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Posted 10 January 2017 - 09:46 PM

Hi,
I also heard about this study, but I couldn't find it in scientific journals. May be it is not published yet, but it is in the news. But I guess it could be true and I am gonna transfer only one embryo, although I always dream about having twins. Worst case scenario I need to repeat it for the other embryo next month.

#5 From0to3

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Posted 11 January 2017 - 12:04 AM

I really think there is little rhyme or reason and really up to the embryos and a little simple luck whether they take. I transferred two top quality perfect looking blasts with my first fresh cycle and neither took. My first fet I transferred two and one took although I miscarried at nine weeks. Second cycle I transferred two average embryos and both took resulting in twins and my second fet I transferred one sad looking degenerating embryo and it resulted in my daughter. My crazy mishmash of results would have me believe that transfering one or two ultimately made no difference on end result and especially that the not so beautiful embryos are capable of producing the beautiful babies.
  • amp77, annatarz79 and Murried like this

IVF#1:17 Eggs, 4-5 Day Blasts: Transferred 2: th_abfn.gif

 FET#1: Transferred 2: th_abfp.gif m/c@9weeks th_agrr.gif 

IVF#2: 5 Eggs, 5-5 Day Blasts: Transferred 2: th_abfp.gif Boy/Girl Twins born DEC 2013 babygirl.gif babyboy.gif 

 

FET#2:Transferred 1: th_abfp.gif Baby Girl born July 2016 babygirl.gif  

 

2 Frosties Remaining.


#6 kristeen033

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Posted 11 January 2017 - 10:12 AM

I had two transferred and have twins. I did a natural transfer which to date was the only thing that worked for me. No meds. I was 36 at time of transfer. I have 5 frosties left but from now on will only transfer one at a time because I don't want another set of twins.


Me: 37, Tubal Ligation 2002, Tubal Reversal 2008
DH: 34, Normal
DS 16yrs & DD 14yrs from previous marriage
Trying for 7 years
November 2009 - BFP - Chemical Pregnancy
September 2011 - Clomid 3 rounds all BFN
March 2012 - Start IVF #1 at RFP in Calgary
April 2012 - 16 eggs retrieved, 14 fertilized, 8 5 day blasts
Transfered 1 hatching blast - BFP!!!!! 7 blasts frozen.
May 2012 - 7 week U/S - baby measured good and had heartbeat
June 2012 - Stopped Prometrium 10 weeks, started bleeding 3 days later, U/S showed baby died right after 7 week U/S
August 25, 2012 - Start Suprefact for FET #1
September 8, 2012 - Start Estrace
September 21, 2012 - U/S Booked!
September 26, 2012 - FET Transferred one perfect blast. F/X
October 6, 2012 - 10dp5dt BFFN
October 9, 2012 - POAS test at Doctor's Office BFN
November 27, 2012 - Start Suprefact for FET #2
December 29, 2012 - U/S Booked
January 3, 2013 - Transferred One Hatching Blast!!! Still have 3 more in the freezer
January 10, 2013 - 7dp5dt - HPT - BFP!!!!!!
January 15, 2013 - Beta 96
January 17, 2013 - Beta 16 = Chemical Pregnancy
January 19, 2013 - FRER HPT - BFFN
June 6, 2013 - FET #3 - Starting Suprefact...hoping third time is the charm!
July 3, 2013 - U/S Booked
July 9, 2013 - FET date!!!
July 20, 2013 - 11dp5dt HPT = BFN sad.png
July 2014 - Fresh IVF Cycle Estrogen Priming Protocol

August 2, 2014 - 24 eggs retrieved!

August 3, 2014 - 11 Eggs fertilized

August 7, 2014 - Transferred 1 beautiful blast. 3 more frozen.

August 8, 2014 - Got call from clinic 6 more blasts frozen!!!  9 snow babies total and one in the oven smile.png

August 20, 2014 - First beta BFN

February 1, 2015 - FET Natural Cycle - Transferred 2 blasts one hatched. FXFX!!!

February 6, 2015 - POAS even though I know it's early...and surprise...BFP!!!!

February 10, 2015 - 9dp5dt - BFP on Clearblue Digital!!!!! th_abfp.gifyahoo.gif

February 19, 2015 - Beta 8928!!!! EDD Oct 23/15

March 7, 2015 - Ultrasound shows TWINS!!!! 2 little beans measuring 8 weeks with two little flutters for heartbeats preggo.gif

March  31, 2015 - 11 Weeks U/S. Baby A measures 11w3d Baby B measures 11w5d!!!!

May 2015 - 5 month ultrasound. Both babies look fantastic!!!! TEAM GREEN!!!giggle.gif

October 5, 2015 - C-Section date booked to meet my little babes!!! Can't wait the countdown is on!!!!!

September 19, 2015 - Babies decided to make an early appearance at 35 weeks 4 days!!!

Connor Melvin - Born 5:11am weighing 4lb15oz

Emily May - Born 5:13am weighing 5lb8oz

We are so in love! babygirl.gifbabyboy.gif

 

 

 


#7 sami99

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Posted 11 January 2017 - 11:00 AM

I had 2 good quality blasts transferred when I was 44 (donor) which resulted in 1 gorgeous baby! :)


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1993 - started ttc, Aug 97-1st IVF BFN, Nov 97 FET BFN,  Aug 98 - 2nd IVF BFN, Nov 98 FET BFN, 1999-2000 - several IUI's - all BFN's, 2002 - 3rd IVF BFN, FET BFN, 2004 - 4th IVF - cancelled for poor response, 5th IVF with known donor (poor response)  BFN

June 2006 - ***** BFP (naturally)******  2007 *****DS was born

2008 - TTC again, 2010- started peri-menopause, 2013 - full menopause , 2014 -exploring donor egg

Nov 2014 - transfer 2 5 day embryos  Dec 2014 - BFP


#8 quandry

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Posted 11 January 2017 - 12:04 PM

I had two top quality hatching morulas transferred (DE cycle) and had a singleton pregnancy. In my regular ivf fresh cycle we transferred two three day embryos of ok quality and had a miscarriage at seven weeks. I have had five losses to date with my OE though. And two living non ivf children from when I was in my twenties (42 now).

See about me page.

 

 


#9 Zoe13

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Posted 11 January 2017 - 09:28 PM

That sounds like an interesting study because it would run counter to the general belief that transferring two increases the chance of pregnancy (but also multiples).  It might be a good question to pose in the "Ask the RE" section.  I wonder if Dr. Hartman has seen this study and if he thinks there's merit in it.  For me personally, we transferred two in a fresh cycle and ended up with one sticking, then in a FET transferred one and it didn't stick.  I wish you all the best with your little embabies and whatever you decide.


IUI#1 - April 2011 - Clomid, Ovidrel, and Endometrin - BFN
IUI#2 - July 2011 - Letrozol, Ovidrel and Endometrin - BFN
IUI#3 - October 2011 - Gonal F (75iu), Ovidrel and Endometrin - BFN

 

IVF - July 2012 - Gonal F, Luveris, Cetrotide, Ovidrel, Prometrium and Estrace
13 eggs retrieved, 10 fertilized, 2 day 5 blasts transferred, 4 frozen BFP!
Feb. 2013 - Daughter born via emergency c-section at 30 weeks due to PPROM.  She's a healthy little one now!

 

FET #1 - Aug. 2016.  Short Protocol.  Transferred one perfect 6AA fully hatched blastocyst - BFN!
FET #2 - Oct. 2016?   Sometime in 2017.... long protocol.


#10 TryingForOur2ndChild

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Posted 12 January 2017 - 03:00 PM

In my previous IVF cycle we only had day-3 embryos which my RE suggested two at a time for my fet's, but if they were day-5 embryos it would have only been one at a time. First fet was a BFN and second resulted in my daughter.


See full journey details on my profile:

 

About Us:

​Trying to conceive since 2013 (male factor); Me: 39 yrs old; DH: 37 yrs old; low testosterone; very low sperm count; on Clomid for testosterone

 

~ 2014 ~ IVF Cycle #1:

 

Cycle Info:

- Antagonist protocol

- Retrieval: 22 eggs retrieved; 8 injected (ICSI); 6 fertilized; 4 embryos divided - 2 embryos are 4 cell grade 1, 1 embryo is 5 cell grade 2, and 1 embryo is 8 cell grade 2

 

FET #1 - medicated cycle (2014)

- transferred two day-3s: one 10 cell grade 1 and one 12 cell grade 2; Beta: BFN; approved to do a natural FET next time

 

FET #2 - Non-medicated cycle (2014)

- added Teva-Doxycycline 100mg (antibiotic) started one day before procedure: 1 tab 2xdaily until finished) 

- transferred two day-3 embies (1 is 10 cell grade 2 and 1 is 12 cell grade 2); took 1 tab of Apo-Diazepam (valium) 5mg 45mins before FET        

​- HPT = th_abfp.gifbanana.gifbanana.gifth_abfp.gif  Welcomed our little babygirl.gif in summer of 2015

 

~ 2016/17IVF Cycle #2: Project Sibling

 

Cycle Info:

Oct. 29: Retrieval - 23 eggs retrieved; will be a freeze all cycle

Nov. 2: Dostinex 0.5mg every other day for a total of 8 days has started to alleviate OHSS 

Nov. 4: Day 6 report: 5 embryos on ice... yay! 4 day-5s (4AA and 3 are 4BC quality) and 1 day-6 (5BC quality)

 

FET #1 - Non-medicated cycle (2017)

Feb. 6: start Teva-Doxycycline antibiotic100mg one day before procedure
Feb. 7: scheduled transfer at 11:45am; 1 tab of Apo-Diazepam (valium) 5mg taken 45mins before transfer; transfer of one 4AA blast

Feb.20: BETA - BFN; approved to go right into another natural FET with no cycle in between

 

FET #2 - Non-medicated cycle (2017)

Feb.24: CD3 - u/s and b/w= nothing said about lining; E2 19, LH 4.4 IU/L, FSH 6.6 IU/L, Prolactin 8.1 Ng/mL, TSH 2.22 IU/L, Progesterone 1.6 nmol/L, Glucose 4.1 - I requested (norm is 3.6-7.7); back on CD15; acupuncture 2x weekly until fet to try and bring on LH surge sooner than CD17.

Mar.6: OPK positive in the evening so looks like I will be going into the clinic tomorrow

Mar.7: CD14 - u/s and b/w= 11mm triple lining; E2 712, LH 32 IU/L

Mar.8: CD15 - b/w= confirmed LH surge was yesterday; E2 343, LH 8.12 IU/L; start Endometrin 3x/daily

Mar.11: start Doxycycline antibiotic 100mg (8 pills total) one day before procedure: 1 tab 2xdaily until finished

Mar.12: scheduled transfer at 10am of one 4BA blast; 1 tab of Apo-Diazepam (valium) 5mg taken 45mins before transfer

Mar.23: HPT = th_abfp.gifbanana.gifbanana.gifth_abfp.gif

​Mar.25: Beta #1= 788 hcg, Progesterone 107 nmol/L; RE happy with results so skipping beta #2 and going right to u/s

​Apr.4: had light bleeding last night so went to clinic where they did an u/s; too early to really see much but did see a gestational sac; u/s moved from Apr.8th to 15th

Apr.18: First u/s scheduled (at 8 wks).... omg there are twins!!! One had a heartbeat of 140 and the other only 80 so being referred to the head OB of internal fetal medicine as it looks like I may have a vanishing twin which RE said 50% of twins go down to one before the 2nd trimester.

 

 

 

 

 


#11 mia11

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Posted 22 April 2017 - 11:34 PM

We just transferred 2 babyboy.gif babygirl.gif  in a FET cycle. I am 42 and will be 43 in August. We just found out we are pregnant and they think both implanted. We are hoping so. We won't find out until our ultrasound. We did a fresh transfer last year of 4 and none of them stuck. We decided to go with two to improve our chances. So stressful at the time as it was our last two and I don't think my body could take another cycle. 


FET #1 (Transfer- 6 day blast):      April 12, 2017- babyboy.gif babygirl.gif  (Transfer of a very active boy and girl)

HPT:                                               April 16, 2017   th_abfp.gif         4dpt

First Beta:                                       April 24, 2017   th_abfp.gif         845 Beta - 12dpt

2nd Beta:                                        April 26, 2017                        1,810 Beta - 14dpt

1st Ultrasound:                               May 10, 2017               One healthy baby on ultrasound. Heartbeat excellent

2nd Ultrasound Scheduled:            May 20, 2017

 

Me: 43

DH: 30


#12 scotTsgirl14

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Posted 09 May 2017 - 10:59 AM

I'm 39, DH is 47. We just did a transfer with 3 frozen embryos on May 2. Going this Friday for first Beta. This was our first IVF attempt.


Fertility treatment started in January 2016 - 3 IUI's all unsuccessful. Began IVF treatment in January 2017. 20 eggs at retrieval - 16 embryos - but only 3 made it to day 7. Freeze all due to E2 being over 5000. Due to age and quality of embryos (1 great, 1 moderate and 1 not that good), embryologist suggested transferring all 3. Transfer was done on May 2, 2017. First beta on 5/11/17.