i am not intending to offend any one. i just want to discuss studies pertaining to PGS i have a balanced translocation very low chance of an unbalanced child. I am not happy with the pushy doctors so i want to get the info my self. is it worth the cost for the fancy lotto ticket?
Preimplantation genetic diagnosis (PGD) using fluorescence in situ hybridisation probes was carried out for 59 couples carrying reciprocal translocations. Before treatment, 85% of pregnancies had resulted in spontaneous miscarriage and five couples had achieved a healthy live-birth delivery. Following treatment, 33% of pregnancies failed and 21of 59 couples had a healthy live-born child. The accuracy of diagnosis was 92% (8% false abnormal and 0% false normal results). The overall incidence of 2:2 alternate segregation products was 44%; however, products consistent with 2:2 adjacent segregation were ~twice as likely from male heterozygotes, and those with 3:1 disjunction were three times more likely from female heterozygotes. Our results indicate that up to three stimulation cycles per couple would give an ~50% chance of a successful live birth, with the risk of miscarriage reduced to the level found in the general population. In our study, 87% of all normal/balanced embryos available were identified as being suitable for transfer. We conclude that PGD provides benefit for couples with high-risk translocations by reducing the risk of miscarriage and avoiding a pregnancy with an unbalanced form of the translocation; however, for fertile carriers of translocations with a low risk of conceiving a chromosomally unbalanced offspring, natural conception may be a more viable option.
so PGD reduces miscarriages and doesn't improve live birthrates?
anyone else got any studies supporting, disagreeing?
PGD and PGS are very different, and from reading your post I'm not certain if you are clear on the difference as you used both terms in different spots. Though perhaps it was a typo....
PGS can check if there are the correct number and size of chromosomes. So it determines significant chromosomal abnormalities, that would almost always lead to early pregnancy loss. PGS is the same test for everyone. It looks at the big picture of the chromosomes.
PGD is a personalized test for each couple. It screens for a particular genetic mutation that either one, or both parents are carriers for. These mutations could be for anything from a balanced translocation to specific genetic disorder such as cystic fibrosis, huntingtons disease or muscular dystrophy. The outcome of what would have happened had those embryos been transferred depends entirely on the particular genetic abnormality in that situation.
The science behind both tests is phenomenal. That is to say, if PGD says that an embryo does not carry a genetic mutation, then it doesn't carry that mutation. That doesn't guarantee a healthy baby, as nothing else is tested for except for the particular mutation.
Have you spoken to a genetic councellor about your particular translocation? My understanding with balanced translocations is that 50% of gametes would be unbalanced, but I'm pretty rusty on my genetics. I do know someone on the site who had a balanced translocation and did PGD and every single embryo came back unbalanced. She was devastated, but relieved to not have to experience each of those as a pregnancy loss as she had already previously had 8 losses.
At the end of the day, even the article that you cite confirms what so many people decide on their own; if you're fertile, you can always keep trying on your own. Pregnancy losses are hard both physically and emotionally. But IVF is hard physically, emotionally and financially! And at the end of the day neither decision is final. You can choose either method and then choose to change your mind.
I'm sorry you're in this boat. IF is brutal.
I hope that you get the information that you need to make decisions that you feel confident with.
I am 37, DH - 38
Genetic - IVF&PGD to prevent Genetic Disorder
IVF #1 - Nov/08 - MC @ 6 weeks, no embryos frozen
IVF #2 - Aug/09 - bfn
IUI #1 - Feb/10 - ectopic
PRIDE - Apr/10
Homestudy - July/10
Given the gift of donor embryos - Jan/12
Donor FET Jun/12 - 9 weeks - no heartbeat... MC
Donor FET Oct/12 - we're PG
===> Beautiful baby boy born 2013
Donor FET Oct/16 - chemical