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Which size of gonal F has the most 'excess' drug?


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#1 Watermelon

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Posted 19 November 2016 - 10:30 PM

I'll be starting ivf # 2 soon and this time the RE has me on gonal F. This is the first time I'll be using the pens. I've heard rumour that they often have some overflow in them so if I'm smart I might be able to save myself a few hundred bucks. Which size pens have the most overflow relative to their volume?
Thanks guys!

Me -29 31- unexplained poor egg quality. I was told I had endometriomas.....but repeat ultrasounds at other clinics have said no sign of endometriomas. Maybe PCOS-like ovaries, but no PCOS - AMH, AFC are great. No one can explain why my eggs are so poor sad.png

DH 30 - severe teratospermia, count and motility are excellent.

May 2014 - 2.5mg femara - BFN (ovulated night before)

June 2014 - IUI with 5mg femara - BFN (ovulated night before)

August 2014 - IVF with ICSI - Antagonist protocol, 150Bravelle, 75 menopur, stimmed 8 days

- 19 follicles (all 15-22mm at trigger), 12 eggs retrieved, 7 mature,, 5 fertilized with ICSIsad.png

- only 7 mature eggs with an estrogen of 20000?! wtf?! Sigh...Freeze All

-only one BB Blast made it. Freeze "all" became "freeze one". All others arrested between day 3 and 4 sad.png

January 2015 - FET of lone embryo - c'mon little figher

- BFP!!! Beta 1 475 at 10dp5dt , Beta 2 - 1495 at 12dp5dt

Baby boy born Sept 28/15


#2 hs4816

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Posted 19 November 2016 - 11:21 PM

I got approximately 100 units out of each 300 unit pen. Ended up with 2 "free" doses.

I'm 39 with endo

 

IVF #1: March 2016: Long protocol: Suprefact (200)/Menopur (225)

    9 follicles => 4 eggs => 3 mature => 3 fertilized (ICSI) => 2 blasts (one transferred, one frozen)

    BFN

 

IVF #2: June 2016: Microdose flare: Suprefact (40 BID)/Menopur (150)/ Gonal (300)

     7-10 follicles (?) => 12 mature eggs => only 4 fertilized w/ICSI => transferred 2 @ 3days and 1 blast frozen

     BFP:  day 14 beta = 93, day 18 beta 557 (37h doubling time)

     Ultrasound July 21 = single, live intrauterine pregnancy

     .... so hopeful it sticks!

 

 

 


#3 returnable

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Posted 20 November 2016 - 10:26 AM

I had the 450 and 900 pens and all consistently had 75 overfill.

Two IVFs and no chromosomally normal blasts to transfer...we are done with my eggs.


#4 lumnay

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Posted 20 November 2016 - 12:16 PM

Watermelon, I found this link for you:

 

http://thencomesfami.../gonal-overfill


Who stole ambushed my stork?  So many failed cycles with nothing to show but bills, receipts, and empty bottles of medications/herbs/supplements. See my profile for details...

 

UPDATE: I'm counting the days and hours waiting for this miracle to unfold. Christina Perri's A Thousand Years pretty much sums up my experience.


#5 Hopingfor1

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Posted 20 November 2016 - 01:13 PM

If you will be using the pens, go for the 300 unit pens since you'll get the most overfill.  Even though I was on high doses, when I used the pens, I always asked for the 300 unit pens because of the overfill.  Additionally, you can use a syringe to pull even more overfill out of the pen than you would get otherwise - this can also help you avoid multiple jabs if you want.  You can draw the overfill out of multiple pens with a syringe and use that instead of jabbing  yourself multiple times to get your full dose.

 

If you want even further savings, Gonal F actually comes in a multidose formula as well.  You mix it - if you've ever used something like Menopur, it is the exact some process.  Fertility clinics don't seem to let patients know about this and pretty much everyone uses the pens as it is considered convenient.  I mixed my Menopur and had no problems with mixing my Gonal F for extra savings.

 

I did research on it and found out about the Gonal F multidose myself.  My clinic didn't carry it, but had no problem giving me a prescription and a local pharmacy that dealt in fertility drugs had it and ordered me more as I needed it.  By the time I got to my second cycle I requested the multidose and it saved me a lot - especially since I was on high doses.

 

There is a 450 iu multidose Gonal F and it is overfilled to 600 iu.  (The manufacturer figures you might lose more with the multidose than the pen.)  I never lost any and would get exactly 2, 300 iu doses out of the 450 multidose.  Where I went the 450 multidose  cost the same as the pen.

 

If you do want to do this, you have to specifically ask the office to write Gonal F 450 iu MULTIDOSE on the prescription.  Glen Shields in the Toronto area had it, but if you are in a different area, you'd need to check that someone in your area stocks it or will order it for you.  There is a larger mutlidose, but it also has 150 overfill, so you are better off going with the 450 multidose.

 

Regarding the pens, things may have changed but when I was cycling, the 300 iu and 450 iu pens were overfilled by 50 iu and the 900 iu pen  was overfilled by 75 iu, so if you go for the pens, the 300 is the best for overfill - using a syringe I was able to pull out a little bit more than what the overfill was 'officially' said to be.

 

If you decide to try the multidose, the process is the same if you have ever mixed anything else such as Menopur.  If not, this video will give you an idea of what is involved - not quite as convenient as the pen, but definitely worth it for me due to the overfill savings (you'll see on the bottle in the video it says 600 IU as that is what it is overfilled to even though it is the 450 multidose):

 


  • lumnay likes this

Me: 40  = High FSH (ranges from 8 - 15), Low AMH (2.7), Low AFC = DOR

DH: 43 = borderline sperm analysis

Started TTC#1 January 2010

 

2011 - 2012 - First fertility clinic, lots of testing, operative hysteroscopy to remove polyps, multiple unsuccessful IUIs, 1 IVF (150 Menopur/150 Gonal F) converted to IUI due to poor response

 

2012 - got second opinion and after AMH results came back, advised at 36 I had a less than 5% chance of conceiving via IVF.  Donor eggs strongly recommended but not yet ready for that (I should say - hubby not ready for that.  I was ready for donor eggs - I just wanted to be a Mom).  Decided clinic wasn't for us and back to clinic #1

 

2013 - IVF #1 (after 1st converted to IUI).  Estrogen Priming protocol - start Climara patch 7 days post ovulation and change every other day.  3 orgalutran injections beginning day after first Climara patch applied.  Start stims day 2 triggered on night 15 of stims = 3 eggs retrieved, 0 fertilized via ICSI = no transfer  (300 Gonal F/150 Menopur & Orgalutran)

 

2013 - Switch clinics

 

Office hysteroscopy = all clear

 

IVF #2 (37 years old) June 2013 - Estrace priming protocol.  4 mg estrace started 7 days post ovulation.  Start stims Day 3 (300 Gonal F/150 Menopur & Orgalutran)

Slow response as usual

Triggered on night 12 of stims (given the option to cancel as it looked like we'd get 3 eggs - knew we wouldn't do any better so continued).

ER:  6 eggs, but advised some were small and would be immature

Fert report:  5 of 6 eggs immature.  2 fertilized via ICSI (including one of the immature eggs)

ET:  Transferred our only 2 embryos - a 5 cell and an 8 cell

11dp3dt = BFP - HCG = 65

16dp3dt = HCG 1,305 (cautiously pregnant)

7 week ultrasound = 1 baby HB = 141

12 weeks ultrasound NT scan = NT = 1.7mm all looks good.  Combined with blood work risk is 1/1,400

Got Harmony blood test results back (done for peace of mind) - all clear and we're having a GIRL!

EDD = March 2014 (cautiously looking forward to that date)

However - baby had plans to arrive early. After PPROM and managing to cook the little one a bit longer, our bundle of joy arrived at 33 weeks.  After a 3 week NICU stay, she is finally home.  We are totally in love and forever thankful for our little miracle baby - Ashley Nicole.

 

 


#6 begin.again

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Posted 20 November 2016 - 03:39 PM

Great info!  I wish I knew this overfill when I was using my 450 Gonal F pens!  Ugh.....



#7 returnable

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Posted 22 November 2016 - 10:36 AM

If you will be using the pens, go for the 300 unit pens since you'll get the most overfill.  Even though I was on high doses, when I used the pens, I always asked for the 300 unit pens because of the overfill.  Additionally, you can use a syringe to pull even more overfill out of the pen than you would get otherwise - this can also help you avoid multiple jabs if you want.  You can draw the overfill out of multiple pens with a syringe and use that instead of jabbing  yourself multiple times to get your full dose.

 

If you want even further savings, Gonal F actually comes in a multidose formula as well.  You mix it - if you've ever used something like Menopur, it is the exact some process.  Fertility clinics don't seem to let patients know about this and pretty much everyone uses the pens as it is considered convenient.  I mixed my Menopur and had no problems with mixing my Gonal F for extra savings.

 

I did research on it and found out about the Gonal F multidose myself.  My clinic didn't carry it, but had no problem giving me a prescription and a local pharmacy that dealt in fertility drugs had it and ordered me more as I needed it.  By the time I got to my second cycle I requested the multidose and it saved me a lot - especially since I was on high doses.

 

There is a 450 iu multidose Gonal F and it is overfilled to 600 iu.  (The manufacturer figures you might lose more with the multidose than the pen.)  I never lost any and would get exactly 2, 300 iu doses out of the 450 multidose.  Where I went the 450 multidose  cost the same as the pen.

 

If you do want to do this, you have to specifically ask the office to write Gonal F 450 iu MULTIDOSE on the prescription.  Glen Shields in the Toronto area had it, but if you are in a different area, you'd need to check that someone in your area stocks it or will order it for you.  There is a larger mutlidose, but it also has 150 overfill, so you are better off going with the 450 multidose.

 

Regarding the pens, things may have changed but when I was cycling, the 300 iu and 450 iu pens were overfilled by 50 iu and the 900 iu pen  was overfilled by 75 iu, so if you go for the pens, the 300 is the best for overfill - using a syringe I was able to pull out a little bit more than what the overfill was 'officially' said to be.

 

If you decide to try the multidose, the process is the same if you have ever mixed anything else such as Menopur.  If not, this video will give you an idea of what is involved - not quite as convenient as the pen, but definitely worth it for me due to the overfill savings (you'll see on the bottle in the video it says 600 IU as that is what it is overfilled to even though it is the 450 multidose):

 

 

 

Hopingfor1 thanks for clarifying in such detail. When others spoke of the 450 multidose, I thought it was the multidose pens and not a vial. The pens only had 75IU overfill. How much was the 450 multidose vial at Glen Shields, and how long did it take for them to order it in? 


Two IVFs and no chromosomally normal blasts to transfer...we are done with my eggs.


#8 Hopingfor1

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Posted 22 November 2016 - 11:04 AM

If you will be using the pens, go for the 300 unit pens since you'll get the most overfill.  Even though I was on high doses, when I used the pens, I always asked for the 300 unit pens because of the overfill.  Additionally, you can use a syringe to pull even more overfill out of the pen than you would get otherwise - this can also help you avoid multiple jabs if you want.  You can draw the overfill out of multiple pens with a syringe and use that instead of jabbing  yourself multiple times to get your full dose.
 
If you want even further savings, Gonal F actually comes in a multidose formula as well.  You mix it - if you've ever used something like Menopur, it is the exact some process.  Fertility clinics don't seem to let patients know about this and pretty much everyone uses the pens as it is considered convenient.  I mixed my Menopur and had no problems with mixing my Gonal F for extra savings.
 
I did research on it and found out about the Gonal F multidose myself.  My clinic didn't carry it, but had no problem giving me a prescription and a local pharmacy that dealt in fertility drugs had it and ordered me more as I needed it.  By the time I got to my second cycle I requested the multidose and it saved me a lot - especially since I was on high doses.
 
There is a 450 iu multidose Gonal F and it is overfilled to 600 iu.  (The manufacturer figures you might lose more with the multidose than the pen.)  I never lost any and would get exactly 2, 300 iu doses out of the 450 multidose.  Where I went the 450 multidose  cost the same as the pen.
 

If you do want to do this, you have to specifically ask the office to write Gonal F 450 iu MULTIDOSE on the prescription.  Glen Shields in the Toronto area had it, but if you are in a different area, you'd need to check that someone in your area stocks it or will order it for you.  There is a larger mutlidose, but it also has 150 overfill, so you are better off going with the 450 multidose.

 

Regarding the pens, things may have changed but when I was cycling, the 300 iu and 450 iu pens were overfilled by 50 iu and the 900 iu pen  was overfilled by 75 iu, so if you go for the pens, the 300 is the best for overfill - using a syringe I was able to pull out a little bit more than what the overfill was 'officially' said to be.

 

If you decide to try the multidose, the process is the same if you have ever mixed anything else such as Menopur.  If not, this video will give you an idea of what is involved - not quite as convenient as the pen, but definitely worth it for me due to the overfill savings (you'll see on the bottle in the video it says 600 IU as that is what it is overfilled to even though it is the 450 multidose):

 

 

 
Hopingfor1 thanks for clarifying in such detail. When others spoke of the 450 multidose, I thought it was the multidose pens and not a vial. The pens only had 75IU overfill. How much was the 450 multidose vial at Glen Shields, and how long did it take for them to order it in? 

Hi returnable,

I'm really happy to help anyone save some money.

When I was cycling the 450 pen or multidose was $458.22. This was in 2013.

When I cycled I called in advance to check. They usually had one or two of the multidose in stock but didn't keep much because it isn't often used. They could get more in a day or 2.

I don't know why clinics give patients the Menopur multidose but only use the Gonal F pens. I'm positive many more patients would use the Gonal F multidose if they knew how much they could save.
  • returnable likes this

Me: 40  = High FSH (ranges from 8 - 15), Low AMH (2.7), Low AFC = DOR

DH: 43 = borderline sperm analysis

Started TTC#1 January 2010

 

2011 - 2012 - First fertility clinic, lots of testing, operative hysteroscopy to remove polyps, multiple unsuccessful IUIs, 1 IVF (150 Menopur/150 Gonal F) converted to IUI due to poor response

 

2012 - got second opinion and after AMH results came back, advised at 36 I had a less than 5% chance of conceiving via IVF.  Donor eggs strongly recommended but not yet ready for that (I should say - hubby not ready for that.  I was ready for donor eggs - I just wanted to be a Mom).  Decided clinic wasn't for us and back to clinic #1

 

2013 - IVF #1 (after 1st converted to IUI).  Estrogen Priming protocol - start Climara patch 7 days post ovulation and change every other day.  3 orgalutran injections beginning day after first Climara patch applied.  Start stims day 2 triggered on night 15 of stims = 3 eggs retrieved, 0 fertilized via ICSI = no transfer  (300 Gonal F/150 Menopur & Orgalutran)

 

2013 - Switch clinics

 

Office hysteroscopy = all clear

 

IVF #2 (37 years old) June 2013 - Estrace priming protocol.  4 mg estrace started 7 days post ovulation.  Start stims Day 3 (300 Gonal F/150 Menopur & Orgalutran)

Slow response as usual

Triggered on night 12 of stims (given the option to cancel as it looked like we'd get 3 eggs - knew we wouldn't do any better so continued).

ER:  6 eggs, but advised some were small and would be immature

Fert report:  5 of 6 eggs immature.  2 fertilized via ICSI (including one of the immature eggs)

ET:  Transferred our only 2 embryos - a 5 cell and an 8 cell

11dp3dt = BFP - HCG = 65

16dp3dt = HCG 1,305 (cautiously pregnant)

7 week ultrasound = 1 baby HB = 141

12 weeks ultrasound NT scan = NT = 1.7mm all looks good.  Combined with blood work risk is 1/1,400

Got Harmony blood test results back (done for peace of mind) - all clear and we're having a GIRL!

EDD = March 2014 (cautiously looking forward to that date)

However - baby had plans to arrive early. After PPROM and managing to cook the little one a bit longer, our bundle of joy arrived at 33 weeks.  After a 3 week NICU stay, she is finally home.  We are totally in love and forever thankful for our little miracle baby - Ashley Nicole.

 

 


#9 returnable

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Posted 22 November 2016 - 11:12 AM

Hopingfor1 I think their cost is the same even now, because that is what I paid for the 450IU multidose pen this October. Did they give you needles for mixing and to inject? When I compare with the 150IU overfill, that's almost as good as purchasing the meds online, and I definitely was very happy with Glen Shields during my first round of IVF. And just to make absolutely sure there was always 600IU of medication?


Two IVFs and no chromosomally normal blasts to transfer...we are done with my eggs.


#10 Hopingfor1

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Posted 22 November 2016 - 11:58 AM

Hopingfor1 I think their cost is the same even now, because that is what I paid for the 450IU multidose pen this October. Did they give you needles for mixing and to inject? When I compare with the 150IU overfill, that's almost as good as purchasing the meds online, and I definitely was very happy with Glen Shields during my first round of IVF. And just to make absolutely sure there was always 600IU of medication?

 That is great that their prices haven't gone up in 3 years!

 

I definitely got the needles and everything included.  I can't remember if it was in the multidose box or a separate package that they gave me, but I remember I had a lot of extra needles since I was on high doses so only needed to use 2 needles with each package - most people would use more.

 

Unless things have changed in 3 years, it was always always 600IU.  The box even indicates that is what is in there.  Keep in mind they provide 600IU to deliver 450IU as they think people may have accidents and lose some.  They figure this with both the pen and multidose but give more overfill with the multidose since they figure there is more room for error. I was always extremely careful and never lost a drop.  I went through a lot of these and always got exactly 2, 300IU doses every single time.

 

As well, I agree Glen Shields is great.  Just be sure that your prescription says Multidose vial and point it out to them.  They don't get this request very often.  They were great though.  One night my husband went to pick up my prescription.  He didn't have a clue about the meds and they gave him the pen in error.  I felt bad, but called them about it and they had me come in and exchange it for the multidose as it was their error.  I felt bad as I knew they couldn't resell what I had returned but they let me exchange it no complaints. It wasn't the regular person that filled the order when my husband went and if I'd gone I would have made sure I got the multidose.  The regular ladies there also knew I always got the multidose.

 

According to this site below, it is still 600 IU, but please double check:

 

https://fertilitylif...nal-f-multidose

 

The Gonal‑f® Multi-Dose 450 IU (33 mcg) vial is filled with 600 IU of drug in order to deliver 450 IU in several smaller daily doses. This provides between 2 and 6 commonly prescribed daily doses.

The Gonal‑f® Multi-Dose 1050 IU (77 mcg) vial is filled with 1200 IU of drug in order to deliver 1050 IU in several smaller daily doses. This provides between 3 and 14 commonly prescribed daily doses.


  • returnable likes this

Me: 40  = High FSH (ranges from 8 - 15), Low AMH (2.7), Low AFC = DOR

DH: 43 = borderline sperm analysis

Started TTC#1 January 2010

 

2011 - 2012 - First fertility clinic, lots of testing, operative hysteroscopy to remove polyps, multiple unsuccessful IUIs, 1 IVF (150 Menopur/150 Gonal F) converted to IUI due to poor response

 

2012 - got second opinion and after AMH results came back, advised at 36 I had a less than 5% chance of conceiving via IVF.  Donor eggs strongly recommended but not yet ready for that (I should say - hubby not ready for that.  I was ready for donor eggs - I just wanted to be a Mom).  Decided clinic wasn't for us and back to clinic #1

 

2013 - IVF #1 (after 1st converted to IUI).  Estrogen Priming protocol - start Climara patch 7 days post ovulation and change every other day.  3 orgalutran injections beginning day after first Climara patch applied.  Start stims day 2 triggered on night 15 of stims = 3 eggs retrieved, 0 fertilized via ICSI = no transfer  (300 Gonal F/150 Menopur & Orgalutran)

 

2013 - Switch clinics

 

Office hysteroscopy = all clear

 

IVF #2 (37 years old) June 2013 - Estrace priming protocol.  4 mg estrace started 7 days post ovulation.  Start stims Day 3 (300 Gonal F/150 Menopur & Orgalutran)

Slow response as usual

Triggered on night 12 of stims (given the option to cancel as it looked like we'd get 3 eggs - knew we wouldn't do any better so continued).

ER:  6 eggs, but advised some were small and would be immature

Fert report:  5 of 6 eggs immature.  2 fertilized via ICSI (including one of the immature eggs)

ET:  Transferred our only 2 embryos - a 5 cell and an 8 cell

11dp3dt = BFP - HCG = 65

16dp3dt = HCG 1,305 (cautiously pregnant)

7 week ultrasound = 1 baby HB = 141

12 weeks ultrasound NT scan = NT = 1.7mm all looks good.  Combined with blood work risk is 1/1,400

Got Harmony blood test results back (done for peace of mind) - all clear and we're having a GIRL!

EDD = March 2014 (cautiously looking forward to that date)

However - baby had plans to arrive early. After PPROM and managing to cook the little one a bit longer, our bundle of joy arrived at 33 weeks.  After a 3 week NICU stay, she is finally home.  We are totally in love and forever thankful for our little miracle baby - Ashley Nicole.

 

 


#11 returnable

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Posted 22 November 2016 - 01:02 PM

Thanks so much I will look into this.


  • Hopingfor1 likes this

Two IVFs and no chromosomally normal blasts to transfer...we are done with my eggs.