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Stem Cell IVF / Augment


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#1 Bretta63

Bretta63
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Posted 31 October 2016 - 02:49 PM

I am almost 45 years old and over the last three years have done four rounds of IVF in NYC: 2 at NYU and 2 at Cornell (among the best clinics in the US). I have retrieved 7-8 eggs each round, fertilized 3-5 and have had 1-3 embryos to transfer each time. I have never had an embryo implant. At NYU we did frozen transfers with genetic testing (PGD) and at Cornell we did 3 day fresh transfers with endometrial coculture. My husband is 47. Neither of us have any specific issues, just infertility consistent with our age; i.e. lower egg quality and reserve.

 

Augment - a stem cell IVF using your own mitochondrial DNA extracted from your ovarian lining is injected into your retrieved eggs to "revitalize" them.  The procedure is approved in Canada and a few other countries and is currently under FDA testing in the US. This is not the same as using a donor egg or donor DNA!  It also will not help with genetically abnormal eggs, but is supposed to assist women under 50 with low egg quality.  The initial results are promising, increasing success rates to 30%, but this is based on a small study.  As a last resort, I am thinking of trying this procedure at one of the Toronto clinics; I live in NYC.  I am wondering if anyone has done this procedure and what their experience was and any other thoughts on it?  Any success stories with similar patient profile? I am also wondering which clinics in Ontario people recommend? I am ok with a large clinic, I just like a responsive staff and doctor.  At Cornell, I particularly liked that I had a nurse who was assigned to me that I could call or email with questions or prescriptions.

 

These are the clinics that offer Augment:

First Steps - Dr. Dixon did the first successful Augment procedure in Canada and was profiled in Time Magazine and CBS news in the US. I have read good things about Dr. Dixon, but the forum seems to give mostly negative reviews to the clinic staff.

TRIO

Anova

CReATe

NewLife

 

Any feedback is most welcome!

Thank you.

 

 



#2 hopefulmommy2

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Posted 03 November 2016 - 02:26 PM

Hi Bretta,

 

I haven't done Augment or used the Toronto Clinics, but thought I'd mention that I believe that HRC Fertility (Huntington Reproductive Center) in California does Augment as well and they have amazing reviews and great SART scores.  Might be something to check out.

 

Good luck to you! 



#3 Bretta63

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Posted 07 November 2016 - 09:10 AM

Thank you so much Hopefulmommy2 for the reply and suggestion of HRC!

 

I spoke with my doctor at Cornell, and as expected, he was quite skeptical of stem cell therapy. Cornell, though highly effective, is also known for a conservative approach. We are going to try low dose IVF next with Clomid in the hopes that milder stimulation will yield less, though better quality eggs. 

 

I am still keeping Augment/stem cell therapy as an option if needed. OvaScience, the lab that does Augment, sent me the current pricing and it is $9900 in addition to the other costs of IVF, meds, hospital, etc. If unsuccessful the first round, one may be able to qualify for a second round at no additional cost. Definitely another major financial commitment, but worthwhile if it works! So still interested to hear about any personal experiences.  

 

Thank you again. Wishing you much luck!



#4 Bretta63

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Posted 02 January 2017 - 12:40 PM

I just wanted to give an update. After consultation I found out Augment has a strict cutoff age of 42, as they have had limited success with patients over 40. However, OvaPrime is in clinical trials or will be starting at some clinics currently offering Augment. I do not know the criteria to qualify. Regarding my initial inquiry about recommended clinics, a family friend who is an RE in the US, recommended Create and TCART.

 

Happy New Year and may everyone's dearest wishes come true in 2017!