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FET - Thin Lining. What did you do? Estrace vs Estradot? Advice Needed!


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#101 schlepp

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Posted 26 February 2017 - 08:03 PM

My lining has definitely thickened but I'm not sure if it is the vitamin E, black cohosh or l arginine. I started them all at the same time back in November. AF is much heavier and I've had some higher readings. Will find out this cycle if it results in a higher lining during FET.

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#102 emaKG

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Posted 26 February 2017 - 10:42 PM

Does your clinic let you take the black cohosh? I was told no herbs.

#103 schlepp

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Posted 27 February 2017 - 09:45 AM

Does your clinic let you take the black cohosh? I was told no herbs.

The two clinics I've been at were very encouraging of visiting a naturopath and when I told them the recommended supplements, they were fine with them. My acupuncturist also recommends Chinese herbal medicines but he doesn't have you take them if you're cycling or taking any medications. They're just for in-between cycling (FET or IVF).

 

I plan to stop the black cohosh if I get into a 2ww but continue on with vit E and l argininie until beta.


See my 'about me' page for treatment history.


#104 emaKG

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Posted 27 February 2017 - 09:12 PM

Thanks!

#105 Pom

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Posted 09 March 2017 - 10:10 AM

Thin lining gals, has anyone tried the combo of pentoxifillyne and tocopherol (vitamin e) to boost lining? One study used this to help boost blood flow and increase endometrial thickness. I was wondering anyone has tried it? I emailed my clinic to see if this is something they will consider for me. Still waiting to hear back. Thought I would see if anyone else has tried it?

 

Hello ladies, as an update. I spoke with my RE about the PTX (pentoxifylline) Vitamin E combo for thin lining and he said that at their clinic they had not seen any success with this so does not recommend it. He is ok with me taking Vitamin E (400IU 2 times a day) for the next two months in preparation for our cycle in May, but would not continue it after transfer. I am also starting acupuncture as of today, so hoping that can help get things going as well. 

Historically the thickest lining I have achieved in a mock cycle is 0.6mm, so really need all the help I can get.


Follow me on: ifpomgranate.wordpress.com 

Dx: POF due to Chemo & Radiation;1996: bone marrow transplant, chemo & radiation fried ovaries, never got to meet AF;

2009: married;

2011: start exploring DE IVF options;

2012: referred to 2nd clinic for second opinion -confirmed POF. DE only option. 3 Mock cycles could not get uterine lining thicker than 0.4mm. Clinic said I need to explore other options and sent me on my way.

2013: On hold - started HRT for premature menopause symptoms;

2016: Another round of mock cycles - thin lining issues persist. Thickest lining achieved: 0.6mm. On waiting list for government funded cycle with DE in Winter 2017

2017: Moved up on the waiting list. New cycle date May 2017!

DE IVF #1: Starting May 2017

 


#106 emaKG

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Posted 11 March 2017 - 09:41 PM

Thanks for updating. Why does he say to stop vitamin e after transfer?

#107 breezyboo

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Posted 12 March 2017 - 08:18 AM

Vitamin e (1,000mg) was part of vitamin regimen for lining....I did see an improvement
Me: 30Hypothyroid,Endo, MTHFR, elevated Cytokines,TNF 36.8 (13.2-30.6) IFN 27.5(5.8-20.5). 2006-Twin m/c @ 8wks w/ex BF followed by 22 BFN's ... 6 months on clomid & 4 IUI's.Married for 5yrs to the love of my life. We want to make that love childDH: 31 Azoospermia (NOA) FSH 28.3, LH & testosterone levels normal Normal genetics. NOA possibly due to injury when younger.IVF/ICSI Barbados 201312/3-ER! 18 eggs, 12 mature & 10 fertilized!12/8-ET! 2 beautiful beans snuggled into place! 7 snowflakes!12/13- BFP12/17- Beta 9dp5dt 255!12/19 Beta 11dp5dt 392, 13dp5dt 585???12/26 Beta 3,388!1/2 U/S TWINS!! HB's 122& 1211/20 U/S Lost Baby B @ 7-8 weeks. Baby A doing great!IT'S A BOY!!!4/29 @ 6 months our sweet boy became an angel ABSOLUTELY HEARTBROKENFET January 2015 CANCELLED thin lining WTF?FET September 2015 CANCELLED due to a cyst/delayed period...You gotta be kidding me?!FET October 2015 BFNICSI/PGS Banking @ MCRM Feb & May 2016Feb & May 2016= 3 girls & 4 boys
FET October 13 2016 1 PGS normal girl = BFP!!!!! :D

#108 Pom

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Posted 12 March 2017 - 08:26 PM

Thanks for updating. Why does he say to stop vitamin e after transfer?


I think it is because we don't know the effect extra vitamin E can have on the fetus. Vitamin E is one of thos vitamins that you can overdose on.

Follow me on: ifpomgranate.wordpress.com 

Dx: POF due to Chemo & Radiation;1996: bone marrow transplant, chemo & radiation fried ovaries, never got to meet AF;

2009: married;

2011: start exploring DE IVF options;

2012: referred to 2nd clinic for second opinion -confirmed POF. DE only option. 3 Mock cycles could not get uterine lining thicker than 0.4mm. Clinic said I need to explore other options and sent me on my way.

2013: On hold - started HRT for premature menopause symptoms;

2016: Another round of mock cycles - thin lining issues persist. Thickest lining achieved: 0.6mm. On waiting list for government funded cycle with DE in Winter 2017

2017: Moved up on the waiting list. New cycle date May 2017!

DE IVF #1: Starting May 2017

 


#109 emaKG

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Posted 14 March 2017 - 08:06 PM

Oh wow. When should I stop taking it?

#110 schlepp

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Posted 14 March 2017 - 08:33 PM

I think based on the earlier post, stop before you transfer. I'm going to stop all but my normal vitamins the day before transfer...if I get to a transfer.

I was at just over 7mm today. Best lining for me ever. I've done so many different things I can't even pinpoint what has made the change.
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#111 schlepp

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Posted 15 March 2017 - 03:05 PM

I've been reading through the threads about the matris ultrasound and I am still debating it. My RE thinks we should definitely do it but I am questioning if I would really cancel the transfer if the score is low. This is the highest lining I've had and I'm worried it is partly owed to last cycle's hsyterscopy. That will be tough to recreate if we get cancelled. 

 

Thoughts? 


See my 'about me' page for treatment history.


#112 4 years and counting

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Posted 16 March 2017 - 08:21 AM

schlepp - I did it for one of my cycle's and the score came back at 7.5 (anything higher then 7 is considered good). My lining got to 7 that cycle but because of the program I am on, we had to cancel cycle; not because of the results from matris but the lining.

 

What is your lining at? Where are you in the cycle? 

 

I am not really sure how accurate the results are for the matris. I have since transferred twice and the first one ended in chemical pregnancy and the most recent I believe will end in BFN (will confirm on Monday).

 

Not sure if that helps or not :)


Me 43, DH 43

 

Trying since 2012

 

Natural Pregnancy May 2012, ended blighted ovum

Natural Pregnancy June 2013, miscarriage 6 weeks (chemical pregnancy)

Natural Pregnancy January 2014, miscarriage 8 weeks

IVF Pregnancy December 2016, miscarriage 4 weeks (chemical pregnancy)
IVF Pregnancy May 2017, 1st beta May 23 hcg 3,290, 2nd beta May 25 th_abfp.gif

First clinic 2012-2014

Second clinic 2014-present

 

Dx: diminished ovarian reserve; thin lining

 

Unsuccessful protocols: estrace, estradot patches, gonal f, natural cycle

 

Lining gets to 8.0 mm

 

Using donor eggs

 

FET attempts 15, transferred 4 times (2 BFN, 2 BFP), cycles canceled 11.

IUI attempts 2 (2 BFN)

 

Successful protocol for lining: estradot patches, Viagra

Successful protocol for FET: medrol, lovenox, PIO

 


#113 schlepp

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Posted 16 March 2017 - 09:15 AM

@4 years - I was at just over 7mm on Tuesday after 17 days of estrace and patches. I go back tomorrow for another lining check and to see if Tuesday's neupogen wash did anything. I've spent a few thousand on supplements and acupuncture over the last 5 months and just don't see how it will ever get better than it is now. My RE thinks that possibly I just have thinner than average lining but there is no evidence yet that it means I can't get pregnant (our IF issues are with my partner's vasectomy). Even at 5mm in October it was tri-laminar so it could be healthy. 

 

I'm worried a bad score will make me stress. My partner and I talked about it last night and now I'm thinking of saying tomorrow that as long as I'm at 7mm I want to transfer.  We only have one embryo so this is why we're proceeding with caution but it isn't PGS tested so it still has less than a 50% chance of being viable. 

 

I think sometimes I forget that we are the patients/customers and can make these decisions ourselves. 


See my 'about me' page for treatment history.


#114 4 years and counting

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Posted 16 March 2017 - 09:27 AM

@schlepp - I have learned over the last couple of months that we need to take control of our treatment and decisions. As much as I like my RE, I am just a number and I need to be comfortable at the end of the day. Hopefully by the time you transfer, and the addition of the hcg shot and progesterone, the lining will thicken more. I did find keeping active and fertility yoga helped as well.

 

I like you, have spent money on supplements and acupuncture to try to increase my lining. What does neupogen do? My RE only tells me the measurement not the healthiness of my lining. For me, they determined that reason I kept miscarrying was the quality of my eggs and we decided to use donor eggs. It might be the reason now, as I am not older, but I don't think that was the reason when we first started this process. For whatever reason, my lining does not want to let the embryo implant. And if it does, it doesn't like to hang on. I really wish I knew why. 

 

At the end of the day, you need to be happy and have no regrets about the decision you make. Good luck :)


Me 43, DH 43

 

Trying since 2012

 

Natural Pregnancy May 2012, ended blighted ovum

Natural Pregnancy June 2013, miscarriage 6 weeks (chemical pregnancy)

Natural Pregnancy January 2014, miscarriage 8 weeks

IVF Pregnancy December 2016, miscarriage 4 weeks (chemical pregnancy)
IVF Pregnancy May 2017, 1st beta May 23 hcg 3,290, 2nd beta May 25 th_abfp.gif

First clinic 2012-2014

Second clinic 2014-present

 

Dx: diminished ovarian reserve; thin lining

 

Unsuccessful protocols: estrace, estradot patches, gonal f, natural cycle

 

Lining gets to 8.0 mm

 

Using donor eggs

 

FET attempts 15, transferred 4 times (2 BFN, 2 BFP), cycles canceled 11.

IUI attempts 2 (2 BFN)

 

Successful protocol for lining: estradot patches, Viagra

Successful protocol for FET: medrol, lovenox, PIO

 


#115 schlepp

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Posted 16 March 2017 - 12:22 PM

@ 4 years - Below is a link to the studies done on neupogen / G-CSF. Super fascinating! Some people do it as an injection and others as a uterine wash. The amazing part is it looks like it increases lining by 2-3mm! It is used in cancer patients to increase blood cells. I'll post an updated tomorrow on if it has any impact on my lining. 

 

https://www.centerforhumanreprod.com/about/clinicaltrials/thin-endometrium-trial/ 

 

My RE has not mentioned if we will use and HCG shot. I was working out a bunch and in the last three day am suddenly so tired I just want to go for walks. I feel the estrogen is causing it. Trying to force myself to the gym today. 


See my 'about me' page for treatment history.


#116 schlepp

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Posted 16 March 2017 - 12:23 PM

@4 years - Re: health of lining, my RE is just looking for the tri-laminar appearance. 


See my 'about me' page for treatment history.


#117 4 years and counting

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Posted 16 March 2017 - 04:15 PM

Schlepp - hcg is for ovulation.
By the time of transfer, I am just tired of all of it....making sure I am active to increase blood flow, doing yoga to increase relaxation and circulation, eating healthy, taking supplements, no caffeine, no alcohol....it is so wearing. Especially since sometimes it doesn't make a difference to the lining.

The last cycles I have been on Viagra and estrogen (either Estrace and/or patches) and it got me over the hump of 7. This cycle was 8, previous cycle was 9. Now we just have to figure out why my body is rejecting the embroyos. I am just wondering if I add neupron it will thicken it more.

Me 43, DH 43

 

Trying since 2012

 

Natural Pregnancy May 2012, ended blighted ovum

Natural Pregnancy June 2013, miscarriage 6 weeks (chemical pregnancy)

Natural Pregnancy January 2014, miscarriage 8 weeks

IVF Pregnancy December 2016, miscarriage 4 weeks (chemical pregnancy)
IVF Pregnancy May 2017, 1st beta May 23 hcg 3,290, 2nd beta May 25 th_abfp.gif

First clinic 2012-2014

Second clinic 2014-present

 

Dx: diminished ovarian reserve; thin lining

 

Unsuccessful protocols: estrace, estradot patches, gonal f, natural cycle

 

Lining gets to 8.0 mm

 

Using donor eggs

 

FET attempts 15, transferred 4 times (2 BFN, 2 BFP), cycles canceled 11.

IUI attempts 2 (2 BFN)

 

Successful protocol for lining: estradot patches, Viagra

Successful protocol for FET: medrol, lovenox, PIO

 


#118 schlepp

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Posted 16 March 2017 - 06:23 PM

@4 years - Neupogen probably can't hurt? Although it is another cost; mine was $275 for one treatment.

 

I feel for you. I've only been on the IF road for a year and a half, the thin lining path for 5 months and I feel like my life is sometimes ruled by the fact that I have 5 rounds of supplements and two teas to drink each day. All to get another 2mm of lining!

 

My fingers are crossed that your beta goes well. 


See my 'about me' page for treatment history.


#119 schlepp

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Posted 17 March 2017 - 10:10 AM

I'm at 8mm and we scheduled the transfer for next Wednesday. I decided to pass on the matris ultrasound. I didn't want it to psych me out if the score was low and we have done everything possible for my lining to get this thick so I can't see it ever being better. My RE was fine with my decision. We're using embryo glue and I didn't even question it. As long as the embryo thaws properly I'll finally get to transfer! I'm super exicited. I was even excited for the PIO injection.

See my 'about me' page for treatment history.


#120 4 years and counting

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Posted 17 March 2017 - 11:03 AM

schlepp - I am so happy for you. Are you doing an hcg shot as well? I was going to ask my RE about the glue but wasn't sure if they used it. Happy thoughts for you :)


Me 43, DH 43

 

Trying since 2012

 

Natural Pregnancy May 2012, ended blighted ovum

Natural Pregnancy June 2013, miscarriage 6 weeks (chemical pregnancy)

Natural Pregnancy January 2014, miscarriage 8 weeks

IVF Pregnancy December 2016, miscarriage 4 weeks (chemical pregnancy)
IVF Pregnancy May 2017, 1st beta May 23 hcg 3,290, 2nd beta May 25 th_abfp.gif

First clinic 2012-2014

Second clinic 2014-present

 

Dx: diminished ovarian reserve; thin lining

 

Unsuccessful protocols: estrace, estradot patches, gonal f, natural cycle

 

Lining gets to 8.0 mm

 

Using donor eggs

 

FET attempts 15, transferred 4 times (2 BFN, 2 BFP), cycles canceled 11.

IUI attempts 2 (2 BFN)

 

Successful protocol for lining: estradot patches, Viagra

Successful protocol for FET: medrol, lovenox, PIO

 


#121 schlepp

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Posted 17 March 2017 - 01:39 PM

4 years - Thanks! No HCG shot. Not sure why. We spoke about intralipids for a brief moment today but then he revisited my history and decided not to do them. This is my first attempted transfer and I did have one pregnancy in my twenties that did not go to term. My partner has a vasectomy so we haven't been able to try naturally. They do have me on medrol and doxycycline before transfer. 

 

So many different protocols! I am now just trying to relax and not think about whether my embryo thaws well on Wednesday. I bought an adult coloring book. I'm obviously losing it. I just don't want to spend the next 2.5 weeks distracting myself with Netflix.


See my 'about me' page for treatment history.


#122 4 years and counting

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Posted 17 March 2017 - 02:57 PM

schlepp - do you have immune issues? sounds like all the meds they have you on is for immune issues. I was on medrol but not doxycycline. they test me for immune issues but i think the results came back negative.'

 

hoping this cycle works for you.....


Me 43, DH 43

 

Trying since 2012

 

Natural Pregnancy May 2012, ended blighted ovum

Natural Pregnancy June 2013, miscarriage 6 weeks (chemical pregnancy)

Natural Pregnancy January 2014, miscarriage 8 weeks

IVF Pregnancy December 2016, miscarriage 4 weeks (chemical pregnancy)
IVF Pregnancy May 2017, 1st beta May 23 hcg 3,290, 2nd beta May 25 th_abfp.gif

First clinic 2012-2014

Second clinic 2014-present

 

Dx: diminished ovarian reserve; thin lining

 

Unsuccessful protocols: estrace, estradot patches, gonal f, natural cycle

 

Lining gets to 8.0 mm

 

Using donor eggs

 

FET attempts 15, transferred 4 times (2 BFN, 2 BFP), cycles canceled 11.

IUI attempts 2 (2 BFN)

 

Successful protocol for lining: estradot patches, Viagra

Successful protocol for FET: medrol, lovenox, PIO

 


#123 schlepp

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Posted 17 March 2017 - 03:01 PM

@4 years - No immune issues that I know of. Maybe because this is my one and only embryo they are throwing everything at it. The nurse made it sound like everyone is on Medrol that does a frozen transfer because of something to do with the body rejecting the embryo possibly due to something on the embryo post-freeze. Maybe it is the standard of care at my clinic or with my RE. 


See my 'about me' page for treatment history.


#124 4 years and counting

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Posted 17 March 2017 - 03:10 PM

Schlepp - what clinic are you at?

Last cycle was first time on medrol but I wish they would throw everything at me too

Me 43, DH 43

 

Trying since 2012

 

Natural Pregnancy May 2012, ended blighted ovum

Natural Pregnancy June 2013, miscarriage 6 weeks (chemical pregnancy)

Natural Pregnancy January 2014, miscarriage 8 weeks

IVF Pregnancy December 2016, miscarriage 4 weeks (chemical pregnancy)
IVF Pregnancy May 2017, 1st beta May 23 hcg 3,290, 2nd beta May 25 th_abfp.gif

First clinic 2012-2014

Second clinic 2014-present

 

Dx: diminished ovarian reserve; thin lining

 

Unsuccessful protocols: estrace, estradot patches, gonal f, natural cycle

 

Lining gets to 8.0 mm

 

Using donor eggs

 

FET attempts 15, transferred 4 times (2 BFN, 2 BFP), cycles canceled 11.

IUI attempts 2 (2 BFN)

 

Successful protocol for lining: estradot patches, Viagra

Successful protocol for FET: medrol, lovenox, PIO

 


#125 4 years and counting

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Posted 17 March 2017 - 03:10 PM

Schlepp - what clinic are you at?

Last cycle was first time on medrol but I wish they would throw everything at me too

Me 43, DH 43

 

Trying since 2012

 

Natural Pregnancy May 2012, ended blighted ovum

Natural Pregnancy June 2013, miscarriage 6 weeks (chemical pregnancy)

Natural Pregnancy January 2014, miscarriage 8 weeks

IVF Pregnancy December 2016, miscarriage 4 weeks (chemical pregnancy)
IVF Pregnancy May 2017, 1st beta May 23 hcg 3,290, 2nd beta May 25 th_abfp.gif

First clinic 2012-2014

Second clinic 2014-present

 

Dx: diminished ovarian reserve; thin lining

 

Unsuccessful protocols: estrace, estradot patches, gonal f, natural cycle

 

Lining gets to 8.0 mm

 

Using donor eggs

 

FET attempts 15, transferred 4 times (2 BFN, 2 BFP), cycles canceled 11.

IUI attempts 2 (2 BFN)

 

Successful protocol for lining: estradot patches, Viagra

Successful protocol for FET: medrol, lovenox, PIO