Hi Bre. Exciting that you might try another cycle. How is the diet change going? Are you taking any supplements or more focusing on healthy eating?
I don't have any experience with Invocell IVF, but I did a quick search if there is any scientific publication about it. I found 3 publications:
1. A small study with 10 women. On average, after IVF egg retrieval, 8 mature oocytes were placed in the invocell, and the invocell was then inserted for 3 days. After 3 days, the device was removed and 1-3 embryos were transferred. These embryos were then compared to the oocytes that were retrieved at the same time, but instead of placed in the invocell they did conventional IVF (no ICSI). Comparing the groups showed that fertilization was better in the IVF group, and there was a higher number of high quality embryos (suitable for transfer) in the IVF group. They mention a clinical pregnancy rate of 30% for the invocell device in this study. But the number of participants is so low (10 in total) that it is not really a reliable number.
2. The second study compared the Invocell-ICSI (24 cycles) with IVF-ICSI (74 cycles). In this study, on average 5 oocytes were placed in the invocell. There was no difference in embryo quality on day 3. The pregnancy rate between the groups was similar, but more embryos were transferred in the Invocell-ICSI group which likely influences the pregnancy rate.
3. A total of 40 women participated in the third study: 20 with the invocell and 20 with convential IVF. IVF resulted in a greater number of higher quality embryos, but the quality of the embryos that were transferred was still the same between the groups. The clinical pregnancy rate and live birth rate were also similar between the groups.
So overall not a lot of studies done using the Invocell device. The first study is very preliminary with only 10 participants, but it shows that a clinical pregnancy is possible using the device. The other studies have better numbers, but show slightly different results. In general, it seems that if you have enough embryos to select the ones with the highest quality for transfer, you will have a similar pregnancy rate as when you do conventional IVF.
I didn't find any data on how well women with DOR would do this device. One study doesn't mention the exact inclusion criteria, but for the other two studies you needed a AMH of at 1.1 or 1.0 ng/mL. So not sure how the results would be for someone with low(er) AMH.