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Fibristal


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#1 Elle22

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Posted 04 October 2016 - 04:32 PM

After a few failed transferred with no lining issues, I have now been unable to get my lining thick enough for a FET and was told it could be because of fibroids. I've just started 1 Fibristal pill a day in the hopes of shrinking it. 

 

I'm wondering if anyone else has used Fibristal successfully? What size fibroids did you start with and how long did it take you to shrink them down? Did you still have to have surgery after using the Fibristal? 

What kind of side effects did you have?

 

Any insights would be great.


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#2 amp77

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Posted 04 October 2016 - 08:33 PM

After a few failed transferred with no lining issues, I have now been unable to get my lining thick enough for a FET and was told it could be because of fibroids. I've just started 1 Fibristal pill a day in the hopes of shrinking it. 

 

I'm wondering if anyone else has used Fibristal successfully? What size fibroids did you start with and how long did it take you to shrink them down? Did you still have to have surgery after using the Fibristal? 

What kind of side effects did you have?

 

Any insights would be great.

I don't have experience with that but I read a book called Womancode, and it has information on changing your diet to align with your endocrine system which can regulate hormones and people have had fibroids disappear.  Might be worth reading. But, if that is true, then I would assume there are supplements that can help.  Good luck to you!


  • Elle22 likes this

Age 39, DH 43 in Oct.

TTC on and off since 2007 before our second IVF, in 2014, brought us our beautiful son.

 

FET #1 -  Sept 2016

Day 1 - Sept. 9

Monitoring - Sept. 18-22

Lining Check - Sept. 22 (11.3 mm)

Transferred 5B-BB Sept. 25 - BFP!!!  HCG 890 @ 12dp5dt and Progesterone 95.
Midwife appointment Sept. 19 and first ultrasound Nov. 4
3 Frosties left

 

<a href="https://lilypie.com/"><img src="https://lbdf.lilypie.com/9GKrm4.png" width="400" height="80" border="0" alt="Lilypie Pregnancy tickers" /></a>

 

-------------------------------------------------------------------------------------------------------------------------------------

 

Seems like forever ago...

 

Age 37, DH 40.

TTC on and off since 2007

Unexplained Infertility

 

IVF #1 - April 2014 - BFN - no frosties

 

IVF #2 - July 2014 - BFP - 5B-AB and 4 frosties (5B-BB, 2x4B-BB and 3B-BB)

Apr. 13, 2015 - Daniel Erik was born at 5:05 am, weight 8 lbs, 13 oz, and 22" long.  He is perfect in every way.

 

 


#3 makingabebe

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Posted 05 October 2016 - 12:49 PM

I have some personal experience and have done some reading and research on Fibristal:

 

I have one fibroid (~6-7 cm) and have done two 3-month courses of Fibristal over the last year to try to shrink it. Unfortunately, my fibroid did not respond. No shrinkage observed on the sonos done before and after each course. Two REs have recommended against surgery if I want to preserve my fertility due to the location of the fibroid. 

 

I have scanned at the anecdotal experience (internet forums where fibroid patients taking Fibristal (Esmya in Europe)) and scientific research behind Fibristal (generic name - ulipristal acetate). 

 

From the anecdotal experience, it appears that the drug does work for most people in shrinking the fibroid or stopping heavy bleeding/period symptoms associated with fibroids. 

 

In Europe, ulipristal acetate has been studied and approved for 8+ years. There are journal articles authored by Jacques Donnez et al., called the Pearl I-IV studies.  The Pearl I study shows that after one 13 week treatment - the fibroid volume decreases by 21%. The Pearl III studied 4 repeated 13 weeks of treatment, the fibroid volume size decreased 45, 63, 67, 72%, respectively. The studies followed the subjects up to 6 months following the treatment and did not see any regrowth but the medical research does say that fibroids feed off estrogen and progesterone hormones and will likely regrow. 

 

In terms of side effects, these were fairly manageable for me. I took the pill at night and had some headaches. My periods ceased but one month, I did spot and have somewhat of a random period. I found the drug also knocked me out at night, I slept very well and felt very tired/groggy waking up in the mornings. 

 

I hope all goes well.  Take Care. 


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#4 BeeM

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Posted 13 December 2016 - 03:30 PM

Hello Elle,

 

I am 3wks into my first pack of fibristal. I have multiple fibroids, largest is about 9cm. I had a misscariage in October, but my gyno said it couldn't have been because of the fibroids as I was  only 5wks.  She advised to do two courses (6 months) to hopefully reduce them before trying again to reduce complications - miscarriage, pre-term labour, post-partum hemorrhage, blah! blah! blah!th_angrywife.gif

 

So far so good. No noticeable side effects. I started noticing this weird pain in my right leg, where my largest fibroid is hanging out. It may not be related to the drug, but who knows! I have also been searching for people on the same drug to share their experiences. Did you finish your 3 month course yet? And did you see results? I got in touch with a lady called Alice King on Facebook who had incredible results. She has pictures up and is quite open with sharing her experience. She took it as a pre-op for a hysterectomy.

 

I will be interested to know how things are working out for you.

 

Cheers!



#5 Elle22

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Posted 13 December 2016 - 08:16 PM

Hi BeeM, sorry to hear about your miscarriage. I had one too in May at about 7 weeks, and they also said it probably wasn't fibroid related but I should get them out now. I am almost at the end of the 3 months. I had an ultrasound at the half way point to see if things were working and the fibroids had already shrunk in half. I was really excited to hear that and hopefully at the next check (which is this friday) they will be totally gone or close to it. 

As for side effects - the longer i've been on the meds the more side effects I felt.  Mainly a lot of headaches and some hot flashes. 



#6 BeeM

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Posted 13 December 2016 - 08:38 PM

Wow Elle22!

 

Am really glad to learn you've had success with fibristal. I guess there's hope for me yet.

 

My belly still looks the same (about the size of a 5mth pregnancy), but I guess its too early to expect any miracles.

 

I really do wish you all the best on this baby making journey. I now have to delay mine until summer 2017 when I would be done with the 2 courses of fibristal. Am actually thinking of freezing my eggs in the event I'll have to go for IVF. I will be turning 34 next year, and who knows where this fibroid journey will lead?

 

Please do keep me posted on how things unfold at your appointment.

 

Cheers!



#7 BeeM

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Posted 05 January 2017 - 10:17 AM

Happy New year Elle22,



#8 BeeM

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Posted 05 January 2017 - 10:21 AM

oops! accidentally hit send.

 

I hope things going well with your fertility journey.

 

I just wanted to know if you did experience expected shrinkage of your fibroids with fibristal.  

 

I am halfway through my first 3-month treatment, but am not seeing any change. Belly's still pretty big - if not even bigger.

 

All the best,



#9 Elle22

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Posted 06 January 2017 - 01:38 PM

Happy new year BeeM - I finished my 3 months and the fibroids did continue to shrink but still not fully gone where i can safely try to get pregnant. 

I actually got my funded IVF cycle for January, so I am going to do that and in the meantime I have my follow up with a surgeon in a few weeks to decide how to move forward with the fibroids. 



#10 BeeM

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Posted 11 January 2017 - 09:44 AM

Hello Elle,

 

Am sorry to hear fibristal did not get you to where you wanted to be. I'll see how mine goes, I see my doctor mid February for a half way point check up.

 

I really do wish you success with this cycle.

 

All the best!