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Bravelle and Menopur Doses?

dose medication ivf bravelle menopur

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#1 ggirl

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Posted 23 July 2014 - 11:12 AM

Hi Ladies,

 

I have started my first ever IVF cycle. We're doing PGS - embryo testing - due to a couple previous losses. We are aiming for a higher number of eggs so that we have some selection of embryos to test. 

 

I am on Day 4 of Stims 250 Bravelle 150 Menopur. I am going in Thursday to see what's happening with the follicles. I am wondering if this dosage is on the conservative side for meds. And if not much is happening say by Friday, is there still time to increase the meds and have an impact? I really want to maximize this cycle and just wanted to know your experiences/thoughts/

 

What meds and doses have you gals been given? At what stage are you in your stimulation and follicle growth? Are you meds being increased? etc.

 

Thanks so much everyone for your amazing feedback and support.

 

Ggirl

                   



#2 amp77

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Posted 23 July 2014 - 11:47 AM

Hi Gigi, I was on different meds so I can't speak to those or the doses, but my dose was increased on day 6 and again on day 7 and it went from a cycle that looked like crap to me getting 11 eggs (10 mature).  You can see the details in my signature for IVF #2.  Good luck and I hope that you get lots of wonderful eggs!


Age 40, DH 44 in Oct.

TTC on and off since 2007 before our second IVF, in 2014, brought us our beautiful son and our first FET brought us our second son in 2017.  Our family is complete!

 

IVF #1 - April 2014 - BFN - no frosties

 

IVF #2 - July 2014 - BFP - 5B-AB and 4 frosties (5B-BB, 2x4B-BB and 3B-BB)

Apr. 13, 2015 - Daniel Erik was born at 5:05 am, weight 8 lbs, 13 oz, and 22" long.  He is perfect in every way.

 

FET #1 - September 2016 - BFP - 5B-BB and 3 frosties (2x4B-BB and 3B-BB)

June 18, 2017 - Matthew William was born at 2:46 am, weight 8 lbs, 11 oz and 21" long.  He is perfect in every way too!

 

 


#3 CJ38

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Posted 23 July 2014 - 12:07 PM

Hi GGirl,

 

I was on bravelle and menopur, I believe I started off on the exact same dose as you for the 1st 4 days of the stims.  I wasnt responding the way my RE had hoped so I was increased to the max dose 450 bravelle, 150 menopur. Once you go in tmr they will know what you should be at, if you are not there your RE will increase your meds and there is a lot of time to respond.  I was increased at Day 5, I went from very few follies to retrieval of 12 eggs (11 matured)...a big jump from the 4 that the RE was expecting.

 

Good luck with your cycle!! Have faith in the process and dont panic.  PS.  Try not to google too much, it will drive you insane...take it from me, I was second guessing everything because I was read what other people were experiencing, remember we all react differently.  This is wonderful forum tho, any question just ask on here, the ladies are wonderful.  Take care!!


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#4 tjluvbug

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Posted 23 July 2014 - 01:20 PM

Hi ggirl - I am currently on bravelle and menopur. My dose is 75 menopure and 225 bravelle. I'm currently on day 3 of injections and go for my first bloodwork on Friday. As the others have said, there is lots of time to up med dosages. They don't want to start high doses right off the bat as this can increase chances of OHSS. Good Luck and keep us posted!


<p>Me 38 (28 when we did first IVF) DH 52 3 IVF's, 2 FET's, & 2 IUI's.  Boy/Girl twins born March 12th, 2015 at 33w6d. Our family is complete


#5 Watermelon

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Posted 23 July 2014 - 01:27 PM

I will be taking 150 Bravelle and 75 of Menopur.  I was told this was an average dose....but who knows. I'm now wondering if my RE has me on a plan that is too low hearing others talk about their dosage.......ARGH.  But anyways, to me yours seems to be starting on the higher side...but this is all new to me too!


Me -29 31 - unexplained poor egg quality.  I was told I had endometriomas.....but repeat ultrasounds at other clinics have said no sign of endometriomas. Maybe PCOS-like ovaries, but no PCOS - AMH, AFC are great. No one can explain why my eggs are so poor sad.png

DH 30 - severe teratospermia, count and motility are excellent.  

 

May 2014 - 2.5mg femara - BFN (ovulated night before)

June 2014 - IUI with 5mg femara - BFN (ovulated night before)

August 2014 -  IVF with ICSI - Antagonist protocol, 150Bravelle, 75 menopur, stimmed 8 days

                      - 19 follicles (all 15-22mm at trigger), 12 eggs retrieved, 7 mature,, 5 fertilized with ICSI sad.png

                      - only 7 mature eggs with an estrogen of 20000?! wtf?! Sigh...Freeze All

                       -only one BB Blast made it. Freeze "all" became "freeze one".  All others arrested between day 3 and 4 sad.png

 

January 2015 - FET of lone embryo  - c'mon little figher

                      - BFP!!! Beta 1 475 at 10dp5dt , Beta 2 - 1495 at 12dp5dt

 

 

 Baby boy born Sept 28/15


#6 ilovemydogs

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Posted 23 July 2014 - 03:32 PM

I started on two vials of each. I was upped one at a time till I was 4 bravelle and 3 menopur. I am now in the 2ww. My first cycle I was on 2 bravelle and 1 menopur. Much slower response this time.
Finally seeing the light at the end of the tunnel.

See "About Me" for details.

#7 ggirl

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Posted 23 July 2014 - 05:07 PM

Hi There,

 

Thanks so much for your responses! I started 150 of each and then was bumped to 225 bravelle. We should keep each other posted for those who are currently cycling.  Will give an update!



#8 wanting#2

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Posted 23 July 2014 - 10:39 PM

I did 375 Bravelle, and 75 Repronex for 8 days, then 375 Bravelle and 150 Repronex for 2 days.


Me: 37
Dh: 63

Mar-June 2010- 4 cycles of Clomid - BFN x 4
IUI #1
August 6 2010-BFN
Sept-October - natural cycles -BFN x 2
IUI #2
November 6 2010-BFN
December - January - natural cycles - BFN x2
IUI#3
February 6 2011-BFN
March -cyst found -Birth Control Pills - BFN
IUI#4
B2B March 31-April 1, 2011- BFN


IVF#1
May 2011
Started 21 days BCP April 15
May 12 started Lupron 2 x day
May 14 add GonalF 225iu & Repronex 150iu (2)x day x 8days
ER -May 24 -17 Retrieved, 14 Mature, 11 Fertilized
ET -May 29 Day 5 Transfer - 1 Blast, 2 Blast Frozen

HPT -June 8 - 10dp5dt bfp.gifpreggo.gif
Beta #1 -June 9 -11dp5dt -520.5
Beta #2 -June 11 -13dp5dt -1408
Beta #3 -June 13 -15dp5dt -3496
Beta #4 -June 16 -18dp5dt -10,262
First u/s -July 7 - 8wks, 2d 11.gifWe saw our Beautiful Baby. Measuring 8 wks 3days, Heartbeat 165bpm
Next u/s Aug 4 - 12wks, 2d. HR-150 Measuring 12wks 1 day.

 

babygirl.gifBaby Girl Born Feb 7, 2012!!!th_awelcome.gif

Frozen Embryo Cycle - December 2012...... Both Snowbabies did not survive the thaw. cry.gif

 

IVF #2

January 2014

Estrace primed micro dose flare

Lupron, Gonal F, Repronex x 17 days

ER - 8 Retrieved, 6 Mature, 4 Fertilized

ET - Day 3 transfer of 2 Embryos, other 2 did not make it to freeze

AF started 6 days after transfer cry.gif BFN

 

IVF #3

June 2014

May 9 -started Estrace & Provera x 21 days

May 14- started Androjel (testosterone) for 21 days

June 4 - Baseline scan showed 8 follicles

June 10- Scan showed 5 follicles in the running

June 16 - ER - 12 Mature Eggs, 9 Fertilize

June 19 - Day 3 Report - 8 out of the 9 still growing.

June 21 - ET - Transferred (2) day 5 Blasts.  No others made it to freeze.

 

Beta #1 - July 2 -  11dp5dt-  363.9 (one day after last HCG booster)

Beta #2 - July 4 -  13dp5dt-  630.2

Beta #3 - July 7 -  16dp5dt1480

Beta #4 - July 9 -  18dp5dt-  2870

Beta #5 - July 15- 24dp5dt-  16040

Beta #5 - July 17- 26dp5dt 22119

 

1st  U/S - July 16 - 6wk2d - Saw a Sac but no Fetal Pole sad.png

2nd U/S - July 18 - 6wk4d - Saw a baby with a Heart Beat, measuring 6wk2d

3rd  U/S - July 31 - 8wk3d-  Baby doing great, measured 8w0d, HR 166 preggo.gifyahoo.gif

Anatomy u/s - it's a Boy babyboy.gif And everything looks fantastic!!

Due Date - March 9, 2015

 

* Sawyer Jake ~ Born Feb 27, 2015 at 38weeks, 4 days.  Weighed 7lbs, 3oz*

 


#9 ggirl

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Posted 24 July 2014 - 02:56 PM

Hi Everyone, here's my update:

 

follicles appear to be growing. Saw a bunch on the ultrasound. None yet over 1.5 but we are still day 5. I was told to start cetritide tonight for suppression. So things are going. I am trying to be cautiously optimistic. 

 

Hi ilovemydog - how many eggs did you retrieve? And were you happy with it? 

 

Hi Watermelon - regarding your protocol, you are younger than me by 10 years (yikes) which is something taken into account I believe.e 

 

Good luck on the pregnancy so far wanting#2. 


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#10 ilovemydogs

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Posted 24 July 2014 - 03:40 PM

I retrieved 7 mature eggs. We had to leave 2 behind because they could not be retrieved - not sure if they were mature. We ended up with 4 blasts. Transferred 2 (4aa, 2ab) at day 5. By day 6 we had two blasts to freeze (4aa, 4cb). I am now 9dp5dt.

I am 37, to put it into perspective.
Finally seeing the light at the end of the tunnel.

See "About Me" for details.

#11 TryingForOur2ndChild

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Posted 25 July 2014 - 12:07 PM

I was on 150 of Bravelle and 75 of Menopur and even that dose caused me to be a freeze all case due to OHSS. I'm 36 and they retreived 22 eggs from me though I have quite a high AMH level.


See full journey details on my profile:

 

About Us:

​Trying to conceive since 2013 (male factor); Me: 39 yrs old; DH: 37 yrs old; low testosterone; very low sperm count; on Clomid for testosterone

 

~ 2014 ~ IVF Cycle #1:

 

Cycle Info:

- Antagonist protocol

- Retrieval: 22 eggs retrieved; 8 injected (ICSI); 6 fertilized; 4 embryos divided - 2 embryos are 4 cell grade 1, 1 embryo is 5 cell grade 2, and 1 embryo is 8 cell grade 2

 

FET #1 - medicated cycle (2014)

- transferred two day-3s: one 10 cell grade 1 and one 12 cell grade 2; Beta: BFN; approved to do a natural FET next time

 

FET #2 - Non-medicated cycle (2014)

- added Teva-Doxycycline 100mg (antibiotic) started one day before procedure: 1 tab 2xdaily until finished) 

- transferred two day-3 embies (1 is 10 cell grade 2 and 1 is 12 cell grade 2); took 1 tab of Apo-Diazepam (valium) 5mg 45mins before FET        

​- HPT = th_abfp.gifbanana.gifbanana.gifth_abfp.gif  Welcomed our little babygirl.gif in summer of 2015

 

~ 2016/17IVF Cycle #2: Project Sibling

 

Cycle Info:

Oct. 29: Retrieval - 23 eggs retrieved; will be a freeze all cycle

Nov. 2: Dostinex 0.5mg every other day for a total of 8 days has started to alleviate OHSS 

Nov. 4: Day 6 report: 5 embryos on ice... yay! 4 day-5s (4AA and 3 are 4BC quality) and 1 day-6 (5BC quality)

 

FET #1 - Non-medicated cycle (2017)

Feb. 6: start Teva-Doxycycline antibiotic100mg one day before procedure
Feb. 7: scheduled transfer at 11:45am; 1 tab of Apo-Diazepam (valium) 5mg taken 45mins before transfer; transfer of one 4AA blast

Feb.20: BETA - BFN; approved to go right into another natural FET with no cycle in between

 

FET #2 - Non-medicated cycle (2017)

Feb.24: CD3 - u/s and b/w= nothing said about lining; E2 19, LH 4.4 IU/L, FSH 6.6 IU/L, Prolactin 8.1 Ng/mL, TSH 2.22 IU/L, Progesterone 1.6 nmol/L, Glucose 4.1 - I requested (norm is 3.6-7.7); back on CD15; acupuncture 2x weekly until fet to try and bring on LH surge sooner than CD17.

Mar.6: OPK positive in the evening so looks like I will be going into the clinic tomorrow

Mar.7: CD14 - u/s and b/w= 11mm triple lining; E2 712, LH 32 IU/L

Mar.8: CD15 - b/w= confirmed LH surge was yesterday; E2 343, LH 8.12 IU/L; start Endometrin 3x/daily

Mar.11: start Doxycycline antibiotic 100mg (8 pills total) one day before procedure: 1 tab 2xdaily until finished

Mar.12: scheduled transfer at 10am of one 4BA blast; 1 tab of Apo-Diazepam (valium) 5mg taken 45mins before transfer

Mar.23: HPT = th_abfp.gifbanana.gifbanana.gifth_abfp.gif

​Mar.25: Beta #1= 788 hcg, Progesterone 107 nmol/L; RE happy with results so skipping beta #2 and going right to u/s

​Apr.4: had light bleeding last night so went to clinic where they did an u/s; too early to really see much but did see a gestational sac; u/s moved from Apr.8th to 15th

Apr.18: First u/s scheduled (at 8 wks).... omg there are twins!!! One had a heartbeat of 140 and the other only 80 so being referred to the head OB of internal fetal medicine as it looks like I may have a vanishing twin which RE said 50% of twins go down to one before the 2nd trimester.

 

 

 

 

 


#12 tjluvbug

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Posted 25 July 2014 - 05:13 PM

After 4 days of stims my E2 was 442. They've upped my menopure dose from 75iu to 225iu and my Bravelle stays the same at 225.


<p>Me 38 (28 when we did first IVF) DH 52 3 IVF's, 2 FET's, & 2 IUI's.  Boy/Girl twins born March 12th, 2015 at 33w6d. Our family is complete


#13 TeamKissock

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Posted 17 August 2014 - 09:20 AM

I'm currently on day 5 of stims and taking 20 units Suprefact, 150 Bravelle and 300 Menopur. This is my second IVF cycle, the first was cancelled due to poor response to medication (was on antagonist protocol). I go in for bw and us in 3 days to find out follicle growth. Hoping and wishing there's a way better response this time! Also, I'm 30 years old. 

 

Hoping you all have an awesome response to the medication and have lots of healthy eggs to choose from!



#14 iheartmemories

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Posted 17 August 2014 - 10:02 AM

I started with 150IU Gonal F and 75IU Menopur.

 

Dosage was decreased after three days, to 100IU Gonal F and 75IU Menopur.

 

Then, bumped up to 125IU Gonal F (after Cetrotide was started).  Cetrotide is known to lower estradiol levels.  I did 125 until my final stim day, 10 days.  Along, with the 75IU Menopur.

 

They saw 17 follicles on my u/s but I've learned not all follicles contain an egg.  They retrieved 10 eggs, 8 mature, 6 fertilized.  I currently have 4 blastocysts, frozen (had to do a "freeze all" because my estrogen was really high).


Angela (36) and James (43)

Mia (9)

TTC # 2 via IVF Tubal Factor & Male Factor IF

 

Egg Retrieval

August 6, 2014

10 eggs / 8 mature / 6 fertilized

By day 5 and 6, four embryos made it to blast stage

FET #1 (Day 5 Blasts), failed icon_speech_sigh.gif 

FET # 2 (Day 6 Blasts), June 2015 eusa_pray.gif 

 

FET #2 Protocol:

BCP for 14-15 Days (start on June 1, 2015)

Endometrium Scratch & Saline Ultrasound (Day 12 while on BCP)

Estrogen Patches, PIO, Medrol, Aspirin, Prenatals, Vitamin D

Accupuncture

Transfer Date:   July 7, 2015

Beta Blood Test:  July 21, 2015

BFP ++++

babygirl.gif  Ava Marie due March 21, 2016 babygirl.gif 

FIND ME ON INSTAGRAM | angelamtonkin

 

BAAMm5.png

 

 

 

 






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