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Can a early blastocyst arrest at day 5?

DOR IVF blastocyst

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#1 Positivepatty

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Posted 25 March 2014 - 06:29 PM

I have DOR: AMH 0.34 and FSH 10.5. I finished my first cycle last week and had 7 eggs retrieved. As of today, day 5, none of the remaining 3 viable embryos were ready to be biopsied. Two are in the early blastocyst stage, and one is in the early morula stage. So, the only two that look promising are the two early blastocyst embryos. They will check on them again tomorrow. I'm hoping that they don't arrest and we at least have two to send of for CCS testing. Anyone have a similar experience that ended positively?



#2 mrsfinxy

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Posted 25 March 2014 - 06:53 PM

I have never had a day 5 blastocyst.  By day 5, I only ever had early blasts.  I had a couple of transfers with early blasts, one resulted in a BFN, one in a chemical pregnancy.  They let the remaining blasts go to day 6 and they blasted were frozen.  I am currently pregnant with one of those day 6 blasts! 


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#3 Positivepatty

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Posted 25 March 2014 - 06:55 PM

wow, that's encouraging mrsfinxy! I will hold out hope that my two early blasts will make it to full blast by tomorrow. So scared!



#4 Merry33

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Posted 25 March 2014 - 07:24 PM

I think it could go either way. During our last IVF cycle we ended up with 4 early blasts on Day 5. They transferred two of them, so I can't know if they would've made it to Day 6, and the other two arrested by Day 6 (well, I'm not sure they arrested...but we were told that they weren't "good enough" for freezing).

 

Best of luck!



#5 ilovemydogs

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Posted 25 March 2014 - 07:31 PM

On my IVF cycle, I had 4 early blasts. One was transferred along with a more developed blast. Two arrested and one ended up the highest grade and was frozen. I didn't get a BFP out of them, but I suspect there are other issues that may have prevented that.


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#6 Positivepatty

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Posted 25 March 2014 - 07:41 PM

Thank you merry, I hope your dream came true. Thank you for taking the time to share. 

 

ilovemydog, wow thanks for sharing. I guess it really can go either way. I will keep you posted. So stressful and gut-wrenching.



#7 Kim2013

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Posted 25 March 2014 - 10:28 PM

Hi ladies just to clarify are early blasts cavitating morulas?? I was told all 5 of my embryos were cavitating morulas when they were frozen on day 5. just confused with the stages of development. thanks in advance


Me-31 and DH-34-

Aug 2010- started trying right away

june 2011- natural BFP but.... m/c at 8 weeks8388.gifcry.gif

Nov 2012-Jan 2013-  200 mg prometrium,  started acupuncture, supplements and healthy diet for both of us.
Feb 2013- April 2013- 50 mg Clomid and 100 mg prometrium

June 2013- DH advanced SA- poor morphology 2-4% normal, I continue to spot between  CD9-CD13

July 2013- IUI #1 with 100mg clomid-BFN!!!!

Aug 2013- Consult  Victoria-Dr Hudson

Sept 2013- shsg (normal) endometrial biopsy(normal)  DH booked for U/S and referral to urologist

OCT 2013- lap oct 24- Found Stage 3 endometriosis -adhesions removed successfully

NOV 2013-IUI -BFN

 

IVF #1- Long protocol

Dec 16- BCP superfact,  Dexamethosone 

Jan 12-Jan 22- menopur 225iu

Jan 25--> ER 22 eggs retrieved 17 fertilized ivf/icsi split,,,, E2-22000 risk of OHSS no embryo transfer

Jan 30--> 5 x day 5 embryos to freeze (cavitating blastocysts 2x19 and 3x17+)

Plan for MAY FET!

 

FET # 1-->May 12 - Transfer of early blastocyst grade 18

                 May 23-  BFP!!!!!!!! Beta 1- 159

                 May 26- Beta 2 - 686

                 May 28- Beta 3 - 1517

                 June 11- First U/S

DD- Jan 28/2015

 

 


#8 Positivepatty

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Posted 25 March 2014 - 10:45 PM

A morula is in the development stage prior to a blast.

#9 rollergirl

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Posted 25 March 2014 - 11:53 PM

It is that important that you do the CCS testing? 


Me-72 DH-26 It is what it is...

#10 Positivepatty

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Posted 26 March 2014 - 12:33 AM

Rollergirl, bc I'm 36 and pregnsncy rate is 70% with a genetically-sound embryo, we decided to do CCS testing. It's a gamble either way. Very scared about the need tomorrow...

#11 #3@44

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Posted 26 March 2014 - 02:27 AM

I kinda agree with Rollergirl especially since they are all early blasts.  I would put them all 3 back without CCS - but I am old and the chances of multiples are non-existent.  It would save you a lot of money.


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Me - 44, DH - 45
3 CONSECUTIVE IVF CYCLES AT 43 YEARS OLD = 16 eggs > 13 embryos > 10 transferred > 1 BABY!!!!


Years of anovulation (but this has saved me some eggs for my 40's!) and decreased count/motility.
4 years of trying naturally and tests - then surprise pregnancy in 2003, DD born 11/2003
6 cycles of clomid/iui - BFN, 2 cycles of FSH/IUI - x2 chemical pregnancy, 1 cycle of FSH/IUI - bfp! DS born 08/2006

2009 I decide I want another. Crazy I know - DH has had Vx.
2012 DH finally on board. Has TESE (super ouch).
03/12 and 04/12: FSH = 5, AFC = 4
IVF#1 - June 2012 - long lupron, 300 Bravelle, 150 Menopur, ICSI - 10 follicles, 3 eggs (WTF??), 2 fertilized, transferred 2 Day 3 4-cells - bfn.
IVF#2 - Aug/Sept 2012 - flare, 450 Bravelle, ICSI, 5 eggs, 4 fertilized, transferred 4 (2 8-cell, 2 10-cell) - chemical

IVF#3 - LAST CHANCE FOR ROMANCE![/b]
Oct/Nov 2012 - flare, lupron BID, 450 Bravelle, ICSI
Sept 15 - start BCP
Oct 11 - endo biopsy
Oct 14 - last BCP
Oct 17 - baseline: E2=286, start lupron microdose twice daily
Oct 19 - start 450 Bravelle
Oct 24 - U/S: 7 10mm follicles, bw: E2=964
Oct 26 - U/S, bw 9 follicles (all 10 -16mm), bw: E2=1867, lining: 9mm
Oct 28, u/s, bw 9 follicles (1 @10mm, 7 @16-17mm, 1 @23.5mm), bw: 3600+, lining: 10mm

Oct 29, u/s, bw 9 follicles (1 @12mm, 8 @18-21mm), bw: 5500+, lining: 10mm - trigger AND 450 Bravelle!
Oct 31 - ER 8 eggs!
Nov 1 - 7 fertilised!
Nov 2 - three grade 2 (all 4-cell), two grade 3 (2-cell and 5-cell) and two grade 4 (all 5-cell)
Nov 3 -two grade 2 (all 8-cell), four grade 3 (8-cell and 10-cell) and one grade 4 (6-cell)

Nov 4 - four good morulas, one border-line quality morula, two 10-cell embies
Nov 5 - ET of 2 blasts (2BB, 3BA), one cavitating morula and one other crap morula - NO FROSTIES!

Nov 10 - Day 10 - HPT ---- BFP!
Nov 14 - beta = 78

Nov 16 - beta = 179
Dec 7 - first u/s! 7w2d: CRL=10mm, HR=139
Dec 11 - first appt w/ high risk OB & another in office u/s (all good)
Dec 18 - u/s 8w6d: CRL=21mm, HR=172
Dec 27 - genetic testing and consult
Jan 11 - nuchal testing and IPS with soft markers (FTS) (for fun as will have already done NIPS) - NT=1.19mm = PERFECT
Jan 21 - 13w5d on u/s - we are having a boy!!!!!
July 24 - due! induced on July 6th - healthy, 7 lbs 2 oz at 37w3d - can't believe this happened!!

#12 Positivepatty

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Posted 26 March 2014 - 01:09 PM

#3, I'm afraid of miscarrying an embryo has chromosomal anomalies.....rate of pregnsncy with a healthy embryo is 70%.....I'll keep you guys posted:)

#13 Positivepatty

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Posted 26 March 2014 - 06:54 PM

Thank you for the support guys:) 1 grew to a grade 1 and was biopsied. The second grew a little overnight, and they will check it tomorrow to see if it made it to blast. The third is too far behind. Fingers crossed:)

#14 #3@44

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Posted 27 March 2014 - 12:07 AM

Good luck.  I understand your fears.  it is so incredibly hard no matter what.


Me - 44, DH - 45
3 CONSECUTIVE IVF CYCLES AT 43 YEARS OLD = 16 eggs > 13 embryos > 10 transferred > 1 BABY!!!!


Years of anovulation (but this has saved me some eggs for my 40's!) and decreased count/motility.
4 years of trying naturally and tests - then surprise pregnancy in 2003, DD born 11/2003
6 cycles of clomid/iui - BFN, 2 cycles of FSH/IUI - x2 chemical pregnancy, 1 cycle of FSH/IUI - bfp! DS born 08/2006

2009 I decide I want another. Crazy I know - DH has had Vx.
2012 DH finally on board. Has TESE (super ouch).
03/12 and 04/12: FSH = 5, AFC = 4
IVF#1 - June 2012 - long lupron, 300 Bravelle, 150 Menopur, ICSI - 10 follicles, 3 eggs (WTF??), 2 fertilized, transferred 2 Day 3 4-cells - bfn.
IVF#2 - Aug/Sept 2012 - flare, 450 Bravelle, ICSI, 5 eggs, 4 fertilized, transferred 4 (2 8-cell, 2 10-cell) - chemical

IVF#3 - LAST CHANCE FOR ROMANCE![/b]
Oct/Nov 2012 - flare, lupron BID, 450 Bravelle, ICSI
Sept 15 - start BCP
Oct 11 - endo biopsy
Oct 14 - last BCP
Oct 17 - baseline: E2=286, start lupron microdose twice daily
Oct 19 - start 450 Bravelle
Oct 24 - U/S: 7 10mm follicles, bw: E2=964
Oct 26 - U/S, bw 9 follicles (all 10 -16mm), bw: E2=1867, lining: 9mm
Oct 28, u/s, bw 9 follicles (1 @10mm, 7 @16-17mm, 1 @23.5mm), bw: 3600+, lining: 10mm

Oct 29, u/s, bw 9 follicles (1 @12mm, 8 @18-21mm), bw: 5500+, lining: 10mm - trigger AND 450 Bravelle!
Oct 31 - ER 8 eggs!
Nov 1 - 7 fertilised!
Nov 2 - three grade 2 (all 4-cell), two grade 3 (2-cell and 5-cell) and two grade 4 (all 5-cell)
Nov 3 -two grade 2 (all 8-cell), four grade 3 (8-cell and 10-cell) and one grade 4 (6-cell)

Nov 4 - four good morulas, one border-line quality morula, two 10-cell embies
Nov 5 - ET of 2 blasts (2BB, 3BA), one cavitating morula and one other crap morula - NO FROSTIES!

Nov 10 - Day 10 - HPT ---- BFP!
Nov 14 - beta = 78

Nov 16 - beta = 179
Dec 7 - first u/s! 7w2d: CRL=10mm, HR=139
Dec 11 - first appt w/ high risk OB & another in office u/s (all good)
Dec 18 - u/s 8w6d: CRL=21mm, HR=172
Dec 27 - genetic testing and consult
Jan 11 - nuchal testing and IPS with soft markers (FTS) (for fun as will have already done NIPS) - NT=1.19mm = PERFECT
Jan 21 - 13w5d on u/s - we are having a boy!!!!!
July 24 - due! induced on July 6th - healthy, 7 lbs 2 oz at 37w3d - can't believe this happened!!

#15 Positivepatty

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Posted 27 March 2014 - 12:28 PM

Only one grade 2 (fair) made it. Feeling scared, but will wait for CCS results.

#16 Positivepatty

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Posted 27 March 2014 - 12:30 PM

Anyone in a similar situation?

#17 Positivepatty

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Posted 27 March 2014 - 04:24 PM

just spoke to the embryologist and thank God I misread the report! We have a frozen grade one hatched blast and a grade 2 hatched blast, so now we wait two weeks for CCS results!

#18 MB.

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Posted 27 March 2014 - 05:25 PM

Good news. Good luck!

#19 leigh14

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Posted 27 March 2014 - 06:47 PM

This is sounding positive, Positive Patty! Good luck! :)


Me: 40
Dx: DH: Vasectomy; need IVF/ICSI ME: D.O.R. and many immunological issues. (Initially presented as "normal" but issues were only discovered after IVF attempt #2 and #3 after testing at new clinic)
IVF attempt #1 Nov.2009, Age 37: Long "Lupron" protocol
Dec.2009: Cycle cancelled due to oversuppression
IVF attempt #2, Age 38: April 2010: 3 eggs retrieved, 2 mature, 2 fertilized, ET of 2 embryos BFN
IVF atempt #3 at new clinic: November 2010, Age 38: 5 eggs retrieved, 4 mature, 4 fertilized, ET of 2 blastocysts BFP
Strong beta numbers but babies not measuring on track but one heartbeat is present. Followup u/s reveals no HB's :( Had D&C--so sad.
Moved to new clinic closer to home + more of a focus on testing for potential immunological factors:
Further testing reveals three mutations related to inherited thrombophilia (2 MTHFR mutations and PA1-1 mutation), positive ANA, elevated NK cells and cytokines and low levels of leukocyte antibodies (LADS), Recommended Immunological treatment: Humira, LIT, IVig and blood thinners if PG
IVF Protocol: Low stim for me/ TESE needed for DH; took Humira in late August and early September; taking DHEA plus Co-Enzyme Q10, vitamins for DH just for good measure! September--two trips to Mexico for LIT treatment, treatments 3 weeks apart
Initial re-testing through Alan Beer Centre after some of the immune treatments reveals only cytokines were lowered, NKs still high and LAD numbers still low. Another LIT in Mexico is recommended. We decide to begin cycle on doctor's recommendation of just doing IVIG.
IVF#4, Age 39 : November 2011: Worst AFC EVER--a whopping 4! Three follicles responded, two eggs were retrieved. Three day transfer of two Grade 1 8 cell embryos: "Fahita" & "Burrito" Stick, stick, stick little ones!
BFP! Beta of 569
Viability u/s at 6 w 2d shows TWO babies measuring on track with heartbeats of 121. Looks like babies might be sharing the same amniotic sac.
Second u/s at 7w 2 d shows ONE baby with hb of 150, measuring 7 w 3 days. No sign of twin. Vanishing twin syndrome?
Third u/s at 8 w 2d shows ONE baby with hb of 170, measuring 8 w 3 days. Looks like a little jellybean!
12 week u/s at 12 w 2 days and baby is measuring 12 w 5 days with a heart beat of 150. Baby mooned us and waved at us with one hand....looked like a "royal" wave to me!
13 week doctor's appointment, HB=155 on doppler
14 week u/s to check cervix, HB=148
16 week u/s to check cervix, HB=138, baby had hiccups!
20 week u/s--everything looks good! HB=130, looks like we're having a GIRL!
IPS results very good!
39 weeks: Our baby girl arrived!!! She is healthy and beautiful! We are so happy! :)

Lilypie Maternity tickers

#20 sprbaby

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Posted 09 April 2014 - 10:59 AM

I almost wish I hadn't read this thread... I transferred two early blasts last week. I like to think that making the jump from morula to blast puts them much more out of the woods of arresting (although they are still 50/50). I had several other promising ones left to go to day 6, but I haven't received the report yet. I don't really know the line between the cavitating morula and the early blast, but there is a great video  link of it on my blog (entry - "Introducing the twins").


http://dustyolewombs.blogspot.ca

Dx: Tubal

Me (38) DH (37)

 

IVF Cycle #1

Dec 2013 13 retrieved, 11 fertilized,

day 3: 7 great embryos

day 5: no blasts; transferred 1 morula

day 6: still no blasts, nothing to freeze

day 13: spotting

day 14: BFN

 

IVF Cycle #2 - March 2014

*added 3 months CoQ10 and omnitrope with stims*

Mar 2014: 14 eggs retrieved, 13 fertilized

day 5: two early blasts, both transferred!

day 6: one more blast frozen!

day 14: AF arrived, BFN confirmed on day 16.

 

FET cycle - Nov 2014

transferred one and only frozen blast - BFN






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