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Any success with IUI in DOR?

Started By Curlygirl77 , Aug 18 2013 09:43 PM

diminished ovarian reserve IUI DOR IVF

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7 replies to this topic

#1 Curlygirl77

Global 100+
148 posts

Gender:Female
Dx:DOR
My Clinic:Olive Fertility Centre

Posted 18 August 2013 - 09:43 PM

Hey out there....

Just was chatting with a friend tonight who also has DOR, and she had been offered IUI by her RE. She tried this a few times, without success, but had been offered nonetheless. I was not offered this by our RE, but it was suggested that we go straight to IVF ASAP or donor egg IVF.

Has anyone tried this with DOR and had success? It's so much cheaper and less invasive and while I am waiting to do DE IVF, I thought to myself that it might be worth a try??

Thanks for any stories you have to share.

Diagnosed with DOR in October 2012

Surprise BFP October 2012! Chemical pregnancy

January 2013- decided to pursue donor egg IVF with my sister- she is diagnosed with DOR as well :-(

July 2013- decided on donor egg IVF in Europe, planning on early 2014 to give time to try naturally

Surprise BFP September 2013. Another chemical pregnancy :-( At the same time, a dear friend offers to donate her eggs to us! Her testing begins...

Surprise BFP October 2013!!!

First beta 29/10- 36

Second beta 31/10- 106, right on track!

Third beta 03/11- 277

Fourth beta 09/11- only 622... doubling time more than 3 days :-( Bracing ourselves for another miscarriage.

Fifth and final beta 12/11- 1875! Tripled in 3 days. RE wondering about ectopic...

13/11- first ultrasound- gestational sac, yolk sac and fetal pole seen! Baby measuring exactly right on for dates! We are ecstatic!!! Too early for heartbeat so now waiting patiently for next ultrasound.

05/12- 8+6 - beautiful heartbeat of 165 heard and baby is exactly the right size (and also very photogenic). Can't believe it!!!!!!

12/12- 9+5 - first OB appointment. New due date is July 12th by our 8 week scan. Can't believe how much baby was moving in there on the ultrasound today!!! Happy little heartbeat too.

June 17, 2014- our little miracle baby boy born by c-section for pre-eclampsia and breech at 36 weeks! He is so awesome. So incredibly thankful....

Surprise BFP July 2015. Third chemical pregnancy. Ugh.

Surprise BFP August 2015. Seems too good to be true. Very cautious but holding out a bit of hope...

First beta 02/09 - 2811

Second beta 10/09 - 29 455

22/09 - first ultrasound at 7+5! Little baby measuring right on track with a beautiful heartbeat. Due date May 5th!

April 21, 2016 - our second miracle boy is born naturally after a c-section the first time. What an experience… We are so thankful to the universe and feel that our family is now complete.

#2 nettibug

Cyclebase
1074 posts

Gender:Female
Dx:DOR
My Clinic:N/A

Posted 19 August 2013 - 02:30 AM

I would listen to your RE. Age also plays a big factor in IUI success.

Lisa1981 likes this

Single with secondary infertility, AMA, DOR, RPL. TTC started with four failed IUI's.

IVF #1: converted to another IUI after 2 of 10 follies went rogue during stims --> BFN

IVF #2: 6 eggs retrieved, 5 fertilized with ICSI --> 3dt of 4 high grade embryos with AH --> BFN

IVF #3: 6 eggs retrieved, 4 fertilized with ICSI --> vitrified at 2PN (had to put TTC on hold)

IVF #4: 11 eggs retrieved, 9 fertilized with ICSI --> 5dt of 3 blasts --> --> lost HB at 8w4d

IVF #5: 7 eggs retrieved, 6 fertilized with ICSI --> 5dt of 2 blasts --> --> missed m/c at 7w3d

IVF #6: cancelled due to poor response --> IUI --> totally unexpected --> chemical

Getting off the IVF train and happily moving on to international adoption

Dossier approved & registered! Waiting for a referral...

Nine months later, still waiting...

#3 Lisa1981

Cyclebase
1698 posts

Gender:Female
Location:Gatineau
Interests:Getting my sanity back
Dx:Endometriosis
My Clinic:N/A at the moment

Posted 19 August 2013 - 06:06 AM

Hi,

I wish I would have skipped the IUIs and went straight to IVF... Like nettibug said, age plays a big factor. But even in the early 30s, egg quality is affected by DOR. I think it also depends at what stage you are. If your test results are off the chart and have a very low AFC, skip the IUIs, but if you still have a good number of follicles and your test results aren't that bad... Maybe one or two IUIs would be worth it.

However; in the end, you may regret spending so much time and money towards IUIs when that energy could have been put towards your IVF (if the IUIs don't work or course).

Good luck

Lisa

Me: 33 - DH: 36

July 2012: referred to Ottawa fertility center
August 2012: Test results are back
High FSH, Low AFC (only 6)
Endo (duuuh) & DOR (great....)

And may has well make it a trio...male factor (motility)

After 2 failed IUIs, 5 Failed IVF:

Trying on our own until spring come's along...

Feb 09: A little Miracle, a natural BFP. Praying it sticks around for 9 months.

Feb 11: Beta 25 (yikes)- P4: 47 oh boy, put on progesterone

Feb 13: Beta 86 - P4: 144

Feb 18: Beta 544 - P4: 96

Feb 20: Beta 1128 - P4: 81... increased progesterone to 600mg

Feb 24: Beta 1608 - P4: 100... oh boy, not looking promissing

Feb 25: Beta: 1942 (no P4) at another hospital.. ok, looking better... U/S: sac and yolk. Nothing else.

March 04: HB 115. Problem: Sac is small... repeat u/s next week

March 14: U/S , HB (abdominal) 167bpm (internal) 158bpm. Problem: Sac still small, reapeat u/s in 10 days..

March 24: U/S confirmed no HB.. stop progesterone. M/C that same evening

#4 Dillydally

Cupcake guru

Cyclebase
630 posts

Gender:Female
Location:Montreal
Interests:Cupcakes! Gardening, reading mystery books and salivating at pictures in cookbooks.
Dx:DOR
My Clinic:McGill reproductive center

Posted 19 August 2013 - 10:06 AM

I am glad I did 2 IUIs so that my dr had an idea of how I responded to stims, but I am also glad I did not keep going with IUIs because there were other issues at hand that I would not have discovered.

Me- 37, DH - 46
Dx: DOR

Please see my profile for prior history

Blood test to check for antiovarian antibodies (AOA) in early September 2013

Follow up appointment with endocrinologist October 10th 2013 (FX AOA please be gone!)

Oct. 10th 2013 - AOA are gone!!!!

Oct. 18th 2013 - Appointment with Dr. H to review protocol

Oct. 24th 2013 - Start taking prednisone

Oct. 31st 2013 - Stop marvelon after taking 6 packs continuously (yay!!!). Happy Halloween:)

IVF 2.2 - November 2013

Low dose protocol with prednisone

Nov. 4th 2013 - U/S 1, all clear, start stims (150 Repronex)

Nov. 7th 2013 - U/S 2: one lonesome follie

Nov. 9th 2013 - Start Orgalutran

Nov. 11th 2013 - U/S3:

Nov. 13th 2013 - U/S4:

Nov. 14th 2013 - U/S5: 3 follies on right (18, 7 and 6 mm) and 1 follie on left (8 mm), trigger at 10 pm

Nov. 16th 2013 - ER...FX!

Nov.17th 2013 - Game over - none fertilized.

2014 - Taking a (permanent?) break from IVF

#5 MrsOrchid

Member
51 posts

Gender:Female
Location:Vancouver
Dx:DOR
My Clinic:PCRM

Posted 19 August 2013 - 10:46 AM

I'm glad we tried one IUI (which got cancelled btw) to a) ease into the process and learn what it means and

give the clinic valuable information on how my body responds to the meds.
But I'm also very glad we didn't waist any more time and jumped right into IVF after that.

Me: 31, DOR
DH: 32, no MF

12.2010 - Off BCP
06.2011 - starting TTC
12.2011 - FSH 12.6 referred to RE
01.2012 - AFC 10; DX with DOR
01.2012 - start TCM (Acupuncture and Chinese Herbs) + supplements (CoQ10, EPA, Prenatal vitamin)
04.2012 - FSH 13.1; stop Chinese Herbs
09.2012 - Injectables/IUI (Gonal-F). First converted to IVF (more than 9 follies), then cancelled (E2 levels dropped)

03.2013 - IVF#1 Long lupron protocolStims: Bravelle (300iU) and Menopur (150iU)
30.03.2013 - ER: 8 eggs, 6 mature, 5 fertilized
04.04.2013 - ET: d5t; transfered 1 blast (graded at 4BB); 1 frostie put on ice
13.04 2013 - Beta#1: 149!!!
14.04.2013 - Finally POAS - first ever BFP!
15.04.2013 - Beta#2: 639!!!
07.05.2013 - first U/S - 1 happy bean with a strong heartbeat of 157. Team green
24.11.2013 - healthy baby girl born breech at 36+4

10.2015 - FET#1
24.09.2015 - CD 1, start Estrace, 3x 2mg, orally
13.10.2015 - CD 20, lining check, 6.5mm, add 1 tablet, vaginally
20.10.2015 - CD 27, lining check, no difference
05.11.2015 - CD 43, sET (d6 Blast, graded 4AB, lost 30% of the cells during thawing process)
14.11.2015 - 9dp5dt, Beta#1: 130
16.11.2015 -11dp5dt, Beta#2: 397
10.12.2015 - viability U/S

#6 Bubby99

1000+
1344 posts

Gender:Female
Location:Toronto
Dx:DOR
My Clinic:Hannam, US DE clinic TBD

Posted 19 August 2013 - 11:50 AM

We did one IUI with our previous clinic (BFN) and when we switched clinics the RE suggested we not waste our time our money and move straight to IVF (after DOR diagnosis). IVF was also unsuccessful and we are now waiting to see the RE and see what to do next. Best of luck with whatever you decide.

Me - 37 38 DOR

DH - 39 40 (swimmers perfect)

TTC December 2010

Nautral cycle with clomid - too many to count 2012
Cancelled IUI - July 2012 (cysts)
September 2012 IUI mt Sinai BFN
Switched clinics January 2013 to Hannam
IVF #1
ER July 2013 - 4 follies 1 egg
ET July 2013 - transferred 1 embryo grade 2 7 cell
Current 2ww
Aug 2013

Sept 2013 Told IVF with my OE is not going to work ...time to move onto to Plan B.

2015 Plan B donor eggs

#7 Still_Hoping

Member
94 posts

Dx:N/A
My Clinic:Create

Posted 20 August 2013 - 09:13 PM

i did 6 IUIs, all of which failed. I was just in denial and kept thinking the next cycle was the one. On the upside, it helped us figure out my response to meds. It was a pricey lesson. Also, it gave me assurance that IVF was the right next step and that we weren't willy-nilly spending a larger amount of money. All-in-all, it set us back by at least 6 months and $5000 (procedures and meds) which is just about half the cost of one IVF, and alot of emotional ups and downs.

Good luck.

My_time likes this

Me: 38, fibroids, DOR

DH: 37 and doing great!

May 2009 - natural DS arrives!!!

March 2011 - TTC

Feb 2012 - Diagnosed with extensive uterine fibroids and premature ovarian aging (high FSH, low AMH) and DOR. RE recommends donour eggs and surrogate - - but we're not ready for that as we've only just begun.

Spring/Summer 2012 - Underwent 3 hysteroscopic myomectomies.

Summer/Fall/Winter 2012 - Underwent 6 IUIs, all BFNs

March 2013 - IVF #1: 4 mature follies, retrieved 3, only 2 fertilized, only 1 made it to day 5 and then was frozen (devastated). Transfer cancelled due to recurring fluid in endometrium (devastated again).

April 2013 - Cancelled FET due to endometrial fluid despite treatment with estrogen patches. Office hysteroscopy showed no scarring of endometrium. Fluid likely from the uteran muscle.

May 2013 - Decreased fluid in endometrium. RE said "maybe hysteroscopy knocked something loose" and recommended FET. Chose natural cycle instead in hopes of further clearing my fluid - BFN.

June 2013 - pneumonia. Cancelled FET. Natural cycle with intralips - BFN.

July 2, 2013 - Natural FET of my only frostie with intralips and accupuncture. BFP!!!

EDD March 21, 2014

#8 Curlygirl77

Global 100+
148 posts

Gender:Female
Dx:DOR
My Clinic:Olive Fertility Centre

Posted 22 August 2013 - 09:24 PM

Thanks for your feedback everyone... this is so frustrating that the 'cheaper' options just don't seem to work with DOR. Sigh. I think we will carry on with our plan for donor eggs after reading your responses.....

Best of luck to everyone.

Bubby99 likes this