Jump to content



Photo
- - - - -

Anyone do PGS and have all embryos genetically abnormal


  • Please log in to reply
19 replies to this topic

#1 Sara1

Sara1
  • Member
  • 33 posts
  • Dx:Male Factor

Posted 10 December 2012 - 06:16 PM

Hi,

I am a 41 year old female. I have just gone through a fresh IVF cycle. They retrieved 18 eggs, 10 mature, 7 made it to a 5 day blast. We did preimplantation genetic screening. We went in today for transfer. I was hoping to have 1 or 2 normal embryos. The thought did occur to me that there was a possibility of getting no normal embryos. Well, there I was seated with full bladder and hospital gown on, and I found out right before the transfer that none of the embryos are genetically normal. Posted Image I have read all the gruesome stats on over 40 females and fertility, but I guess there was a part of me that was holding out hope and in denial!

My husband and I are pretty heartbroken. Has this happened to anyone? I respect other's choice to use donor egg, but we are not prepared to go that route. Has anyone had this happen and do another round of IVF with PGS and be successful? The treatments are taking a financial, physical and emotional toll, and I will go ahead if there is a decent chance, but not if the chances are close to nil. My clinic uses a genetic lab called Genesis that is located in the US (I think maybe in Detroit). Does anyone know how accurate this genetic testing is, and what the rate of false positives and negatives?


Thanks!

#2 Ira-babylover

Ira-babylover

    Ira

  • Global 100+
  • 132 posts
  • Gender:Female
  • Dx:Unexplained
  • My Clinic:PCRM

Posted 10 December 2012 - 07:38 PM

Hi
I'm really sorry, I understand your feeling completely.
In my case I had only one bad embryo to transfer. I had 14 egg, 6 fertilized, 5 arrested and the 6 th one with 6cell day 3.
Any waxy I end up with bfn. My doctor is trying to get me in thinking of getting donor egg but I am not ready for it too.
I'm fortifying myself for the next IVF. Doing mind body program. Take good supplements, CoQ10, vitamin D, royal jelly.
Please do so and I'm sure next time you will be fine. I'm doing second nod in Feb 2013.
Ill keep you posted.

#3 Myrtle

Myrtle
  • Cyclebase
  • 434 posts
  • Gender:Female
  • Dx:Unexplained
  • My Clinic:McGill

Posted 11 December 2012 - 07:52 AM

I read a news article published on this website, recently about using chromosomal screening for 40+ women and how it basically said, the ones that it deemed normal, were, but the ones deemed abnormal, well not all of them were. It was actually like 25% or something that were actually normal in the end.

We did PGD for our last cycle, and now our RE has recommended against it for the next one. I am not sure which way I want to go. We had 2 out of 11 embryos declared normal, and neither of them took. After I read that article, it did make me question whether or not we discarded one that was actually normal and could have become a child.

Here's the article:

http://ivf.ca/forums...undergoing-ivf/

See my profile for more details.  

 

Me: 42 DH: 37

DS #1 conceived naturally, born Dec. 1st, 2008

January 2010, Begin TTC #2
September 2011 start charting
April 2011 Consult with RE.
All tests normal. No problems found.
Two IUIs. BFN.
February 2012 IVF #1 -BFN.
FET July 2012- BFN.
IVF#2  Fall 2012
Hysteroscopy Tues. 8/21
PGD 2 out of 11 embryos are normal and put back in. Beta November 7th. BFN.

 

Further testing - the RPL test- results in suspected immune issues.  Recommended protocol to take baby aspirin 

and possibly steroid.

Start taking baby aspirin.

April 4th 2013. Surprise BFP, chemical pregnancy.

IVF #3 - May 2013

April 8th start BCP.  Keep taking baby aspirin.  

April 19th - start 5mg/day of dexamethasone (steroid) 

Starting weekly acupuncture April 19th.  

May 1st- blood test come back positive for hyperthyroidism.  STOP EVERYTHING.

Referral to endocrinologist.  Appointment on June 20th, 2013.  

Have a prescription for vitamin d and for propylthiouracil.  started June 26th.

Blood tests at the end of July and end of August to see if all is well.  

Doctor hinted I might be cleared to go back to IVF as soon as September.  

 

October 8th, thyroid is now fine.  Cleared to start IVF.

 

IVF #3.5 October 2013

Oct. 18th - start BCP, dexamethasone and baby aspirin.

Nov. 1st - start .5ml buserelin each night.

Nov. 4th - last BCP

Nov. 14th - 1st u/s.  

Nov. 27h - ER.  11 Eggs Retrieved.  

Nov. 28th- Embryo update:  12 eggs retrieved.  10 mature.  8 fertilized.  

Dec. 2nd 2 embryos transferred 5-d-t.  Also mild OHSS diagnosis.

Dec. 13th - Beta blood test.  BFN.

 

Done with IVFs.  

 


#4 Feisty

Feisty
  • 1000+
  • 1,469 posts
  • Gender:Female
  • Dx:N/A

Posted 11 December 2012 - 12:24 PM

I just finished my 4th IVF and we decided to do PGD because my RE was concerned about me maybe never making good eggs since I've had 2 miscarriages, 1 of which was far enough along to do genetic testing on and found to have had down syndromes. I had 16 eggs, all mature but 1 must of been no good, 14 out of 16 fertilized normally and were sent for PGD. The morning of blast transfer we found out 5 of 14 were normal (3 boys and 2 girls). One of the abnormal ones looked very good and would of been transferred if it didnt come back abnormal after PGD, this embryo had downs. The embryologist believes this is why we lost our last pregnancy, the embryo looked good but it was abnormal. This gave DH and I chills to know that if we didnt do PGD we would of suffered the same heartache that we did only a couple months earlier. We had 2 boys and 1 girl blasts transferred and I was getting faint positive hpts and had symptoms up until two days before beta. My hpts became negative, symptoms subsided and beta was considered negative. A chemical pregnancy is what I got. DH and I are going to try again in Jan 2013 and hope this next one sticks. After all the abnormalities noted on our report I would never do another ivf without PGD. I do have faith that the info provided to us was correct. We are hoping for a better outcome next time. My embryos were sent to Viagene. If you go to their website they explain and give you lots of information on PGD I hope this will help you find the answers you are looking for and I wish you all nothing short of success.
DH 40, ME 39 expecting our first (it's a girl!) 4/6/13 after 11+ yrs TTC and 4 back to back lossesI have endo, PCOS, both gene mutations MTHFR, slightly elevated thyroid,blood clotting disorder, had endometrial polyps, born with large uterine septum that was removed and urological abnormality that will cost me my kidney in a couple yrs.14 GYN surgeries, and 6 other surgeries including multiple lumbar surgeries IVF# 9 W ICSI and PGD, stims started 7/1/13, ER 7/14/139 embryos sent out for PGD 4 came back normal 2 girls & 1 boy survived andwere transferred on 7/19/13. 5DP5DT faint positive and each day getting darker.8/4/13 5 weeks emergency scan due to severe pain, shows enlarged ovaries and ruptured cyst. we also saw a tiny gestational sac, put on restrictions and basically can do nothing 8/15/13 2nd scan @ 6.4 weeks shows strong little heartbeat and enlarged ovaries, still on restrictions. 8/23 urgent scan @ 7.5 weeks for clotting and bleeding showed heart beating away and growing baby, no bleed seen in around baby or in uterus. Continue restrictions, DC baby aspirin continue all other meds including Lovenox and 4th scan scheduled for 9/4. Ended up having 6 massive bleeds and taken off Lovenox. Spent the entire first tri on bedrest. taken off PIO, Estrogen and prednisone at 12.1 weeks. First OB appt 13.1 weeks. Spotting, bleeding and some massive bleeds thru the entire 1st tri and part of the 2nd. 2nd tri had placenta previa and cervical shortening issues. Made it to 26 weeks which wasn't far enough along to have steriod injections, more rest. Made it to 28 weeks and cervix was long enough not to be too concerned, steroid injections are on hold. Was officially off bed rest @28 weeks. 30 weeks lost 8lbs. 32 weeks gained 8lbs and the start of preeclampsia. Currently being monitored very closely and seeing several specialists to find out when exactly we need to deliver. Lots of tests done and a couple ultrasounds to date (33.6 weeks) 02/22/14. After being carefully monitored several times a week DD was born via c-section 3/13/14. 5.9lbs, 18 inches, spent 6 days in NICU born @ 36 weeks

#5 My_time

My_time

    The world says give up! Hope whispers one more time

  • Cyclebase
  • 1,817 posts
  • Gender:Female
  • Dx:Other

Posted 11 December 2012 - 02:55 PM

Sara and other girls, I just read this as I am going to do PGD test with my IVF and I wanted to give you all hugs for the bad news that you got... I trully wish this was easier for all of us!

Diagnosis: Repeated Pregnancy Loss + DOR + Advance maternal Age.

So far no luck with IVF attempts. Hope things take a turn soon.

 


#6 Sara1

Sara1
  • Member
  • 33 posts
  • Dx:Male Factor

Posted 11 December 2012 - 05:40 PM

Thank you for all of you replies! Over the last year I have had an ectopic and a miscarriage, but I think this result has hit me the hardest because it has taken away a lot of hope from me.

Ira-babylover: I am sorry about your last cycle. What is royal jelly? Do you find it in the health food store? I was thinking that I should improve my overall health like diet, exercise and add supplements and anything else that may help! All the best with the cycle coming up in the new year!

Myrtle -I am sorry that your last cycle did not work out. Thanks for the link, that is very interesting and makes me wonder if one of those 7 embyos could have been normal which makes me really sad to think that that potential life was lost. I think I may forward the article to my RE and ask him what he thinks. Did your RE explain why he will not do PGD on the next cycle? Good luck on your next cycle!

GInger7- I am so sorry that your last cycle did not work. That sounds really good that you got back 5 good embryos! Why did your RE think that those 3 embryos did not take if they were chromosomally normal, did he think it was a result of not implanting? If the PGD is accurate, and having gone through the heartbreak of having lost the last pregnancy due to downs I totally understand the advantage of the PGD. I keep trying to look at the positive and think that they could have implanted 2 abnormal embryos (mine included one with downs and turner's syndrome) and I think that would have been even harder. I looked up the Viagene website. My clinic used a lab called Genesis - I think they are in detroit. But I still wish I had just 1 normal. Now, I am left wondering whether all my eggs are bad. I wish you all the best with your next cycle.

My time will come - thanks for the kind words. I wish you much success with this cycle! I agree that I wish no woman would have to go through the struggles that come with infertility.

#7 Feisty

Feisty
  • 1000+
  • 1,469 posts
  • Gender:Female
  • Dx:N/A

Posted 11 December 2012 - 10:19 PM

Sara I get to consult with my RE next week, he's out of the country. My cycle just ended with the beta on Friday. I much rather of had this chemical then have the 2 MC's I had in may and aug this year. Do you take supplements? I don't know if they really help but I'm afraid not to take them at this point. I had less eggs to work with this time and the cycle prior to this was cancelled because I had 1/2 as many eggs. At 38 in feb I might be approaching the end of my luck with my eggs. I did get valuable info from this cycle so I can't say it was a total loss. I just hope my next one brings us our one and only baby.
I hope your next cycle brings you a few normal good looking blasts to transfer!
DH 40, ME 39 expecting our first (it's a girl!) 4/6/13 after 11+ yrs TTC and 4 back to back lossesI have endo, PCOS, both gene mutations MTHFR, slightly elevated thyroid,blood clotting disorder, had endometrial polyps, born with large uterine septum that was removed and urological abnormality that will cost me my kidney in a couple yrs.14 GYN surgeries, and 6 other surgeries including multiple lumbar surgeries IVF# 9 W ICSI and PGD, stims started 7/1/13, ER 7/14/139 embryos sent out for PGD 4 came back normal 2 girls & 1 boy survived andwere transferred on 7/19/13. 5DP5DT faint positive and each day getting darker.8/4/13 5 weeks emergency scan due to severe pain, shows enlarged ovaries and ruptured cyst. we also saw a tiny gestational sac, put on restrictions and basically can do nothing 8/15/13 2nd scan @ 6.4 weeks shows strong little heartbeat and enlarged ovaries, still on restrictions. 8/23 urgent scan @ 7.5 weeks for clotting and bleeding showed heart beating away and growing baby, no bleed seen in around baby or in uterus. Continue restrictions, DC baby aspirin continue all other meds including Lovenox and 4th scan scheduled for 9/4. Ended up having 6 massive bleeds and taken off Lovenox. Spent the entire first tri on bedrest. taken off PIO, Estrogen and prednisone at 12.1 weeks. First OB appt 13.1 weeks. Spotting, bleeding and some massive bleeds thru the entire 1st tri and part of the 2nd. 2nd tri had placenta previa and cervical shortening issues. Made it to 26 weeks which wasn't far enough along to have steriod injections, more rest. Made it to 28 weeks and cervix was long enough not to be too concerned, steroid injections are on hold. Was officially off bed rest @28 weeks. 30 weeks lost 8lbs. 32 weeks gained 8lbs and the start of preeclampsia. Currently being monitored very closely and seeing several specialists to find out when exactly we need to deliver. Lots of tests done and a couple ultrasounds to date (33.6 weeks) 02/22/14. After being carefully monitored several times a week DD was born via c-section 3/13/14. 5.9lbs, 18 inches, spent 6 days in NICU born @ 36 weeks

#8 Tryinguntilsuccess

Tryinguntilsuccess
  • Member
  • 9 posts
  • Gender:Female
  • Dx:PCOS
  • My Clinic:Ontario

Posted 29 March 2014 - 05:23 PM

Hi, i know this is an old post but thats what happening to me. I am 42, single. ttc 1 year, 1st ivf, 5 made to day 5. All were abnnormal with pgs. I am thankful i did not transfer. I am out of money and almost out of hope. Any one of you did you try again, how were the results again? Thank you

#9 manhattangirl

manhattangirl
  • Global 100+
  • 183 posts
  • Gender:Female
  • Dx:DOR

Posted 29 March 2014 - 10:05 PM

Hi Trying,

 

I don't have anything very useful to say but I want to at least send you a cyber hug. 

Did you use a sperm donor?  Is there a chance that the donor was the issue?


Me 41, Husband 38

DX:  AMA, DOR

TTC since 5/27/15

Egg freezing: March 2014

7/2/16- natural BFP


#10 ideagirl

ideagirl
  • Global 100+
  • 261 posts
  • Gender:Female
  • Dx:N/A
  • My Clinic:CCRM (Denver, CO)

Posted 30 March 2014 - 10:41 AM

Yes, it happened to us. I'm so sorry it happened to you. I know how hard it is.

 

After it happened to us--I was 41--we moved on to egg donor and I'm now in my second trimester with twins. It's wonderful!

 

If you do CCS or CGH testing (the type of PGD that's normally done on blasts, which tests all 23 chromosomes), the error rate (false negative or positive) is only about 3%. If you do PDG that does NOT test all 23 chromosomes--some tests only look at the ones that are most commonly a problem, such as 21 (Down's) and a few others--the false positive rate is higher because other chromosomes that don't get tested could be bad. When we did CCS none of the bad chromosomes were the common ones--if we'd just done PGD to test the common ones, we would have gotten false positives.

 

Our RE told us that once you've had an all-abnormal cycle, doing one more cycle can make sense, but if that second cycle is also all-abnormal, the chances of any normals after that are so incredibly small that in her view it is unethical for a clinic to do a third cycle.


  • mouse likes this

#11 Pegmraul06

Pegmraul06
  • Member
  • 4 posts
  • Dx:N/A
  • My Clinic:Hrc

Posted 23 February 2017 - 12:15 PM

Hi Sara1, I know this is an old post but was wondering if you can give us an update as I also experienced all abnormal embryos yesterday. It was my first ivf and I am 42 I had 1 miscarriage 5 yrs ago. We had 12 egg retrieved, 3 survived and only 2 biopsy on day 5. Both were abnormal and no transfer was done. I look forward to your response. Thanks

#12 Hopefulrealist

Hopefulrealist
  • Global 100+
  • 583 posts
  • Gender:Female
  • Dx:Male Factor
  • My Clinic:TRIO

Posted 23 February 2017 - 12:58 PM

Hey Peg,

I had this same thing happen our first IVF cycle. We sent 6 embryos for transfer and none were normal (various abnormalities in different chromosomes). We were shocked that this could happen at age 32 with no explanation. We repeated IVF /PGS and got 2 out of 9 normal embryos. I did one transfer which was BFN unfortunately. I have one left so still hoping for a happy ending.

Some women do a few banking cycles if you can afford it. Most places allow up to 8 blasts to be tested for the the same price (but you have to pay for each IVF cycle obviously). If you have the resources it might make sense to try again.
  • Pegmraul06 likes this

Me- 32 33, DH - 33 34

 

2 Failed IUIs (2015). 1 Failed IVF (April 2016). IVF#2- Sept 2016 (Freeze all). FET#1 Jan 2017 - BFN.


#13 sunnyside2020

sunnyside2020
  • Member
  • 17 posts
  • Dx:Unexplained

Posted 23 February 2017 - 09:52 PM

I went to a good clinic in Toronto. At age 38, I had 5 blastocysts and only 1 was PGS normal. 

Unfortunately, this embryo split and I miscarried at 7.5 weeks.

 

2 of the 5 blasts were deemed 'chaotic profile'.

 

I had a consult with RMA in USA (one of the best clinics) and they told me that they never get that kind of a reading 'chaotic profile'.  So those 2 could have been normal but they didn't get a reading on them.  That's unfortunate to know. I wanted to see if those could be tested now, but I think that it's too late?

 

I don't know how quickly these clinics dispose/experiment with embryos like this.....


  • Pegmraul06 likes this

#14 returnable

returnable
  • 1000+
  • 1,904 posts
  • Gender:Female
  • Location:Whitby, ON
  • Interests:running, cooking, gardening, travelling
  • Dx:DOR
  • My Clinic:Trio, cycle monitoring at Lakeridge

Posted 24 February 2017 - 08:01 AM

Our first IVF round we ended up with one blastcosyst but unfortunately it ended up being chromosomally abnormal. Our second and last IVF we just got one blastocyst as well and are waiting for our PGS results. For us if this one doesn't work out, we are ready to move on to DE. I am sure I will still have my moments of sadness, but I do really want to be a parent.


Two IVFs and no chromosomally normal blasts to transfer...we are done with my eggs.


#15 Pegmraul06

Pegmraul06
  • Member
  • 4 posts
  • Dx:N/A
  • My Clinic:Hrc

Posted 24 February 2017 - 03:45 PM

Hey Peg,

I had this same thing happen our first IVF cycle. We sent 6 embryos for transfer and none were normal (various abnormalities in different chromosomes). We were shocked that this could happen at age 32 with no explanation. We repeated IVF /PGS and got 2 out of 9 normal embryos. I did one transfer which was BFN unfortunately. I have one left so still hoping for a happy ending.

Some women do a few banking cycles if you can afford it. Most places allow up to 8 blasts to be tested for the the same price (but you have to pay for each IVF cycle obviously). If you have the resources it might make sense to try again.

 

Thank you for your response.  We found out yesterday the PGS results were poor quality eggs due to my age.   We have decided to do one more round of IVF but first I'm going to try improving my egg quality naturally for the next few weeks.  My husband is not convinced on using an egg donor but maybe he'll change his mind later.  I have an older son so I wouldn't mind using an ed.   Sending you good vibes for this next transfer!!!!



#16 Pegmraul06

Pegmraul06
  • Member
  • 4 posts
  • Dx:N/A
  • My Clinic:Hrc

Posted 24 February 2017 - 03:47 PM

I went to a good clinic in Toronto. At age 38, I had 5 blastocysts and only 1 was PGS normal. 

Unfortunately, this embryo split and I miscarried at 7.5 weeks.

 

2 of the 5 blasts were deemed 'chaotic profile'.

 

I had a consult with RMA in USA (one of the best clinics) and they told me that they never get that kind of a reading 'chaotic profile'.  So those 2 could have been normal but they didn't get a reading on them.  That's unfortunate to know. I wanted to see if those could be tested now, but I think that it's too late?

 

I don't know how quickly these clinics dispose/experiment with embryos like this.....

Hi I am new to this terminology but I have not heard of chaotic profile.  I'm pretty sure they dispose immediately, as that is what I was told by my office. I also which they could freeze but I guess they know what they are doing.  Wishing you all the best!!



#17 returnable

returnable
  • 1000+
  • 1,904 posts
  • Gender:Female
  • Location:Whitby, ON
  • Interests:running, cooking, gardening, travelling
  • Dx:DOR
  • My Clinic:Trio, cycle monitoring at Lakeridge

Posted 24 February 2017 - 03:54 PM

 

 

 

How do you intend to improve your eggs? Our RE said that any changes in supplements will take at least 3 months to have an effect? Any way you can delay your next IVF?


Two IVFs and no chromosomally normal blasts to transfer...we are done with my eggs.


#18 Pegmraul06

Pegmraul06
  • Member
  • 4 posts
  • Dx:N/A
  • My Clinic:Hrc

Posted 24 February 2017 - 04:24 PM

 

 

 

 

How do you intend to improve your eggs? Our RE said that any changes in supplements will take at least 3 months to have an effect? Any way you can delay your next IVF?

Yes, that is true, most supplements take a couple of months to have an affect.   I have been in the Nutraceutical Industry for over 20 yrs and very familiar with most supplements.  I have been taking most for a few months, but will add a couple more to see if it makes a difference.  I will also continue acupuncture.  I started 2 wks into my IFV so this time I hope it helps more since I plan on waiting at least 2 months.   if I do it for the next couple of months it will play a better role.  My acupuncturist seems to be extremely knowledgeable in infertility so that helps.  I will also stop drinking alcohol which I did not stop until before the retrieval.  I was drinking about 2-3 glasses of wine per week, mostly on weekends so I will stop that.  

Here is a list of supplements that I have been taking.  You can research them. I also try to buy the Jarrow brand as I worked for them up to last Sept before I quit to prep for IVF process.  I did all the Sourcing and they are all about quality and science based brands, no Chinese brands as much as possible. 

So here is what I will be taking.  Underlined Is what I will be adding. 

  • CoQ10  Ubiquinol not Ubiquinone.  I took this for about 2 wks before my transfer so now I will take consistently moving forward.  Make sure you buy a brand that you see that uses Kaneka material (it'll reference it on the back of bottle) as that is the one with studies some others are Chinese and it is not the same. 
  • DHA- I use the Jarrow Brand DHA MAX 
  • Prenatal I don't use their brand as they are not strong with multi's, but I do make sure the B12 in the prenatal is Methyl and not Cyano.
  • Melatonin, from Trader Joes or any brand.  I have done some research and found that there are studies that this helps with IVF.
  • Bromelain, which helps with implantation.
  • Royal Jelly   I have not read studies but it seems to have good feedback from women.
  • Methyl folate  Once again I like the  Jarrow brand as it is most biologically active form of folic acid.
  • DHEA I will do some further research and see if it is something I should consider. 

thanks for your feedback. 

 

 



#19 Kris10cdn77

Kris10cdn77
  • Member
  • 11 posts
  • Gender:Female
  • Location:Canadian in Los Angeles
  • Dx:Unexplained
  • My Clinic:Reproductive partners

Posted 24 February 2017 - 11:30 PM

I suggest reading or listening to the book on improving egg quality "It Starts with an Egg". Wish I read it long before my first cycle. It tells you what the supplements do and what studies have been done on each. It tells you a lot more than that...

 

In short it suggests (but don't skip they book, it's amazing):

Vitamin E

Vitamin C

Selenium

Ubiquinol

Alpha Lipoic Acid

Zinc

Melatonin

Prenatal

Mediterranean diet


  • Pegmraul06 likes this

Kristen (39) Natural Pregnancy June 2014, Chemical. Natural Pregnancy September 2014, mc// 2015: 2 climid w TI: BFN, 3 IUI: BFN// 2016: Natural Pregnancy, Ectopic w tube removal. IVF#1 Canceled, not enough follies. IVF#2 micro flare 23 eggs =5 blasts= 1 PGS normal. IVF#3 16 eggs=4 blasts=1 PGS Normal. 1st Transfer cancelled day before bc high thyroid. Transferred in Nov 2016 1 PGS embaby, mmc @ 8 weeks. Still have one PGS embaby on ice. Coming Soon: Fresh IVF + fresh Transfer, no PGS.

#20 LittleFlame

LittleFlame
  • Member
  • 39 posts
  • Gender:Female
  • Location:DC
  • Dx:Other
  • My Clinic:SGF

Posted 25 February 2017 - 09:00 AM

Hello all,

I would agree with others that different cycles can have wildly different outcomes and that the first cycle can often be the most disappointing as the docs figure out how your ovaries work and best respond to meds. I know my first retrieval resulted as no PGS normal blasts - the two fresh (not tested) blasts transferred resulted in only a chemical pregnancy, which is most likely due to abnormalities and once  we had the lone frozen blast tested, it was abnormal. In round 2, 1 of the 2 was normal, and round 3, 3 of the 8 were normal.  Unfortunately, 1 did not survive the thaw,  and none of the other 3 resulted in a successful pregnancy. For the last round, I ate a higher protein diet ( esp plant based proteins), organic foods, Omegas, etc. In retrospect, I wish that I been taking COQ10/Ubiquinol at that time. Even my very conservative clinic, who basically will recommend nothing unless there is substantial serious science behind, started recommending a pre-conception multi-vitamin that includes COQ10 but only after we had finished with fertility treatments. 

 

Good luck everyone. These forums were a critical source of support when we were in the midst of fertility treatments, and even now as I struggle with accepting that it is over.


2010: At age 37, fall in love with husband (36). Start discussing adoption immediately as I am assume I can't get pregnant at my age and because I have always had very irregular and infrequent cycles  - will be diagnosed with PCOS in 2014. Spontaneous (and obviously completely astonished at our luck) pregnancy.

2011(38) : Get married and our son is born. 

2012 (39): TTC for a sibling

2013 (40) : 4 rounds of clomid prescribed by Ob/Gyn

2014 (41): Referred to fertility specialist. Diagnosis - Advanced age and PCOS. 3 failed IUIs

2015 (42): Start IVF

May 2015: IVF#1 - 29 retrieved, 19 mature, 10 fertilized. 2 5-day blasts transferred (Assisted Hatching -AH used). 1 frozen (testing later revealed it was abnormal)

Chemical Pregnancy that ends in June.

Good to know the process itself works, but decide to bank & do PGS testing in 2 more rounds to try to find a good egg and avoid another painful emotional battle of hope and despair when a pregnancy is not viable. 

October 2015: IVF Retrieval #2 - 19 retrieved, 12 mature, 7 fertilize w/ICSI, 2 frozen, 1 normal.

Nov-Dec 2015: Freak out that out of almost 50 eggs, only 1, 1! made it to a chromosomally normal embryo. Start avoiding phalates, eating more plant-based proteins, and doing anything else I can find, legitimate or not, that promises to increase egg quality. It's a dark time. 

December 2015: IVF Retrieval #3 - 31 retrieved, 24 mature, 21 fertilized w/ICSI, 8 frozen, 3 normal

 2016 (43) : Start FETs

March 24, 2016: FET# of 1 blastocyst. BFN.

May 19, 2016: FET #2 of 1 blastocyst. BFN

July 20, 2016: FET #3. Planned to transfer 2 blasts, only 1 survived the thaw. Positive. Lost pregnancy just past 6 weeks.

No more Fertility treatments.