I actually sought out this dx, because after 14yr of TTC, dh and I have had 3 ivf, 1 resulting in twins. I wanted my dr to expand his treatment plan for me, and since I am 38 now, and only have one ovary, DOR makes sense. We have decided to try DHEA, and a flare protocol. What can you ladies tell me about flare protocols?
New Dx of DOR
Started By
snowmom
, Jul 26 2012 02:58 PM
succesx ment. failure ment. DHEA? flare protocol?
7 replies to this topic
#1
snowmom
-
- Cyclebase
-
- 2067 posts
Raving Lunatic
- Gender:Female
- Dx:Tubal
- My Clinic:VFC
Posted 26 July 2012 - 02:58 PM
Me 40: Total tubal blockage, 1 ovary, DOR DH 35: Poor motilityTTC since 1998DS natural conception 1996DS&DD ivf icsi 2008DS ivf icsi 2013.Our family is complete.Donated four frosties. IP's got bfp!
#2
lm501
-
- Global 100+
-
- 184 posts
- Gender:Female
- Location:Toronto
- Dx:Endometriosis
Posted 26 July 2012 - 08:10 PM
I don't have any advice on the flare protocol. There is a chat in area 51 for poor responders I'm sure some of the women there will be able to help. I also have DOR, but I did an estrogen priming cycle in the Spring which unfortunately didn't work but I responded better than they expected.
Good luck with the DHEA and new protocol.
Good luck with the DHEA and new protocol.
Me: 42 and DH: 41
8 failed IUI's
Lap discovered Endo Stage 4 & tubes not working b/c of scar tissue
IVF/ICSI #1 with 3 blasts 2 transferred one frozen - Chemical pregnancy July 2007
IVF #2 cancelled due to poor response Fall 2007
IVF/ICSI #3with 2 good blasts BFN - January 2008
FET #1 - One transferred BFP!!! October 2008
DS Born 2009
Natural pregnancy (it's actually possible??) miscarriage at 7 weeks June 2011
IVF #4 - EPP - 450 gonal -f 75 Luveris - 3 embryos 2 put back on a 3DT - BFN - no frosties May 2012
IVF DE #1 Dec 2013 - Blighted Ovum D&C 9 weeks 3 frosties FET DE #1 June 2013 - slow growth weak HB at 7 weeks, gone at 9 weeks...2 frosties FET DE #2 June 2014 - 2 Blasts transferred....Ectopic.....Methotrexate shot 10 weeks....
8 failed IUI's
Lap discovered Endo Stage 4 & tubes not working b/c of scar tissue
IVF/ICSI #1 with 3 blasts 2 transferred one frozen - Chemical pregnancy July 2007
IVF #2 cancelled due to poor response Fall 2007
IVF/ICSI #3with 2 good blasts BFN - January 2008
FET #1 - One transferred BFP!!! October 2008
DS Born 2009
Natural pregnancy (it's actually possible??) miscarriage at 7 weeks June 2011
IVF #4 - EPP - 450 gonal -f 75 Luveris - 3 embryos 2 put back on a 3DT - BFN - no frosties May 2012
IVF DE #1 Dec 2013 - Blighted Ovum D&C 9 weeks 3 frosties FET DE #1 June 2013 - slow growth weak HB at 7 weeks, gone at 9 weeks...2 frosties FET DE #2 June 2014 - 2 Blasts transferred....Ectopic.....Methotrexate shot 10 weeks....
#3
AnnieM
-
- Member
-
- 20 posts
- Gender:Female
- Location:Calgary
- Dx:DOR
- My Clinic:Regional Fertility Program/Foothills
Posted 06 January 2013 - 01:16 AM
On Dec. 11 I was diagnosed with DOR. I am 29 and TTC #1. My AFC was only 5 and my FSH was 9 (a bit elevated for my age). I forget my estradiol level, but it was within normal range. AMH wasn't tested. I was (still sometimes am) crushed, but this forum is giving me hope.
Me: 29 DH: 31
TTC#1
Diagnosed with DOR on Dec 11, 2012
AFC = 5
FSH = 9
Have tried acupuncture, herbs, supplements, preseed, OPKs, BBT, and checking cervical position and mucus
Planning on proceeding with IVF (max of 3 rounds because of finances)
TTC#1
Diagnosed with DOR on Dec 11, 2012
AFC = 5
FSH = 9
Have tried acupuncture, herbs, supplements, preseed, OPKs, BBT, and checking cervical position and mucus
Planning on proceeding with IVF (max of 3 rounds because of finances)
#4
leigh14
-
- Cyclebase
-
- 1454 posts
- Gender:Female
- Dx:Immunological
- My Clinic:Markham
Posted 06 January 2013 - 04:17 AM
Just remember that you need one good one! I had an AFC of 4 and had two eggs retrieved and have one beautiful daughter!
Me: 40
Dx: DH: Vasectomy; need IVF/ICSI ME: D.O.R. and many immunological issues. (Initially presented as "normal" but issues were only discovered after IVF attempt #2 and #3 after testing at new clinic)
IVF attempt #1 Nov.2009, Age 37: Long "Lupron" protocol
Dec.2009: Cycle cancelled due to oversuppression
IVF attempt #2, Age 38: April 2010: 3 eggs retrieved, 2 mature, 2 fertilized, ET of 2 embryos BFN
IVF atempt #3 at new clinic: November 2010, Age 38: 5 eggs retrieved, 4 mature, 4 fertilized, ET of 2 blastocysts BFP
Strong beta numbers but babies not measuring on track but one heartbeat is present. Followup u/s reveals no HB's
Had D&C--so sad.
Moved to new clinic closer to home + more of a focus on testing for potential immunological factors:
Further testing reveals three mutations related to inherited thrombophilia (2 MTHFR mutations and PA1-1 mutation), positive ANA, elevated NK cells and cytokines and low levels of leukocyte antibodies (LADS), Recommended Immunological treatment: Humira, LIT, IVig and blood thinners if PG
IVF Protocol: Low stim for me/ TESE needed for DH; took Humira in late August and early September; taking DHEA plus Co-Enzyme Q10, vitamins for DH just for good measure! September--two trips to Mexico for LIT treatment, treatments 3 weeks apart
Initial re-testing through Alan Beer Centre after some of the immune treatments reveals only cytokines were lowered, NKs still high and LAD numbers still low. Another LIT in Mexico is recommended. We decide to begin cycle on doctor's recommendation of just doing IVIG.
IVF#4, Age 39 : November 2011: Worst AFC EVER--a whopping 4! Three follicles responded, two eggs were retrieved. Three day transfer of two Grade 1 8 cell embryos: "Fahita" & "Burrito" Stick, stick, stick little ones!
BFP! Beta of 569
Viability u/s at 6 w 2d shows TWO babies measuring on track with heartbeats of 121. Looks like babies might be sharing the same amniotic sac.
Second u/s at 7w 2 d shows ONE baby with hb of 150, measuring 7 w 3 days. No sign of twin. Vanishing twin syndrome?
Third u/s at 8 w 2d shows ONE baby with hb of 170, measuring 8 w 3 days. Looks like a little jellybean!
12 week u/s at 12 w 2 days and baby is measuring 12 w 5 days with a heart beat of 150. Baby mooned us and waved at us with one hand....looked like a "royal" wave to me!
13 week doctor's appointment, HB=155 on doppler
14 week u/s to check cervix, HB=148
16 week u/s to check cervix, HB=138, baby had hiccups!
20 week u/s--everything looks good! HB=130, looks like we're having a GIRL!
IPS results very good!
39 weeks: Our baby girl arrived!!! She is healthy and beautiful! We are so happy!
Dx: DH: Vasectomy; need IVF/ICSI ME: D.O.R. and many immunological issues. (Initially presented as "normal" but issues were only discovered after IVF attempt #2 and #3 after testing at new clinic)
IVF attempt #1 Nov.2009, Age 37: Long "Lupron" protocol
Dec.2009: Cycle cancelled due to oversuppression
IVF attempt #2, Age 38: April 2010: 3 eggs retrieved, 2 mature, 2 fertilized, ET of 2 embryos BFN
IVF atempt #3 at new clinic: November 2010, Age 38: 5 eggs retrieved, 4 mature, 4 fertilized, ET of 2 blastocysts BFP
Strong beta numbers but babies not measuring on track but one heartbeat is present. Followup u/s reveals no HB's
Had D&C--so sad.Moved to new clinic closer to home + more of a focus on testing for potential immunological factors:
Further testing reveals three mutations related to inherited thrombophilia (2 MTHFR mutations and PA1-1 mutation), positive ANA, elevated NK cells and cytokines and low levels of leukocyte antibodies (LADS), Recommended Immunological treatment: Humira, LIT, IVig and blood thinners if PG
IVF Protocol: Low stim for me/ TESE needed for DH; took Humira in late August and early September; taking DHEA plus Co-Enzyme Q10, vitamins for DH just for good measure! September--two trips to Mexico for LIT treatment, treatments 3 weeks apart
Initial re-testing through Alan Beer Centre after some of the immune treatments reveals only cytokines were lowered, NKs still high and LAD numbers still low. Another LIT in Mexico is recommended. We decide to begin cycle on doctor's recommendation of just doing IVIG.
IVF#4, Age 39 : November 2011: Worst AFC EVER--a whopping 4! Three follicles responded, two eggs were retrieved. Three day transfer of two Grade 1 8 cell embryos: "Fahita" & "Burrito" Stick, stick, stick little ones!
BFP! Beta of 569
Viability u/s at 6 w 2d shows TWO babies measuring on track with heartbeats of 121. Looks like babies might be sharing the same amniotic sac.
Second u/s at 7w 2 d shows ONE baby with hb of 150, measuring 7 w 3 days. No sign of twin. Vanishing twin syndrome?
Third u/s at 8 w 2d shows ONE baby with hb of 170, measuring 8 w 3 days. Looks like a little jellybean!
12 week u/s at 12 w 2 days and baby is measuring 12 w 5 days with a heart beat of 150. Baby mooned us and waved at us with one hand....looked like a "royal" wave to me!
13 week doctor's appointment, HB=155 on doppler
14 week u/s to check cervix, HB=148
16 week u/s to check cervix, HB=138, baby had hiccups!
20 week u/s--everything looks good! HB=130, looks like we're having a GIRL!
IPS results very good!
39 weeks: Our baby girl arrived!!! She is healthy and beautiful! We are so happy!
#5
silverdollar
-
- Cyclebase
-
- 3483 posts
- Gender:Female
- Location:Vancouver Island, BC
-
Interests:Outdoor sports and activities of all types.
Kids, sewing, photography, cooking, growing stuff in my garden. - Dx:DOR
- My Clinic:Victoria Fertility Centre
Posted 06 January 2013 - 08:27 AM
I was diagnosed with DOR at 31 and can relate to how devastating it is especially at such a young age. Please don't lose hope as Leigh said. When you are younger you might have less eggs to work with, but the ones you have are still of good quality. It can sometimes take some tinkering to get the right protocol, but doesnt mean you can't be successful. Hang in there.
Unexplained IF/ DOR. Began TTC in 2008.
After a wild and crazy ride on the treatment train, our baby GIRL arrived on Jan 6, 2012
Hold on.... Surprise spontaneous just 7 months postpartum while still breastfeeding!!! Baby boy born May 2, 2013
My heart couldn't be more full
Full details are now in my profile "About Me" page
#6
AnnieM
-
- Member
-
- 20 posts
- Gender:Female
- Location:Calgary
- Dx:DOR
- My Clinic:Regional Fertility Program/Foothills
Posted 06 January 2013 - 12:23 PM
I have read about the quality likely being better a couple times. Is that a typical finding? I have been so scared that my low number also meant poor quality.
Me: 29 DH: 31
TTC#1
Diagnosed with DOR on Dec 11, 2012
AFC = 5
FSH = 9
Have tried acupuncture, herbs, supplements, preseed, OPKs, BBT, and checking cervical position and mucus
Planning on proceeding with IVF (max of 3 rounds because of finances)
TTC#1
Diagnosed with DOR on Dec 11, 2012
AFC = 5
FSH = 9
Have tried acupuncture, herbs, supplements, preseed, OPKs, BBT, and checking cervical position and mucus
Planning on proceeding with IVF (max of 3 rounds because of finances)
#7
silverdollar
-
- Cyclebase
-
- 3483 posts
- Gender:Female
- Location:Vancouver Island, BC
-
Interests:Outdoor sports and activities of all types.
Kids, sewing, photography, cooking, growing stuff in my garden. - Dx:DOR
- My Clinic:Victoria Fertility Centre
Posted 06 January 2013 - 09:25 PM
Quality is much more related to age than to numbers of eggs. Treating a 29 year old DOR patient the same as a 40 year old is not appropriate because its very different.
Unexplained IF/ DOR. Began TTC in 2008.
After a wild and crazy ride on the treatment train, our baby GIRL arrived on Jan 6, 2012
Hold on.... Surprise spontaneous just 7 months postpartum while still breastfeeding!!! Baby boy born May 2, 2013
My heart couldn't be more full
Full details are now in my profile "About Me" page
#8
#3@44
-
- Cyclebase
-
- 492 posts
- Gender:Female
- Dx:Other
- My Clinic:PCRM
Posted 07 January 2013 - 12:25 AM
Flare worked for me. See my signature. Best to you.
Me - 44, DH - 45
3 CONSECUTIVE IVF CYCLES AT 43 YEARS OLD = 16 eggs > 13 embryos > 10 transferred > 1 BABY!!!!
Years of anovulation (but this has saved me some eggs for my 40's!) and decreased count/motility.
4 years of trying naturally and tests - then surprise pregnancy in 2003, DD born 11/2003
6 cycles of clomid/iui - BFN, 2 cycles of FSH/IUI - x2 chemical pregnancy, 1 cycle of FSH/IUI - bfp! DS born 08/2006
2009 I decide I want another. Crazy I know - DH has had Vx.
2012 DH finally on board. Has TESE (super ouch).
03/12 and 04/12: FSH = 5, AFC = 4
IVF#1 - June 2012 - long lupron, 300 Bravelle, 150 Menopur, ICSI - 10 follicles, 3 eggs (WTF??), 2 fertilized, transferred 2 Day 3 4-cells - bfn.
IVF#2 - Aug/Sept 2012 - flare, 450 Bravelle, ICSI, 5 eggs, 4 fertilized, transferred 4 (2 8-cell, 2 10-cell) - chemical
IVF#3 - LAST CHANCE FOR ROMANCE![/b]
Oct/Nov 2012 - flare, lupron BID, 450 Bravelle, ICSI
Sept 15 - start BCP
Oct 11 - endo biopsy
Oct 14 - last BCP
Oct 17 - baseline: E2=286, start lupron microdose twice daily
Oct 19 - start 450 Bravelle
Oct 24 - U/S: 7 10mm follicles, bw: E2=964
Oct 26 - U/S, bw 9 follicles (all 10 -16mm), bw: E2=1867, lining: 9mm
Oct 28, u/s, bw 9 follicles (1 @10mm, 7 @16-17mm, 1 @23.5mm), bw: 3600+, lining: 10mm
Oct 29, u/s, bw 9 follicles (1 @12mm, 8 @18-21mm), bw: 5500+, lining: 10mm - trigger AND 450 Bravelle!
Oct 31 - ER 8 eggs!
Nov 1 - 7 fertilised!
Nov 2 - three grade 2 (all 4-cell), two grade 3 (2-cell and 5-cell) and two grade 4 (all 5-cell)
Nov 3 -two grade 2 (all 8-cell), four grade 3 (8-cell and 10-cell) and one grade 4 (6-cell)
Nov 4 - four good morulas, one border-line quality morula, two 10-cell embies
Nov 5 - ET of 2 blasts (2BB, 3BA), one cavitating morula and one other crap morula - NO FROSTIES!
Nov 10 - Day 10 - HPT ---- BFP!
Nov 14 - beta = 78
Nov 16 - beta = 179
Dec 7 - first u/s! 7w2d: CRL=10mm, HR=139
Dec 11 - first appt w/ high risk OB & another in office u/s (all good)
Dec 18 - u/s 8w6d: CRL=21mm, HR=172
Dec 27 - genetic testing and consult
Jan 11 - nuchal testing and IPS with soft markers (FTS) (for fun as will have already done NIPS) - NT=1.19mm = PERFECT
Jan 21 - 13w5d on u/s - we are having a boy!!!!!
July 24 - due! induced on July 6th - healthy, 7 lbs 2 oz at 37w3d - can't believe this happened!!
3 CONSECUTIVE IVF CYCLES AT 43 YEARS OLD = 16 eggs > 13 embryos > 10 transferred > 1 BABY!!!!
Years of anovulation (but this has saved me some eggs for my 40's!) and decreased count/motility.
4 years of trying naturally and tests - then surprise pregnancy in 2003, DD born 11/2003
6 cycles of clomid/iui - BFN, 2 cycles of FSH/IUI - x2 chemical pregnancy, 1 cycle of FSH/IUI - bfp! DS born 08/2006
2009 I decide I want another. Crazy I know - DH has had Vx.
2012 DH finally on board. Has TESE (super ouch).
03/12 and 04/12: FSH = 5, AFC = 4
IVF#1 - June 2012 - long lupron, 300 Bravelle, 150 Menopur, ICSI - 10 follicles, 3 eggs (WTF??), 2 fertilized, transferred 2 Day 3 4-cells - bfn.
IVF#2 - Aug/Sept 2012 - flare, 450 Bravelle, ICSI, 5 eggs, 4 fertilized, transferred 4 (2 8-cell, 2 10-cell) - chemical
IVF#3 - LAST CHANCE FOR ROMANCE![/b]
Oct/Nov 2012 - flare, lupron BID, 450 Bravelle, ICSI
Sept 15 - start BCP
Oct 11 - endo biopsy
Oct 14 - last BCP
Oct 17 - baseline: E2=286, start lupron microdose twice daily
Oct 19 - start 450 Bravelle
Oct 24 - U/S: 7 10mm follicles, bw: E2=964
Oct 26 - U/S, bw 9 follicles (all 10 -16mm), bw: E2=1867, lining: 9mm
Oct 28, u/s, bw 9 follicles (1 @10mm, 7 @16-17mm, 1 @23.5mm), bw: 3600+, lining: 10mm
Oct 29, u/s, bw 9 follicles (1 @12mm, 8 @18-21mm), bw: 5500+, lining: 10mm - trigger AND 450 Bravelle!
Oct 31 - ER 8 eggs!
Nov 1 - 7 fertilised!
Nov 2 - three grade 2 (all 4-cell), two grade 3 (2-cell and 5-cell) and two grade 4 (all 5-cell)
Nov 3 -two grade 2 (all 8-cell), four grade 3 (8-cell and 10-cell) and one grade 4 (6-cell)
Nov 4 - four good morulas, one border-line quality morula, two 10-cell embies
Nov 5 - ET of 2 blasts (2BB, 3BA), one cavitating morula and one other crap morula - NO FROSTIES!
Nov 10 - Day 10 - HPT ---- BFP!
Nov 14 - beta = 78
Nov 16 - beta = 179
Dec 7 - first u/s! 7w2d: CRL=10mm, HR=139
Dec 11 - first appt w/ high risk OB & another in office u/s (all good)
Dec 18 - u/s 8w6d: CRL=21mm, HR=172
Dec 27 - genetic testing and consult
Jan 11 - nuchal testing and IPS with soft markers (FTS) (for fun as will have already done NIPS) - NT=1.19mm = PERFECT
Jan 21 - 13w5d on u/s - we are having a boy!!!!!
July 24 - due! induced on July 6th - healthy, 7 lbs 2 oz at 37w3d - can't believe this happened!!
Your Privacy Choices