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DH: poor morphology - IUI or IVF/ISCI?

morphology IUI IVF ICSI

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#1 thistooshallpass

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Posted 27 January 2012 - 09:14 PM

Hello,

It is my first post here, and I am looking for some advice and feedback from those who have been (or who currently are) in a similar situation.

My DH is in his late 20s: poor sperm morphology as per Kruger testing (4.1%) but all other parameters were normal. I am also in my late 20s with stage 1-2 endometriosis outside of the uterus (eradicated with surgery) and low ovarian reserve for my age (AFC on US was normal, but blood testing proved otherwise, but still within moderate range). We have been TTC for 21 months, with no luck whatsoever, even after my surgery.

Our fertility specialist has given us our options for ART: either IUI or IVF with ICSI. He gave us some general information and statistics, but am wondering if IUI would be worth the try given the morphology results, or would it just be best to go directly with IVF? My DH would like to go on a less invasive route to begin with, but if success rate for IUI is low, I would rather save our time and energy for something that could yield a better success rate...

Thank you for your help Posted Image

#2 feydruss

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Posted 27 January 2012 - 09:26 PM

We thought exactly the same way you did, and went straight to IVF/ICSI.

3rd cycle was the charm (despite everything going wrong)!
History and details in my profile
Twin boys Milan and Duncan born at 32w4d on 15 November 2010


#3 Wish

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Posted 27 January 2012 - 09:47 PM

We concieved twice with IUI (once with clomid and once with gonal-f) both ending in miscarriage. I am now 29 weeks pregnant with twins after IVF/ICSI.
Good Luck with whatever you decide.
Me 36yrs DH 35yrs
Furbabies - Peanut and Cashew (cats)
Aug. 2007 to Aug. 2009
2 IUI unmedicated
4 IUI clomid
1 bfp
m/c May 2008
Moved on to injectibles
Nov. 2009 BFP
Dec. 29/09 u/s shows blighted ovum. m/c later in the evening.
Jan. 20/10 D&C
Feb/Mar/Apr..... waiting game, hopefully back at the clinic in May
May 2010 IUI, BFN
Sept 2010 IUI.... BFN ended up with hemorrahgic cyst on rt. ovary start BCP so cyst doesn't get any bigger.
Nov. 2010 IUI BFN
Apr. 2011 IVF cancelled, converted to IUI BFN
July 24/11 ER
July 28/11 ET
Aug. 7/11 Beta 256
Aug. 8/11 Beta 542
Aug. 13/11 Beta 2483
U/S Aug. 30/11 shows 2 healthy babies!!! Baby A hb 124 Baby B hb 130
March 23/12 Babies are here!! 36 weeks 5 days
Welcome to the world! Samuel Marcel & Nathan Thomas

#4 Dr. Tamer Said

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Posted 30 January 2012 - 08:06 AM

The sperm morphology result (4%) should be considered as borderline not poor. It may be worth considering IUI cyclesX3 before proceeding to ICSI.

Best wishes.
Tamer M. Said, MD, PhD, HCLD(ABB)
Director, Andrology Laboratory & Reproductive Tissue Bank
The Toronto Institute for Reproductive Medicine - ReproMed
56 Aberfoyle Crescent, Suite 300
Toronto, ON M8X 2W4
Email: tsaid@repromed.ca

#5 Heregoesnothing

Heregoesnothing

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Posted 27 February 2012 - 08:28 PM

Dr. Tamer, when should we consider ICSI?

"Courage doesn't always roar. Sometimes, courage is the tiny voice at the end of the day saying, 'I will try again tomorrow'"

Me: 33 - DH: 34
Dx: Male Factor


IVF #1 - March 2012
Egg Retrieval: Only 5 wee-guys - 3 fertilized - None of them survived... cycle cancelled.


IVF #2 June 2012
Retrieval: 13 eggs - 5 fertilized - transferred two grade A embryos on Day 3.
One blast at day 6 - but not good enough quality to freeze - th_abfn.gif


IVF #3 - August 2012
Retrieval - 15 eggs retrieved, 14 fertilized - Transferred 2 blasts. None to freeze -
Aug. 27th: BFP
May 6th, 2013
Our baby boy is born with 10 fingers and 10 toes!


(See my profile page for more details)

______________________________________________________________________________________________________

IVF 2.0 - The Quest for Sibling Begins

IVF #4 - March 2014
Egg retrieval: 4 eggs - 3 fertilized
Day 3: 2 left - 1- 6 cells - 1 - 8 cells
Day 5: Cycle cancelled. Both embryos have stopped developing.


IVF #5: June 2014
Retrieved 9 - 8 mature.
Day 3: 4 embryos ranging from 5-7 cells. Not very hopeful at this point.
Hoping for a day 5 blast to transfer...

Day 5:  Embryologist called - there are no embryos of high quality to transfer.  Cycle is once again cancelled.


#6 sharlene

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Posted 28 February 2012 - 02:51 PM

Dr. Tamer, when should we consider ICSI?


Once a question is answered, I don't think the doctors tend to re-read a thread - so you are better off posting a new question/starting a new thread.

I would personally trust your RE/embryologist to know when to use ICSI - I would hope they would recognize when it would be helpful when they see the sperm and egg combination with which they are dealing. It wasn't really my question (in my IVF) to answer - and in the end, ICSI was used and all went well. Good luck!

#7 sharlene

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Posted 28 February 2012 - 02:53 PM

Hello,

It is my first post here, and I am looking for some advice and feedback from those who have been (or who currently are) in a similar situation.

My DH is in his late 20s: poor sperm morphology as per Kruger testing (4.1%) but all other parameters were normal. I am also in my late 20s with stage 1-2 endometriosis outside of the uterus (eradicated with surgery) and low ovarian reserve for my age (AFC on US was normal, but blood testing proved otherwise, but still within moderate range). We have been TTC for 21 months, with no luck whatsoever, even after my surgery.

Our fertility specialist has given us our options for ART: either IUI or IVF with ICSI. He gave us some general information and statistics, but am wondering if IUI would be worth the try given the morphology results, or would it just be best to go directly with IVF? My DH would like to go on a less invasive route to begin with, but if success rate for IUI is low, I would rather save our time and energy for something that could yield a better success rate...

Thank you for your help Posted Image


Want to wish you luck - and I agree with your husband - less invasive to start is always a good idea - while IVF has become more routine than it ever was, there is still a lot involved - drugs, injections, bloodwork, and finally retrieval and transfer. It's not anything like an IUI, which, by comparison, is a walk in the part. Considering what the doctor said, and your ages, I would definitely try a few IUIs first (they are also a ton cheaper!).

Good luck!





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