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IVF cancelled due to progesterone level


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#1 mcashley

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Posted 07 November 2011 - 04:06 PM

Hi everyone,

Im just so depresed and frustrated, Ive been on my day 13 of cycle. i just finished the ultrasound and dr sagle said that my follicles are very good. at 1:30 i received a call from the nurse saying that my CYCLE got cancelled. Hows that happen? she said it is because of my progesterone level.. first how did they let me know take all the way down to day 13 of the cycle if they will going to cancelled the cycle,? iv been paying for all my medications from day 1 and its been 5 days now that im taking 5 vials of menopur. is there any accountability of the clinic once the cycle was canclled? is this means that i will going to pay that much money for the next cycle?. iv spend 3k form this cycle...
im so stressed and dont know what to do right now, i have to wait january they said to do the next one.

anyone who can shed a light please


thank you
TTC- since 2009
male factor
mild PCOS
jan 2010 - ovulated chlomid and metformin- cancelled due to not enough sperm

october 2011- IVF #1
october 26 2011- menopaur at 150units
october 30-menopaur at 225 units
Nov 2- menopur at 375 units
Nov 5- added olgalutron( 9 eggs measure , 18,17,9,12,14,11,11,12,10)
Nov 7- cycle CANCELLED due to high progesterone level:

IVF # 2 April 2012

March 29-baseline ultrasound
April 3-menopur at 300 iu

#2 Ope

Ope
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Posted 07 November 2011 - 04:36 PM

I am so sorry that happened to you. I have had 3 canceled cycle due to the progesterone level, but luckily that was prior to any stimulation, so we didn't had to pay anything.
If I were you, I would call the clinic and would ask to talk to the financial department. I do not remember the lady name, but they should able to tell you how much refund ( or credit) you can expect to ward further cycles.

The problem with high progesterone is that it prevent implantation. After 3 canceled cycle due to high progesterone , I have been told that unfortunately they can not prevent my progesterone to escalate. So the next treatment is to go forward with the cycle, have retrieval, fertilize the egg with ICSI , but not to have a transfer, but freeze all of my embryos.

I am not saying that will be the case with you, but after 3 canceled cycle that is the option they gave me.
Do you have any coverage for meds? since you were on very high level of menopur with is so expensive, it might be something you would prefer then cancellation at this point.
Probably it is too late now, but keep thins in mind for future treatment. also call in TODAY and ask for a follow-up appointment, unless you are already given a time for that.
right now me : 37 Dh:40

TTC #1: natural TTC 1.5 yrs
Dh: 35, Severe Male factor infertility, morphology is 1-2%
Me: 32 , tubes open, no endo, regular ovulation, all hormones are good, 3rd day FSH 5.3 , antral follicle count is 12, only problem is my weight BMI: 30

IVF/ ICSI #1: 2008 February -McGill, Montreal
Long protocol: BCP for 1 month, burselin from CD21, 300 Gonal F and 150 Luveris for 10 days
ER: 11 egg , 6 mature , 5 fertilized, 3rd day transfer:a 7 cell & an 8 cell embyos, no frosties.
1st beta : 13dp3dt: 77, BFP
2008,November 19th: Adam has arrived 7 lb 4 oz, 21"

TTC #2: natural TTC 1.5 yr
Dh :39 morphology went up to 4%, we meet the IUI cutoff! count are fluctuating from 30 to 105 million, motility is great. Caryotyping is normal
Me: 36 FSH is slightly elevated and keep rising 8.5, 8.8, 8.9, 9.8 , AFC is still 12, everything else looks good.

IUI #1: Edmonton, 2011 January ,Clomid 50mg (x5), 106 mil ,68% motile, grade 4 :BFN
IUI #2: Edmonton, 2011 February, Clomid 50mg (x5), 30 mil, 57% motile, grade 3: BFN
IUI #3: Edmonton, 2011 March, Clomid 50mg (x5), 88 mil , 49% motile, grade 4: BFN
IVF#2: 2011 May, Edmonton: long protocol , nasal suprefact : CANCELLED due to high progresteron & cyst
IVF#3: 2011 August, Edmonton: short protocol/natural start: CANCELLED due to high progesterone
IVF#4: 2001 September, Edmonton: short protocol with BCP: CANCELLED due to high progresteron & cyst
Change clinic

IVF #5: 2012 March-April Hungary: stimulation starts march 28, 300 Menopur
mixed protocol: BCP for months, CD3: Menopur 300& lupron for 8 days
ER : April 8th , 4 eggs retrieved, all were mature and fertilized with ICSI and AH
ET : April 11th, 1 A quality 8 cell, and 1 A quality 4 cell embryo transferred, no frosties.
BFP on the HPT at 7dp3dt: happy 37th birthday to me :D
Beta: , 12dp3dt: 150, 2nd Beta, 15dp3dt: 550
Anna has arrived on 21st December after being induced at 39 week. She is 6 lb 9 oz, 20" , and has blue eyes, and long dark brown hair and just perfect !

#3 angelpoo11

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  • Dx:Endometriosis
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Posted 07 November 2011 - 05:22 PM

So high progesterone is bad? Why is it that we take progesterone shots or pills after ET? Or is it just high progesterone at the wrong time is bad? My doc mentioned that my progesterone levels are higher than normal but she said that it was great? confused!
src="http://pdgf.pitapata.com/TikiPic.php/ydyYBxR.jpg" width="60" height="80" border="0" alt="PitaPata - Personal picture" /> width="400" height="80" border="0" alt="PitaPata Dog tickers" />

Me: 28 DH: 28
Dx: Stage IV Endometrosis
Jan 2011 - First Laparoscopy, removed 2 cysts: 12 and 5 cm
Jun 2011 - Ultrasound revealed both tubes blocked

At the OFC:
Nov 2011 - 1st IVF w/ ICSI - Antagonist patch protocol
Oct 31 - CD1
ER: Retrieved 10 (follie count: 11 total, 3>15mm), only 6 mature, 1 abnormal
ET: Injected 4 eggs, 3 fertilized, 1 made it to day 3, transferred 1 good quality 8 cell embryo
M/C at 6 weeks...

Apr 2012 - 2nd IVF w/ ICSI - Antagonist patch protocol
Mar 24 - CD1
ER: Retrieved 6 (follie count: 12 total, 5 >15mm), 4 mature
No transfer, none fertilized

Changed clinic: Hannam
Currently: 3rd IVF w/ ICSI - Antagonist with OCP (GonalF+Luvervis, Etroxin)
Sept 18 - CD1
Sept 22-Oct 20 - BCP (Alesse)
Oct 26 - Baseline check: AFC 13, E2 210 pmol/l
Nov 6 - Triggered! E2: 9100, Lead follicle: 24mm, 6 between 17-21mm, 4 smaller ones. Fingers crossed!
Nov 8 - 8 Eggs retrieved.
Nov 11 - 6 mature, 4 fertilized
Nov 12 - 3 7-8-cell embryos, 1 9-cell embryo, all of good quality!
Nov 13 - transferred 2 good quality blasts!
Nov 14 - Froze 1 snow baby! <3
Nov 22 - Beta 9dp5dt 145 BFP!!! <3
Nov 26 - Beta 13dp5dt 915
Dec 10 - u/s @ 6w4d - 1 bean measuring 6w4d, hb @ 111 bpm
Dec 17 - 7w4d - hb@ 152!!
Jan 21 - NT Scan
Read more about me here ---------> http://angelpoo11.blogspot.com/

#4 mcashley

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Posted 07 November 2011 - 05:51 PM

thats the thing , they should monitor that one on my bloodwork prior given a green ;ight to take 13 days of stimulation. when the nurse called she said that i can refund the 7500. and used that one on the next cycle. i dont have any coverage on my medication tahts why for this cycle i spend 3500 for nothing!!. they said my body need to rest for next month and do the cycle January. but i will ask for the appointment . i just need to be clear for this things. its easy to cancel the cycle but please explained it to me especially i reach the cd 13.

im trying to reaserach in the internet. the higher the progesterone thats means your ovulating. its kinda confusing though..


im thinking to change clinic but i dont want to wait that long...

thanks ladies. this forum really help me a lot.
TTC- since 2009
male factor
mild PCOS
jan 2010 - ovulated chlomid and metformin- cancelled due to not enough sperm

october 2011- IVF #1
october 26 2011- menopaur at 150units
october 30-menopaur at 225 units
Nov 2- menopur at 375 units
Nov 5- added olgalutron( 9 eggs measure , 18,17,9,12,14,11,11,12,10)
Nov 7- cycle CANCELLED due to high progesterone level:

IVF # 2 April 2012

March 29-baseline ultrasound
April 3-menopur at 300 iu

#5 Valasia

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Posted 07 November 2011 - 07:23 PM

Is it possible that you ovulated?
Me: 33 DH: 37
PCOS Mild MFI
IUI#1 September 2006 Clomid 100mg & Trigger BFP MMC 8w2d
IUI#2 January 2007 Clomid 100mg & Trigger BFN
IUI#3 February 2007 Gonal F 112.5iu BFP DS born @ 37w5d 10/31/07
IUI#4 August 2009 Gonal F 112.5iu BFP DS born @ 20w6d 01/09/10
IUI#5 June 2010 Gonal F 112.5iu Canceled due to over-stimulation
IUI#5 Take 2 August 2010 Puregon 100iu/50iu Canceled due to over-stimulation
IUI#5 Take 3 November 2010 Puregon 75iu BFN
IUI#6 December 2010 75iu Gonal F BFN
January 2011 Clomid 100mg and TI O cd 28 BFP!!! MMC 9w4d
IUI#7 Gonal F 75iu May 2011 BFN
IUI#8 Gonal F 75iu June 2011 BFN
IUI#9 Gonal F 75iu July 2011 BFN
IVF#1 Jan/Feb/Mar 2012
Jan 9 AFC >12 on each ovary
Jan 17 SIS all good
Feb 4 CD 1
Feb 6 CD 3 put in new Nuva Ring
Feb 24 CD 21 baseline u/s & b/w
Feb 29 start stims 300iu Menopur
Mar 4 u/s & b/w Lining 8mm RS 9x2, 10, 11x2, 15x2 LS 10x2, 11, 12x2, 14, 15, 16 Continue Menopur 300iu, add Orgalutron
Mar 6 u/s & b/w Lots of follies biggest at 21, E2 >8000 Lower Menopur to 150iu, continue Orgalutron
Mar 7 b/w E2 >9000 meds stay the same
Mar 8 u/s & b/w Lining 11mm 18 Mature follies, HCG trigger 8:30 pm
Mar 10 ER 8:30 am 17 eggs retrieved
Mar 11 found out only 8 eggs were mature and only 4 fertilized
Mar 13 3dt 1, 6 celled embryo
Mar 24 BFN
April 2012 100mg Clomid, O cd 20, BFP 11dpo 20/05/12.....Seriously unbelievable!!!
15 dpo HCG 103 23 dpo HCG 15 MC
IUI#10 Puregon 100iu April 2013 BFN
June 27, 2013 Placed with Little C born Oct 2011. Adoption in the works.

#6 mcashley

mcashley
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Posted 07 November 2011 - 07:43 PM

hi ope,


during the early stage of your cycle. how do they determined that you have high progesterone? before they cancelled your treatment. during my cycle they didnt get me into superfact. i go straight to menopur.
TTC- since 2009
male factor
mild PCOS
jan 2010 - ovulated chlomid and metformin- cancelled due to not enough sperm

october 2011- IVF #1
october 26 2011- menopaur at 150units
october 30-menopaur at 225 units
Nov 2- menopur at 375 units
Nov 5- added olgalutron( 9 eggs measure , 18,17,9,12,14,11,11,12,10)
Nov 7- cycle CANCELLED due to high progesterone level:

IVF # 2 April 2012

March 29-baseline ultrasound
April 3-menopur at 300 iu

#7 Ope

Ope
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Posted 07 November 2011 - 10:57 PM

The last few month I spent a lot of time researching high progesterone level, so I can share what I have find so far. Progesterone is the hormone that creates the chemical balance in the uterus that makes it the perfect environment for implantation. You do need progesterone, but you need it only a certain amount and certain times. It is a bit confusing to read about progesterone level on the internet, because most places are from the US where they use the old British units and the levels are totally different from the Canadian numbers , where the SI metric system used. ( 1 ng/ml =3.18 nmol/L)
This is the normal ranges:

follicular phase (before ovulation) below 5.0 nmol/l in Canada( <1.5 or 2 ng/ml US)
luteral phase (after ovulation) between 15.00 and 90.00 nmol/l inCanada ( or between 2 and 28 ng/ml in the US)
1st trimester : 30-150 nmol/l in Canada ( or 9-48 ng/ml in the US) ( Here 1st trimester really refer to the time after you have your missed period)
2nd trimester: 50-450 nmol/ l in Canada ( 47-147 ng/ml in the Us)
3rd trimester: 175- 650 nmol/ l in Canada ( 55-200 ng/ml in the US)

Practically progesterone should drop almost to close to zero when the uterine lining sheds and you get your period. On the baseline (CD3) and during the stimulation it should be below 5 ( very often US sites refer to be below 2, but because of the different units used). Normally when we ovulate a single follicle release an egg and the follicle became a so called corpus luteum, which starts to produce progesterone at that point. Progesterone level increases at a fixed level per day ~ 2-5 nmol/ l. Normally progesterone is not produced before ovulation, and this timing ensures the perfect level at the time of implantation. Around 1 week after the ovulation the progesterone level peaks, and start to drop unless implantation occurred. When it drops to a very low level as a response the uterine lining shreads and you get your period. When implantation occurs the body keeps producing progesterone.

During IVF women often get extra progesterone support, because the stimulation can mess up things and you may or may not produce enough progesterone on your own. Usually this level won't be too high even with the added support, UNLESS you already have high level before ovulation.

Usually the too low level of progesterone is the problem. If the progesterone is not high enough the lining starts to deteriorate and the women may miscarry.

Too high progesterone is actually rare, and there is very little information about it. Based on what I find, the following scenarios could be the reason:
1. cyst: Sometimes the corpus luteum , which produce the progesterone, do not disappear once the women have her period. For some reason it keeps producing hormones and become a functional cyst. It is common condition,and most childbearing age women experience this in their lifetime. Usually women do not even know about it, unless it cause pain when it burst. It doesn't cause any abnormal thing, and it usually dissapear in a couple of months. However it sucks if it is happens during IVF.
2. Sometimes the uterine lining is not responding sufficiently to the progesterone hormone, so the body keeps producing extra amount to make sure the lining respond well. The only thing I have read about this that sometimes result from lack of vitamin B6.
3. The lining and the progesterone production get dis-synchronized. Normally the progesterone drops very low, then the lining sheds. However if the lining sheds before the progesterone drops suffitiently, it make a high initial progesterone level for the next cycle. Probably this is the case with me, and there is next to none information out there about it.


mcashley: Were you on short protocol? ( e.g no suprefact, but start stimulation on CD3 baseline?) If that is the case , they probably put you on long protocol next time, and you would take suprefact at the end of the cycle prior to the stimulation. It generally works, but it didn't for me :( Nothing worked on me, so I have no idea what is the solution.
  • Stacy likes this
right now me : 37 Dh:40

TTC #1: natural TTC 1.5 yrs
Dh: 35, Severe Male factor infertility, morphology is 1-2%
Me: 32 , tubes open, no endo, regular ovulation, all hormones are good, 3rd day FSH 5.3 , antral follicle count is 12, only problem is my weight BMI: 30

IVF/ ICSI #1: 2008 February -McGill, Montreal
Long protocol: BCP for 1 month, burselin from CD21, 300 Gonal F and 150 Luveris for 10 days
ER: 11 egg , 6 mature , 5 fertilized, 3rd day transfer:a 7 cell & an 8 cell embyos, no frosties.
1st beta : 13dp3dt: 77, BFP
2008,November 19th: Adam has arrived 7 lb 4 oz, 21"

TTC #2: natural TTC 1.5 yr
Dh :39 morphology went up to 4%, we meet the IUI cutoff! count are fluctuating from 30 to 105 million, motility is great. Caryotyping is normal
Me: 36 FSH is slightly elevated and keep rising 8.5, 8.8, 8.9, 9.8 , AFC is still 12, everything else looks good.

IUI #1: Edmonton, 2011 January ,Clomid 50mg (x5), 106 mil ,68% motile, grade 4 :BFN
IUI #2: Edmonton, 2011 February, Clomid 50mg (x5), 30 mil, 57% motile, grade 3: BFN
IUI #3: Edmonton, 2011 March, Clomid 50mg (x5), 88 mil , 49% motile, grade 4: BFN
IVF#2: 2011 May, Edmonton: long protocol , nasal suprefact : CANCELLED due to high progresteron & cyst
IVF#3: 2011 August, Edmonton: short protocol/natural start: CANCELLED due to high progesterone
IVF#4: 2001 September, Edmonton: short protocol with BCP: CANCELLED due to high progresteron & cyst
Change clinic

IVF #5: 2012 March-April Hungary: stimulation starts march 28, 300 Menopur
mixed protocol: BCP for months, CD3: Menopur 300& lupron for 8 days
ER : April 8th , 4 eggs retrieved, all were mature and fertilized with ICSI and AH
ET : April 11th, 1 A quality 8 cell, and 1 A quality 4 cell embryo transferred, no frosties.
BFP on the HPT at 7dp3dt: happy 37th birthday to me :D
Beta: , 12dp3dt: 150, 2nd Beta, 15dp3dt: 550
Anna has arrived on 21st December after being induced at 39 week. She is 6 lb 9 oz, 20" , and has blue eyes, and long dark brown hair and just perfect !

#8 wannakid

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Posted 07 November 2011 - 11:11 PM

I had my last cycle converted to a "freeze all" due to increasing p4 during stims. When the P4 raises prematurely - rather than in the luteal phase - the lining starts to increase and so by the time of a transfer, the lining is ready for an embryo that is further along than is really the case, which is not optimal for implantation. Can u proceed with ER and freeze the embryos for a subsequent FET?

#9 Ope

Ope
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Posted 07 November 2011 - 11:29 PM

wannakid: Have you had transfer from those frostiees yet? Or do you have any grading on your embryos? This freeze them all approach is the option my clinic suggested, but I am a bit afraid the quality after the freezing , plus the added cost is really stretching our budget.
right now me : 37 Dh:40

TTC #1: natural TTC 1.5 yrs
Dh: 35, Severe Male factor infertility, morphology is 1-2%
Me: 32 , tubes open, no endo, regular ovulation, all hormones are good, 3rd day FSH 5.3 , antral follicle count is 12, only problem is my weight BMI: 30

IVF/ ICSI #1: 2008 February -McGill, Montreal
Long protocol: BCP for 1 month, burselin from CD21, 300 Gonal F and 150 Luveris for 10 days
ER: 11 egg , 6 mature , 5 fertilized, 3rd day transfer:a 7 cell & an 8 cell embyos, no frosties.
1st beta : 13dp3dt: 77, BFP
2008,November 19th: Adam has arrived 7 lb 4 oz, 21"

TTC #2: natural TTC 1.5 yr
Dh :39 morphology went up to 4%, we meet the IUI cutoff! count are fluctuating from 30 to 105 million, motility is great. Caryotyping is normal
Me: 36 FSH is slightly elevated and keep rising 8.5, 8.8, 8.9, 9.8 , AFC is still 12, everything else looks good.

IUI #1: Edmonton, 2011 January ,Clomid 50mg (x5), 106 mil ,68% motile, grade 4 :BFN
IUI #2: Edmonton, 2011 February, Clomid 50mg (x5), 30 mil, 57% motile, grade 3: BFN
IUI #3: Edmonton, 2011 March, Clomid 50mg (x5), 88 mil , 49% motile, grade 4: BFN
IVF#2: 2011 May, Edmonton: long protocol , nasal suprefact : CANCELLED due to high progresteron & cyst
IVF#3: 2011 August, Edmonton: short protocol/natural start: CANCELLED due to high progesterone
IVF#4: 2001 September, Edmonton: short protocol with BCP: CANCELLED due to high progresteron & cyst
Change clinic

IVF #5: 2012 March-April Hungary: stimulation starts march 28, 300 Menopur
mixed protocol: BCP for months, CD3: Menopur 300& lupron for 8 days
ER : April 8th , 4 eggs retrieved, all were mature and fertilized with ICSI and AH
ET : April 11th, 1 A quality 8 cell, and 1 A quality 4 cell embryo transferred, no frosties.
BFP on the HPT at 7dp3dt: happy 37th birthday to me :D
Beta: , 12dp3dt: 150, 2nd Beta, 15dp3dt: 550
Anna has arrived on 21st December after being induced at 39 week. She is 6 lb 9 oz, 20" , and has blue eyes, and long dark brown hair and just perfect !

#10 clauabad

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Posted 10 March 2013 - 06:22 PM

Hi,

The dr cancelled my cycle this week, because the progesterone was too high. I'm sad, I don't know why.

#11 Stacy

Stacy
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Posted 10 March 2013 - 10:25 PM

The last few month I spent a lot of time researching high progesterone level, so I can share what I have find so far. Progesterone is the hormone that creates the chemical balance in the uterus that makes it the perfect environment for implantation. You do need progesterone, but you need it only a certain amount and certain times. It is a bit confusing to read about progesterone level on the internet, because most places are from the US where they use the old British units and the levels are totally different from the Canadian numbers , where the SI metric system used. ( 1 ng/ml =3.18 nmol/L)
This is the normal ranges:

follicular phase (before ovulation) below 5.0 nmol/l in Canada( <1.5 or 2 ng/ml US)
luteral phase (after ovulation) between 15.00 and 90.00 nmol/l inCanada ( or between 2 and 28 ng/ml in the US)
1st trimester : 30-150 nmol/l in Canada ( or 9-48 ng/ml in the US) ( Here 1st trimester really refer to the time after you have your missed period)
2nd trimester: 50-450 nmol/ l in Canada ( 47-147 ng/ml in the Us)
3rd trimester: 175- 650 nmol/ l in Canada ( 55-200 ng/ml in the US)

Practically progesterone should drop almost to close to zero when the uterine lining sheds and you get your period. On the baseline (CD3) and during the stimulation it should be below 5 ( very often US sites refer to be below 2, but because of the different units used). Normally when we ovulate a single follicle release an egg and the follicle became a so called corpus luteum, which starts to produce progesterone at that point. Progesterone level increases at a fixed level per day ~ 2-5 nmol/ l. Normally progesterone is not produced before ovulation, and this timing ensures the perfect level at the time of implantation. Around 1 week after the ovulation the progesterone level peaks, and start to drop unless implantation occurred. When it drops to a very low level as a response the uterine lining shreads and you get your period. When implantation occurs the body keeps producing progesterone.

During IVF women often get extra progesterone support, because the stimulation can mess up things and you may or may not produce enough progesterone on your own. Usually this level won't be too high even with the added support, UNLESS you already have high level before ovulation.

Usually the too low level of progesterone is the problem. If the progesterone is not high enough the lining starts to deteriorate and the women may miscarry.

Too high progesterone is actually rare, and there is very little information about it. Based on what I find, the following scenarios could be the reason:
1. cyst: Sometimes the corpus luteum , which produce the progesterone, do not disappear once the women have her period. For some reason it keeps producing hormones and become a functional cyst. It is common condition,and most childbearing age women experience this in their lifetime. Usually women do not even know about it, unless it cause pain when it burst. It doesn't cause any abnormal thing, and it usually dissapear in a couple of months. However it sucks if it is happens during IVF.
2. Sometimes the uterine lining is not responding sufficiently to the progesterone hormone, so the body keeps producing extra amount to make sure the lining respond well. The only thing I have read about this that sometimes result from lack of vitamin B6.
3. The lining and the progesterone production get dis-synchronized. Normally the progesterone drops very low, then the lining sheds. However if the lining sheds before the progesterone drops suffitiently, it make a high initial progesterone level for the next cycle. Probably this is the case with me, and there is next to none information out there about it.


mcashley: Were you on short protocol? ( e.g no suprefact, but start stimulation on CD3 baseline?) If that is the case , they probably put you on long protocol next time, and you would take suprefact at the end of the cycle prior to the stimulation. It generally works, but it didn't for me sad.png Nothing worked on me, so I have no idea what is the solution.

 

Excellent post Ope. You have SOoo done your research to a "T" !!! I didn't know we shared that early P4 rise in the follicluar phase together. Sorry that we are in the same trench. I read as well that there can be different reasons for this early elevation ....The European Lining King is Dr.Dominic de Zielger- just in case you haven't read any of his material yet. My progesterone levels are dropping as we speak due to his publications. I don't know where you are in your journey but if you need info PM me. Ope, how are your P4 levels during FET's ? Mine even rise during synthetic estrogen...or should I say they just rise all the bloody time. That is where the frustration started for me, but now I have learned from de Ziegler that early P4 elevation is not always associated with a higher LH, (although you and I are very rare- too bad that is never a good thing in IVF.) PM me if you like.

 

 

clauabad- I think the other ladies on here have described  what the early rise on progesteorne levels due to LH surging can do to your lining so I think by now you probably understand the cancellation for that reason. There are also a few studies out there showing that too much of a  progesteorne rise may effect the quality of the eggs. The best one to ask about this is your RE, either directly or through your nurses as to why you are cancelled(And not 'just' that you are cancelled). His reason may be great and make all the sense in the world to you once you know it, for a lot of us here being able to understand the decisions helps the process wink.png For me, I think it takes guts to cancel a cycle/fet when things can be better..I never understood why patients looked at a clinics cancellation rates to mae a decision on wether or not to go there. I really hope your hormones have an easier time of it on your next cycle. Maybe ask what your RE's plan is next time to counteract an early P4 rise.

Good luck with your next attempt.

 

 

 

S



#12 Ope

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Posted 10 March 2013 - 10:53 PM

Excellent post Ope. You have SOoo done your research to a "T" !!! I didn't know we shared that early P4 rise in the follicluar phase together. Sorry that we are in the same trench. I read as well that there can be different reasons for this early elevation but I can tell you that one way to combat it is with dexamethasone. The European Lining King is Dr.Dominic de Zielger- just in case you haven't read any of his material yet. My progesterone levels are dropping as we speak due to dex. I don't know where you are in your journey but if you need info PM me. Ope, how are your P4 levels during FET's ? Mine even rise during synthetic estrogen...or should I say they just rise all the bloody time. That is where the frustration started for me, but now I have learned from de Ziegler that early P4 elevation is not always associated with a higher LH, (although you and I are very rare- too bad that is never a good thing in IVF.) PM me if you
S

I never had any embryos to freeze, so never had a FET. Hence I have no idea how my progesterone would behave an estrogen only cycle. I suspect it would be high , because it was high when I was not even given anything.
Luckily none of these matter anymore for me. I have a left Edmonton fertility and went to cycle in Europe last spring. Now i have a 2.5 months old daugther result of that cycle :) My Dr over there was not concerned of my progesterone level at all! They didn't even monitor it on the 3 rd day. He said if there is no cyst on the baseline, it doesn't matter. Becaue they do not meause it, I have no idea how high it was in that cycle. Although I had only 4 eggs retrieved , all fertilized and all were around on 3 days later. We transfered 2 , and the other 2 didn't make it to freezing. In any case I got pregnant and had a baby girl in December.
Good luck on your journey! I hope you will experience a happy ending as well.
right now me : 37 Dh:40

TTC #1: natural TTC 1.5 yrs
Dh: 35, Severe Male factor infertility, morphology is 1-2%
Me: 32 , tubes open, no endo, regular ovulation, all hormones are good, 3rd day FSH 5.3 , antral follicle count is 12, only problem is my weight BMI: 30

IVF/ ICSI #1: 2008 February -McGill, Montreal
Long protocol: BCP for 1 month, burselin from CD21, 300 Gonal F and 150 Luveris for 10 days
ER: 11 egg , 6 mature , 5 fertilized, 3rd day transfer:a 7 cell & an 8 cell embyos, no frosties.
1st beta : 13dp3dt: 77, BFP
2008,November 19th: Adam has arrived 7 lb 4 oz, 21"

TTC #2: natural TTC 1.5 yr
Dh :39 morphology went up to 4%, we meet the IUI cutoff! count are fluctuating from 30 to 105 million, motility is great. Caryotyping is normal
Me: 36 FSH is slightly elevated and keep rising 8.5, 8.8, 8.9, 9.8 , AFC is still 12, everything else looks good.

IUI #1: Edmonton, 2011 January ,Clomid 50mg (x5), 106 mil ,68% motile, grade 4 :BFN
IUI #2: Edmonton, 2011 February, Clomid 50mg (x5), 30 mil, 57% motile, grade 3: BFN
IUI #3: Edmonton, 2011 March, Clomid 50mg (x5), 88 mil , 49% motile, grade 4: BFN
IVF#2: 2011 May, Edmonton: long protocol , nasal suprefact : CANCELLED due to high progresteron & cyst
IVF#3: 2011 August, Edmonton: short protocol/natural start: CANCELLED due to high progesterone
IVF#4: 2001 September, Edmonton: short protocol with BCP: CANCELLED due to high progresteron & cyst
Change clinic

IVF #5: 2012 March-April Hungary: stimulation starts march 28, 300 Menopur
mixed protocol: BCP for months, CD3: Menopur 300& lupron for 8 days
ER : April 8th , 4 eggs retrieved, all were mature and fertilized with ICSI and AH
ET : April 11th, 1 A quality 8 cell, and 1 A quality 4 cell embryo transferred, no frosties.
BFP on the HPT at 7dp3dt: happy 37th birthday to me :D
Beta: , 12dp3dt: 150, 2nd Beta, 15dp3dt: 550
Anna has arrived on 21st December after being induced at 39 week. She is 6 lb 9 oz, 20" , and has blue eyes, and long dark brown hair and just perfect !

#13 Stacy

Stacy
  • 1000+
  • 1,650 posts
  • Gender:Female
  • Dx:Other

Posted 11 March 2013 - 07:06 AM

Ope ! Yes I see that you have a daughter! I didn't realize that this post started in 2011 -lol. It's been a Long and crazy ivf train you were on, I am so glad it paid off for you. Congratualtions. on your DD !I think we've both been here forever. It's good to see you are helping others. Me too, it makes it feel like all the $$ I spent outsourcing my problems to the U.S. are part way justified if I help just one person, it might help to keep my sanity. I have one normal embryo left and high P4 levels in follicular that no one can figure out- hence my research. My house looks like a research station of it's own -lol. Perfect post on progeserone for the newer ladies Ope. Great to see you on here.

Yeah for little girls ! smile.png (Me too!- mine was a total IVF fluke wink.png Makes me realise that luck outweighs wisdom sometimes.

See you around the boards,

Stacy



#14 suzanne0877

suzanne0877
  • Just Hatched
  • 1 posts
  • Gender:Female
  • Location:Indianapolis, IN
  • Dx:DOR
  • My Clinic:FCI

Posted 03 June 2013 - 10:36 AM

Hi ladies, I know this thread is kind of old, but I have had issues the past few months with elevated e2 and p4 at baseline. We thought it finally dropped enough to start, so on cd5 we began stims. I under suppressed on bcps a few months ago and my body even tried to ovulate, so we did not do any sort of suppression this time. I have very low AMH and high FSH so I knew I wouldn't get a lot of follicles. This weekend we found out I have 3, but my p4 is around 4. I also have fluid in my uterus (they will drain at ER). We chose to move forward and try for our 3 and hope they make it to freeze to do a FET later. If they won't make it to freeze, we'll do a hail mary transfer with anything we have. I'm so nervous and realize what a long shot this all is. I don't understand what would make my p4 elevated like this. Should I expect this issue going forward? Did anyone get pregnant with elevated p4? Would love to hear some positive feedback, or even if we are making a mistake and should cancel, I'd love to hear that as well. Our ER is scheduled for tomorrow morning. 

Thanks,

Suzanne


Suzanne (35) 

DOR & Stage III Endo

FSH - 18.4

AMH - <.16

TTC since July, 2011

 


#15 Zoeby

Zoeby
  • Member
  • 94 posts
  • Gender:Female
  • Location:Spruce Grove, AB
  • Dx:PCOS
  • My Clinic:Edmonton clinic

Posted 03 June 2013 - 07:35 PM

Suzanne I have not experiences this but wanted to wish you the best of luck tomorrow. I will be there having another iui tomorrow. Sending positive thoughts your way

Fertility Journey so far
Have been on Synthroid for since I was 16 years old.
Married to my Loving Husband March 2008. (We have two Lovely Fur-Babies. Dogs named Shelby & Zoey)
April 27, 2008-Stopped taking Birth Control Pill, to start trying to conceive
March 10, 2009- Finally had an Appointment with Gynecologist Dr.Kim for Fertility Issues.
May17, 2009-Started Clomid 50mg for the first time on Day 3
May 21, 2009-Had HSG, very painful but showed no issues
From May 17, 2009- Feb 4, 2010- Did 9 cycles of clomid at different doses of 50mg or 100mg
February 5, 2010- new period started (cycles are really getting out of whack again)
February 23, 2010- Appointment follow-up with Dr. K
March 11, 2010- First Appointment with Dr. S @ RAH Edmonton Fertility-Plan is to try injectables with intercourse for now. Dr. S always makes her patients take a month break between each cycle.
April 14, 2010- Injection Training
April 27, 2010- Day 1 of first cycle of injectables #1
April 29, 2010-Day 3 started on 50 IU of puregon daily. Did injections from Day 3 Day 14, then HCG trigger injection on May 11, 2010-BFN
May 25, 2010- Period off & on until June 17, 2010 and then went without a period until July 30, 2010.
Aug 2010-end of year- Cycles were all over the place. I was away from city too many times to start another cycle yet.
January 15, 2011- Day 1 of next cycle of injectables. Ultrasound on January 17, 2011. #2
January 17, 2011- Day 3 started 75 IU of Puregon daily (75 IU for 9 days & then 7 days of 150 IU). Did injections from Day 3 Day18, then HCG Trigger injection on February 2, 2011BFN
February 17, 2011- Started Bromocriptine for elevated Prolactin. Had to wait to do any other cycles until Follow-up appt with Dr. S.
April 8, 2011- Follow-up appt with Dr. S
July 3, 2011- Started Prometrium to start a cycle.
July 13, 2011- Day 1 of this Cycle #3
July 15, 2011- Day 3 started 150mg IU of Injectables for 5 days then switched to 75 IU for 2 days.
July 22, 2011- Cycle Cancelled for too many follicles produced. Now have to wait to talk to Dr. S again for Follow-up Appt.
October 26, 2011- Follow-up appt with Dr. S. Will proceed with trying IUI now.
October 28, 2011- Started Prometrium again to start a cycle.
November 7, 2011- Day 1 of this cycle #4
November 9, 2011- Day 3 started 100 IU of Puregon injections daily. Did Injections until Day 11.
November 18, 2011- HCG Trigger Injection.
November 20, 2011- First IUI Attempt. Didn't hurt at all and was fairly quick
November 30, 2011- Started spotting & period only 10 days after IUI. Heart-broken.
November 30, 2011- was bleeding off & on from this date to Dec 24, 2011 until given Provera for 7 days. Stopped bleeding until January 4, 2012. Doctor's office finally called me back on January 11, 2012. Bleeding finally stopped naturally until Jan 23, 2012. Had to go to RAH for another Ultrasound to check everything on Jan 25, 2012. Everything looks fine and given Provera again for 14 days. Started bleeding again on Feb 3, 2012. Had another Ultrasound on February 13, 2012 and given Marvelon to try to adjust my hormones to stop the bleeding.
March 12, 2012- Day 1 of this Cycle #5
March 14, 2012- Day 3 started 100 IU puregon injections daily. Did injections until March 19, 2012. (Asked 2 nurses, 1 doctor and left 1 message to ask about possible progesterone supplements to lengthen luteal phase-no return call from message left and the doctor & nurses didn't seem to think it was necessary)
March 20, 2012- HCG Trigger Injection.
March 22, 2012- IUI attempt number two
April 1, 2012- Period started. Again only 10 days after IUI, Very sad and very frustrated.

April 4, 2012- Taking a break right now to save up and emotionally relax. Also can't get into see my doctor until July 6, 2012. The Wait is on......
July 22, 2012- random positive hcg test of 206 when I was just doing the test to double check just so I could start meds to start a cycle
July 23,2012- hcg decreasing so it's a chemical pregnancy too bad... Felt the joy for one day.
Oct 13, 2012- Day 1 of 3rd IUI
Oct 15, 2012- Day 3 staring puregon injections of 100iu/day.
Oct 30, 2012- Hcg trigger injection
Nov 1, 2012- IUI attempt number 3 but this time with progesterone suppositories. resulted in BFN- I think iui was done way too late in cycle
Dec 12, 2012- Followup with Dr. Sagle We are still going to follow the same path just up dose and i have requested to try Gonal F for the first time instead of puregon just to give it a whirl. I have to wait a few months as i am having knee surgery
Dec 13, 2012-Rt knee ACL repair knee surgery-have to wait a few months until next IUI
April 4, 2013-Day 3 of IUI number 4- Baseline ultrasound shows Cyst on left side-cycle cancelled
May22, 2013-Day 3 of IUI number 4(attempt2)-baseline ultrasound looks clear-started gonal f 125iu/day
June 4, 2013-Day 16 IUI done today will continue to use progesterone suppositories. Resulted in BFN
June 22,2013-Followup with Dr. sagle- She thinks i am responding well to injectable iui cycles and bloodwork wise everything looks perfect. I asked if i could try femara in between iui cycles and she said yes. She doesn't think anymore diagnostic tests are required at this time.
Aug2, 2013-day 1 of first femara cycle. taking femara day 3-7 on the off cycles when not doing iui. next iui cycle will be in September/octobert as we are going on vacation to disneyland early september. Maybe femara will work in the meantime.....

Aug 27, 2013-Day 26-postive preg test at home!!! first time ever!!!

Aug 28, 2013-HCG only 17 very low (clinic requested repeat in one week but we were leaving on holidays the next week and i needed an answer before we left) Repeat labs done on Saturday and HCG was 24 but by the tuesday i had started spotting and HCG was 7. BOOOOO :( But glimmer of hope knowing that the femara worked and just need to find a way for it to stick!

Oct 12, 2013-Did another Femara cycle @ 5mg but BFN(based on labs i don't think i ovulated)

Nov 14, 2013-CD1, starting another femara cycle @ 10mg for cd 3-7-everything crossed for this cycle!!!!