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Single embryo transfer


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#1 zoeoz

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Posted 17 December 2010 - 02:33 PM

I just had a single embryo transfer yesterday on day 3, what would be my chances of getting a BFP considering the below facts:
My age : 43
Donor age : 20

We had 8 eggs out of 16 follicles 7 of those matured out of those 5 fertilized,
Day 3 transfer if my best embryo a good 8 cell I was told.
The other embryos are as follows: a good 7 cell, average 5 cell, a 4 cell and a 2 cell.
The last two did not develop from day 2-3 and now if any make it to blast they will be frozen so they told me.

I feel like this was not a great cycle but I am no expert, this being my 2nd IVF and the first was a shared cycle that produced 3 good and 1 not so good embryos.
Never got pregnant.

What is your take on singlton IVF and what are my chances ?
And please let me know what you think on this cycle as I fear evan thinking about going through another with this donor as she does want to do it again if it does not work ?

Thank you so much !!!

z

#2 LisainSK

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Posted 17 December 2010 - 02:39 PM

I'm a big eSET advocate. Of course its easy to be a big advocate when it works on its first try...but that's with a blastocyst transfer (or Day 5). Given your stats...I'd consider transferring two day threes...if I were in your shoes.
Me (33) and DH (35)....married 10 years (small town sweethearts)

December 2006: TTC # 1
May 2007: DH S/A...normal.
September 2007: BFP au naturelle...holy smokes!
November 2007: M/C # 1 @ 12 wk. DNC reveals a Partial Molar Pregnancy.
January 2009: Referral to local OB/GYN
April 2009: Dx Unexplained. Referral to Calgary RFP.
May 2009: Clomid Cycle # 1...BFN
June 2009: IUI # 1 w/ Clomid # 2 and HCG...BFN
July 2009: Clomid Cycle # 3...BFP! Happy but terrified of another m/c.
September 2009: Worst fears confirmed...M/C # 2 @ 8 weeks
October 2009: IVF Orientation at Calgary RFP and on wait list.
January 2010: Dx (Me) Abnormal Karyotype (Pericentric Inversion Chromosome 16)
March 2010: RFP Referral/Consultation with Reprogenetics in New Jersey
March/April 2010: PGD/IVF success odds very low...20% estimated "normal embryos" per cycle and a 41% pg rate
May 2010: Consult with Dr. Schoolcraft of Colorado Center for Reproductive Medicine
June 2010: One Day Work Up @ CCRM (Denver, CO)
June 2010: Predicted Low Responder (Low AFC and AMH). Inversion in difficult spot...We're doing Donor Eggs!!
July 2010: Discovery that I am also a carrier of Fragile X...my eggs didn't have a chance.
July 2010: Annonymous Egg Donor chosen through CCRM
August 2010: Mock FET Cycle completed.
DE IVF # 1
September 2010: Donor Eggs retrieved. Blastocysts to undergo PCR genetic screeing.
October 21, 2010: U/S showing 9.9 mm lining with triple stripe; E2 = 1600 and 1397 US units
November 1st, 2010: FET # 1 (Elective Single Embryo Transfer - eSET)
November 10th, 2010: Beta HCG # 1 = 82, P4 = 23.1 US units
November 12th, 2010: Beta HCG # 2 = 186! BFP!!
November 17th, 2010: Beta HCG # 3 = 1461
November 19th, 2010: Beta HCG # 4 = 3740
November 26th, 2010 U/S: hb = 120 bpm, measuring 6w1d, actual gestation is 6w2d since transfer, CRL = 3.8 mm
Dec. 10th, 2010 U/S: hb = 180 bpm, measuring 8w2d - exactly 8w2d since FET, CRL = 1.8 cm
February 18, 2011: Anatomy scan
EDD = July 20th, 2011

June 28th, 2011 @ 3:19 AM MTN: Levi Darrell John born at 36w6d at 6lbs 14oz and 18" long. He is precious beyond measure.

Visit my blog at:

http://wantedonegood...o.blogspot.com/

February 2012: Bye Bye IVF.ca community...you are the reason I got to where I am today. I am forever reached via pm as my email alerts me. Take care all...wishing you all peace in your hearts soon.

#3 wannakid

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Posted 17 December 2010 - 03:17 PM

i really think it depends on the stats for your particular clinic. Statistics differ from clinic to clinic. It would also depend on the grading of the embryo (aside from cell count). It's great that your donor is 20! That certainly bodes well for good eggs.

My DH and I always thought that sET was something we would do. That is, until we realized that getting pregnant with IVF wasn't going to be as easy as we thought. Now, we're more likely to put back 3 than 1.

Good luck to you!

Wannakid

#4 zoeoz

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Posted 17 December 2010 - 04:25 PM

In Quebec we do not have any choice because if I did I would have asked for 7 cell too.
If the egg donor is under 35 it's 1 but if I had my own I could put in up to 3.
What I fear is the embryos will not make it to blastocyst to freeze so this lil bean inside is my only chance and that is if this cycle is not flawed, the eggs have something wrong with them....

#5 kookacola

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Posted 17 December 2010 - 04:29 PM

aww sweetie, try not to worry, I know easier said than done:) I'm rootin for ya;)
married since 1996. '98 went to first ob and given clomid and written off at the door. '99 went to second ob and he did a lap and said if we weren't pg in 6 months referral to RFP. '00 went to RFP and re said she couldn't explain why we couldn't get pg but didn't investigate ether. '03 natural bfp and had m/c at 12 weeks. '04 went to another ob who was an re. he did iui, testing. '05 iui with letrazole-bfn. '06 iui and clomid and cancelled cycle and went in for surgery. Lap and hysteroscopy. did iui and injections and bfn. Referred to RFP again because re got us as far as he could and re said I had high fsh, lh and pof and pcos and endo, also suggested egg donation. If it weren't for him, we wouldn't have dd. went to RFP and were told ivf was not a good idea because I respond poorly to meds. ok, let's move onto d/e. Couldn't do d/e until we had a failed cycle under out belts with my eggs. '07 did ivf with my eggs, retrived 3 and 1 made it to transfer- chemical. So moved onto d/e. '09 went back to RFP again for the orientation and consult for d/e and cycled in April '09- 13 eggs retrieved and 4 made it to day 3. Two transferred and bgp with dd. Dd born on 01/01/10!!!! Were crown the New Years Baby!!!! '14 came back for consult and did fet in Nov which was a bfn sad.png we're out of embies and options. Meet re/ob in '15 to discuss options. Considering adoption.

#6 zoeoz

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Posted 17 December 2010 - 05:48 PM

Thanks, I am trying Kooka : )
Just like to make sense of all this embryo quality stuff since it seems like they stopped growing a few of them.

They said they will call Saterday day 5 if any make it to freeze but if not they do not call !
I sure hope for a call.

#7 LisainSK

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Posted 17 December 2010 - 06:04 PM

Tough decisions zoeoz...thinking of you. your gut will tell you what to do...
Me (33) and DH (35)....married 10 years (small town sweethearts)

December 2006: TTC # 1
May 2007: DH S/A...normal.
September 2007: BFP au naturelle...holy smokes!
November 2007: M/C # 1 @ 12 wk. DNC reveals a Partial Molar Pregnancy.
January 2009: Referral to local OB/GYN
April 2009: Dx Unexplained. Referral to Calgary RFP.
May 2009: Clomid Cycle # 1...BFN
June 2009: IUI # 1 w/ Clomid # 2 and HCG...BFN
July 2009: Clomid Cycle # 3...BFP! Happy but terrified of another m/c.
September 2009: Worst fears confirmed...M/C # 2 @ 8 weeks
October 2009: IVF Orientation at Calgary RFP and on wait list.
January 2010: Dx (Me) Abnormal Karyotype (Pericentric Inversion Chromosome 16)
March 2010: RFP Referral/Consultation with Reprogenetics in New Jersey
March/April 2010: PGD/IVF success odds very low...20% estimated "normal embryos" per cycle and a 41% pg rate
May 2010: Consult with Dr. Schoolcraft of Colorado Center for Reproductive Medicine
June 2010: One Day Work Up @ CCRM (Denver, CO)
June 2010: Predicted Low Responder (Low AFC and AMH). Inversion in difficult spot...We're doing Donor Eggs!!
July 2010: Discovery that I am also a carrier of Fragile X...my eggs didn't have a chance.
July 2010: Annonymous Egg Donor chosen through CCRM
August 2010: Mock FET Cycle completed.
DE IVF # 1
September 2010: Donor Eggs retrieved. Blastocysts to undergo PCR genetic screeing.
October 21, 2010: U/S showing 9.9 mm lining with triple stripe; E2 = 1600 and 1397 US units
November 1st, 2010: FET # 1 (Elective Single Embryo Transfer - eSET)
November 10th, 2010: Beta HCG # 1 = 82, P4 = 23.1 US units
November 12th, 2010: Beta HCG # 2 = 186! BFP!!
November 17th, 2010: Beta HCG # 3 = 1461
November 19th, 2010: Beta HCG # 4 = 3740
November 26th, 2010 U/S: hb = 120 bpm, measuring 6w1d, actual gestation is 6w2d since transfer, CRL = 3.8 mm
Dec. 10th, 2010 U/S: hb = 180 bpm, measuring 8w2d - exactly 8w2d since FET, CRL = 1.8 cm
February 18, 2011: Anatomy scan
EDD = July 20th, 2011

June 28th, 2011 @ 3:19 AM MTN: Levi Darrell John born at 36w6d at 6lbs 14oz and 18" long. He is precious beyond measure.

Visit my blog at:

http://wantedonegood...o.blogspot.com/

February 2012: Bye Bye IVF.ca community...you are the reason I got to where I am today. I am forever reached via pm as my email alerts me. Take care all...wishing you all peace in your hearts soon.

#8 Emily81

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Posted 17 December 2010 - 07:34 PM

Wishing you lots of luck! We had a 3 day transfer of two embies, we transferred in the afternoon and the embie that had been a 8 cell in the AM, was a 10 cell by the time we arrived at noon. We are pg with twins so even if we had transferred 1 it would of worked. Try to stay +!! FWIW- We had poor fert, and ended up with none to freeze but sometimes one is all it takes!

Me: 31, DH:34
? Mild PCOS/ Mild Male factor- Low Morph- 9%
TTC- Since Dec 2005

August/Sept 2009- IUI + injectabes cycle- BFN- was converted from IUI to IVF(20 follies growing) and then back to IUI(3 mature follies)....

IVF/ICSI cycle Sept/Oct 2010- BFP- (I insisisted on ICSI against my Drs wishes, and in the end we needed it)..
Oct 12- ER- 19 eggs, 15 mature, 6 fert
Oct 15- ET- morula- 18/20 & a 10 cell- 19/20 (Faith & Wish)
- OHSS starts 8dp3dt- Early beta in ER-636- 12dp3dt, #2- 4,267- 17dp3dt
Nov 23- 8 week u/s- TWINS
Incompetent Cervix diagnosed at 24 weeks. Hospital bedrest 24- 33 weeks due to 0.6 cm cervix, 1-2 cms dialated(at 24 weeks)
May 16th- 2011- Baby A breaks his water
May 18th- 2011- Boys arrive 33w1d
Baby A- CM- 4 lbs 4 oz, 17.5 in, 3:01 PM Baby B- CL- 4 lbs 2 oz, 16.5 in, 3:55 PM Lilypie Kids Birthday tickers


#9 zoeoz

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Posted 17 December 2010 - 07:51 PM

Thanks ladies, will wait and see if the phone rings...
Not many single embryo transfers ... ?

#10 Emily81

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Posted 17 December 2010 - 08:05 PM

Thanks ladies, will wait and see if the phone rings...
Not many single embryo transfers ... ?

If the gov't paid for it here I'd be all for an ESET. My clinic also has a lower sucess rate with FET's and that also factored into my decision. Wish the gov't would just pay for it here than we wouldn't have a choice!

Me: 31, DH:34
? Mild PCOS/ Mild Male factor- Low Morph- 9%
TTC- Since Dec 2005

August/Sept 2009- IUI + injectabes cycle- BFN- was converted from IUI to IVF(20 follies growing) and then back to IUI(3 mature follies)....

IVF/ICSI cycle Sept/Oct 2010- BFP- (I insisisted on ICSI against my Drs wishes, and in the end we needed it)..
Oct 12- ER- 19 eggs, 15 mature, 6 fert
Oct 15- ET- morula- 18/20 & a 10 cell- 19/20 (Faith & Wish)
- OHSS starts 8dp3dt- Early beta in ER-636- 12dp3dt, #2- 4,267- 17dp3dt
Nov 23- 8 week u/s- TWINS
Incompetent Cervix diagnosed at 24 weeks. Hospital bedrest 24- 33 weeks due to 0.6 cm cervix, 1-2 cms dialated(at 24 weeks)
May 16th- 2011- Baby A breaks his water
May 18th- 2011- Boys arrive 33w1d
Baby A- CM- 4 lbs 4 oz, 17.5 in, 3:01 PM Baby B- CL- 4 lbs 2 oz, 16.5 in, 3:55 PM Lilypie Kids Birthday tickers


#11 zoeoz

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Posted 17 December 2010 - 08:19 PM

Thanks ladies, will wait and see if the phone rings...
Not many single embryo transfers ... ?

Just my point of view, but if the gov't paid for it I'd be all for an ESET. However if I'm paying for it out of pocket I wanted to do all that I could, I didn't want any regrets so decided on two, whether 3 or 5 day transfer..I decided if I transferred two and got twins I would never regret transferring two. But if I had chosen to transfer one and didn't get pg I would always wonder what would have happend if I had transferred two...My clinic also has a lower sucess rate with FET's and that also factored into my decision. Wish the gov't would just pay for it here than we wouldn't have a choice!



The thing here is it's a donor cycle so not everything is paid for , the meds alone are over 1K after the insurance paid 65% of the bill.
Then you have donor fees and final cost so I feel like you do.
See we can't afford to go through this again for atleast 2 yesrs and were praying for extra embryos for atleast a FET but I am worried about that also since there was some slow growing.
I will still hope all works out, thanks : )

#12 zoeoz

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Posted 17 December 2010 - 08:23 PM

i really think it depends on the stats for your particular clinic. Statistics differ from clinic to clinic. It would also depend on the grading of the embryo (aside from cell count). It's great that your donor is 20! That certainly bodes well for good eggs.

My DH and I always thought that sET was something we would do. That is, until we realized that getting pregnant with IVF wasn't going to be as easy as we thought. Now, we're more likely to put back 3 than 1.

Good luck to you!

Wannakid


I thought my donor would produce more eggs also since all her tests were great !
Ya this is my 2nd try at a fresh cycle, I sure hope it works I am not getting younger...

#13 zoeoz

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Posted 18 December 2010 - 09:23 AM

None made it to blastocyst so I guess the one that's inside me won't either.

#14 mouse

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Posted 18 December 2010 - 09:43 AM

Crashing the thread to say that's not a given zoeoz.

Each egg and each sperm has an independent chance of 'taking' so even though having none go to blast in the lab is both scary and discouraging, you can't write off the one you transferred just yet. The one you transferred is presumably the 'pick of the litter' and has it's own unique genetic content; just 'cause the others couldn't sustain growth, doesn't automatically mean this one can't. There is a line of thought that embies might do better in their natural environment than in the petrie dish as well. I know it's hard to balance being realistic with hope (and trying to protect yourself), esp in the face of this perhaps suggestive but certainly not conclusive news, so I'll just say I'm still keeping fingers crossed for you and your embie.
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#15 Victoria

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Posted 18 December 2010 - 11:26 AM

It's unfortunate the other embryos didn't make it blast knowing that the donor is young. Hoping the day 3 transfer will work for you.:Emoticons09710: .
1st Clomid Cycle - Summer 2005, BFN/ 1st Monitored Natural Cyle - 2008, BFN/ 1st IVF - September 2008, BFN/ 2nd IVF - January 2009, BFN/ 1st IUI (medicated) - October 2009, BFN/; 1st Donor Egg Cycle Jan 2011, low beta - BFN; 1st FET - February 2011, BFN; Second DE cycle - July 2011, BFN. ON ROAD TO ADOPTION or SURROGACY - 2012 OR 2013
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#16 zoeoz

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Posted 18 December 2010 - 11:33 AM

Thanks mouse and Victoria,

I have to stop looking back and continue my meds now.
Need to find another way to try again that's not too expensive because I promised myself I would not be doing this at 45, that gives me 18 months to get pregnant and I know it's not likely.

#17 anytime now

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Posted 22 December 2010 - 05:02 PM

Hi Zoe

I agree completely with Mouse. I'm sad that you don't have any frozen embryos as a backup, but I do believe that a good 8 cell embryo has a good chance.
Hell, the chances of my getting pregnant with 4 embryos at 42 were for sure far less than yours at getting pregnant with a good quality embryo from a 20 year old.

I'll be crossing my fingers...
Do try to believe it's possible Zoe...if positive thinking can make any difference, then you might be doing something good :)

A.N.
Me: 44 (sigh) DB is 40 (Dear boyfriend!)

TTC from March 2009-March 2011 before DB had arrived on the scene
About 9 IUIs, 3 IVFs total

2 pregnancies with 7 week miscarriage requiring D&C
2 chemical pregnancies


April 2011 began a relationship now with a wonderful guy with an 8 year old son.
Sept 2011 Natural BFP while trying not to conceive (how ironic)
First Beta Day 15 from LMP was 851, Beta 4, 19 days post ovulation 5382
7wk US showed a heartbeat of 150! 9 wk US HB 185

May 19 2012 DS is born!!