We have been diagnosed with MFI but have done IVF with ICSI & all negatives. I do not seem to have any issues as to why implanation has not happened. My Husband's initial problem was sperm motility as most were not moving. He went to get a sperm antibody test done but they were unable to do it due to the lack of motility? So we still do not know if that was a concern.
Am I correct that by doing ICSI it would solve that ? Our Embryo's fertilized great but still not pregnancy.
Sperm antibodies
Started By
Riley22
, Sep 18 2010 03:39 PM
1 reply to this topic
#1
Riley22
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- Member
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- 121 posts
- Gender:Female
- Dx:Male Factor
Posted 18 September 2010 - 03:39 PM
ME- 35 DH-35
TTC since November 2006
5 Failed IUI's
MFI Poor Motility
October / November 09- Cancelled IVF just before retreival due to high progesterone
Jan / Feb 2010 IVF/ICSI -9 fertilized -transfered one perfect blast - BFN
March / April 2010 Natural FET - Transfered one blast- BFN
April 2010 Endo Biopsy done - No issues found
June 2010 Natural FET (2) 3 day Embryos BFN
September 2010 Natural FET- 2 Blasts - BFP! Beta 64 @ 7dp5dt
Second Beta 9dp5dt 210
First ultrasound showed TWINS
<a href="http://lilypie.com/"><img src="http://lmtm.lilypie....com/lq2Gm4.png" width="200" height="80" border="0" alt="Lilypie Maternity tickers" /></a>
TTC since November 2006
5 Failed IUI's
MFI Poor Motility
October / November 09- Cancelled IVF just before retreival due to high progesterone
Jan / Feb 2010 IVF/ICSI -9 fertilized -transfered one perfect blast - BFN
March / April 2010 Natural FET - Transfered one blast- BFN
April 2010 Endo Biopsy done - No issues found
June 2010 Natural FET (2) 3 day Embryos BFN
September 2010 Natural FET- 2 Blasts - BFP! Beta 64 @ 7dp5dt
Second Beta 9dp5dt 210
First ultrasound showed TWINS
<a href="http://lilypie.com/"><img src="http://lmtm.lilypie....com/lq2Gm4.png" width="200" height="80" border="0" alt="Lilypie Maternity tickers" /></a>
#2
Dr. Tamer Said
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- Scientific Advisor
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- 134 posts
- Gender:Male
- Dx:N/A
- My Clinic:ReproMed
Posted 21 September 2010 - 01:27 PM
Dear Riley:
There is an indirect approach that allows the detection of antisperm antibodies wthout relying on the sperm motility. However, there is no urgent need to conduct these tests since you are absolutely correct about the use of ICSI for management of cases with antisperm antibodies. ICSI has been shown to increase fertilization when compared to conventional IVF in cases of male immunologic infertility.
In similar cases with very low sperm motility, I would be interested in evaluating sperm morphology using the strict criteria to detect sperm tail problems. If needed, we can take it one step further and conduct electron microscopy on the sperm. Also, it is very important to look at the sperm viability. Are most of the sperm not moving and alive or not moving and dead? These results will help the embryologists develop an approach to choose the sperm with the highest fertilization potential during ICSI.
Best wishes.
There is an indirect approach that allows the detection of antisperm antibodies wthout relying on the sperm motility. However, there is no urgent need to conduct these tests since you are absolutely correct about the use of ICSI for management of cases with antisperm antibodies. ICSI has been shown to increase fertilization when compared to conventional IVF in cases of male immunologic infertility.
In similar cases with very low sperm motility, I would be interested in evaluating sperm morphology using the strict criteria to detect sperm tail problems. If needed, we can take it one step further and conduct electron microscopy on the sperm. Also, it is very important to look at the sperm viability. Are most of the sperm not moving and alive or not moving and dead? These results will help the embryologists develop an approach to choose the sperm with the highest fertilization potential during ICSI.
Best wishes.
Tamer M. Said, MD, PhD, HCLD(ABB)
Director, Andrology Laboratory & Reproductive Tissue Bank
The Toronto Institute for Reproductive Medicine - ReproMed
56 Aberfoyle Crescent, Suite 300
Toronto, ON M8X 2W4
Email: tsaid@repromed.ca
Director, Andrology Laboratory & Reproductive Tissue Bank
The Toronto Institute for Reproductive Medicine - ReproMed
56 Aberfoyle Crescent, Suite 300
Toronto, ON M8X 2W4
Email: tsaid@repromed.ca
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