I am on CoQ10 and DHEA as well. I thought I would post this info here on CoQ10 - I thought more people knew about this!
For women with DOR - diminished ovarian reserve (a.k.a. premature ovarian failure or pre-menopause or whatever you want to call it) - i.e. women with high FHS, CoQ10 has been shown to be quite beneficial.
I quote the abstract of the original article here:
CO-ENZYME Q10 SUPPLEMENTATION IMPROVES OVARIAN RESPONSE AND MITOCHONDRIAL FUNCTION IN AGED MICE.
Eliezer Burstein[F](1)(2), Alla Perumalsamy (2), Yaakov Bentov (1)(2),Navid Esfandiari (1), Andrea Jurisicova (2) and Robert F. Casper (1)(2).
(1) Toronto Center for Advanced Reproductive Technologies (TCART), (2) Samuel Lunenfeld Research Institute (SLRI).
Background and Objectives: Evidence exists that mitochondrial defects may in part be responsible for the decline in fertility as women age. Increased maternal age is accompanied by accumulation of mitochondrial DNA (mtDNA) mutations, changes in mitochondrial membrane potential (MMP) and overall metabolic activity of oocytes. As mitochondria are exclusively maternally inherited, alterations in their activity or abundance may severely compromise future embryo development. The objective of this study was to compare the effects of maternal treatment with CoQ10, resveratrol or R-alpha lipoic acid (ALA) on MMP, and reactive oxygen species (ROS) in oocytes from aged ICR mice and compare these parameters to placebo treated (aged control) or 10 week old (young) mice.
Methods: Retired breeder (8 month old) ICR female mice (n = 10 per group) were randomized to receive coQ10, resveratrol, R-ALA or vehicle alone for the period of 18 weeks. Upon completion of treatment, mice were subjected to hormonal stimulation and obtained oocytes were analyzed for mitochondrial localization, membrane potential (JC1) and accumulation of ROS (H2 DCFDA). The fluorescence of both dies was analyzed using a deconvolution microscope and the amount of fluorescence was recorded using the Delta Vision software package (Silicon Graphics). All obtained values were compared to oocytes obtained from young mice of identical genetic background.
Results: Compared to aged vehicle treated controls, CoQ10 treatment significantly improved the number of ovulated oocytes (11.7 vs 19.2) while R-ALA and resveratrol had no significant effect. In addition, mitochondrial membrane potential (JC 1 red to green ratio) as well as ROS levels were significantly affected by the treatment and reached levels comparable to those detected in the young oocytes. Neither of these parameters was affected by the maternal treatment with the resveratrol or R-ALA.
Conclusions: CoQ10 appears to improve ovarian response and mitochondrial function in old female ICR mice.
There is currently a clinical trial out of TCART for women 38+ where you either get put in the treatment (CoQ10) or placebo group (but you don't have a choice which and won't know it either). In compensation for participating in the trial, they cover the cost of the drugs (injectables for ovarian stimulation), but not other cost of the treatments.
I would also like to add that one should not count out alpha lipoic acid (one of the supplements used in the above study where they did not see an effect). In many other studies alpha lipoic acid was FAR more effective when used in conjunction with carnitine - 100 to 1000 times. Here it was used alone. It is possible, that like in many other organ systems, if they L-carnitine and alpha lipoic acid are used together they might be effective. (If you want more info on this, just let me know, I have researched this stuff extensively, this being my only hope!)
The dosage to take is 800 mg/day, preferable in 2 doses of 400 mg each. CoQ10 does not absorb well on its own, and should be taken with a fatty meal. I take it with my omega-3/salmon oil supplements as that is fat anyway. Vitamin B6 also helps its absorption.
Another option is to take the CoQ10 precursor "ubiquinol", which is water soluble and thus absorbs much better, so you only need half the dosage (i.e. 400 mg a day).
Lastly - where to get pills that have a lot of CoQ10 - assuming you don't want to eat a whole bottle of pills for breakfast (it would take 27 pills if each only contained only 30 mg! )
One option is to go order from www.iherb.com - they've got very good prices. I've ordered a bunch of stuff from them in the past and service has been good and quick. (note: make sure they ship via US Postal because courier companies will charge you upwards of $30 in brokerage fees in *addition* to duty while US Postal charges only $5 for brokerage.)
An online retailer in Canada that I've used is http://www.nationalnutrition.ca/
No duty and brokerage fee as they are in Canada. Again, shipping was quick and fast. Plus, if you order over $70 worth of products (or there abouts), shipping is free!
Another Canadian company is www.aor.ca
They have very high quality products, but tend to be on the pricey side. Their products are even more expensive if you buy them in the local natural/supplement stores (which will slap on 10-20% on the price tha AOR charges). I have bought stuff from them, but no free shipping unless you order something like $300 worth of products
My local nutrition/supplement store occasionally has these amazing sales where they beat or match the prices of these online sites.
There might be other good ones out there, these are just the ones I've found!
If you want to know where to get DHEA, just message me.
Any other questions, just ask!
P.S. I don't own stocks in any of these companies or receive any commission. (maybe I should though)
Me - POF. DH - Azo
4 year journey to this point, all bad news, all the time
SIL offers eggs, then changes her mind a week before her 1st appt with RE
First (commercial) egg donor fails at Lupron suppression check
2nd egg donor: 33 eggs, 27 mature, 14 fertilized
Jan 28/13 - 2 day 5 embryos transferred, 9 frozen
For this cycle: EB, GCSF, babyASA, dexa, etc.
Feb 8th; BFP on HPT
Day 17: 1st HCG 562, Day 20: 2nd HCG 1867, Day 24: 3rd HCG 6291
6w1d u/s: WE HAVE A HEARTBEAT!! 97!
9w2d u/s: 2.6cm, HR 179, everything looking good!